SGMR1_HUMAN
Evidence for PS localization
Functions
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed, PubMed). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002080 | TRG_ER_diArg_1 | TRG | 7 | 9 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SGMR1_HUMAN |
|---|---|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | 31.8182 | 4 | yes |
| GO:0046872 | metal ion binding | 22.7273 | 4 | no |
| GO:0004985 | G protein-coupled opioid receptor activity | 13.6364 | 5 | yes |
| GO:0008528 | G protein-coupled peptide receptor activity | 13.6364 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SGMR1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 54.5455 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0051049 | regulation of transport | 50.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 45.4545 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 45.4545 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.9091 | 4 | no |
| GO:0010468 | regulation of gene expression | 40.9091 | 5 | no |
| GO:0043269 | regulation of ion transport | 40.9091 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 40.9091 | 5 | no |
| GO:0023056 | positive regulation of signaling | 40.9091 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.9091 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.9091 | 4 | no |
| GO:0009966 | regulation of signal transduction | 40.9091 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 36.3636 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 36.3636 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 36.3636 | 4 | no |
| GO:0071702 | organic substance transport | 36.3636 | 4 | yes |
| GO:0034762 | regulation of transmembrane transport | 36.3636 | 4 | no |
| GO:0034765 | regulation of ion transmembrane transport | 36.3636 | 5 | no |
| GO:0080134 | regulation of response to stress | 31.8182 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.8182 | 5 | no |
| GO:0032101 | regulation of response to external stimulus | 31.8182 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 31.8182 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 31.8182 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 31.8182 | 6 | no |
| GO:0010941 | regulation of cell death | 31.8182 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 31.8182 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 31.8182 | 5 | yes |
| GO:0044057 | regulation of system process | 31.8182 | 4 | no |
| GO:0032880 | regulation of protein localization | 31.8182 | 5 | no |
| GO:0051223 | regulation of protein transport | 31.8182 | 5 | no |
| GO:0060341 | regulation of cellular localization | 31.8182 | 4 | no |
| GO:0070201 | regulation of establishment of protein localization | 31.8182 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.8182 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 31.8182 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 31.8182 | 5 | no |
| GO:0001817 | regulation of cytokine production | 27.2727 | 4 | no |
| GO:0032103 | positive regulation of response to external stimulus | 27.2727 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 27.2727 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 27.2727 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 27.2727 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.2727 | 5 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 27.2727 | 4 | no |
| GO:0032412 | regulation of ion transmembrane transporter activity | 27.2727 | 5 | no |
| GO:0051050 | positive regulation of transport | 27.2727 | 4 | no |
| GO:1904062 | regulation of cation transmembrane transport | 27.2727 | 6 | no |
| GO:2001257 | regulation of cation channel activity | 27.2727 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 27.2727 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 27.2727 | 5 | no |
| GO:0051046 | regulation of secretion | 27.2727 | 5 | no |
| GO:0051051 | negative regulation of transport | 27.2727 | 4 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 27.2727 | 4 | no |
| GO:1903530 | regulation of secretion by cell | 27.2727 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 27.2727 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 27.2727 | 5 | no |
| GO:0014070 | response to organic cyclic compound | 27.2727 | 4 | no |
| GO:0023057 | negative regulation of signaling | 27.2727 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 27.2727 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 27.2727 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.2727 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.2727 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.7273 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.7273 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 22.7273 | 4 | no |
| GO:0045597 | positive regulation of cell differentiation | 22.7273 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 22.7273 | 4 | no |
| GO:0043408 | regulation of MAPK cascade | 22.7273 | 6 | no |
| GO:0043410 | positive regulation of MAPK cascade | 22.7273 | 7 | no |
| GO:1903828 | negative regulation of protein localization | 22.7273 | 5 | no |
| GO:0031347 | regulation of defense response | 22.7273 | 5 | no |
| GO:0006869 | lipid transport | 22.7273 | 5 | yes |
| GO:0051259 | protein complex oligomerization | 22.7273 | 6 | yes |
| GO:0051260 | protein homooligomerization | 22.7273 | 7 | yes |
| GO:0006811 | ion transport | 22.7273 | 4 | no |
| GO:0006812 | cation transport | 22.7273 | 5 | no |
| GO:0030001 | metal ion transport | 22.7273 | 6 | no |
| GO:1903522 | regulation of blood circulation | 22.7273 | 5 | no |
| GO:0050708 | regulation of protein secretion | 22.7273 | 5 | no |
| GO:0031399 | regulation of protein modification process | 22.7273 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 22.7273 | 7 | no |
| GO:0031667 | response to nutrient levels | 22.7273 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.7273 | 6 | no |
| GO:0060548 | negative regulation of cell death | 22.7273 | 5 | no |
| GO:0043523 | regulation of neuron apoptotic process | 13.6364 | 6 | yes |
| GO:0070206 | protein trimerization | 13.6364 | 7 | yes |
| GO:1901214 | regulation of neuron death | 13.6364 | 5 | yes |
| GO:0007399 | nervous system development | 9.0909 | 4 | yes |
| GO:0036474 | cell death in response to hydrogen peroxide | 9.0909 | 4 | yes |
| GO:0070207 | protein homotrimerization | 9.0909 | 8 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KCNA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SORCN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DRD2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SGMR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GHSR_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GHRL_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ITPR3_HUMAN | [view interactions] | Low throughput | no | yes |
| ANK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCNH2_HUMAN | [view interactions] | Low throughput | no | no |
| OPRM_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CAC1B_HUMAN | [view interactions] | Low throughput | no | yes |
| RTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T184A_HUMAN | [view interactions] | High throughput | no | no |
| GPR52_HUMAN | [view interactions] | High throughput | no | no |
| CDS2_HUMAN | [view interactions] | High throughput | no | yes |
| CML1_HUMAN | [view interactions] | High throughput | no | yes |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| ALG3_HUMAN | [view interactions] | High throughput | no | yes |
| FPR2_HUMAN | [view interactions] | High throughput | no | yes |
| YIPF3_HUMAN | [view interactions] | High throughput | no | yes |
| LPAR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RETR3_HUMAN | [view interactions] | High throughput | no | yes |
| VEZA_HUMAN | [view interactions] | High throughput | no | yes |
| TSN2_HUMAN | [view interactions] | High throughput | no | no |
| P2RY8_HUMAN | [view interactions] | High throughput | no | no |
| FZD7_HUMAN | [view interactions] | High throughput | no | yes |
| S43A3_HUMAN | [view interactions] | High throughput | no | yes |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| DHC24_HUMAN | [view interactions] | High throughput | no | yes |
| 5HT1B_HUMAN | [view interactions] | High throughput | no | no |
| PRAF3_HUMAN | [view interactions] | High throughput | no | yes |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| PLCB_HUMAN | [view interactions] | High throughput | no | yes |
| COPT2_HUMAN | [view interactions] | High throughput | no | yes |
| AA2BR_HUMAN | [view interactions] | High throughput | no | no |
| VIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| GPC5B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GOT1A_HUMAN | [view interactions] | High throughput | no | no |
| SMDC1_HUMAN | [view interactions] | High throughput | no | no |
| PIGN_HUMAN | [view interactions] | High throughput | no | yes |
| GTR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SC6A5_HUMAN | [view interactions] | High throughput | no | no |
| NK1R_HUMAN | [view interactions] | High throughput | no | no |
| SHSL1_HUMAN | [view interactions] | High throughput | no | yes |
| THIL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAD2_HUMAN | [view interactions] | High throughput | no | no |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| T106B_HUMAN | [view interactions] | High throughput | no | yes |
| CLN3_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNR2_HUMAN | [view interactions] | High throughput | no | yes |
| SG196_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| PDZ11_HUMAN | [view interactions] | High throughput | no | yes |
| STOM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCP4_HUMAN | [view interactions] | High throughput | no | yes |
| TECT3_HUMAN | [view interactions] | High throughput | no | yes |
| FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| RTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGRG5_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| RN185_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| ATP5L_HUMAN | [view interactions] | High throughput | no | yes |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| CGRF1_HUMAN | [view interactions] | High throughput | no | yes |
| RN139_HUMAN | [view interactions] | High throughput | no | yes |
| ZNRF4_HUMAN | [view interactions] | High throughput | no | no |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| TMPSD_HUMAN | [view interactions] | High throughput | no | no |
| APJ_HUMAN | [view interactions] | High throughput | no | yes |
| S1PR4_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| SERC2_HUMAN | [view interactions] | High throughput | no | yes |
| TM87A_HUMAN | [view interactions] | High throughput | no | yes |
| KCNK1_HUMAN | [view interactions] | High throughput | no | yes |
| TM208_HUMAN | [view interactions] | High throughput | no | yes |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| BRI3B_HUMAN | [view interactions] | High throughput | no | yes |
| ACKR2_HUMAN | [view interactions] | High throughput | no | no |
| PLS1_HUMAN | [view interactions] | High throughput | no | no |
| CXCR4_HUMAN | [view interactions] | High throughput | no | no |
| C5AR1_HUMAN | [view interactions] | High throughput | no | yes |
| PLCC_HUMAN | [view interactions] | High throughput | no | no |
| CD63_HUMAN | [view interactions] | High throughput | no | no |
| CSCL1_HUMAN | [view interactions] | High throughput | no | no |
| RABL3_HUMAN | [view interactions] | High throughput | no | yes |
| ASPH_HUMAN | [view interactions] | High throughput | no | yes |
| B3A2_HUMAN | [view interactions] | High throughput | no | yes |
| MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
| RER1_HUMAN | [view interactions] | High throughput | no | yes |
| GP173_HUMAN | [view interactions] | High throughput | no | no |
| GPR84_HUMAN | [view interactions] | High throughput | no | no |
| S35F2_HUMAN | [view interactions] | High throughput | no | yes |
| ERD21_HUMAN | [view interactions] | High throughput | no | yes |
| SPP2B_HUMAN | [view interactions] | High throughput | no | yes |
| TMM72_HUMAN | [view interactions] | High throughput | no | no |
| FXDC2_HUMAN | [view interactions] | Computational | no | no |
| KCNA4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ERG28_HUMAN | [view interactions] | Computational | no | yes |
| ERG24_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SC5D_HUMAN | [view interactions] | Computational | no | yes |
| DHCR7_HUMAN | [view interactions] | Computational | no | yes |
| CH25H_HUMAN | [view interactions] | Computational | no | no |
| LBR_HUMAN | [view interactions] | Computational | no | yes |
| CP51A_HUMAN | [view interactions] | Computational | no | no |
| KCNH6_HUMAN | [view interactions] | Computational | no | no |
| ERG1_HUMAN | [view interactions] | Computational | no | no |
| NSDHL_HUMAN | [view interactions] | Computational | no | yes |
| MSMO1_HUMAN | [view interactions] | Computational | no | yes |