RTN1_HUMAN
Evidence for PS localization
Functions
Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
No data found.
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RTN1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 62.5000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 55.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 52.5000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 47.5000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 45.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 45.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 45.0000 | 4 | no |
| GO:0051049 | regulation of transport | 42.5000 | 4 | no |
| GO:0006996 | organelle organization | 42.5000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | yes |
| GO:0008104 | protein localization | 40.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 40.0000 | 5 | no |
| GO:0071702 | organic substance transport | 32.5000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 32.5000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.5000 | 5 | no |
| GO:0060341 | regulation of cellular localization | 32.5000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 32.5000 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 32.5000 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 32.5000 | 5 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 30.0000 | 5 | yes |
| GO:0042127 | regulation of cell population proliferation | 30.0000 | 4 | no |
| GO:0051050 | positive regulation of transport | 30.0000 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.5000 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 27.5000 | 4 | no |
| GO:0071310 | cellular response to organic substance | 27.5000 | 4 | no |
| GO:0032880 | regulation of protein localization | 27.5000 | 5 | no |
| GO:0033043 | regulation of organelle organization | 27.5000 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.5000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.5000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 27.5000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 27.5000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.5000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 27.5000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 27.5000 | 5 | no |
| GO:0030030 | cell projection organization | 27.5000 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 27.5000 | 5 | no |
| GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 25.0000 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 25.0000 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.0000 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 25.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.0000 | 4 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 25.0000 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 22.5000 | 6 | yes |
| GO:0006886 | intracellular protein transport | 22.5000 | 4 | no |
| GO:0015031 | protein transport | 22.5000 | 4 | no |
| GO:0071417 | cellular response to organonitrogen compound | 22.5000 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 22.5000 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 22.5000 | 4 | no |
| GO:0061024 | membrane organization | 22.5000 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 22.5000 | 6 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 22.5000 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 22.5000 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.5000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 22.5000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 22.5000 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 22.5000 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.5000 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 22.5000 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 22.5000 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 22.5000 | 5 | no |
| GO:0034248 | regulation of cellular amide metabolic process | 15.0000 | 5 | yes |
| GO:0034249 | negative regulation of cellular amide metabolic process | 10.0000 | 6 | yes |
| GO:1902003 | regulation of amyloid-beta formation | 10.0000 | 6 | yes |
| GO:1902430 | negative regulation of amyloid-beta formation | 10.0000 | 7 | yes |
| GO:1902991 | regulation of amyloid precursor protein catabolic process | 10.0000 | 6 | yes |
| GO:1902992 | negative regulation of amyloid precursor protein catabolic process | 10.0000 | 7 | yes |
| GO:0030182 | neuron differentiation | 5.0000 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in RTN1_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 5.0000 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 5.0000 | 5 | no |
| DOID:114 | heart disease | 5.0000 | 3 | no |
| DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 5.0000 | 7 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 5.0000 | 6 | no |
| DOID:440 | neuromuscular disease | 5.0000 | 5 | no |
| DOID:574 | peripheral nervous system disease | 5.0000 | 3 | no |
| DOID:870 | neuropathy | 5.0000 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RYR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HDAC8_HUMAN | [view interactions] | Low throughput | no | yes |
| MANF_HUMAN | [view interactions] | Low throughput | no | yes |
| B2CL1_HUMAN | [view interactions] | Low throughput | no | yes |
| CEGT_HUMAN | [view interactions] | Low throughput | no | yes |
| FGFR1_HUMAN | [view interactions] | Low throughput | no | yes |
| NDRG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RTN4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| RTN2_HUMAN | [view interactions] | High throughput | no | no |
| PLS1_HUMAN | [view interactions] | High throughput | no | no |
| F210B_HUMAN | [view interactions] | High throughput | no | yes |
| MET7A_HUMAN | [view interactions] | High throughput | no | no |
| F241A_HUMAN | [view interactions] | High throughput | no | yes |
| GLPB_HUMAN | [view interactions] | High throughput | no | no |
| GDN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
| TMM43_HUMAN | [view interactions] | High throughput | no | no |
| TMM70_HUMAN | [view interactions] | High throughput | no | yes |
| SGMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTR3_HUMAN | [view interactions] | High throughput | no | no |
| T120B_HUMAN | [view interactions] | High throughput | no | yes |
| TYSY_HUMAN | [view interactions] | High throughput | no | yes |
| PRAF3_HUMAN | [view interactions] | High throughput | no | yes |
| DERL2_HUMAN | [view interactions] | High throughput | no | yes |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PXL2A_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCAM2_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| SMCA5_HUMAN | [view interactions] | High throughput | no | yes |
| NOL11_HUMAN | [view interactions] | High throughput | no | yes |
| TBL3_HUMAN | [view interactions] | High throughput | no | yes |
| UTP15_HUMAN | [view interactions] | High throughput | no | no |
| NOC2L_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| TDIF2_HUMAN | [view interactions] | High throughput | no | yes |
| BLK_HUMAN | [view interactions] | High throughput | no | no |
| UTP18_HUMAN | [view interactions] | High throughput | no | yes |
| LETM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPC_HUMAN | [view interactions] | High throughput | no | yes |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| DESM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| H2A2B_HUMAN | [view interactions] | High throughput | no | yes |
| SP16H_HUMAN | [view interactions] | High throughput | no | yes |
| SSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR3_HUMAN | [view interactions] | High throughput | no | no |
| RTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2AY_HUMAN | [view interactions] | High throughput | no | yes |
| NEP1_HUMAN | [view interactions] | High throughput | no | yes |
| RAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DHC24_HUMAN | [view interactions] | High throughput | no | yes |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| NEUM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCG3_HUMAN | [view interactions] | High throughput | no | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPAST_HUMAN | [view interactions] | High throughput | no | yes |
| TAGL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| SYVN1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NU155_HUMAN | [view interactions] | High throughput | no | yes |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| RAB3B_HUMAN | [view interactions] | High throughput | no | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| VASP_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHF2_HUMAN | [view interactions] | High throughput | no | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCR4_HUMAN | [view interactions] | High throughput | no | yes |
| DRD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACM5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAF1A_HUMAN | [view interactions] | High throughput | no | yes |
| ATLA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |