Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ATRX_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3 exons of zinc-finger genes (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
190 Pro Ala Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
192 Leu Phe Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
200 Cys Ser Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
220 Cys Arg Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
222 Trp Ser Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
243 Cys Phe Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
246 Arg Cys Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
249 Gly Asp Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
1609 His Arg Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
1614 Cys Arg Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
1650 Lys Asn Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
2035 Asp Val Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
2084 Tyr His Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
2131 Arg Gln Intellectualdisability-hypotonicfaciessyndrome,X-linked,1(MRXHF1) -
2163 Tyr Cys Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
246 Arg Leu Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
175 Gly Glu Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
179 Asn Ser Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
190 Pro Leu Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
190 Pro Ser Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
194 Val Ile Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
219 Gln Pro Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
249 Gly Cys Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
1552 Val Phe Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
1645 Leu Ser Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
1713 Pro Ser Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
1742 Arg Lys Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
1847 Tyr Cys Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
2050 Ile Thr Intellectualdisability-hypotonicfaciessyndrome,X-linked,1(MRXHF1) -
1621 Thr Met Alpha-thalassemia/intellectualdisabilitysyndrome,X-linked(ATRX) -
220 Cys Tyr Intellectualdisability-hypotonicfaciessyndrome,X-linked,1(MRXHF1) -
409 Leu Ser Intellectualdisability-hypotonicfaciessyndrome,X-linked,1(MRXHF1) -
2271 Arg Gly Intellectualdisability-hypotonicfaciessyndrome,X-linked,1(MRXHF1) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ATRX_HUMAN
GO:0017076 purine nucleotide binding 37.2093 4 yes
GO:0032555 purine ribonucleotide binding 37.2093 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 37.2093 4 yes
GO:0005524 ATP binding 34.8837 5 yes
GO:0030554 adenyl nucleotide binding 34.8837 5 yes
GO:0032559 adenyl ribonucleotide binding 34.8837 5 yes
GO:0003723 RNA binding 27.9070 4 no
GO:0046872 metal ion binding 23.2558 4 yes
GO:0003677 DNA binding 16.2791 4 yes
GO:0016462 pyrophosphatase activity 16.2791 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 16.2791 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 16.2791 6 yes
GO:0016887 ATP hydrolysis activity 13.9535 7 yes
GO:0035064 methylated histone binding 6.9767 4 yes
GO:0140034 methylation-dependent protein binding 6.9767 4 yes
GO:0070087 chromo shadow domain binding 4.6512 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ATRX_HUMAN
GO:0031323 regulation of cellular metabolic process 60.4651 4 yes
GO:0048522 positive regulation of cellular process 55.8140 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 55.8140 4 yes
GO:0060255 regulation of macromolecule metabolic process 55.8140 4 yes
GO:0080090 regulation of primary metabolic process 55.8140 4 yes
GO:0048523 negative regulation of cellular process 51.1628 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 46.5116 5 yes
GO:0009893 positive regulation of metabolic process 46.5116 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 46.5116 5 yes
GO:0031325 positive regulation of cellular metabolic process 44.1860 5 yes
GO:0051246 regulation of protein metabolic process 44.1860 5 yes
GO:0006996 organelle organization 44.1860 4 yes
GO:0051128 regulation of cellular component organization 41.8605 4 yes
GO:0010646 regulation of cell communication 41.8605 4 no
GO:0043412 macromolecule modification 37.2093 4 yes
GO:0008104 protein localization 37.2093 4 yes
GO:0009892 negative regulation of metabolic process 37.2093 4 yes
GO:0031324 negative regulation of cellular metabolic process 34.8837 5 yes
GO:0051247 positive regulation of protein metabolic process 34.8837 6 no
GO:0010605 negative regulation of macromolecule metabolic process 34.8837 5 yes
GO:0022607 cellular component assembly 34.8837 4 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 32.5581 5 yes
GO:0006796 phosphate-containing compound metabolic process 32.5581 4 no
GO:0009966 regulation of signal transduction 32.5581 4 no
GO:0036211 protein modification process 32.5581 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 32.5581 5 yes
GO:0031326 regulation of cellular biosynthetic process 30.2326 5 yes
GO:0031399 regulation of protein modification process 30.2326 6 yes
GO:0090304 nucleic acid metabolic process 30.2326 4 yes
GO:0009889 regulation of biosynthetic process 30.2326 4 yes
GO:0010468 regulation of gene expression 30.2326 5 yes
GO:0051252 regulation of RNA metabolic process 27.9070 5 yes
GO:0051726 regulation of cell cycle 27.9070 4 yes
GO:0010941 regulation of cell death 27.9070 4 no
GO:0009894 regulation of catabolic process 27.9070 4 no
GO:0031329 regulation of cellular catabolic process 27.9070 5 no
GO:0010556 regulation of macromolecule biosynthetic process 27.9070 5 yes
GO:0010564 regulation of cell cycle process 27.9070 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 25.5814 7 yes
GO:2001141 regulation of RNA biosynthetic process 25.5814 6 yes
GO:0019220 regulation of phosphate metabolic process 25.5814 6 no
GO:0051174 regulation of phosphorus metabolic process 25.5814 5 no
GO:0042981 regulation of apoptotic process 25.5814 6 no
GO:0043067 regulation of programmed cell death 25.5814 5 no
GO:0007010 cytoskeleton organization 25.5814 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 23.2558 6 yes
GO:0044271 cellular nitrogen compound biosynthetic process 23.2558 4 no
GO:0031401 positive regulation of protein modification process 23.2558 7 no
GO:0048584 positive regulation of response to stimulus 23.2558 4 no
GO:0045595 regulation of cell differentiation 23.2558 4 no
GO:0051248 negative regulation of protein metabolic process 23.2558 6 no
GO:0006355 regulation of DNA-templated transcription 23.2558 6 yes
GO:0009891 positive regulation of biosynthetic process 23.2558 5 yes
GO:0033043 regulation of organelle organization 20.9302 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 20.9302 6 yes
GO:0051130 positive regulation of cellular component organization 20.9302 5 yes
GO:0009059 macromolecule biosynthetic process 20.9302 4 no
GO:0071702 organic substance transport 20.9302 4 no
GO:0071705 nitrogen compound transport 20.9302 4 no
GO:0001932 regulation of protein phosphorylation 20.9302 7 no
GO:0006468 protein phosphorylation 20.9302 5 no
GO:0010647 positive regulation of cell communication 20.9302 5 no
GO:0016310 phosphorylation 20.9302 5 no
GO:0023056 positive regulation of signaling 20.9302 4 no
GO:0042325 regulation of phosphorylation 20.9302 7 no
GO:0060548 negative regulation of cell death 20.9302 5 no
GO:0009896 positive regulation of catabolic process 20.9302 5 no
GO:0030162 regulation of proteolysis 20.9302 6 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 20.9302 7 no
GO:0010557 positive regulation of macromolecule biosynthetic process 20.9302 6 yes
GO:0033365 protein localization to organelle 18.6047 5 yes
GO:0045893 positive regulation of DNA-templated transcription 18.6047 7 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 18.6047 8 yes
GO:0051254 positive regulation of RNA metabolic process 18.6047 6 yes
GO:1902680 positive regulation of RNA biosynthetic process 18.6047 7 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 18.6047 8 yes
GO:0006357 regulation of transcription by RNA polymerase II 18.6047 7 yes
GO:0006974 cellular response to DNA damage stimulus 18.6047 4 yes
GO:0043933 protein-containing complex organization 16.2791 4 yes
GO:0051052 regulation of DNA metabolic process 16.2791 5 yes
GO:1901699 cellular response to nitrogen compound 16.2791 4 yes
GO:0006259 DNA metabolic process 16.2791 4 yes
GO:0006281 DNA repair 16.2791 5 yes
GO:0031327 negative regulation of cellular biosynthetic process 13.9535 6 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 13.9535 6 yes
GO:0051054 positive regulation of DNA metabolic process 13.9535 6 yes
GO:0051129 negative regulation of cellular component organization 13.9535 5 yes
GO:0051253 negative regulation of RNA metabolic process 13.9535 6 yes
GO:0071241 cellular response to inorganic substance 13.9535 4 yes
GO:0009890 negative regulation of biosynthetic process 13.9535 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 13.9535 6 yes
GO:0051276 chromosome organization 11.6279 5 yes
GO:0065003 protein-containing complex assembly 11.6279 5 yes
GO:0010638 positive regulation of organelle organization 11.6279 6 yes
GO:0010639 negative regulation of organelle organization 11.6279 6 yes
GO:0032204 regulation of telomere maintenance 9.3023 6 yes
GO:0033044 regulation of chromosome organization 9.3023 6 yes
GO:0045786 negative regulation of cell cycle 9.3023 5 yes
GO:0045787 positive regulation of cell cycle 9.3023 5 yes
GO:0048232 male gamete generation 9.3023 4 yes
GO:0090068 positive regulation of cell cycle process 9.3023 6 yes
GO:1902679 negative regulation of RNA biosynthetic process 9.3023 7 yes
GO:1903507 negative regulation of nucleic acid-templated transcription 9.3023 8 yes
GO:0010948 negative regulation of cell cycle process 9.3023 6 yes
GO:0032206 positive regulation of telomere maintenance 6.9767 7 yes
GO:0042770 signal transduction in response to DNA damage 6.9767 4 yes
GO:0045892 negative regulation of DNA-templated transcription 6.9767 7 yes
GO:0072710 response to hydroxyurea 6.9767 4 yes
GO:0072711 cellular response to hydroxyurea 6.9767 5 yes
GO:2001251 negative regulation of chromosome organization 6.9767 7 yes
GO:2001252 positive regulation of chromosome organization 6.9767 7 yes
GO:0000122 negative regulation of transcription by RNA polymerase II 6.9767 8 yes
GO:0006275 regulation of DNA replication 6.9767 6 yes
GO:0006304 DNA modification 6.9767 5 yes
GO:0031056 regulation of histone modification 4.6512 7 yes
GO:0031060 regulation of histone methylation 4.6512 5 yes
GO:0031297 replication fork processing 4.6512 6 yes
GO:0033262 regulation of nuclear cell cycle DNA replication 4.6512 6 yes
GO:0034091 regulation of maintenance of sister chromatid cohesion 4.6512 7 yes
GO:0034092 negative regulation of maintenance of sister chromatid cohesion 4.6512 8 yes
GO:0034182 regulation of maintenance of mitotic sister chromatid cohesion 4.6512 8 yes
GO:0034183 negative regulation of maintenance of mitotic sister chromatid cohesion 4.6512 9 yes
GO:0034502 protein localization to chromosome 4.6512 6 yes
GO:0034728 nucleosome organization 4.6512 6 yes
GO:0035108 limb morphogenesis 4.6512 4 yes
GO:0035120 post-embryonic appendage morphogenesis 4.6512 4 yes
GO:0035127 post-embryonic limb morphogenesis 4.6512 5 yes
GO:0035128 post-embryonic forelimb morphogenesis 4.6512 6 yes
GO:0035136 forelimb morphogenesis 4.6512 5 yes
GO:0044728 DNA methylation or demethylation 4.6512 6 yes
GO:0045005 DNA-templated DNA replication maintenance of fidelity 4.6512 5 yes
GO:0045740 positive regulation of DNA replication 4.6512 7 yes
GO:0045875 negative regulation of sister chromatid cohesion 4.6512 7 yes
GO:0051570 regulation of histone H3-K9 methylation 4.6512 6 yes
GO:0065004 protein-DNA complex assembly 4.6512 6 yes
GO:0070198 protein localization to chromosome, telomeric region 4.6512 7 yes
GO:0071824 protein-DNA complex subunit organization 4.6512 5 yes
GO:0072331 signal transduction by p53 class mediator 4.6512 4 yes
GO:0072520 seminiferous tubule development 4.6512 4 yes
GO:0090329 regulation of DNA-templated DNA replication 4.6512 7 yes
GO:0140747 regulation of ncRNA transcription 4.6512 7 yes
GO:1900112 regulation of histone H3-K9 trimethylation 4.6512 7 yes
GO:1901580 regulation of telomeric RNA transcription from RNA pol II promoter 4.6512 8 yes
GO:1901581 negative regulation of telomeric RNA transcription from RNA pol II promoter 4.6512 9 yes
GO:1901582 positive regulation of telomeric RNA transcription from RNA pol II promoter 4.6512 9 yes
GO:1904907 regulation of maintenance of mitotic sister chromatid cohesion, telomeric 4.6512 9 yes
GO:1904908 negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric 4.6512 10 yes
GO:2000105 positive regulation of DNA-templated DNA replication 4.6512 8 yes
GO:0002064 epithelial cell development 4.6512 4 yes
GO:0006305 DNA alkylation 4.6512 6 yes
GO:0006306 DNA methylation 4.6512 4 yes
GO:0006325 chromatin organization 4.6512 4 yes
GO:0006334 nucleosome assembly 4.6512 7 yes
GO:0006338 chromatin remodeling 4.6512 5 yes
GO:0007063 regulation of sister chromatid cohesion 4.6512 6 yes
GO:0010571 positive regulation of nuclear cell cycle DNA replication 4.6512 7 yes
GO:0030330 DNA damage response, signal transduction by p53 class mediator 4.6512 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in ATRX_HUMAN
DOID:0110030 alpha thalassemia-X-linked intellectual disability syndrome 4.6512 8 yes
DOID:10241 thalassemia 4.6512 6 yes
DOID:1099 alpha thalassemia 4.6512 7 yes
DOID:2355 anemia 4.6512 3 yes
DOID:583 hemolytic anemia 4.6512 5 yes
DOID:720 normocytic anemia 4.6512 4 yes
DOID:0050686 organ system cancer 4.6512 3 no
DOID:6457 Cowden syndrome 4.6512 3 no
DOID:0050700 cardiomyopathy 4.6512 4 no
DOID:0060036 intrinsic cardiomyopathy 4.6512 5 no
DOID:114 heart disease 4.6512 3 no
DOID:2843 long QT syndrome 4.6512 6 no
DOID:331 central nervous system disease 4.6512 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
H31_HUMAN [view interactions] Low throughput no yes
RAD51_HUMAN [view interactions] Low throughput no yes
CTCF_HUMAN [view interactions] Low throughput no yes
ANDR_HUMAN [view interactions] Low throughput no no
ZBED1_HUMAN [view interactions] Low throughput no yes
BLM_HUMAN [view interactions] Low throughput no yes
P53_HUMAN [view interactions] Low throughput no no
PML_HUMAN [view interactions] Low throughput no yes
ZN274_HUMAN [view interactions] Low throughput no yes
TIF1B_HUMAN [view interactions] Low throughput no yes
SETB1_HUMAN [view interactions] Low throughput no yes
BMI1_HUMAN [view interactions] Low throughput no yes
MEN1_HUMAN [view interactions] Low throughput no yes
RFC1_HUMAN [view interactions] Low throughput no yes
FACD2_HUMAN [view interactions] Low throughput no no
BRD4_HUMAN [view interactions] Low throughput no yes
BRD9_HUMAN [view interactions] Low throughput no yes
NUCKS_HUMAN [view interactions] Low throughput no yes
IMP3_HUMAN [view interactions] Low throughput no no
ATRX_HUMAN [view entry] [view interactions] Low throughput yes yes
MCM4_HUMAN [view interactions] Low throughput no yes
MCM6_HUMAN [view interactions] Low throughput no yes
MCM2_HUMAN [view interactions] Low throughput no no
R51A1_HUMAN [view interactions] Low throughput no no
SLX9_HUMAN [view interactions] Low throughput no yes
NSD1_HUMAN [view interactions] Low throughput no yes
H32_HUMAN [view interactions] Low throughput no yes
WRN_HUMAN [view interactions] Low throughput no yes
RASF1_HUMAN [view interactions] Low throughput no yes
MDM2_HUMAN [view interactions] Low throughput no yes
H2AX_HUMAN [view interactions] Low throughput no yes
WWOX_HUMAN [view interactions] Low throughput no yes
