Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GTR1_HUMAN

GO
G2C
SynGO

Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed, PubMed, PubMed, PubMed, PubMed). Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (PubMed, PubMed). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (PubMed). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors . [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in GTR1_HUMAN
GO:0017076 purine nucleotide binding 39.7059 4 no
GO:0032555 purine ribonucleotide binding 39.7059 4 no
GO:0035639 purine ribonucleoside triphosphate binding 39.7059 4 no
GO:0019900 kinase binding 29.4118 4 yes
GO:0016462 pyrophosphatase activity 26.4706 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 26.4706 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 26.4706 6 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0005525 GTP binding 23.5294 5 no
GO:0019001 guanyl nucleotide binding 23.5294 5 no
GO:0032561 guanyl ribonucleotide binding 23.5294 5 no
GO:0003924 GTPase activity 22.0588 7 no
GO:0008509 anion transmembrane transporter activity 5.8824 4 yes
GO:0008514 organic anion transmembrane transporter activity 5.8824 5 yes
GO:0005355 glucose transmembrane transporter activity 2.9412 7 yes
GO:0015145 monosaccharide transmembrane transporter activity 2.9412 5 yes
GO:0015149 hexose transmembrane transporter activity 2.9412 6 yes
GO:0033300 dehydroascorbic acid transmembrane transporter activity 2.9412 4 yes
GO:0051119 sugar transmembrane transporter activity 2.9412 4 yes
GO:0055056 D-glucose transmembrane transporter activity 2.9412 8 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GTR1_HUMAN
GO:0048522 positive regulation of cellular process 52.9412 4 no
GO:0031323 regulation of cellular metabolic process 42.6471 4 no
GO:0071702 organic substance transport 41.1765 4 yes
GO:0006996 organelle organization 41.1765 4 no
GO:0008104 protein localization 38.2353 4 no
GO:0060255 regulation of macromolecule metabolic process 38.2353 4 no
GO:0080090 regulation of primary metabolic process 38.2353 4 no
GO:0022607 cellular component assembly 36.7647 4 yes
GO:0051049 regulation of transport 36.7647 4 no
GO:0048523 negative regulation of cellular process 36.7647 4 no
GO:0010646 regulation of cell communication 36.7647 4 no
GO:0051171 regulation of nitrogen compound metabolic process 35.2941 4 no
GO:0009893 positive regulation of metabolic process 33.8235 4 no
GO:0071705 nitrogen compound transport 33.8235 4 no
GO:0051128 regulation of cellular component organization 33.8235 4 no
GO:0009966 regulation of signal transduction 32.3529 4 no
GO:0015031 protein transport 30.8824 4 no
GO:0010604 positive regulation of macromolecule metabolic process 29.4118 5 no
GO:0031325 positive regulation of cellular metabolic process 27.9412 5 no
GO:0023056 positive regulation of signaling 27.9412 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 26.4706 5 no
GO:0010647 positive regulation of cell communication 26.4706 5 no
GO:0043933 protein-containing complex organization 25.0000 4 yes
GO:0065003 protein-containing complex assembly 25.0000 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0010468 regulation of gene expression 23.5294 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.5294 5 no
GO:0032880 regulation of protein localization 23.5294 5 no
GO:0060341 regulation of cellular localization 23.5294 4 no
GO:0009967 positive regulation of signal transduction 23.5294 5 no
GO:0006886 intracellular protein transport 22.0588 4 no
GO:0009889 regulation of biosynthetic process 22.0588 4 no
GO:0031326 regulation of cellular biosynthetic process 22.0588 5 no
GO:0097435 supramolecular fiber organization 22.0588 4 no
GO:0010941 regulation of cell death 22.0588 4 no
GO:0033043 regulation of organelle organization 22.0588 5 no
GO:0051094 positive regulation of developmental process 22.0588 4 no
GO:0030030 cell projection organization 22.0588 4 no
GO:0051246 regulation of protein metabolic process 22.0588 5 no
GO:0016192 vesicle-mediated transport 20.5882 4 no
GO:0061024 membrane organization 20.5882 4 no
GO:0043067 regulation of programmed cell death 20.5882 5 no
GO:0007010 cytoskeleton organization 20.5882 5 no
GO:1903829 positive regulation of protein localization 20.5882 5 no
GO:0010243 response to organonitrogen compound 17.6471 4 yes
GO:0019752 carboxylic acid metabolic process 10.2941 5 yes
GO:0043436 oxoacid metabolic process 10.2941 4 yes
GO:0062197 cellular response to chemical stress 10.2941 4 yes
GO:0036293 response to decreased oxygen levels 8.8235 4 yes
GO:0006869 lipid transport 7.3529 5 yes
GO:0003018 vascular process in circulatory system 5.8824 4 yes
GO:0015849 organic acid transport 5.8824 5 yes
GO:0098657 import into cell 5.8824 4 yes
GO:0006972 hyperosmotic response 4.4118 4 yes
GO:0007417 central nervous system development 4.4118 4 yes
GO:0008643 carbohydrate transport 4.4118 5 yes
GO:0010232 vascular transport 4.4118 4 yes
GO:0015908 fatty acid transport 4.4118 6 yes
GO:0015909 long-chain fatty acid transport 4.4118 7 yes
GO:0031667 response to nutrient levels 4.4118 4 yes
GO:0071260 cellular response to mechanical stimulus 4.4118 4 yes
GO:0071470 cellular response to osmotic stress 4.4118 4 yes
GO:0071474 cellular hyperosmotic response 4.4118 5 yes
GO:0150104 transport across blood-brain barrier 4.4118 5 yes
GO:1901652 response to peptide 4.4118 4 yes
GO:1902001 fatty acid transmembrane transport 4.4118 5 yes
GO:1905039 carboxylic acid transmembrane transport 4.4118 4 yes
GO:0006767 water-soluble vitamin metabolic process 2.9412 4 yes
GO:0008645 hexose transmembrane transport 2.9412 5 yes
GO:0009267 cellular response to starvation 2.9412 4 yes
GO:0015749 monosaccharide transmembrane transport 2.9412 4 yes
GO:0015911 long-chain fatty acid import across plasma membrane 2.9412 4 yes
GO:0019852 L-ascorbic acid metabolic process 2.9412 4 yes
GO:0031669 cellular response to nutrient levels 2.9412 4 yes
GO:0032868 response to insulin 2.9412 5 yes
GO:0042149 cellular response to glucose starvation 2.9412 5 yes
GO:0043434 response to peptide hormone 2.9412 4 yes
GO:0044539 long-chain fatty acid import into cell 2.9412 6 yes
GO:0098704 carbohydrate import across plasma membrane 2.9412 4 yes
GO:0098708 glucose import across plasma membrane 2.9412 6 yes
GO:0140271 hexose import across plasma membrane 2.9412 5 yes
GO:0140354 lipid import into cell 2.9412 5 yes
GO:1901334 lactone metabolic process 2.9412 4 yes
GO:1904016 response to Thyroglobulin triiodothyronine 2.9412 4 yes
GO:1904659 glucose transmembrane transport 2.9412 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in GTR1_HUMAN
DOID:0050686 organ system cancer 2.9412 3 no
DOID:0060038 specific developmental disorder 2.9412 3 no
DOID:1059 intellectual disability 2.9412 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SYVN1_HUMAN [view interactions] Low throughput no yes
PDIA3_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC9_HUMAN [view interactions] Low throughput no yes
CALX_HUMAN [view entry] [view interactions] Low throughput yes yes
CALR_HUMAN [view interactions] Low throughput no yes
HIF1A_HUMAN [view interactions] Low throughput no no
GIPC1_HUMAN [view entry] [view interactions] Low throughput yes yes
B3AT_HUMAN [view entry] [view interactions] Low throughput yes no
GTR1_HUMAN [view entry] [view interactions] Low throughput yes no
STOM_HUMAN [view entry] [view interactions] Low throughput yes yes
FAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
TXNIP_HUMAN [view interactions] Low throughput no no
SNX27_HUMAN [view entry] [view interactions] Low throughput yes no
TBB4A_HUMAN [view interactions] Low throughput no yes
TMM70_HUMAN [view interactions] High throughput no yes
CP2S1_HUMAN [view interactions] High throughput no no
FIS1_HUMAN [view entry] [view interactions] High throughput yes yes
PI3R4_HUMAN [view interactions] High throughput no yes
PYRG2_HUMAN [view interactions] High throughput no yes
VA0D2_HUMAN [view interactions] High throughput no no
MIC25_HUMAN [view entry] [view interactions] High throughput yes yes
PARL_HUMAN [view interactions] High throughput no yes
ACSL4_HUMAN [view entry] [view interactions] High throughput yes yes
RENR_HUMAN [view entry] [view interactions] High throughput yes yes
ERD22_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
COQ8B_HUMAN [view interactions] High throughput no yes
SURF4_HUMAN [view interactions] High throughput no yes
BTAF1_HUMAN [view interactions] High throughput no no
ERD21_HUMAN [view interactions] High throughput no yes
SYJ2B_HUMAN [view entry] [view interactions] High throughput yes no
TOM22_HUMAN [view interactions] High throughput no yes
AUP1_HUMAN [view interactions] High throughput no yes
ADT1_HUMAN [view entry] [view interactions] High throughput yes yes
AGM1_HUMAN [view interactions] High throughput no no
ACATN_HUMAN [view interactions] High throughput no yes
XPO2_HUMAN [view entry] [view interactions] High throughput yes no
RAB7L_HUMAN [view interactions] High throughput no yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
SL7A1_HUMAN [view interactions] High throughput no no
ECM29_HUMAN [view interactions] High throughput no no
BRAT1_HUMAN [view interactions] High throughput no yes
EI24_HUMAN [view interactions] High throughput no yes
XPOT_HUMAN [view interactions] High throughput no no
S2533_HUMAN [view interactions] High throughput no yes
SAM50_HUMAN [view entry] [view interactions] High throughput yes yes
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
T161A_HUMAN [view interactions] High throughput no yes
PDXD1_HUMAN [view interactions] High throughput no no
INT1_HUMAN [view interactions] High throughput no yes
CCD47_HUMAN [view interactions] High throughput no yes
MTX2_HUMAN [view entry] [view interactions] High throughput yes yes
MIC13_HUMAN [view interactions] High throughput no yes
VATH_HUMAN [view entry] [view interactions] High throughput yes yes
OXA1L_HUMAN [view interactions] High throughput no yes
TIDC1_HUMAN [view interactions] High throughput no yes
PLS1_HUMAN [view interactions] High throughput no no
SYEM_HUMAN [view interactions] High throughput no yes
ICMT_HUMAN [view interactions] High throughput no no
YIPF5_HUMAN [view interactions] High throughput no yes
YIF1B_HUMAN [view interactions] High throughput no yes
GCN1_HUMAN [view interactions] High throughput no yes
MIC60_HUMAN [view entry] [view interactions] High throughput yes yes
SPG7_HUMAN [view interactions] High throughput no no
SGMR1_HUMAN [view entry] [view interactions] High throughput yes yes
COX15_HUMAN [view interactions] High throughput no yes
MPU1_HUMAN [view interactions] High throughput no yes
ERD23_HUMAN [view interactions] High throughput no yes
GBF1_HUMAN [view interactions] High throughput no yes
TFB2M_HUMAN [view interactions] High throughput no no
SFXN2_HUMAN [view interactions] High throughput no no
CIAO1_HUMAN [view interactions] High throughput no yes
GEMI4_HUMAN [view interactions] High throughput no yes
TMM43_HUMAN [view interactions] High throughput no no
TTI2_HUMAN [view interactions] High throughput no yes
NU205_HUMAN [view interactions] High throughput no no
BTF3_HUMAN [view interactions] High throughput no yes
TM192_HUMAN [view interactions] High throughput no yes
KCNA3_HUMAN [view entry] [view interactions] High throughput yes no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND2_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
RHBT1_HUMAN [view interactions] High throughput no yes
RHBT2_HUMAN [view interactions] High throughput no no
RND1_HUMAN [view interactions] High throughput no no
RND3_HUMAN [view interactions] High throughput no no
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
VAMP3_HUMAN [view entry] [view interactions] High throughput yes no
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
DAF_HUMAN [view interactions] High throughput no no
ACAD9_HUMAN [view interactions] High throughput no yes
MRES1_HUMAN [view interactions] High throughput no yes
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
RT12_HUMAN [view interactions] High throughput no yes
IF2M_HUMAN [view interactions] High throughput no yes
S2551_HUMAN [view interactions] High throughput no no
EFTS_HUMAN [view interactions] High throughput no no
EXD2_HUMAN [view interactions] High throughput no yes
LEG9_HUMAN [view interactions] High throughput no yes
DNJC5_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
B3GA1_HUMAN [view interactions] High throughput no yes
CK052_HUMAN [view interactions] High throughput no no
COIL_HUMAN [view interactions] High throughput no yes
ELOV5_HUMAN [view interactions] High throughput no yes
ERGI1_HUMAN [view interactions] High throughput no yes
CXD3_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LAMP1_HUMAN [view interactions] High throughput no yes
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
DPP4_HUMAN [view interactions] High throughput no no
TOLIP_HUMAN [view entry] [view interactions] High throughput yes yes
CACO2_HUMAN [view interactions] High throughput no yes
TNR1A_HUMAN [view interactions] High throughput no yes
HSPB2_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
ATF2_HUMAN [view interactions] High throughput no yes
ILK_HUMAN [view interactions] High throughput no no
IRAK1_HUMAN [view interactions] High throughput no yes
JAK2_HUMAN [view entry] [view interactions] High throughput yes yes
TYK2_HUMAN [view interactions] High throughput no no
BMR1A_HUMAN [view interactions] High throughput no no
TCPQ_HUMAN [view entry] [view interactions] High throughput yes yes
NICA_HUMAN [view interactions] High throughput no yes
TMED2_HUMAN [view interactions] High throughput no yes
NEIL3_HUMAN [view interactions] High throughput no no
ST17B_HUMAN [view interactions] High throughput no yes
MD2L2_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
KPCB_HUMAN [view entry] [view interactions] High throughput yes yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT18_HUMAN [view interactions] High throughput no yes
VCAM1_HUMAN [view interactions] High throughput no no
ALDOA_HUMAN [view entry] [view interactions] High throughput yes no
AQP1_HUMAN [view entry] [view interactions] High throughput yes no
AT2B4_HUMAN [view entry] [view interactions] High throughput yes yes
HECD3_HUMAN [view interactions] High throughput no yes
TTL_HUMAN [view interactions] High throughput no no
RPGR1_HUMAN [view interactions] High throughput no no
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
E2F3_HUMAN [view interactions] High throughput no no
PKHA7_HUMAN [view interactions] High throughput no yes
CD81_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
CSN6_HUMAN [view interactions] High throughput no yes
CCR2_HUMAN [view interactions] High throughput no yes
GPR35_HUMAN [view interactions] High throughput no no
LT4R2_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
BET1_HUMAN [view interactions] High throughput no no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view interactions] High throughput no yes
UFO_HUMAN [view interactions] High throughput no no
DDR2_HUMAN [view interactions] High throughput no no
VGFR1_HUMAN [view interactions] High throughput no no
FLT3_HUMAN [view interactions] High throughput no no
ROS1_HUMAN [view interactions] High throughput no no
ITA4_HUMAN [view interactions] High throughput no no
EED_HUMAN [view interactions] High throughput no yes
RAD18_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
RNF4_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
AGK_HUMAN [view entry] [view interactions] High throughput yes yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
WWP1_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
EMC2_HUMAN [view interactions] High throughput no yes
LRC31_HUMAN [view interactions] High throughput no no
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
RMC1_HUMAN [view interactions] High throughput no no
NPC1_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
STT3A_HUMAN [view interactions] High throughput no yes
OST48_HUMAN [view entry] [view interactions] High throughput yes yes
P53_HUMAN [view interactions] High throughput no no
DX39A_HUMAN [view interactions] High throughput no yes
AT11C_HUMAN [view interactions] High throughput no no
VPP2_HUMAN [view interactions] High throughput no yes
VPP1_HUMAN [view entry] [view interactions] High throughput yes yes
MSH2_HUMAN [view interactions] High throughput no yes
TELO2_HUMAN [view interactions] High throughput no yes
SYRM_HUMAN [view interactions] High throughput no yes
NCLN_HUMAN [view interactions] High throughput no yes
AT1A3_HUMAN [view entry] [view interactions] High throughput yes no
ARF5_HUMAN [view entry] [view interactions] High throughput yes no
PLCB_HUMAN [view interactions] High throughput no yes
PEX3_HUMAN [view interactions] High throughput no yes
TMCO1_HUMAN [view interactions] High throughput no yes
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
DHC24_HUMAN [view interactions] High throughput no yes
VAS1_HUMAN [view interactions] High throughput no yes
TM209_HUMAN [view interactions] High throughput no no
STX17_HUMAN [view interactions] High throughput no yes
GPAT3_HUMAN [view interactions] High throughput no yes
MGST3_HUMAN [view entry] [view interactions] High throughput yes yes
FAKD1_HUMAN [view interactions] High throughput no yes
CPT1A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB28_HUMAN [view interactions] Computational no yes
OTX2_HUMAN [view interactions] Computational no yes
LDHA_HUMAN [view entry] [view interactions] Computational yes yes
GTR2_HUMAN [view interactions] Computational no no
HXK2_HUMAN [view interactions] Computational no yes
INS_HUMAN [view interactions] Computational no no
SEM3A_HUMAN [view interactions] Computational no no
MK_HUMAN [view interactions] Computational no no
KPYM_HUMAN [view interactions] Computational no yes
GLUT4_HUMAN [view interactions] Computational no no
SERPH_HUMAN [view interactions] Computational no no