ATRX_HUMAN
Evidence for PS localization
Functions
Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3 exons of zinc-finger genes (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ATRX_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 38.7755 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 38.7755 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 36.7347 | 6 | yes |
| GO:0032555 | purine ribonucleotide binding | 36.7347 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 36.7347 | 4 | yes |
| GO:0043168 | anion binding | 36.7347 | 4 | yes |
| GO:0005524 | ATP binding | 34.6939 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 34.6939 | 5 | yes |
| GO:0003723 | RNA binding | 28.5714 | 4 | no |
| GO:0043169 | cation binding | 22.4490 | 4 | yes |
| GO:0046872 | metal ion binding | 22.4490 | 5 | yes |
| GO:0016301 | kinase activity | 20.4082 | 4 | no |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 20.4082 | 4 | no |
| GO:0003677 | DNA binding | 14.2857 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 14.2857 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 14.2857 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 14.2857 | 6 | yes |
| GO:0016887 | ATP hydrolysis activity | 12.2449 | 7 | yes |
| GO:0035064 | methylated histone binding | 6.1224 | 4 | yes |
| GO:0140034 | methylation-dependent protein binding | 6.1224 | 4 | yes |
| GO:0031490 | chromatin DNA binding | 4.0816 | 4 | yes |
| GO:0070087 | chromo shadow domain binding | 4.0816 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ATRX_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 59.1837 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 57.1429 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 57.1429 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 53.0612 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 48.9796 | 4 | yes |
| GO:0006996 | organelle organization | 44.8980 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 44.8980 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 44.8980 | 5 | yes |
| GO:0010646 | regulation of cell communication | 44.8980 | 4 | no |
| GO:0008104 | protein localization | 42.8571 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 42.8571 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 40.8163 | 4 | yes |
| GO:0010468 | regulation of gene expression | 40.8163 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.8163 | 5 | yes |
| GO:0022607 | cellular component assembly | 40.8163 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 40.8163 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 38.7755 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 38.7755 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 38.7755 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 36.7347 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 36.7347 | 4 | no |
| GO:0036211 | protein modification process | 36.7347 | 4 | no |
| GO:0043412 | macromolecule modification | 36.7347 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 34.6939 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 34.6939 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 32.6531 | 5 | yes |
| GO:0051726 | regulation of cell cycle | 30.6122 | 4 | yes |
| GO:0090304 | nucleic acid metabolic process | 30.6122 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 30.6122 | 4 | no |
| GO:0009894 | regulation of catabolic process | 30.6122 | 4 | no |
| GO:0010564 | regulation of cell cycle process | 28.5714 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 28.5714 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 28.5714 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.5306 | 7 | yes |
| GO:0007010 | cytoskeleton organization | 26.5306 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 26.5306 | 5 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 26.5306 | 6 | yes |
| GO:0010647 | positive regulation of cell communication | 26.5306 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.5306 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.5306 | 5 | no |
| GO:0009059 | macromolecule biosynthetic process | 24.4898 | 4 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 24.4898 | 5 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 24.4898 | 6 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 24.4898 | 6 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 24.4898 | 6 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 24.4898 | 6 | yes |
| GO:0009896 | positive regulation of catabolic process | 24.4898 | 5 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 22.4490 | 8 | yes |
| GO:0006974 | DNA damage response | 22.4490 | 4 | yes |
| GO:0010629 | negative regulation of gene expression | 22.4490 | 7 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 22.4490 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 22.4490 | 5 | no |
| GO:0016310 | phosphorylation | 22.4490 | 5 | no |
| GO:0030162 | regulation of proteolysis | 22.4490 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.4490 | 4 | no |
| GO:1903050 | regulation of proteolysis involved in protein catabolic process | 22.4490 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.4490 | 6 | no |
| GO:0031399 | regulation of protein modification process | 22.4490 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.4490 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 22.4490 | 4 | no |
| GO:0006259 | DNA metabolic process | 20.4082 | 5 | yes |
| GO:0006281 | DNA repair | 20.4082 | 5 | yes |
| GO:0016070 | RNA metabolic process | 20.4082 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 20.4082 | 5 | yes |
| GO:0033365 | protein localization to organelle | 20.4082 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 20.4082 | 4 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 20.4082 | 8 | yes |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 20.4082 | 9 | yes |
| GO:0051130 | positive regulation of cellular component organization | 20.4082 | 5 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 20.4082 | 6 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 20.4082 | 7 | yes |
| GO:0006468 | protein phosphorylation | 20.4082 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 20.4082 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 20.4082 | 5 | no |
| GO:0018193 | peptidyl-amino acid modification | 20.4082 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.4082 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 20.4082 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 20.4082 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 20.4082 | 6 | no |
| GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | 20.4082 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 20.4082 | 7 | no |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 16.3265 | 4 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 16.3265 | 4 | yes |
| GO:0051052 | regulation of DNA metabolic process | 14.2857 | 5 | yes |
| GO:0065003 | protein-containing complex assembly | 14.2857 | 5 | yes |
| GO:0141187 | nucleic acid biosynthetic process | 14.2857 | 5 | yes |
| GO:1901699 | cellular response to nitrogen compound | 14.2857 | 4 | yes |
| GO:0006351 | DNA-templated transcription | 12.2449 | 6 | yes |
| GO:0006366 | transcription by RNA polymerase II | 12.2449 | 7 | yes |
| GO:0032774 | RNA biosynthetic process | 12.2449 | 5 | yes |
| GO:0051054 | positive regulation of DNA metabolic process | 12.2449 | 6 | yes |
| GO:0051129 | negative regulation of cellular component organization | 12.2449 | 5 | yes |
| GO:0010638 | positive regulation of organelle organization | 10.2041 | 6 | yes |
| GO:0010948 | negative regulation of cell cycle process | 10.2041 | 6 | yes |
| GO:0033044 | regulation of chromosome organization | 10.2041 | 6 | yes |
| GO:0045786 | negative regulation of cell cycle | 10.2041 | 5 | yes |
| GO:0045787 | positive regulation of cell cycle | 10.2041 | 5 | yes |
| GO:0048232 | male gamete generation | 10.2041 | 4 | yes |
| GO:0051276 | chromosome organization | 10.2041 | 5 | yes |
| GO:0071241 | cellular response to inorganic substance | 10.2041 | 4 | yes |
| GO:0090068 | positive regulation of cell cycle process | 10.2041 | 6 | yes |
| GO:0010639 | negative regulation of organelle organization | 8.1633 | 6 | yes |
| GO:0032204 | regulation of telomere maintenance | 8.1633 | 6 | yes |
| GO:0042770 | signal transduction in response to DNA damage | 8.1633 | 4 | yes |
| GO:0006275 | regulation of DNA replication | 6.1224 | 6 | yes |
| GO:0006325 | chromatin organization | 6.1224 | 6 | yes |
| GO:0006338 | chromatin remodeling | 6.1224 | 7 | yes |
| GO:0030330 | DNA damage response, signal transduction by p53 class mediator | 6.1224 | 5 | yes |
| GO:0031297 | replication fork processing | 6.1224 | 7 | yes |
| GO:0031507 | heterochromatin formation | 6.1224 | 9 | yes |
| GO:0032206 | positive regulation of telomere maintenance | 6.1224 | 7 | yes |
| GO:0034502 | protein localization to chromosome | 6.1224 | 6 | yes |
| GO:0040029 | epigenetic regulation of gene expression | 6.1224 | 7 | yes |
| GO:0045005 | DNA-templated DNA replication maintenance of fidelity | 6.1224 | 6 | yes |
| GO:0045814 | negative regulation of gene expression, epigenetic | 6.1224 | 8 | yes |
| GO:0071824 | protein-DNA complex organization | 6.1224 | 5 | yes |
| GO:0072331 | signal transduction by p53 class mediator | 6.1224 | 4 | yes |
| GO:2001251 | negative regulation of chromosome organization | 6.1224 | 7 | yes |
| GO:2001252 | positive regulation of chromosome organization | 6.1224 | 7 | yes |
| GO:0002064 | epithelial cell development | 4.0816 | 4 | yes |
| GO:0006334 | nucleosome assembly | 4.0816 | 7 | yes |
| GO:0007063 | regulation of sister chromatid cohesion | 4.0816 | 6 | yes |
| GO:0010571 | positive regulation of nuclear cell cycle DNA replication | 4.0816 | 7 | yes |
| GO:0031509 | subtelomeric heterochromatin formation | 4.0816 | 11 | yes |
| GO:0033262 | regulation of nuclear cell cycle DNA replication | 4.0816 | 6 | yes |
| GO:0034091 | regulation of maintenance of sister chromatid cohesion | 4.0816 | 7 | yes |
| GO:0034092 | negative regulation of maintenance of sister chromatid cohesion | 4.0816 | 8 | yes |
| GO:0034182 | regulation of maintenance of mitotic sister chromatid cohesion | 4.0816 | 8 | yes |
| GO:0034183 | negative regulation of maintenance of mitotic sister chromatid cohesion | 4.0816 | 9 | yes |
| GO:0034728 | nucleosome organization | 4.0816 | 8 | yes |
| GO:0035108 | limb morphogenesis | 4.0816 | 4 | yes |
| GO:0035120 | post-embryonic appendage morphogenesis | 4.0816 | 4 | yes |
| GO:0035127 | post-embryonic limb morphogenesis | 4.0816 | 5 | yes |
| GO:0035128 | post-embryonic forelimb morphogenesis | 4.0816 | 6 | yes |
| GO:0035136 | forelimb morphogenesis | 4.0816 | 5 | yes |
| GO:0045740 | positive regulation of DNA replication | 4.0816 | 7 | yes |
| GO:0045875 | negative regulation of sister chromatid cohesion | 4.0816 | 7 | yes |
| GO:0065004 | protein-DNA complex assembly | 4.0816 | 6 | yes |
| GO:0070198 | protein localization to chromosome, telomeric region | 4.0816 | 7 | yes |
| GO:0072520 | seminiferous tubule development | 4.0816 | 4 | yes |
| GO:0072710 | response to hydroxyurea | 4.0816 | 4 | yes |
| GO:0072711 | cellular response to hydroxyurea | 4.0816 | 5 | yes |
| GO:0090329 | regulation of DNA-templated DNA replication | 4.0816 | 7 | yes |
| GO:0140719 | constitutive heterochromatin formation | 4.0816 | 10 | yes |
| GO:1904907 | regulation of maintenance of mitotic sister chromatid cohesion, telomeric | 4.0816 | 9 | yes |
| GO:1904908 | negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric | 4.0816 | 10 | yes |
| GO:2000105 | positive regulation of DNA-templated DNA replication | 4.0816 | 8 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SMC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SMC1A_HUMAN | [view interactions] | Low throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | Low throughput | no | yes |
| PCNA_HUMAN | [view interactions] | Low throughput | no | no |
| H31_HUMAN | [view interactions] | Low throughput | no | yes |
| RAD51_HUMAN | [view interactions] | Low throughput | no | yes |
| CTCF_HUMAN | [view interactions] | Low throughput | no | yes |
| ANDR_HUMAN | [view interactions] | Low throughput | no | no |
| ZBED1_HUMAN | [view interactions] | Low throughput | no | yes |
| BLM_HUMAN | [view interactions] | Low throughput | no | yes |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| PML_HUMAN | [view interactions] | Low throughput | no | yes |
| ZN274_HUMAN | [view interactions] | Low throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | Low throughput | no | yes |
| SETB1_HUMAN | [view interactions] | Low throughput | no | yes |
| BMI1_HUMAN | [view interactions] | Low throughput | no | yes |
| MEN1_HUMAN | [view interactions] | Low throughput | no | yes |
| RFC1_HUMAN | [view interactions] | Low throughput | no | yes |
| FACD2_HUMAN | [view interactions] | Low throughput | no | no |
| BRD4_HUMAN | [view interactions] | Low throughput | no | yes |
| BRD9_HUMAN | [view interactions] | Low throughput | no | yes |
| NUCKS_HUMAN | [view interactions] | Low throughput | no | yes |
| IMP3_HUMAN | [view interactions] | Low throughput | no | no |
| ATRX_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MCM4_HUMAN | [view interactions] | Low throughput | no | yes |
| MCM6_HUMAN | [view interactions] | Low throughput | no | yes |
| MCM2_HUMAN | [view interactions] | Low throughput | no | no |
| R51A1_HUMAN | [view interactions] | Low throughput | no | no |
| SLX9_HUMAN | [view interactions] | Low throughput | no | yes |
| NSD1_HUMAN | [view interactions] | Low throughput | no | yes |
| H32_HUMAN | [view interactions] | Low throughput | no | yes |
| WRN_HUMAN | [view interactions] | Low throughput | no | yes |
| RASF1_HUMAN | [view interactions] | Low throughput | no | yes |
| MDM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| H2AX_HUMAN | [view interactions] | Low throughput | no | yes |
| WWOX_HUMAN | [view interactions] | Low throughput | no | yes |
| MCM3_HUMAN | [view interactions] | Low throughput | no | no |
| CCD71_HUMAN | [view interactions] | Low throughput | no | no |
| SLF2_HUMAN | [view interactions] | Low throughput | no | yes |
| ZBTB4_HUMAN | [view interactions] | Low throughput | no | yes |
| ZFHX4_HUMAN | [view interactions] | Low throughput | no | yes |
| MECP2_HUMAN | [view interactions] | Low throughput | no | yes |
| H33_HUMAN | [view interactions] | Low throughput | no | yes |
| H2AY_HUMAN | [view interactions] | Low throughput | no | yes |
| EZH2_HUMAN | [view interactions] | Low throughput | no | no |
| DAXX_HUMAN | [view interactions] | Low throughput | no | yes |
| ANXA5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CBX5_HUMAN | [view interactions] | Low throughput | no | yes |
| RAD50_HUMAN | [view interactions] | Low throughput | no | yes |
| MRE11_HUMAN | [view interactions] | Low throughput | no | yes |
| NBN_HUMAN | [view interactions] | Low throughput | no | yes |
| HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
| CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
| CCSE2_HUMAN | [view interactions] | High throughput | no | yes |
| CE126_HUMAN | [view interactions] | High throughput | no | no |
| LC7L2_HUMAN | [view interactions] | High throughput | no | yes |
| PTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN4_HUMAN | [view interactions] | High throughput | no | no |
| ZMYD8_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DSCAM_HUMAN | [view interactions] | High throughput | no | yes |
| RBM11_HUMAN | [view interactions] | High throughput | no | no |
| CBS_HUMAN | [view interactions] | High throughput | no | yes |
| CLIC6_HUMAN | [view interactions] | High throughput | no | no |
| FEV_HUMAN | [view interactions] | High throughput | no | no |
| HNF4A_HUMAN | [view interactions] | High throughput | no | no |
| DPOD1_HUMAN | [view interactions] | High throughput | no | yes |
| AP3B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E2AK1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX20_HUMAN | [view interactions] | High throughput | no | no |
| MFAP1_HUMAN | [view interactions] | High throughput | no | yes |
| NAF1_HUMAN | [view interactions] | High throughput | no | yes |
| EAF1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| SVIL_HUMAN | [view interactions] | High throughput | no | yes |
| CBP_HUMAN | [view interactions] | High throughput | no | yes |
| PRKDC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XRCC5_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| SSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| RAD9A_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1L_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1B_HUMAN | [view interactions] | High throughput | no | yes |
| RAD1_HUMAN | [view interactions] | High throughput | no | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| CHD1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOC_HUMAN | [view interactions] | High throughput | no | no |
| TOP2B_HUMAN | [view interactions] | High throughput | no | yes |
| BRWD1_HUMAN | [view interactions] | High throughput | no | yes |
| ING5_HUMAN | [view interactions] | High throughput | no | yes |
| WDR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDX2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANO7_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| GID8_HUMAN | [view interactions] | High throughput | no | yes |
| HAT1_HUMAN | [view interactions] | High throughput | no | yes |
| TONSL_HUMAN | [view interactions] | High throughput | no | no |
| SPIN3_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| ING1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPQM_HUMAN | [view interactions] | High throughput | no | no |
| E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THB_HUMAN | [view interactions] | High throughput | no | no |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| CDC27_HUMAN | [view interactions] | High throughput | no | yes |
| TCRG1_HUMAN | [view interactions] | High throughput | no | yes |
| SPT5H_HUMAN | [view interactions] | High throughput | no | yes |
| WRIP1_HUMAN | [view interactions] | High throughput | no | yes |
| ADNP_HUMAN | [view interactions] | High throughput | no | yes |
| PHC1_HUMAN | [view interactions] | High throughput | no | yes |
| NOP56_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT21_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| RB6I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SETD2_HUMAN | [view interactions] | High throughput | no | yes |
| THAP4_HUMAN | [view interactions] | High throughput | no | yes |
| YBOX3_HUMAN | [view interactions] | High throughput | no | yes |
| SMC2_HUMAN | [view interactions] | High throughput | no | yes |
| ABLM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| CBX3_HUMAN | [view interactions] | High throughput | no | yes |
| BCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMC5_HUMAN | [view interactions] | High throughput | no | yes |
| KAT6A_HUMAN | [view interactions] | High throughput | no | yes |
| PPLA_HUMAN | [view interactions] | High throughput | no | no |
| RIR2_HUMAN | [view interactions] | High throughput | no | no |
| STX18_HUMAN | [view interactions] | High throughput | no | yes |
| PMYT1_HUMAN | [view interactions] | High throughput | no | no |
| BOREA_HUMAN | [view interactions] | High throughput | no | yes |
| WDR33_HUMAN | [view interactions] | High throughput | no | yes |
| WEE1_HUMAN | [view interactions] | High throughput | no | yes |
| IF2G_HUMAN | [view interactions] | High throughput | no | yes |
| SYIM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3B_HUMAN | [view interactions] | High throughput | no | yes |
| PGTA_HUMAN | [view interactions] | High throughput | no | yes |
| SG196_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CABIN_HUMAN | [view interactions] | High throughput | no | yes |
| ASF1A_HUMAN | [view interactions] | High throughput | no | no |
| MCES_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC3_HUMAN | [view interactions] | High throughput | no | yes |
| SKA3_HUMAN | [view interactions] | High throughput | no | no |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TIPIN_HUMAN | [view interactions] | High throughput | no | no |
| PSA2_HUMAN | [view interactions] | High throughput | no | yes |
| CSTF1_HUMAN | [view interactions] | High throughput | no | yes |
| DLRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRA2B_HUMAN | [view interactions] | High throughput | no | yes |
| TOPB1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX46_HUMAN | [view interactions] | High throughput | no | yes |
| RBM27_HUMAN | [view interactions] | High throughput | no | yes |
| CENPN_HUMAN | [view interactions] | High throughput | no | no |
| PSMG4_HUMAN | [view interactions] | High throughput | no | yes |
| DBR1_HUMAN | [view interactions] | High throughput | no | no |
| XKR2_HUMAN | [view interactions] | High throughput | no | no |
| ESS2_HUMAN | [view interactions] | High throughput | no | yes |
| SMC6_HUMAN | [view interactions] | High throughput | no | no |
| BT3L4_HUMAN | [view interactions] | High throughput | no | yes |
| SMN_HUMAN | [view interactions] | High throughput | no | yes |
| SMRD1_HUMAN | [view interactions] | High throughput | no | yes |
| CF015_HUMAN | [view interactions] | High throughput | no | no |
| TPPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IL1R2_HUMAN | [view interactions] | High throughput | no | no |
| PDZD7_HUMAN | [view interactions] | High throughput | no | no |
| UB2J1_HUMAN | [view interactions] | High throughput | no | yes |
| RTRAF_HUMAN | [view interactions] | High throughput | no | yes |
| CDK12_HUMAN | [view interactions] | High throughput | no | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| RGPD5_HUMAN | [view interactions] | High throughput | no | no |
| COASY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FNTB_HUMAN | [view interactions] | High throughput | no | no |
| GCP6_HUMAN | [view interactions] | High throughput | no | yes |
| ZAP70_HUMAN | [view interactions] | High throughput | no | no |
| CSTF3_HUMAN | [view interactions] | High throughput | no | yes |
| SPRNG_HUMAN | [view interactions] | High throughput | no | yes |
| HAPR1_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EF1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SETD7_HUMAN | [view interactions] | High throughput | no | yes |
| APC7_HUMAN | [view interactions] | High throughput | no | yes |
| NSD2_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC8_HUMAN | [view interactions] | High throughput | no | yes |
| CENPA_HUMAN | [view interactions] | High throughput | no | no |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| CENPC_HUMAN | [view interactions] | High throughput | no | no |
| MORC2_HUMAN | [view interactions] | High throughput | no | yes |
| ZMAT2_HUMAN | [view interactions] | High throughput | no | yes |
| SENP6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P66B_HUMAN | [view interactions] | High throughput | no | yes |
| P66A_HUMAN | [view interactions] | High throughput | no | yes |
| T2FA_HUMAN | [view interactions] | High throughput | no | yes |
| MTA2_HUMAN | [view interactions] | High throughput | no | yes |
| MBD3_HUMAN | [view interactions] | High throughput | no | yes |
| CFDP1_HUMAN | [view interactions] | High throughput | no | yes |
| MTA1_HUMAN | [view interactions] | High throughput | no | yes |
| NEK1_HUMAN | [view interactions] | High throughput | no | yes |
| CATIN_HUMAN | [view interactions] | High throughput | no | yes |
| Z512B_HUMAN | [view interactions] | High throughput | no | yes |
| PAF1_HUMAN | [view interactions] | High throughput | no | yes |
| HXD13_HUMAN | [view interactions] | High throughput | no | no |
| DOT1L_HUMAN | [view interactions] | High throughput | no | yes |
| IFIX_HUMAN | [view interactions] | High throughput | no | no |
| AP2A_HUMAN | [view interactions] | High throughput | no | no |
| SALL1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN687_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| LRIF1_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT1_HUMAN | [view interactions] | High throughput | no | yes |
| ZMYM2_HUMAN | [view interactions] | High throughput | no | yes |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| FUBP1_HUMAN | [view interactions] | High throughput | no | yes |
| CAF1A_HUMAN | [view interactions] | High throughput | no | yes |
| ZN281_HUMAN | [view interactions] | High throughput | no | no |
| TOP2A_HUMAN | [view interactions] | High throughput | no | no |
| ZN592_HUMAN | [view interactions] | High throughput | no | yes |
| SP16H_HUMAN | [view interactions] | High throughput | no | yes |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| UBF1_HUMAN | [view interactions] | High throughput | no | yes |
| TBK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPY30_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| KAT7_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
| PWP2_HUMAN | [view interactions] | High throughput | no | no |
| ORC1_HUMAN | [view interactions] | High throughput | no | yes |
| RBX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WDR76_HUMAN | [view interactions] | High throughput | no | no |
| NS1BP_HUMAN | [view interactions] | High throughput | no | yes |
| PHIP_HUMAN | [view interactions] | High throughput | no | yes |
| CBX4_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JADE3_HUMAN | [view interactions] | High throughput | no | no |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| SRP72_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOMO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |