RTN1_HUMAN
Evidence for PS localization
Functions
Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI004763 | DOC_PP2B_PxIxIT_1 | DOC | 316 | 321 | - |
| ELMI004763 | DOC_PP2B_PxIxIT_1 | DOC | 316 | 321 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RTN1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 26.0870 | 4 | no |
| GO:0003723 | RNA binding | 23.9130 | 4 | no |
| GO:0043169 | cation binding | 21.7391 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RTN1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 65.2174 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 56.5217 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 56.5217 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 52.1739 | 4 | yes |
| GO:0010646 | regulation of cell communication | 52.1739 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 52.1739 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 52.1739 | 4 | no |
| GO:0022607 | cellular component assembly | 47.8261 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 47.8261 | 4 | no |
| GO:0006996 | organelle organization | 45.6522 | 4 | yes |
| GO:0051049 | regulation of transport | 45.6522 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 43.4783 | 4 | no |
| GO:0010468 | regulation of gene expression | 43.4783 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 43.4783 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 43.4783 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 39.1304 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 39.1304 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 36.9565 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 36.9565 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.9565 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 36.9565 | 5 | no |
| GO:0060341 | regulation of cellular localization | 36.9565 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 34.7826 | 5 | no |
| GO:0008104 | protein localization | 34.7826 | 4 | no |
| GO:0030030 | cell projection organization | 32.6087 | 4 | no |
| GO:0032880 | regulation of protein localization | 32.6087 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 30.4348 | 4 | no |
| GO:0033043 | regulation of organelle organization | 30.4348 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 30.4348 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 30.4348 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 30.4348 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 28.2609 | 5 | no |
| GO:0023056 | positive regulation of signaling | 28.2609 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.2609 | 4 | no |
| GO:0071310 | cellular response to organic substance | 28.2609 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 28.2609 | 5 | no |
| GO:0051050 | positive regulation of transport | 28.2609 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 28.2609 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 28.2609 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.0870 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 26.0870 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.0870 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 26.0870 | 4 | no |
| GO:0043933 | protein-containing complex organization | 26.0870 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 26.0870 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.0870 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 26.0870 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.0870 | 6 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 26.0870 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 26.0870 | 5 | no |
| GO:0023057 | negative regulation of signaling | 26.0870 | 4 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 26.0870 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 26.0870 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 26.0870 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 26.0870 | 4 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 26.0870 | 4 | no |
| GO:0071702 | organic substance transport | 23.9130 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.9130 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 23.9130 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 23.9130 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 23.9130 | 4 | no |
| GO:0031175 | neuron projection development | 23.9130 | 6 | no |
| GO:0061024 | membrane organization | 23.9130 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 23.9130 | 7 | no |
| GO:0043067 | regulation of programmed cell death | 23.9130 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.9130 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.7391 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.7391 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.7391 | 6 | yes |
| GO:0043408 | regulation of MAPK cascade | 21.7391 | 6 | no |
| GO:0071417 | cellular response to organonitrogen compound | 21.7391 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 21.7391 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 21.7391 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 21.7391 | 4 | no |
| GO:0080134 | regulation of response to stress | 21.7391 | 4 | no |
| GO:0009894 | regulation of catabolic process | 21.7391 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.7391 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 21.7391 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.7391 | 5 | no |
| GO:0007029 | endoplasmic reticulum organization | 8.6957 | 5 | yes |
| GO:0030182 | neuron differentiation | 8.6957 | 4 | yes |
| GO:0034248 | regulation of amide metabolic process | 8.6957 | 4 | yes |
| GO:0034249 | negative regulation of amide metabolic process | 8.6957 | 5 | yes |
| GO:1902003 | regulation of amyloid-beta formation | 8.6957 | 5 | yes |
| GO:1902430 | negative regulation of amyloid-beta formation | 8.6957 | 6 | yes |
| GO:1902991 | regulation of amyloid precursor protein catabolic process | 8.6957 | 6 | yes |
| GO:1902992 | negative regulation of amyloid precursor protein catabolic process | 8.6957 | 7 | yes |
| GO:0007420 | brain development | 6.5217 | 4 | yes |
| GO:0071786 | endoplasmic reticulum tubular network organization | 6.5217 | 6 | yes |
| GO:0071787 | endoplasmic reticulum tubular network formation | 6.5217 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| HDAC8_HUMAN | [view interactions] | Low throughput | no | yes |
| MANF_HUMAN | [view interactions] | Low throughput | no | yes |
| B2CL1_HUMAN | [view interactions] | Low throughput | no | yes |
| CEGT_HUMAN | [view interactions] | Low throughput | no | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDRG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RTN4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RYR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GLPB_HUMAN | [view interactions] | High throughput | no | no |
| GDN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
| TMM43_HUMAN | [view interactions] | High throughput | no | no |
| TMM70_HUMAN | [view interactions] | High throughput | no | yes |
| SGMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTR3_HUMAN | [view interactions] | High throughput | no | no |
| T120B_HUMAN | [view interactions] | High throughput | no | yes |
| TYSY_HUMAN | [view interactions] | High throughput | no | yes |
| PRAF3_HUMAN | [view interactions] | High throughput | no | yes |
| DERL2_HUMAN | [view interactions] | High throughput | no | yes |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PXL2A_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCAM2_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| SMCA5_HUMAN | [view interactions] | High throughput | no | yes |
| NOL11_HUMAN | [view interactions] | High throughput | no | yes |
| TBL3_HUMAN | [view interactions] | High throughput | no | yes |
| UTP15_HUMAN | [view interactions] | High throughput | no | no |
| NOC2L_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| TDIF2_HUMAN | [view interactions] | High throughput | no | yes |
| BLK_HUMAN | [view interactions] | High throughput | no | no |
| UTP18_HUMAN | [view interactions] | High throughput | no | yes |
| LETM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPC_HUMAN | [view interactions] | High throughput | no | yes |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| DESM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| H2A2B_HUMAN | [view interactions] | High throughput | no | yes |
| SP16H_HUMAN | [view interactions] | High throughput | no | yes |
| SSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR3_HUMAN | [view interactions] | High throughput | no | no |
| RTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2AY_HUMAN | [view interactions] | High throughput | no | yes |
| NEP1_HUMAN | [view interactions] | High throughput | no | yes |
| RAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DHC24_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| NEUM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCG3_HUMAN | [view interactions] | High throughput | no | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPAST_HUMAN | [view interactions] | High throughput | no | yes |
| TAGL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYVC_HUMAN | [view interactions] | High throughput | no | yes |
| LC7L2_HUMAN | [view interactions] | High throughput | no | yes |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| SYVN1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NU155_HUMAN | [view interactions] | High throughput | no | yes |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| RAB3B_HUMAN | [view interactions] | High throughput | no | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| VASP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
| ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEX2_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHF2_HUMAN | [view interactions] | High throughput | no | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCR4_HUMAN | [view interactions] | High throughput | no | yes |
| DRD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACM5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAF1A_HUMAN | [view interactions] | High throughput | no | yes |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| RTN2_HUMAN | [view interactions] | High throughput | no | no |
| PLS1_HUMAN | [view interactions] | High throughput | no | no |
| F210B_HUMAN | [view interactions] | High throughput | no | yes |
| TMT1A_HUMAN | [view interactions] | High throughput | no | no |
| F241A_HUMAN | [view interactions] | High throughput | no | yes |