SENP6_HUMAN
Evidence for PS localization
Functions
Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. [View more on UniProt]
Protein features
![](/static/images/legend1.gif)
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
![](/static/images/legend2.gif)
Network
SENP6_HUMAN has binary interactions with 11 proteins
Isoforms
![](/static/images/legend3.gif)
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SENP6_HUMAN |
---|---|---|---|---|
GO:0044389 | ubiquitin-like protein ligase binding | 33.3333 | 4 | no |
GO:0043169 | cation binding | 25.0000 | 4 | no |
GO:0046872 | metal ion binding | 25.0000 | 5 | no |
GO:0003677 | DNA binding | 25.0000 | 4 | no |
GO:0003723 | RNA binding | 25.0000 | 4 | no |
GO:0031625 | ubiquitin protein ligase binding | 25.0000 | 5 | no |
GO:0000166 | nucleotide binding | 25.0000 | 4 | no |
GO:0017076 | purine nucleotide binding | 25.0000 | 5 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SENP6_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 75.0000 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 66.6667 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 66.6667 | 4 | no |
GO:0010468 | regulation of gene expression | 66.6667 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 66.6667 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 66.6667 | 5 | no |
GO:0031323 | regulation of cellular metabolic process | 66.6667 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 66.6667 | 5 | no |
GO:0060255 | regulation of macromolecule metabolic process | 66.6667 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 66.6667 | 4 | no |
GO:0051128 | regulation of cellular component organization | 58.3333 | 4 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 58.3333 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 58.3333 | 5 | no |
GO:0036211 | protein modification process | 50.0000 | 4 | yes |
GO:0043412 | macromolecule modification | 50.0000 | 4 | yes |
GO:0006355 | regulation of DNA-templated transcription | 50.0000 | 7 | no |
GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
GO:0051252 | regulation of RNA metabolic process | 50.0000 | 5 | no |
GO:2001141 | regulation of RNA biosynthetic process | 50.0000 | 6 | no |
GO:0009891 | positive regulation of biosynthetic process | 50.0000 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 50.0000 | 6 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 50.0000 | 6 | no |
GO:0043687 | post-translational protein modification | 41.6667 | 5 | yes |
Disease
No data found.
All partners
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
ARNT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATRX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CBX3_HUMAN | [view interactions] | High throughput | no | yes |
CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
CENPA_HUMAN | [view interactions] | High throughput | no | no |
CEP78_HUMAN | [view interactions] | High throughput | no | yes |
COP1_HUMAN | [view interactions] | High throughput | no | no |
CSN5_HUMAN | [view interactions] | High throughput | no | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
EXO1_HUMAN | [view interactions] | Low throughput | no | no |
FANCI_HUMAN | [view interactions] | Low throughput | no | yes |
FHL3_HUMAN | [view interactions] | High throughput | no | no |
H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
H31_HUMAN | [view interactions] | High throughput | no | yes |
H33_HUMAN | [view interactions] | High throughput | no | yes |
KAT5_HUMAN | [view interactions] | High throughput | no | yes |
KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KLH29_HUMAN | [view interactions] | High throughput | no | yes |
LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
NAA40_HUMAN | [view interactions] | High throughput | no | no |
NEMO_HUMAN | [view interactions] | Low throughput | no | yes |
NLE1_HUMAN | [view interactions] | High throughput | no | yes |
NUP43_HUMAN | [view interactions] | High throughput | no | yes |
NUP50_HUMAN | [view interactions] | High throughput | no | yes |