KLC2_HUMAN
Evidence for PS localization
Functions
Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI003037 | LIG_14-3-3_CanoR_1 | LIG | 579 | 584 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KLC2_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 24.0000 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 24.0000 | 5 | no |
| GO:0045296 | cadherin binding | 22.0000 | 4 | yes |
| GO:0005524 | ATP binding | 22.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 22.0000 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.0000 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.0000 | 4 | no |
| GO:0019894 | kinesin binding | 14.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KLC2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 56.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 50.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0008104 | protein localization | 50.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 48.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 48.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 46.0000 | 4 | no |
| GO:0006996 | organelle organization | 42.0000 | 4 | no |
| GO:0071702 | organic substance transport | 42.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 42.0000 | 4 | no |
| GO:0015031 | protein transport | 38.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 36.0000 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 36.0000 | 4 | no |
| GO:0051049 | regulation of transport | 36.0000 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 36.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 36.0000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 34.0000 | 5 | no |
| GO:0030030 | cell projection organization | 34.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 34.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 34.0000 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.0000 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 32.0000 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 32.0000 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 32.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 30.0000 | 6 | no |
| GO:0071310 | cellular response to organic substance | 30.0000 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 30.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 30.0000 | 4 | no |
| GO:0010941 | regulation of cell death | 28.0000 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 28.0000 | 6 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 28.0000 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 28.0000 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 28.0000 | 5 | no |
| GO:0006886 | intracellular protein transport | 28.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.0000 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 28.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.0000 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 26.0000 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 26.0000 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 26.0000 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 26.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.0000 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.0000 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 24.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 24.0000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 24.0000 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 24.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.0000 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.0000 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 24.0000 | 6 | no |
| GO:0051338 | regulation of transferase activity | 24.0000 | 4 | no |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 24.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 24.0000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 24.0000 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 24.0000 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 24.0000 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.0000 | 6 | no |
| GO:0051094 | positive regulation of developmental process | 24.0000 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 24.0000 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 22.0000 | 7 | no |
| GO:0045597 | positive regulation of cell differentiation | 22.0000 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.0000 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 22.0000 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 22.0000 | 4 | no |
| GO:0031400 | negative regulation of protein modification process | 22.0000 | 7 | no |
| GO:0008088 | axo-dendritic transport | 22.0000 | 5 | no |
| GO:0010970 | transport along microtubule | 22.0000 | 4 | no |
| GO:0031175 | neuron projection development | 22.0000 | 6 | no |
| GO:0043269 | regulation of ion transport | 22.0000 | 5 | no |
| GO:0051050 | positive regulation of transport | 22.0000 | 4 | no |
| GO:0060341 | regulation of cellular localization | 22.0000 | 4 | no |
| GO:0099111 | microtubule-based transport | 22.0000 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.0000 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 22.0000 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 22.0000 | 5 | no |
| GO:0032418 | lysosome localization | 8.0000 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in KLC2_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 6.0000 | 3 | no |
| DOID:2476 | hereditary spastic paraplegia | 4.0000 | 5 | no |
| DOID:607 | paraplegia | 4.0000 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SYNE4_HUMAN | [view interactions] | Low throughput | no | yes |
| ATF6A_HUMAN | [view interactions] | Low throughput | no | yes |
| KINH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KLC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| JIP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FAT1_HUMAN | [view interactions] | Low throughput | no | yes |
| FYCO1_HUMAN | [view interactions] | Low throughput | no | no |
| HAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIF5C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIF5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KLC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PKHM2_HUMAN | [view interactions] | Low throughput | no | yes |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| P55G_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| KLC4_HUMAN | [view interactions] | High throughput | no | yes |
| RASF1_HUMAN | [view interactions] | High throughput | no | yes |
| CND2_HUMAN | [view interactions] | High throughput | no | no |
| MIS12_HUMAN | [view interactions] | High throughput | no | yes |
| SMC6_HUMAN | [view interactions] | High throughput | no | no |
| NIPBL_HUMAN | [view interactions] | High throughput | no | yes |
| PP4C_HUMAN | [view interactions] | High throughput | no | yes |
| CENPJ_HUMAN | [view interactions] | High throughput | no | no |
| GEMI7_HUMAN | [view interactions] | High throughput | no | no |
| KLC3_HUMAN | [view interactions] | High throughput | no | no |
| PPIL2_HUMAN | [view interactions] | High throughput | no | yes |
| RT02_HUMAN | [view interactions] | High throughput | no | no |
| CATAC_HUMAN | [view interactions] | High throughput | no | yes |
| TIM8B_HUMAN | [view interactions] | High throughput | no | yes |
| GPKOW_HUMAN | [view interactions] | High throughput | no | yes |
| SRP14_HUMAN | [view interactions] | High throughput | no | no |
| ARX_HUMAN | [view interactions] | High throughput | no | no |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACHA9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COG6_HUMAN | [view interactions] | High throughput | no | yes |
| PAI2_HUMAN | [view interactions] | High throughput | no | no |
| THEM4_HUMAN | [view interactions] | High throughput | no | no |
| TRAK2_HUMAN | [view interactions] | High throughput | no | yes |
| AZIN1_HUMAN | [view interactions] | High throughput | no | yes |
| EID1_HUMAN | [view interactions] | High throughput | no | yes |
| MOCS3_HUMAN | [view interactions] | High throughput | no | yes |
| NUP43_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAKG3_HUMAN | [view interactions] | High throughput | no | no |
| BSDC1_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CXCR2_HUMAN | [view interactions] | High throughput | no | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| S10A8_HUMAN | [view interactions] | High throughput | no | no |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPART_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| CEP43_HUMAN | [view interactions] | High throughput | no | no |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| LMTK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX41_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCP3_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| NADL2_HUMAN | [view interactions] | High throughput | no | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| AP3D1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYCL_HUMAN | [view interactions] | High throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S100P_HUMAN | [view interactions] | High throughput | no | no |
| SPSB4_HUMAN | [view interactions] | High throughput | no | no |
| TRAK1_HUMAN | [view interactions] | High throughput | no | yes |
| RABE2_HUMAN | [view interactions] | High throughput | no | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUP62_HUMAN | [view interactions] | High throughput | no | yes |
| PRPS2_HUMAN | [view interactions] | High throughput | no | no |
| BFSP1_HUMAN | [view interactions] | High throughput | no | no |
| BRK1_HUMAN | [view interactions] | High throughput | no | no |
| TRI52_HUMAN | [view interactions] | High throughput | no | yes |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10A6_HUMAN | [view interactions] | High throughput | no | yes |
| S10A2_HUMAN | [view interactions] | High throughput | no | no |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MB212_HUMAN | [view interactions] | High throughput | no | no |
| DMAP1_HUMAN | [view interactions] | High throughput | no | yes |
| RM42_HUMAN | [view interactions] | High throughput | no | yes |
| NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTNG1_HUMAN | [view interactions] | High throughput | no | no |
| MOB1B_HUMAN | [view interactions] | High throughput | no | yes |
| E41L5_HUMAN | [view interactions] | High throughput | no | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AR6P6_HUMAN | [view interactions] | High throughput | no | yes |
| ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
| MTOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| TPC11_HUMAN | [view interactions] | High throughput | no | no |
| TPC2A_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PATL1_HUMAN | [view interactions] | High throughput | no | yes |
| SLAI2_HUMAN | [view interactions] | High throughput | no | no |
| SEPT2_HUMAN | [view interactions] | High throughput | no | no |
| ACO13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYGO2_HUMAN | [view interactions] | High throughput | no | yes |
| ZPR1_HUMAN | [view interactions] | High throughput | no | yes |
| RBBP5_HUMAN | [view interactions] | High throughput | no | yes |
| PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P4R3B_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LSM4_HUMAN | [view interactions] | High throughput | no | yes |
| LSM3_HUMAN | [view interactions] | High throughput | no | yes |
| LSM7_HUMAN | [view interactions] | High throughput | no | yes |
| LSMD1_HUMAN | [view interactions] | High throughput | no | no |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENTR1_HUMAN | [view interactions] | High throughput | no | no |
| ANC2_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NFM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NFH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KIF1A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GSK3B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |