KIF5C_HUMAN
Evidence for PS localization
Functions
Involved in synaptic transmission (PubMed). Mediates dendritic trafficking of mRNAs . Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 237 | Glu | Lys | Corticaldysplasia,complex,withotherbrainmalformations2(CDCBM2) | - |
| 237 | Glu | Val | Corticaldysplasia,complex,withotherbrainmalformations2(CDCBM2) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KIF5C_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 27.6596 | 4 | yes |
| GO:0000166 | nucleotide binding | 25.5319 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 25.5319 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 25.5319 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.5319 | 4 | yes |
| GO:0005524 | ATP binding | 23.4043 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 23.4043 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 23.4043 | 5 | yes |
| GO:0019900 | kinase binding | 21.2766 | 4 | no |
| GO:0019901 | protein kinase binding | 21.2766 | 5 | no |
| GO:0043169 | cation binding | 21.2766 | 4 | no |
| GO:0046872 | metal ion binding | 21.2766 | 5 | no |
| GO:0008017 | microtubule binding | 14.8936 | 5 | yes |
| GO:0015631 | tubulin binding | 14.8936 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 10.6383 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 10.6383 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 10.6383 | 6 | yes |
| GO:0016887 | ATP hydrolysis activity | 8.5106 | 7 | yes |
| GO:0034190 | apolipoprotein receptor binding | 4.2553 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KIF5C_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 59.5745 | 4 | no |
| GO:0009966 | regulation of signal transduction | 51.0638 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 51.0638 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 48.9362 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 46.8085 | 4 | no |
| GO:0008104 | protein localization | 44.6809 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 44.6809 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 44.6809 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 42.5532 | 4 | no |
| GO:0006996 | organelle organization | 36.1702 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 36.1702 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 36.1702 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 36.1702 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 34.0426 | 5 | no |
| GO:0030030 | cell projection organization | 31.9149 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 31.9149 | 5 | no |
| GO:0023056 | positive regulation of signaling | 31.9149 | 4 | no |
| GO:0022607 | cellular component assembly | 31.9149 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 29.7872 | 5 | no |
| GO:0051049 | regulation of transport | 29.7872 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.6596 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 27.6596 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 27.6596 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 25.5319 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 25.5319 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 25.5319 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 25.5319 | 5 | no |
| GO:0010468 | regulation of gene expression | 25.5319 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.5319 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.5319 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.5319 | 5 | no |
| GO:0036211 | protein modification process | 25.5319 | 4 | no |
| GO:0043412 | macromolecule modification | 25.5319 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 25.5319 | 6 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 25.5319 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 25.5319 | 4 | no |
| GO:0071702 | organic substance transport | 23.4043 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 23.4043 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 23.4043 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.4043 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 23.4043 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.4043 | 6 | no |
| GO:0031399 | regulation of protein modification process | 23.4043 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.4043 | 5 | no |
| GO:0060341 | regulation of cellular localization | 23.4043 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.2766 | 4 | yes |
| GO:0006468 | protein phosphorylation | 21.2766 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.2766 | 4 | no |
| GO:0009894 | regulation of catabolic process | 21.2766 | 4 | no |
| GO:0016310 | phosphorylation | 21.2766 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.2766 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.2766 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 21.2766 | 5 | no |
| GO:0051050 | positive regulation of transport | 21.2766 | 4 | no |
| GO:0010970 | transport along microtubule | 19.1489 | 4 | yes |
| GO:0015031 | protein transport | 19.1489 | 4 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 19.1489 | 4 | yes |
| GO:0031175 | neuron projection development | 19.1489 | 6 | yes |
| GO:0099111 | microtubule-based transport | 19.1489 | 4 | yes |
| GO:0008088 | axo-dendritic transport | 17.0213 | 5 | yes |
| GO:0098930 | axonal transport | 17.0213 | 6 | yes |
| GO:0035418 | protein localization to synapse | 14.8936 | 6 | yes |
| GO:1902414 | protein localization to cell junction | 14.8936 | 5 | yes |
| GO:0006886 | intracellular protein transport | 12.7660 | 4 | yes |
| GO:0008089 | anterograde axonal transport | 12.7660 | 7 | yes |
| GO:0051650 | establishment of vesicle localization | 12.7660 | 4 | yes |
| GO:0007411 | axon guidance | 10.6383 | 8 | yes |
| GO:0097479 | synaptic vesicle localization | 10.6383 | 4 | yes |
| GO:0097485 | neuron projection guidance | 10.6383 | 7 | yes |
| GO:0098840 | protein transport along microtubule | 10.6383 | 4 | yes |
| GO:0099640 | axo-dendritic protein transport | 10.6383 | 5 | yes |
| GO:0099641 | anterograde axonal protein transport | 10.6383 | 6 | yes |
| GO:1905383 | protein localization to presynapse | 10.6383 | 7 | yes |
| GO:0098935 | dendritic transport | 8.5106 | 6 | yes |
| GO:0098937 | anterograde dendritic transport | 8.5106 | 7 | yes |
| GO:0098971 | anterograde dendritic transport of neurotransmitter receptor complex | 8.5106 | 4 | yes |
| GO:0008045 | motor neuron axon guidance | 6.3830 | 9 | yes |
| GO:0015931 | nucleobase-containing compound transport | 6.3830 | 5 | yes |
| GO:0050657 | nucleic acid transport | 6.3830 | 6 | yes |
| GO:0050658 | RNA transport | 6.3830 | 4 | yes |
| GO:0051028 | mRNA transport | 6.3830 | 5 | yes |
| GO:0008298 | intracellular mRNA localization | 4.2553 | 4 | yes |
| GO:0098963 | dendritic transport of messenger ribonucleoprotein complex | 4.2553 | 4 | yes |
| GO:0098964 | anterograde dendritic transport of messenger ribonucleoprotein complex | 4.2553 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NCOA2_HUMAN | [view interactions] | Low throughput | no | no |
| CSK21_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSK22_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TRAK1_HUMAN | [view interactions] | Low throughput | no | yes |
| MIRO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANR27_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAK2_HUMAN | [view interactions] | Low throughput | no | yes |
| FAT1_HUMAN | [view interactions] | Low throughput | no | yes |
| HAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSK2B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIF5C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBRG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KLC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KLC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KINH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KIF5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RBP2_HUMAN | [view interactions] | Low throughput | no | yes |
| KLC3_HUMAN | [view interactions] | Low throughput | no | no |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JIP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNP25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TLK2_HUMAN | [view interactions] | High throughput | no | no |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| SNAPN_HUMAN | [view interactions] | High throughput | no | yes |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| CSAG2_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCNT_HUMAN | [view interactions] | High throughput | no | yes |
| HES4_HUMAN | [view interactions] | High throughput | no | no |
| AKIP_HUMAN | [view interactions] | High throughput | no | yes |
| EEA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| LMTK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| CBY1_HUMAN | [view interactions] | High throughput | no | no |
| TANK_HUMAN | [view interactions] | High throughput | no | yes |
| TNAP3_HUMAN | [view interactions] | High throughput | no | yes |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| CADH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ILF3_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| SYNE4_HUMAN | [view interactions] | High throughput | no | yes |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AZIN1_HUMAN | [view interactions] | High throughput | no | yes |
| TRIP6_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MYCL_HUMAN | [view interactions] | High throughput | no | no |
| COG6_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| MAGA3_HUMAN | [view interactions] | High throughput | no | no |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| NUP62_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRK1_HUMAN | [view interactions] | High throughput | no | no |
| SYCE1_HUMAN | [view interactions] | High throughput | no | no |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HVCN1_HUMAN | [view interactions] | High throughput | no | yes |
| KLC4_HUMAN | [view interactions] | High throughput | no | yes |
| CAVN3_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET14_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANKY2_HUMAN | [view interactions] | High throughput | no | no |
| RTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |