Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SENP6_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SENP6_HUMAN
GO:0044389 ubiquitin-like protein ligase binding 33.3333 4 no
GO:0043169 cation binding 25.0000 4 no
GO:0046872 metal ion binding 25.0000 5 no
GO:0003677 DNA binding 25.0000 4 no
GO:0003723 RNA binding 25.0000 4 no
GO:0031625 ubiquitin protein ligase binding 25.0000 5 no
GO:0000166 nucleotide binding 25.0000 4 no
GO:0017076 purine nucleotide binding 25.0000 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in SENP6_HUMAN
GO:0048522 positive regulation of cellular process 75.0000 4 no
GO:0009889 regulation of biosynthetic process 66.6667 4 no
GO:0009893 positive regulation of metabolic process 66.6667 4 no
GO:0010468 regulation of gene expression 66.6667 6 no
GO:0010556 regulation of macromolecule biosynthetic process 66.6667 5 no
GO:0010604 positive regulation of macromolecule metabolic process 66.6667 5 no
GO:0031323 regulation of cellular metabolic process 66.6667 4 no
GO:0031326 regulation of cellular biosynthetic process 66.6667 5 no
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 no
GO:0080090 regulation of primary metabolic process 66.6667 4 no
GO:0051128 regulation of cellular component organization 58.3333 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 58.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 58.3333 5 no
GO:0036211 protein modification process 50.0000 4 yes
GO:0043412 macromolecule modification 50.0000 4 yes
GO:0006355 regulation of DNA-templated transcription 50.0000 7 no
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0051252 regulation of RNA metabolic process 50.0000 5 no
GO:2001141 regulation of RNA biosynthetic process 50.0000 6 no
GO:0009891 positive regulation of biosynthetic process 50.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 50.0000 6 no
GO:0031328 positive regulation of cellular biosynthetic process 50.0000 6 no
GO:0043687 post-translational protein modification 41.6667 5 yes
GO:0032880 regulation of protein localization 41.6667 5 no
GO:0060341 regulation of cellular localization 41.6667 4 no
GO:0009892 negative regulation of metabolic process 41.6667 4 no
GO:0010605 negative regulation of macromolecule metabolic process 41.6667 5 no
GO:0031324 negative regulation of cellular metabolic process 41.6667 5 no
GO:0045595 regulation of cell differentiation 41.6667 4 no
GO:0051246 regulation of protein metabolic process 41.6667 5 no
GO:0051247 positive regulation of protein metabolic process 41.6667 6 no
GO:0008104 protein localization 41.6667 4 no
GO:0016925 protein sumoylation 33.3333 7 yes
GO:0018193 peptidyl-amino acid modification 33.3333 5 yes
GO:0018205 peptidyl-lysine modification 33.3333 6 yes
GO:0032446 protein modification by small protein conjugation 33.3333 7 yes
GO:0033043 regulation of organelle organization 33.3333 5 yes
GO:0033044 regulation of chromosome organization 33.3333 6 yes
GO:0070647 protein modification by small protein conjugation or removal 33.3333 6 yes
GO:1900180 regulation of protein localization to nucleus 33.3333 6 no
GO:0009894 regulation of catabolic process 33.3333 4 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:0051052 regulation of DNA metabolic process 33.3333 5 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0090304 nucleic acid metabolic process 33.3333 4 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:0006357 regulation of transcription by RNA polymerase II 33.3333 8 no
GO:0042127 regulation of cell population proliferation 33.3333 4 no
GO:0045597 positive regulation of cell differentiation 33.3333 5 no
GO:0045893 positive regulation of DNA-templated transcription 33.3333 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0045944 positive regulation of transcription by RNA polymerase II 33.3333 9 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0051094 positive regulation of developmental process 33.3333 4 no
GO:0051240 positive regulation of multicellular organismal process 33.3333 4 no
GO:0051254 positive regulation of RNA metabolic process 33.3333 6 no
GO:1902680 positive regulation of RNA biosynthetic process 33.3333 7 no
GO:0009890 negative regulation of biosynthetic process 33.3333 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0031327 negative regulation of cellular biosynthetic process 33.3333 6 no
GO:0006996 organelle organization 33.3333 4 no
GO:0043933 protein-containing complex organization 33.3333 4 no
GO:0010564 regulation of cell cycle process 25.0000 5 yes
GO:0043254 regulation of protein-containing complex assembly 25.0000 5 yes
GO:0044087 regulation of cellular component biogenesis 25.0000 4 yes
GO:0051726 regulation of cell cycle 25.0000 4 yes
GO:0006140 regulation of nucleotide metabolic process 25.0000 5 no
GO:0006915 apoptotic process 25.0000 4 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010038 response to metal ion 25.0000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0016070 RNA metabolic process 25.0000 5 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0051093 negative regulation of developmental process 25.0000 4 no
GO:0051241 negative regulation of multicellular organismal process 25.0000 4 no
GO:0062012 regulation of small molecule metabolic process 25.0000 4 no
GO:1900542 regulation of purine nucleotide metabolic process 25.0000 6 no
GO:1903578 regulation of ATP metabolic process 25.0000 7 no
GO:0008284 positive regulation of cell population proliferation 25.0000 5 no
GO:0009896 positive regulation of catabolic process 25.0000 5 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010628 positive regulation of gene expression 25.0000 7 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0032101 regulation of response to external stimulus 25.0000 4 no
GO:0060284 regulation of cell development 25.0000 5 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:2000026 regulation of multicellular organismal development 25.0000 4 no
GO:0006259 DNA metabolic process 25.0000 5 no
GO:0006281 DNA repair 25.0000 5 no
GO:0006974 DNA damage response 25.0000 4 no
GO:0071241 cellular response to inorganic substance 25.0000 4 no
GO:0009059 macromolecule biosynthetic process 25.0000 4 no
GO:0010639 negative regulation of organelle organization 25.0000 6 no
GO:0032204 regulation of telomere maintenance 25.0000 6 no
GO:0033365 protein localization to organelle 25.0000 5 no
GO:0042981 regulation of apoptotic process 25.0000 5 no
GO:0043067 regulation of programmed cell death 25.0000 4 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:0007010 cytoskeleton organization 25.0000 5 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:0006508 proteolysis 16.6667 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SUMO3_HUMAN [view entry] [view interactions] Low throughput yes yes
RUVB2_HUMAN [view interactions] Low throughput no yes
NEMO_HUMAN [view interactions] Low throughput no yes
EXO1_HUMAN [view interactions] Low throughput no no
FANCI_HUMAN [view interactions] Low throughput no yes
SUMO1_HUMAN [view entry] [view interactions] Low throughput yes yes
SUMO2_HUMAN [view entry] [view interactions] Low throughput yes yes
CSN5_HUMAN [view interactions] High throughput no yes
TIAM1_HUMAN [view entry] [view interactions] High throughput yes yes
SCHI1_HUMAN [view interactions] High throughput no yes
SP1_HUMAN [view interactions] High throughput no yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
H31_HUMAN [view interactions] High throughput no yes
KAT5_HUMAN [view interactions] High throughput no yes
FHL3_HUMAN [view interactions] High throughput no no
PP2AA_HUMAN [view entry] [view interactions] High throughput yes yes
CEP78_HUMAN [view interactions] High throughput no yes
PRP19_HUMAN [view interactions] High throughput no yes
ZDBF2_HUMAN [view interactions] High throughput no yes
RIGI_HUMAN [view interactions] High throughput no yes
KCNA3_HUMAN [view entry] [view interactions] High throughput yes no
ZRAN1_HUMAN [view interactions] High throughput no yes
SMC5_HUMAN [view interactions] High throughput no yes
PML_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
PA2GA_HUMAN [view interactions] High throughput no no
KLH29_HUMAN [view interactions] High throughput no yes
ARNT_HUMAN [view entry] [view interactions] High throughput yes yes
SORT_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
CDC5L_HUMAN [view interactions] High throughput no yes
CBX3_HUMAN [view interactions] High throughput no yes
CENPA_HUMAN [view interactions] High throughput no no
H2B1C_HUMAN [view interactions] High throughput no yes
NUP50_HUMAN [view interactions] High throughput no yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
TE2IP_HUMAN [view interactions] High throughput no yes
ZN330_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
ATRX_HUMAN [view entry] [view interactions] High throughput yes yes
H33_HUMAN [view interactions] High throughput no yes
SLX4_HUMAN [view interactions] High throughput no yes
NLE1_HUMAN [view interactions] High throughput no yes
NUP43_HUMAN [view interactions] High throughput no yes
COP1_HUMAN [view interactions] High throughput no no
SNR40_HUMAN [view interactions] High throughput no yes
TLE3_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes