KIF5C_HUMAN
Involved in synaptic transmission (PubMed). Mediates dendritic trafficking of mRNAs . Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
237 | Glu | Lys | Corticaldysplasia,complex,withotherbrainmalformations2(CDCBM2) | - |
237 | Glu | Val | Corticaldysplasia,complex,withotherbrainmalformations2(CDCBM2) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in KIF5C_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 26.9231 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 26.9231 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 26.9231 | 4 | yes |
GO:0005524 | ATP binding | 21.1538 | 5 | yes |
GO:0030554 | adenyl nucleotide binding | 21.1538 | 5 | yes |
GO:0032559 | adenyl ribonucleotide binding | 21.1538 | 5 | yes |
GO:0015631 | tubulin binding | 17.3077 | 4 | yes |
GO:0008017 | microtubule binding | 15.3846 | 5 | yes |
GO:0016462 | pyrophosphatase activity | 13.4615 | 5 | yes |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 13.4615 | 4 | yes |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 13.4615 | 6 | yes |
GO:0016887 | ATP hydrolysis activity | 7.6923 | 7 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in KIF5C_HUMAN |
---|---|---|---|---|
GO:0010646 | regulation of cell communication | 55.7692 | 4 | no |
GO:0048522 | positive regulation of cellular process | 51.9231 | 4 | no |
GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 46.1538 | 4 | no |
GO:0009966 | regulation of signal transduction | 44.2308 | 4 | no |
GO:0051128 | regulation of cellular component organization | 44.2308 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 42.3077 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 42.3077 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 42.3077 | 4 | no |
GO:0006996 | organelle organization | 38.4615 | 4 | yes |
GO:0008104 | protein localization | 38.4615 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 36.5385 | 5 | no |
GO:0051049 | regulation of transport | 36.5385 | 4 | no |
GO:0071702 | organic substance transport | 32.6923 | 4 | yes |
GO:0030030 | cell projection organization | 30.7692 | 4 | yes |
GO:0071705 | nitrogen compound transport | 30.7692 | 4 | yes |
GO:0009892 | negative regulation of metabolic process | 30.7692 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 30.7692 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 30.7692 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 30.7692 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 28.8462 | 4 | no |
GO:0010647 | positive regulation of cell communication | 28.8462 | 5 | no |
GO:0023056 | positive regulation of signaling | 28.8462 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 28.8462 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 28.8462 | 4 | no |
GO:0031344 | regulation of cell projection organization | 28.8462 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 28.8462 | 6 | no |
GO:0019220 | regulation of phosphate metabolic process | 26.9231 | 6 | no |
GO:0022607 | cellular component assembly | 26.9231 | 4 | no |
GO:0051174 | regulation of phosphorus metabolic process | 26.9231 | 5 | no |
GO:0015031 | protein transport | 25.0000 | 4 | yes |
GO:0120036 | plasma membrane bounded cell projection organization | 25.0000 | 5 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
GO:0051050 | positive regulation of transport | 25.0000 | 4 | no |
GO:0051248 | negative regulation of protein metabolic process | 25.0000 | 6 | no |
GO:0042325 | regulation of phosphorylation | 23.0769 | 7 | no |
GO:0051247 | positive regulation of protein metabolic process | 23.0769 | 6 | no |
GO:0060341 | regulation of cellular localization | 23.0769 | 4 | no |
GO:0016192 | vesicle-mediated transport | 23.0769 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 23.0769 | 5 | no |
GO:0010648 | negative regulation of cell communication | 23.0769 | 5 | no |
GO:0023057 | negative regulation of signaling | 23.0769 | 4 | no |
GO:0006886 | intracellular protein transport | 21.1538 | 4 | yes |
GO:0001932 | regulation of protein phosphorylation | 21.1538 | 7 | no |
GO:0009967 | positive regulation of signal transduction | 21.1538 | 5 | no |
GO:0010975 | regulation of neuron projection development | 21.1538 | 7 | no |
GO:0009894 | regulation of catabolic process | 21.1538 | 4 | no |
GO:0030705 | cytoskeleton-dependent intracellular transport | 19.2308 | 4 | yes |
GO:0031175 | neuron projection development | 19.2308 | 6 | yes |
GO:0010970 | transport along microtubule | 17.3077 | 4 | yes |
GO:0099111 | microtubule-based transport | 17.3077 | 4 | yes |
GO:0008088 | axo-dendritic transport | 15.3846 | 5 | yes |
GO:0098930 | axonal transport | 15.3846 | 6 | yes |
GO:0008089 | anterograde axonal transport | 13.4615 | 7 | yes |
GO:0035418 | protein localization to synapse | 11.5385 | 6 | yes |
GO:0051650 | establishment of vesicle localization | 11.5385 | 4 | yes |
GO:1902414 | protein localization to cell junction | 11.5385 | 5 | yes |
GO:0007411 | axon guidance | 9.6154 | 8 | yes |
GO:0048489 | synaptic vesicle transport | 9.6154 | 4 | yes |
GO:0097479 | synaptic vesicle localization | 9.6154 | 4 | yes |
GO:0097485 | neuron projection guidance | 9.6154 | 7 | yes |
GO:0098840 | protein transport along microtubule | 9.6154 | 4 | yes |
GO:0099640 | axo-dendritic protein transport | 9.6154 | 5 | yes |
GO:0099641 | anterograde axonal protein transport | 9.6154 | 6 | yes |
GO:1905383 | protein localization to presynapse | 9.6154 | 7 | yes |
GO:0015931 | nucleobase-containing compound transport | 7.6923 | 5 | yes |
GO:0050657 | nucleic acid transport | 7.6923 | 6 | yes |
GO:0050658 | RNA transport | 7.6923 | 4 | yes |
GO:0098935 | dendritic transport | 7.6923 | 6 | yes |
GO:0098937 | anterograde dendritic transport | 7.6923 | 7 | yes |
GO:0098971 | anterograde dendritic transport of neurotransmitter receptor complex | 7.6923 | 4 | yes |
GO:0008045 | motor neuron axon guidance | 5.7692 | 9 | yes |
GO:0051028 | mRNA transport | 5.7692 | 5 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in KIF5C_HUMAN |
---|---|---|---|---|
DOID:331 | central nervous system disease | 7.6923 | 3 | yes |
DOID:0090131 | complex cortical dysplasia with other brain malformations | 3.8462 | 5 | yes |
DOID:0090133 | complex cortical dysplasia with other brain malformations 2 | 3.8462 | 6 | yes |
DOID:936 | brain disease | 3.8462 | 4 | yes |
DOID:2476 | hereditary spastic paraplegia | 3.8462 | 5 | no |
DOID:607 | paraplegia | 3.8462 | 4 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
NCOA2_HUMAN | [view interactions] | Low throughput | no | no |
CSK21_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CSK22_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
MIRO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TRAK1_HUMAN | [view interactions] | Low throughput | no | yes |
ANR27_HUMAN | [view interactions] | Low throughput | no | yes |
TRAK2_HUMAN | [view interactions] | Low throughput | no | yes |
FAT1_HUMAN | [view interactions] | Low throughput | no | yes |
HAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CSK2B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KIF5C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GBRG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
KLC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
KLC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KINH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
KIF5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RBP2_HUMAN | [view interactions] | Low throughput | no | yes |
KLC3_HUMAN | [view interactions] | Low throughput | no | no |
BRK1_HUMAN | [view interactions] | High throughput | no | no |
SYCE1_HUMAN | [view interactions] | High throughput | no | no |
INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HVCN1_HUMAN | [view interactions] | High throughput | no | yes |
KLC4_HUMAN | [view interactions] | High throughput | no | yes |
ANKY2_HUMAN | [view interactions] | High throughput | no | no |
RTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HOOK1_HUMAN | [view interactions] | High throughput | no | no |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
JIP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNP25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HERC2_HUMAN | [view interactions] | High throughput | no | yes |
HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
SNAPN_HUMAN | [view interactions] | High throughput | no | yes |
CUL1_HUMAN | [view interactions] | High throughput | no | yes |
CSAG2_HUMAN | [view interactions] | High throughput | no | no |
DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HES4_HUMAN | [view interactions] | High throughput | no | no |
AKIP_HUMAN | [view interactions] | High throughput | no | yes |
EEA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TGON2_HUMAN | [view interactions] | High throughput | no | yes |
ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
LMTK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
CBY1_HUMAN | [view interactions] | High throughput | no | no |
TANK_HUMAN | [view interactions] | High throughput | no | yes |
TNAP3_HUMAN | [view interactions] | High throughput | no | yes |
MEOX2_HUMAN | [view interactions] | High throughput | no | no |
CADH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ILF3_HUMAN | [view interactions] | High throughput | no | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
SYNE4_HUMAN | [view interactions] | High throughput | no | yes |
HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AZIN1_HUMAN | [view interactions] | High throughput | no | yes |
TRIP6_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
MYCL_HUMAN | [view interactions] | High throughput | no | no |
COG6_HUMAN | [view interactions] | High throughput | no | yes |
EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
PPT1_HUMAN | [view interactions] | High throughput | no | yes |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
MAGA3_HUMAN | [view interactions] | High throughput | no | no |
NUPR1_HUMAN | [view interactions] | High throughput | no | no |
P53_HUMAN | [view interactions] | High throughput | no | no |
NUP62_HUMAN | [view interactions] | High throughput | no | yes |
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NFM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NFL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TBA1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GRIA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GRIA4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SYUA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
NFH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
INS_HUMAN | [view interactions] | Computational | no | no |
GRIA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GRIA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TBB2B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GSK3B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |