KCNA3_HUMAN
Evidence for PS localization
Functions
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KCNA3_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 38.8235 | 4 | no |
| GO:0017076 | purine nucleotide binding | 31.7647 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 31.7647 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 31.7647 | 4 | no |
| GO:0005524 | ATP binding | 25.8824 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 25.8824 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.8824 | 5 | no |
| GO:0005216 | ion channel activity | 11.7647 | 4 | yes |
| GO:0008324 | cation transmembrane transporter activity | 11.7647 | 4 | yes |
| GO:0015267 | channel activity | 11.7647 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 11.7647 | 4 | yes |
| GO:0005244 | voltage-gated ion channel activity | 10.5882 | 4 | yes |
| GO:0022832 | voltage-gated channel activity | 10.5882 | 6 | yes |
| GO:0022836 | gated channel activity | 10.5882 | 5 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 10.5882 | 5 | yes |
| GO:0005249 | voltage-gated potassium channel activity | 8.2353 | 6 | yes |
| GO:0005261 | cation channel activity | 8.2353 | 5 | yes |
| GO:0005267 | potassium channel activity | 8.2353 | 6 | yes |
| GO:0015079 | potassium ion transmembrane transporter activity | 8.2353 | 6 | yes |
| GO:0022843 | voltage-gated cation channel activity | 8.2353 | 5 | yes |
| GO:0005251 | delayed rectifier potassium channel activity | 7.0588 | 7 | yes |
| GO:0015271 | outward rectifier potassium channel activity | 3.5294 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KCNA3_HUMAN |
|---|---|---|---|---|
| GO:0022607 | cellular component assembly | 41.1765 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 37.6471 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 37.6471 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 37.6471 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 36.4706 | 4 | no |
| GO:0006996 | organelle organization | 35.2941 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 34.1176 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 34.1176 | 4 | no |
| GO:0008104 | protein localization | 32.9412 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 32.9412 | 4 | no |
| GO:0043933 | protein-containing complex organization | 31.7647 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 30.5882 | 4 | no |
| GO:0071702 | organic substance transport | 30.5882 | 4 | no |
| GO:0051049 | regulation of transport | 29.4118 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 29.4118 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.2353 | 5 | no |
| GO:0010646 | regulation of cell communication | 27.0588 | 4 | no |
| GO:0071705 | nitrogen compound transport | 27.0588 | 4 | no |
| GO:0015031 | protein transport | 25.8824 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.7059 | 5 | no |
| GO:0010941 | regulation of cell death | 23.5294 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 23.5294 | 5 | no |
| GO:0009966 | regulation of signal transduction | 22.3529 | 4 | no |
| GO:0010468 | regulation of gene expression | 22.3529 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 22.3529 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 21.1765 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.1765 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.1765 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 21.1765 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 21.1765 | 5 | no |
| GO:0006811 | ion transport | 20.0000 | 4 | yes |
| GO:0034762 | regulation of transmembrane transport | 16.4706 | 4 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 15.2941 | 5 | yes |
| GO:0043269 | regulation of ion transport | 15.2941 | 5 | yes |
| GO:0006812 | cation transport | 12.9412 | 5 | yes |
| GO:0030001 | metal ion transport | 12.9412 | 6 | yes |
| GO:0098660 | inorganic ion transmembrane transport | 12.9412 | 4 | yes |
| GO:0051259 | protein complex oligomerization | 10.5882 | 6 | yes |
| GO:0098655 | cation transmembrane transport | 10.5882 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 10.5882 | 5 | yes |
| GO:0051260 | protein homooligomerization | 9.4118 | 7 | yes |
| GO:0006813 | potassium ion transport | 7.0588 | 7 | yes |
| GO:0071805 | potassium ion transmembrane transport | 7.0588 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in KCNA3_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 4.7059 | 3 | no |
| DOID:1289 | neurodegenerative disease | 2.3529 | 4 | no |
| DOID:0050701 | electroclinical syndrome | 2.3529 | 6 | no |
| DOID:0112202 | developmental and epileptic encephalopathy | 2.3529 | 7 | no |
| DOID:1826 | epilepsy | 2.3529 | 5 | no |
| DOID:936 | brain disease | 2.3529 | 4 | no |
| DOID:574 | peripheral nervous system disease | 2.3529 | 3 | no |
| DOID:870 | neuropathy | 2.3529 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CD3D_HUMAN | [view interactions] | Low throughput | no | no |
| MMP23_HUMAN | [view interactions] | Low throughput | no | no |
| SRC8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HCLS1_HUMAN | [view interactions] | Low throughput | no | no |
| TFR1_HUMAN | [view interactions] | Low throughput | no | yes |
| KCAB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCNA5_HUMAN | [view interactions] | Low throughput | no | no |
| BAX_HUMAN | [view interactions] | Low throughput | no | yes |
| KCNA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCNA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCNA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAV1_HUMAN | [view interactions] | Low throughput | no | no |
| UBF1_HUMAN | [view interactions] | Low throughput | no | yes |
| DFB4A_HUMAN | [view interactions] | Low throughput | no | no |
| NED4L_HUMAN | [view interactions] | Low throughput | no | yes |
| KCNE4_HUMAN | [view interactions] | Low throughput | no | no |
| SC24B_HUMAN | [view interactions] | Low throughput | no | yes |
| NTRK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRB10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHC3_HUMAN | [view interactions] | Low throughput | no | yes |
| FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| IQGA3_HUMAN | [view interactions] | Low throughput | no | no |
| KCNA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PFKAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| SMCA4_HUMAN | [view interactions] | High throughput | no | yes |
| EPIPL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MSH2_HUMAN | [view interactions] | High throughput | no | yes |
| RS3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBBP6_HUMAN | [view interactions] | High throughput | no | yes |
| GDIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYMC_HUMAN | [view interactions] | High throughput | no | yes |
| VCIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CO4A4_HUMAN | [view interactions] | High throughput | no | no |
| YETS2_HUMAN | [view interactions] | High throughput | no | no |
| C1QC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHD9_HUMAN | [view interactions] | High throughput | no | yes |
| NACAM_HUMAN | [view interactions] | High throughput | no | no |
| NALP5_HUMAN | [view interactions] | High throughput | no | no |
| SDA1_HUMAN | [view interactions] | High throughput | no | yes |
| SORL_HUMAN | [view interactions] | High throughput | no | yes |
| KIF11_HUMAN | [view interactions] | High throughput | no | yes |
| MORC2_HUMAN | [view interactions] | High throughput | no | yes |
| ABCAD_HUMAN | [view interactions] | High throughput | no | no |
| MYO9A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACADS_HUMAN | [view interactions] | High throughput | no | yes |
| NCOA2_HUMAN | [view interactions] | High throughput | no | no |
| CAR11_HUMAN | [view interactions] | High throughput | no | no |
| NPY4R_HUMAN | [view interactions] | High throughput | no | yes |
| FABP4_HUMAN | [view interactions] | High throughput | no | no |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| KCNA6_HUMAN | [view interactions] | High throughput | no | no |
| DOLK_HUMAN | [view interactions] | High throughput | no | no |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD3_HUMAN | [view interactions] | High throughput | no | yes |
| SENP6_HUMAN | [view interactions] | High throughput | no | yes |
| ANR17_HUMAN | [view interactions] | High throughput | no | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SURF4_HUMAN | [view interactions] | High throughput | no | yes |
| TBB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4E2_HUMAN | [view interactions] | High throughput | no | no |
| PRS8_HUMAN | [view interactions] | High throughput | no | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4A1_HUMAN | [view interactions] | High throughput | no | no |
| ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS27L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| M2OM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNA3_HUMAN | [view interactions] | High throughput | no | no |
| MPCP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COPB_HUMAN | [view interactions] | High throughput | no | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| STT3A_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BSN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| RL28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRPM1_HUMAN | [view interactions] | High throughput | no | no |
| TLN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HACD3_HUMAN | [view interactions] | High throughput | no | yes |
| TLR3_HUMAN | [view interactions] | High throughput | no | yes |
| SYTL2_HUMAN | [view interactions] | High throughput | no | no |
| KCRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP3M1_HUMAN | [view interactions] | High throughput | no | yes |
| TLN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PEPL_HUMAN | [view interactions] | High throughput | no | yes |
| CLIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYH5_HUMAN | [view interactions] | High throughput | no | no |
| FACR1_HUMAN | [view interactions] | High throughput | no | yes |
| MDHC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S61A1_HUMAN | [view interactions] | High throughput | no | no |
| PRS4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRP2_HUMAN | [view interactions] | High throughput | no | no |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| PUF60_HUMAN | [view interactions] | High throughput | no | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMA1_HUMAN | [view interactions] | High throughput | no | no |
| SRRM1_HUMAN | [view interactions] | High throughput | no | yes |
| TBCD4_HUMAN | [view interactions] | High throughput | no | yes |
| CDC7_HUMAN | [view interactions] | High throughput | no | yes |
| PHTF1_HUMAN | [view interactions] | High throughput | no | no |
| CCD73_HUMAN | [view interactions] | High throughput | no | no |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE112_HUMAN | [view interactions] | High throughput | no | no |
| FYCO1_HUMAN | [view interactions] | High throughput | no | no |
| GPHRB_HUMAN | [view interactions] | High throughput | no | no |
| GPHRA_HUMAN | [view interactions] | High throughput | no | no |
| SZT2_HUMAN | [view interactions] | High throughput | no | yes |
| MYO1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EAA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI18_HUMAN | [view interactions] | High throughput | no | no |
| VP13A_HUMAN | [view interactions] | High throughput | no | yes |
| MYH7B_HUMAN | [view interactions] | High throughput | no | no |
| AP3B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| GTR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK1_HUMAN | [view interactions] | High throughput | no | no |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASAP2_HUMAN | [view interactions] | High throughput | no | yes |
| GAR1_HUMAN | [view interactions] | High throughput | no | yes |
| RYR1_HUMAN | [view interactions] | High throughput | no | no |
| CEP95_HUMAN | [view interactions] | High throughput | no | yes |
| LZTL1_HUMAN | [view interactions] | High throughput | no | no |
| THOC2_HUMAN | [view interactions] | High throughput | no | yes |
| RS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYRC_HUMAN | [view interactions] | High throughput | no | yes |
| MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EHD3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HELQ_HUMAN | [view interactions] | High throughput | no | yes |
| TAF6L_HUMAN | [view interactions] | High throughput | no | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| DAPLE_HUMAN | [view interactions] | High throughput | no | yes |
| NCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
| ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CNOT1_HUMAN | [view interactions] | High throughput | no | yes |
| CAPR2_HUMAN | [view interactions] | High throughput | no | yes |
| MPRIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAC1B_HUMAN | [view interactions] | High throughput | no | yes |
| RL13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHD2_HUMAN | [view interactions] | High throughput | no | yes |
| KMT2A_HUMAN | [view interactions] | High throughput | no | yes |
| SERPH_HUMAN | [view interactions] | High throughput | no | no |
| RP1_HUMAN | [view interactions] | High throughput | no | no |
| ANGP4_HUMAN | [view interactions] | High throughput | no | no |
| ADCYA_HUMAN | [view interactions] | High throughput | no | yes |
| PYGL_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXPH5_HUMAN | [view interactions] | High throughput | no | no |
| ORC1_HUMAN | [view interactions] | High throughput | no | yes |
| CMTR1_HUMAN | [view interactions] | High throughput | no | yes |
| DOC10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MED8_HUMAN | [view interactions] | High throughput | no | yes |
| NRIP1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFF2_HUMAN | [view interactions] | High throughput | no | yes |
| CORA1_HUMAN | [view interactions] | High throughput | no | no |
| LUZP1_HUMAN | [view interactions] | High throughput | no | yes |
| PAPOG_HUMAN | [view interactions] | High throughput | no | yes |
| CYTSA_HUMAN | [view interactions] | High throughput | no | yes |
| SPEF2_HUMAN | [view interactions] | High throughput | no | no |
| CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
| TDR12_HUMAN | [view interactions] | High throughput | no | no |
| CCD62_HUMAN | [view interactions] | High throughput | no | no |
| E2AK4_HUMAN | [view interactions] | High throughput | no | yes |
| RSRC2_HUMAN | [view interactions] | High throughput | no | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COBL_HUMAN | [view interactions] | High throughput | no | yes |
| TECR_HUMAN | [view interactions] | High throughput | no | yes |
| IRS4_HUMAN | [view interactions] | High throughput | no | no |
| SC22B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CO4A3_HUMAN | [view interactions] | High throughput | no | no |
| IFT20_HUMAN | [view interactions] | High throughput | no | yes |
| SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MINT_HUMAN | [view interactions] | High throughput | no | yes |
| YTDC2_HUMAN | [view interactions] | High throughput | no | no |
| KCAB1_HUMAN | [view interactions] | Computational | no | no |
| KCAB3_HUMAN | [view interactions] | Computational | no | no |
| KCNH1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KCNH2_HUMAN | [view interactions] | Computational | no | no |