Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SENP6_HUMAN

Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. [View more on UniProt]

01002003004005006007008009001,0001,100
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%

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02004006008001,0001,2001,400
SENP6_HUMAN
LOADING 67%

SENP6_HUMAN has binary interactions with 11 proteins

SENP6_HUMANSUMO1_HUMANARNT_HUMANLMNA_HUMANTIAM1_HUMANPARP1_HUMANKCNA3_HUMANSUMO2_HUMANSUMO3_HUMANATRX_HUMANRASK_HUMANPP2AA_HUMANSENP6_HUMANSUMO1_HUMANARNT_HUMANLMNA_HUMANTIAM1_HUMANPARP1_HUMANKCNA3_HUMANSUMO2_HUMANSUMO3_HUMANATRX_HUMANRASK_HUMANPP2AA_HUMAN
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01002003004005006007008009001,0001,100
Interacting regions
Canonical [SENP6_HUMAN]
Isoform [D6RJH1] alignment
Isoform [Q9GZR1-2] alignment
Isoform [D6RG09] alignment
Isoform [F8W6D9] alignment
Isoform [H0Y8Y8] alignment
Isoform [H0Y4F4] alignment
LOADING 94%

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Biological process

Disease

No data found.

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