MCM3_HUMAN [view interactions] Low throughput no no
CCD71_HUMAN [view interactions] Low throughput no no
SLF2_HUMAN [view interactions] Low throughput no yes
ZBTB4_HUMAN [view interactions] Low throughput no yes
ZFHX4_HUMAN [view interactions] Low throughput no yes
MECP2_HUMAN [view interactions] Low throughput no yes
H33_HUMAN [view interactions] Low throughput no yes
H2AY_HUMAN [view interactions] Low throughput no yes
EZH2_HUMAN [view interactions] Low throughput no no
DAXX_HUMAN [view interactions] Low throughput no yes
ANXA5_HUMAN [view entry] [view interactions] Low throughput yes no
CBX5_HUMAN [view interactions] Low throughput no yes
NBN_HUMAN [view interactions] Low throughput no yes
RAD50_HUMAN [view interactions] Low throughput no yes
MRE11_HUMAN [view interactions] Low throughput no yes
SMC1A_HUMAN [view interactions] Low throughput no yes
SMC3_HUMAN [view entry] [view interactions] Low throughput yes yes
HDAC4_HUMAN [view interactions] Low throughput no yes
PCNA_HUMAN [view interactions] Low throughput no no
CCSE2_HUMAN [view interactions] High throughput no yes
CE126_HUMAN [view interactions] High throughput no no
LC7L2_HUMAN [view interactions] High throughput no yes
PTN_HUMAN [view entry] [view interactions] High throughput yes yes
PTN4_HUMAN [view interactions] High throughput no no
PKCB1_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
FEV_HUMAN [view interactions] High throughput no no
HNF4A_HUMAN [view interactions] High throughput no no
DPOD1_HUMAN [view interactions] High throughput no yes
DDX20_HUMAN [view interactions] High throughput no no
E2AK1_HUMAN [view interactions] High throughput no yes
AP3B1_HUMAN [view entry] [view interactions] High throughput yes yes
MFAP1_HUMAN [view interactions] High throughput no yes
NAF1_HUMAN [view interactions] High throughput no yes
EAF1_HUMAN [view interactions] High throughput no yes
RBM14_HUMAN [view interactions] High throughput no yes
SVIL_HUMAN [view interactions] High throughput no yes
CBP_HUMAN [view interactions] High throughput no yes
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
XRCC5_HUMAN [view interactions] High throughput no yes
XRCC6_HUMAN [view interactions] High throughput no yes
SSRP1_HUMAN [view interactions] High throughput no yes
H4_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
H12_HUMAN [view interactions] High throughput no yes
RAD9A_HUMAN [view interactions] High throughput no yes
H2B1L_HUMAN [view interactions] High throughput no yes
H2A1B_HUMAN [view interactions] High throughput no yes
RAD1_HUMAN [view interactions] High throughput no yes
LAP2A_HUMAN [view interactions] High throughput no yes
CHD1_HUMAN [view interactions] High throughput no yes
ELOC_HUMAN [view interactions] High throughput no no
TOP2B_HUMAN [view interactions] High throughput no yes
BRWD1_HUMAN [view interactions] High throughput no yes
ING5_HUMAN [view interactions] High throughput no yes
WDR1_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
CDX2_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
ANO7_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
PRC1_HUMAN [view interactions] High throughput no yes
GID8_HUMAN [view interactions] High throughput no yes
HAT1_HUMAN [view interactions] High throughput no yes
TONSL_HUMAN [view interactions] High throughput no no
SPIN3_HUMAN [view interactions] High throughput no yes
MKRN2_HUMAN [view interactions] High throughput no yes
ING1_HUMAN [view interactions] High throughput no yes
TCPQM_HUMAN [view interactions] High throughput no no
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
THB_HUMAN [view interactions] High throughput no no
SIR6_HUMAN [view interactions] High throughput no yes
CDC27_HUMAN [view interactions] High throughput no yes
TCRG1_HUMAN [view interactions] High throughput no yes
SPT5H_HUMAN [view interactions] High throughput no yes
WRIP1_HUMAN [view interactions] High throughput no yes
ADNP_HUMAN [view interactions] High throughput no yes
PHC1_HUMAN [view interactions] High throughput no yes
NOP56_HUMAN [view interactions] High throughput no yes
ZBT21_HUMAN [view interactions] High throughput no yes
RBM39_HUMAN [view interactions] High throughput no yes
RB6I2_HUMAN [view entry] [view interactions] High throughput yes yes
SETD2_HUMAN [view interactions] High throughput no yes
THAP4_HUMAN [view interactions] High throughput no yes
YBOX3_HUMAN [view interactions] High throughput no yes
SMC2_HUMAN [view interactions] High throughput no yes
ABLM3_HUMAN [view entry] [view interactions] High throughput yes yes
MCM7_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
LMNB1_HUMAN [view entry] [view interactions] High throughput yes yes
PPLA_HUMAN [view interactions] High throughput no no
RIR2_HUMAN [view interactions] High throughput no no
STX18_HUMAN [view interactions] High throughput no yes
PMYT1_HUMAN [view interactions] High throughput no no
BOREA_HUMAN [view interactions] High throughput no yes
WDR33_HUMAN [view interactions] High throughput no yes
WEE1_HUMAN [view interactions] High throughput no yes
IF2G_HUMAN [view interactions] High throughput no yes
SYIM_HUMAN [view entry] [view interactions] High throughput yes yes
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3B_HUMAN [view interactions] High throughput no yes
PGTA_HUMAN [view interactions] High throughput no yes
SG196_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1B_HUMAN [view entry] [view interactions] High throughput yes yes
CABIN_HUMAN [view interactions] High throughput no yes
ASF1A_HUMAN [view interactions] High throughput no no
MCES_HUMAN [view interactions] High throughput no yes
NUDC3_HUMAN [view interactions] High throughput no yes
SKA3_HUMAN [view interactions] High throughput no no
VATB2_HUMAN [view entry] [view interactions] High throughput yes yes
RL7A_HUMAN [view entry] [view interactions] High throughput yes no
TIPIN_HUMAN [view interactions] High throughput no no
PSA2_HUMAN [view interactions] High throughput no yes
CSTF1_HUMAN [view interactions] High throughput no yes
DLRB1_HUMAN [view entry] [view interactions] High throughput yes no
TRA2B_HUMAN [view interactions] High throughput no yes
TOPB1_HUMAN [view interactions] High throughput no yes
DDX46_HUMAN [view interactions] High throughput no yes
RBM27_HUMAN [view interactions] High throughput no yes
CENPN_HUMAN [view interactions] High throughput no no
PSMG4_HUMAN [view interactions] High throughput no yes
DBR1_HUMAN [view interactions] High throughput no no
XKR2_HUMAN [view interactions] High throughput no no
SMC5_HUMAN [view interactions] High throughput no yes
ESS2_HUMAN [view interactions] High throughput no yes
SMC6_HUMAN [view interactions] High throughput no no
BT3L4_HUMAN [view interactions] High throughput no yes
SMN_HUMAN [view interactions] High throughput no yes
SMRD1_HUMAN [view interactions] High throughput no yes
CF015_HUMAN [view interactions] High throughput no no
TPPC4_HUMAN [view entry] [view interactions] High throughput yes yes
IL1R2_HUMAN [view interactions] High throughput no no
PDZD7_HUMAN [view interactions] High throughput no no
UB2J1_HUMAN [view interactions] High throughput no yes
RTRAF_HUMAN [view interactions] High throughput no yes
CDK12_HUMAN [view interactions] High throughput no yes
TBB5_HUMAN [view interactions] High throughput no yes
RGPD5_HUMAN [view interactions] High throughput no no
COASY_HUMAN [view entry] [view interactions] High throughput yes yes
FNTB_HUMAN [view interactions] High throughput no no
GCP6_HUMAN [view interactions] High throughput no yes
ZAP70_HUMAN [view interactions] High throughput no no
CSTF3_HUMAN [view interactions] High throughput no yes
SPRNG_HUMAN [view interactions] High throughput no yes
SUMO2_HUMAN [view interactions] High throughput no yes
AURKA_HUMAN [view entry] [view interactions] High throughput yes no
NSD2_HUMAN [view interactions] High throughput no yes
DNJC8_HUMAN [view interactions] High throughput no yes
CBX3_HUMAN [view interactions] High throughput no yes
CENPA_HUMAN [view interactions] High throughput no no
H2B1C_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
CENPC_HUMAN [view interactions] High throughput no no
MORC2_HUMAN [view interactions] High throughput no yes
ZMAT2_HUMAN [view interactions] High throughput no yes
SENP6_HUMAN [view interactions] High throughput no yes
P66B_HUMAN [view interactions] High throughput no yes
P66A_HUMAN [view interactions] High throughput no yes
T2FA_HUMAN [view interactions] High throughput no yes
MTA2_HUMAN [view interactions] High throughput no yes
MBD3_HUMAN [view interactions] High throughput no yes
CFDP1_HUMAN [view interactions] High throughput no yes
MTA1_HUMAN [view interactions] High throughput no yes
CATIN_HUMAN [view interactions] High throughput no yes
PAF1_HUMAN [view interactions] High throughput no yes
HXD13_HUMAN [view interactions] High throughput no no
DOT1L_HUMAN [view interactions] High throughput no yes
AP2A_HUMAN [view interactions] High throughput no no
SALL1_HUMAN [view interactions] High throughput no yes
ZN687_HUMAN [view interactions] High throughput no yes
LRIF1_HUMAN [view interactions] High throughput no yes
ZMYM2_HUMAN [view interactions] High throughput no yes
FUBP1_HUMAN [view interactions] High throughput no yes
ZN281_HUMAN [view interactions] High throughput no no
ZN592_HUMAN [view interactions] High throughput no yes
NEK1_HUMAN [view interactions] High throughput no yes
Z512B_HUMAN [view interactions] High throughput no yes
IFIX_HUMAN [view interactions] High throughput no no
MD2L2_HUMAN [view interactions] High throughput no yes
CNOT1_HUMAN [view interactions] High throughput no yes
CBX1_HUMAN [view interactions] High throughput no yes
CAF1A_HUMAN [view interactions] High throughput no yes
JADE3_HUMAN [view interactions] High throughput no no
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
CBX4_HUMAN [view interactions] High throughput no yes
PHIP_HUMAN [view interactions] High throughput no yes
NS1BP_HUMAN [view interactions] High throughput no yes
WDR76_HUMAN [view interactions] High throughput no no
RBX1_HUMAN [view entry] [view interactions] High throughput yes no
ORC1_HUMAN [view interactions] High throughput no yes
PWP2_HUMAN [view interactions] High throughput no no
H2B2E_HUMAN [view interactions] High throughput no yes
KAT7_HUMAN [view interactions] High throughput no yes
DPY30_HUMAN [view interactions] High throughput no yes
UBF1_HUMAN [view interactions] High throughput no yes
SP16H_HUMAN [view interactions] High throughput no yes
TOP2A_HUMAN [view interactions] High throughput no no
CUL4A_HUMAN [view interactions] High throughput no no
SRP72_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
NOMO1_HUMAN [view entry] [view interactions] High throughput yes yes
RRBP1_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
IF4A2_HUMAN [view entry] [view interactions] High throughput yes yes
SNW1_HUMAN [view interactions] High throughput no yes
HMGB1_HUMAN [view interactions] High throughput no yes
ARI4A_HUMAN [view interactions] Computational no no
MUS81_HUMAN [view interactions] Computational no no
H31T_HUMAN [view interactions] Computational no yes
RSF1_HUMAN [view interactions] Computational no yes
XRCC3_HUMAN [view interactions] Computational no no
PININ_HUMAN [view interactions] Computational no yes
NKTR_HUMAN [view interactions] Computational no no
H2A2C_HUMAN [view interactions] Computational no yes
NIPBL_HUMAN [view interactions] Computational no yes
H3C_HUMAN [view interactions] Computational no yes
IDHC_HUMAN [view interactions] Computational no no
RAD52_HUMAN [view interactions] Computational no no
TPR_HUMAN [view interactions] Computational no yes
BDP1_HUMAN [view interactions] Computational no no
STAG2_HUMAN [view interactions] Computational no yes
SCAFB_HUMAN [view interactions] Computational no yes
BPTF_HUMAN [view interactions] Computational no yes
H37_HUMAN [view interactions] Computational no no