KLC2_HUMAN
Evidence for PS localization
Functions
Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI003037 | LIG_14-3-3_CanoR_1 | LIG | 579 | 584 | - |
| ELMI003037 | LIG_14-3-3_CanoR_1 | LIG | 579 | 584 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KLC2_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 27.5862 | 4 | no |
| GO:0000166 | nucleotide binding | 25.8621 | 4 | no |
| GO:0005524 | ATP binding | 25.8621 | 5 | no |
| GO:0017076 | purine nucleotide binding | 25.8621 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 25.8621 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 25.8621 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.8621 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.8621 | 4 | no |
| GO:0045296 | cadherin binding | 22.4138 | 4 | yes |
| GO:0019900 | kinase binding | 20.6897 | 4 | no |
| GO:0019894 | kinesin binding | 13.7931 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KLC2_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 56.8966 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 55.1724 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 53.4483 | 4 | no |
| GO:0008104 | protein localization | 51.7241 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 44.8276 | 4 | no |
| GO:0006996 | organelle organization | 43.1034 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 43.1034 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 43.1034 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 43.1034 | 5 | no |
| GO:0010468 | regulation of gene expression | 41.3793 | 6 | no |
| GO:0010646 | regulation of cell communication | 41.3793 | 4 | no |
| GO:0022607 | cellular component assembly | 36.2069 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 36.2069 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 32.7586 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.7586 | 5 | no |
| GO:0009966 | regulation of signal transduction | 32.7586 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 32.7586 | 5 | no |
| GO:0051049 | regulation of transport | 32.7586 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 32.7586 | 5 | no |
| GO:0071702 | organic substance transport | 32.7586 | 4 | no |
| GO:0071705 | nitrogen compound transport | 32.7586 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.0345 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.0345 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 31.0345 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 31.0345 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 29.3103 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 29.3103 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 29.3103 | 5 | no |
| GO:0023056 | positive regulation of signaling | 29.3103 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 27.5862 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 27.5862 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 27.5862 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.5862 | 4 | no |
| GO:0015031 | protein transport | 27.5862 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.8621 | 6 | no |
| GO:0031399 | regulation of protein modification process | 25.8621 | 6 | no |
| GO:0043933 | protein-containing complex organization | 25.8621 | 4 | no |
| GO:0060341 | regulation of cellular localization | 25.8621 | 4 | no |
| GO:0030030 | cell projection organization | 24.1379 | 4 | no |
| GO:0071310 | cellular response to organic substance | 24.1379 | 4 | no |
| GO:0032880 | regulation of protein localization | 24.1379 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.4138 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.4138 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 22.4138 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.4138 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.4138 | 5 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 20.6897 | 8 | no |
| GO:0045893 | positive regulation of DNA-templated transcription | 20.6897 | 8 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.6897 | 5 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 20.6897 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.6897 | 5 | no |
| GO:1902680 | positive regulation of RNA biosynthetic process | 20.6897 | 7 | no |
| GO:0009967 | positive regulation of signal transduction | 20.6897 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 20.6897 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 20.6897 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.6897 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 20.6897 | 6 | no |
| GO:2000026 | regulation of multicellular organismal development | 20.6897 | 4 | no |
| GO:0033043 | regulation of organelle organization | 20.6897 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.6897 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 20.6897 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 20.6897 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 20.6897 | 6 | no |
| GO:0006886 | intracellular protein transport | 20.6897 | 4 | no |
| GO:0032418 | lysosome localization | 6.8966 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| KLC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PKHM2_HUMAN | [view interactions] | Low throughput | no | yes |
| SYNE4_HUMAN | [view interactions] | Low throughput | no | yes |
| ATF6A_HUMAN | [view interactions] | Low throughput | no | yes |
| KINH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KLC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| JIP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FAT1_HUMAN | [view interactions] | Low throughput | no | yes |
| FYCO1_HUMAN | [view interactions] | Low throughput | no | no |
| HAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RUSC2_HUMAN | [view interactions] | Low throughput | no | yes |
| TRIB1_HUMAN | [view interactions] | Low throughput | no | no |
| KIF5C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIF5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARMC5_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PATL1_HUMAN | [view interactions] | High throughput | no | yes |
| SLAI2_HUMAN | [view interactions] | High throughput | no | no |
| SEPT2_HUMAN | [view interactions] | High throughput | no | no |
| ACO13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYGO2_HUMAN | [view interactions] | High throughput | no | yes |
| ZPR1_HUMAN | [view interactions] | High throughput | no | yes |
| RBBP5_HUMAN | [view interactions] | High throughput | no | yes |
| PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P4R3B_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LSM4_HUMAN | [view interactions] | High throughput | no | yes |
| LSM3_HUMAN | [view interactions] | High throughput | no | yes |
| LSM7_HUMAN | [view interactions] | High throughput | no | yes |
| LSMD1_HUMAN | [view interactions] | High throughput | no | no |
| KIF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPSF5_HUMAN | [view interactions] | High throughput | no | yes |
| KIF1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS74L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEBPB_HUMAN | [view interactions] | High throughput | no | no |
| LMNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSBP1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP74_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBMX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F10A1_HUMAN | [view interactions] | High throughput | no | yes |
| CEBPG_HUMAN | [view interactions] | High throughput | no | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUF5_HUMAN | [view interactions] | High throughput | no | yes |
| LARP1_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG1_HUMAN | [view interactions] | High throughput | no | no |
| GLMN_HUMAN | [view interactions] | High throughput | no | no |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| SEH1_HUMAN | [view interactions] | High throughput | no | no |
| IPO9_HUMAN | [view interactions] | High throughput | no | no |
| PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBCD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI33_HUMAN | [view interactions] | High throughput | no | yes |
| RBGP1_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL5_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENTR1_HUMAN | [view interactions] | High throughput | no | no |
| ANC2_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| P55G_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| KLC4_HUMAN | [view interactions] | High throughput | no | yes |
| RASF1_HUMAN | [view interactions] | High throughput | no | yes |
| CND2_HUMAN | [view interactions] | High throughput | no | no |
| MIS12_HUMAN | [view interactions] | High throughput | no | yes |
| SMC6_HUMAN | [view interactions] | High throughput | no | no |
| NIPBL_HUMAN | [view interactions] | High throughput | no | yes |
| PP4C_HUMAN | [view interactions] | High throughput | no | yes |
| CENPJ_HUMAN | [view interactions] | High throughput | no | no |
| GEMI7_HUMAN | [view interactions] | High throughput | no | no |
| KLC3_HUMAN | [view interactions] | High throughput | no | no |
| SRP14_HUMAN | [view interactions] | High throughput | no | no |
| GPKOW_HUMAN | [view interactions] | High throughput | no | yes |
| TIM8B_HUMAN | [view interactions] | High throughput | no | yes |
| PPIL2_HUMAN | [view interactions] | High throughput | no | yes |
| CATAC_HUMAN | [view interactions] | High throughput | no | yes |
| RT02_HUMAN | [view interactions] | High throughput | no | no |
| ARX_HUMAN | [view interactions] | High throughput | no | no |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACHA9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COG6_HUMAN | [view interactions] | High throughput | no | yes |
| PAI2_HUMAN | [view interactions] | High throughput | no | no |
| THEM4_HUMAN | [view interactions] | High throughput | no | no |
| TRAK2_HUMAN | [view interactions] | High throughput | no | yes |
| AZIN1_HUMAN | [view interactions] | High throughput | no | yes |
| EID1_HUMAN | [view interactions] | High throughput | no | yes |
| MOCS3_HUMAN | [view interactions] | High throughput | no | yes |
| NUP43_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAKG3_HUMAN | [view interactions] | High throughput | no | no |
| BSDC1_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CXCR2_HUMAN | [view interactions] | High throughput | no | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| S10A8_HUMAN | [view interactions] | High throughput | no | no |
| SPART_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| CEP43_HUMAN | [view interactions] | High throughput | no | no |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| LMTK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX41_HUMAN | [view interactions] | High throughput | no | yes |
| GCP3_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| NADL2_HUMAN | [view interactions] | High throughput | no | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| AP3D1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYCL_HUMAN | [view interactions] | High throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S100P_HUMAN | [view interactions] | High throughput | no | no |
| SPSB4_HUMAN | [view interactions] | High throughput | no | no |
| TRAK1_HUMAN | [view interactions] | High throughput | no | yes |
| RABE2_HUMAN | [view interactions] | High throughput | no | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUP62_HUMAN | [view interactions] | High throughput | no | yes |
| PRPS2_HUMAN | [view interactions] | High throughput | no | no |
| BFSP1_HUMAN | [view interactions] | High throughput | no | no |
| BRK1_HUMAN | [view interactions] | High throughput | no | no |
| TRI52_HUMAN | [view interactions] | High throughput | no | yes |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10A6_HUMAN | [view interactions] | High throughput | no | yes |
| S10A2_HUMAN | [view interactions] | High throughput | no | no |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MB212_HUMAN | [view interactions] | High throughput | no | no |
| DMAP1_HUMAN | [view interactions] | High throughput | no | yes |
| RM42_HUMAN | [view interactions] | High throughput | no | yes |
| NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTNG1_HUMAN | [view interactions] | High throughput | no | no |
| MOB1B_HUMAN | [view interactions] | High throughput | no | yes |
| E41L5_HUMAN | [view interactions] | High throughput | no | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AR6P6_HUMAN | [view interactions] | High throughput | no | yes |
| ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
| MTOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| TPC11_HUMAN | [view interactions] | High throughput | no | no |
| TPC2A_HUMAN | [view interactions] | High throughput | no | yes |