SGMR1_HUMAN
Evidence for PS localization
Functions
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed, PubMed). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002080 | TRG_ER_diArg_1 | TRG | 7 | 9 | - |
| ELMI002080 | TRG_ER_diArg_1 | TRG | 7 | 9 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SGMR1_HUMAN |
|---|---|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | 33.3333 | 4 | yes |
| GO:0043168 | anion binding | 22.2222 | 4 | no |
| GO:0043169 | cation binding | 22.2222 | 4 | no |
| GO:0004985 | G protein-coupled opioid receptor activity | 11.1111 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SGMR1_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 51.8519 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 51.8519 | 4 | no |
| GO:0051049 | regulation of transport | 51.8519 | 4 | no |
| GO:0022607 | cellular component assembly | 48.1481 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 40.7407 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 40.7407 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 37.0370 | 5 | no |
| GO:0023056 | positive regulation of signaling | 37.0370 | 4 | no |
| GO:0071702 | organic substance transport | 33.3333 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.6296 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 29.6296 | 5 | no |
| GO:0010468 | regulation of gene expression | 29.6296 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.6296 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 29.6296 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.6296 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 29.6296 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.6296 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.6296 | 5 | no |
| GO:0044057 | regulation of system process | 29.6296 | 4 | no |
| GO:0051046 | regulation of secretion | 29.6296 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 29.6296 | 4 | no |
| GO:1903530 | regulation of secretion by cell | 29.6296 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 25.9259 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 25.9259 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 25.9259 | 5 | no |
| GO:0032101 | regulation of response to external stimulus | 25.9259 | 4 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 25.9259 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 25.9259 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 25.9259 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.9259 | 4 | no |
| GO:0032880 | regulation of protein localization | 25.9259 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 25.9259 | 5 | no |
| GO:0060341 | regulation of cellular localization | 25.9259 | 4 | no |
| GO:0070201 | regulation of establishment of protein localization | 25.9259 | 6 | no |
| GO:0080134 | regulation of response to stress | 25.9259 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 25.9259 | 4 | no |
| GO:0043933 | protein-containing complex organization | 22.2222 | 4 | yes |
| GO:0001817 | regulation of cytokine production | 22.2222 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 22.2222 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 22.2222 | 5 | no |
| GO:0030334 | regulation of cell migration | 22.2222 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.2222 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.2222 | 5 | no |
| GO:0051051 | negative regulation of transport | 22.2222 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.2222 | 5 | no |
| GO:2000145 | regulation of cell motility | 22.2222 | 4 | no |
| GO:0006937 | regulation of muscle contraction | 22.2222 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 22.2222 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.2222 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 22.2222 | 4 | no |
| GO:0051223 | regulation of protein transport | 22.2222 | 5 | no |
| GO:0071705 | nitrogen compound transport | 22.2222 | 4 | no |
| GO:0090257 | regulation of muscle system process | 22.2222 | 5 | no |
| GO:1903522 | regulation of blood circulation | 22.2222 | 5 | no |
| GO:0006811 | monoatomic ion transport | 22.2222 | 4 | no |
| GO:0006812 | monoatomic cation transport | 22.2222 | 5 | no |
| GO:0030001 | metal ion transport | 22.2222 | 6 | no |
| GO:0034762 | regulation of transmembrane transport | 22.2222 | 4 | no |
| GO:0006869 | lipid transport | 18.5185 | 5 | yes |
| GO:0065003 | protein-containing complex assembly | 18.5185 | 5 | yes |
| GO:0051259 | protein complex oligomerization | 11.1111 | 6 | yes |
| GO:0051260 | protein homooligomerization | 11.1111 | 7 | yes |
| GO:0007399 | nervous system development | 7.4074 | 4 | yes |
| GO:0043523 | regulation of neuron apoptotic process | 7.4074 | 6 | yes |
| GO:0070206 | protein trimerization | 7.4074 | 7 | yes |
| GO:0070207 | protein homotrimerization | 7.4074 | 8 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| KCNA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SORCN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DRD2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SGMR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GHSR_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GHRL_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ITPR3_HUMAN | [view interactions] | Low throughput | no | yes |
| ANK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCNH2_HUMAN | [view interactions] | Low throughput | no | no |
| OPRM_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CAC1B_HUMAN | [view interactions] | Low throughput | no | yes |
| AT2A2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CLN3_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| SG196_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PDZ11_HUMAN | [view interactions] | High throughput | no | yes |
| STOM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCP4_HUMAN | [view interactions] | High throughput | no | yes |
| TECT3_HUMAN | [view interactions] | High throughput | no | yes |
| FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| RTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGRG5_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| RN185_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| ATP5L_HUMAN | [view interactions] | High throughput | no | yes |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| CGRF1_HUMAN | [view interactions] | High throughput | no | yes |
| RN139_HUMAN | [view interactions] | High throughput | no | yes |
| ZNRF4_HUMAN | [view interactions] | High throughput | no | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| TMPSD_HUMAN | [view interactions] | High throughput | no | no |
| APJ_HUMAN | [view interactions] | High throughput | no | yes |
| S1PR4_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| SERC2_HUMAN | [view interactions] | High throughput | no | yes |
| TM87A_HUMAN | [view interactions] | High throughput | no | yes |
| KCNK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM208_HUMAN | [view interactions] | High throughput | no | yes |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| BRI3B_HUMAN | [view interactions] | High throughput | no | yes |
| ACKR2_HUMAN | [view interactions] | High throughput | no | no |
| PLS1_HUMAN | [view interactions] | High throughput | no | no |
| CXCR4_HUMAN | [view interactions] | High throughput | no | no |
| C5AR1_HUMAN | [view interactions] | High throughput | no | yes |
| PLCC_HUMAN | [view interactions] | High throughput | no | no |
| CD63_HUMAN | [view interactions] | High throughput | no | no |
| CSCL1_HUMAN | [view interactions] | High throughput | no | no |
| RABL3_HUMAN | [view interactions] | High throughput | no | yes |
| ASPH_HUMAN | [view interactions] | High throughput | no | yes |
| B3A2_HUMAN | [view interactions] | High throughput | no | yes |
| MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
| RER1_HUMAN | [view interactions] | High throughput | no | yes |
| GP173_HUMAN | [view interactions] | High throughput | no | no |
| GPR84_HUMAN | [view interactions] | High throughput | no | no |
| S35F2_HUMAN | [view interactions] | High throughput | no | yes |
| ERD21_HUMAN | [view interactions] | High throughput | no | yes |
| SPP2B_HUMAN | [view interactions] | High throughput | no | yes |
| TMM72_HUMAN | [view interactions] | High throughput | no | no |
| RTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T184A_HUMAN | [view interactions] | High throughput | no | no |
| GPR52_HUMAN | [view interactions] | High throughput | no | no |
| CDS2_HUMAN | [view interactions] | High throughput | no | yes |
| CML1_HUMAN | [view interactions] | High throughput | no | yes |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| ALG3_HUMAN | [view interactions] | High throughput | no | yes |
| FPR2_HUMAN | [view interactions] | High throughput | no | yes |
| YIPF3_HUMAN | [view interactions] | High throughput | no | yes |
| LPAR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RETR3_HUMAN | [view interactions] | High throughput | no | yes |
| VEZA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSN2_HUMAN | [view interactions] | High throughput | no | no |
| P2RY8_HUMAN | [view interactions] | High throughput | no | no |
| FZD7_HUMAN | [view interactions] | High throughput | no | yes |
| S43A3_HUMAN | [view interactions] | High throughput | no | yes |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| DHC24_HUMAN | [view interactions] | High throughput | no | yes |
| 5HT1B_HUMAN | [view interactions] | High throughput | no | no |
| PRAF3_HUMAN | [view interactions] | High throughput | no | yes |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| PLCB_HUMAN | [view interactions] | High throughput | no | yes |
| COPT2_HUMAN | [view interactions] | High throughput | no | yes |
| AA2BR_HUMAN | [view interactions] | High throughput | no | no |
| VIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| GPC5B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GOT1A_HUMAN | [view interactions] | High throughput | no | no |
| SMDC1_HUMAN | [view interactions] | High throughput | no | no |
| PIGN_HUMAN | [view interactions] | High throughput | no | yes |
| GTR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SC6A5_HUMAN | [view interactions] | High throughput | no | no |
| NK1R_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHSL1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| THIL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAD2_HUMAN | [view interactions] | High throughput | no | no |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| T106B_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |