DTBP1_HUMAN
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
ELM instance | Name | Type | Start | End | Partner |
---|---|---|---|---|---|
ELMI004855 | DOC_PP2B_LxvP_1 | DOC | 283 | 286 | - |
ELMI004855 | DOC_PP2B_LxvP_1 | DOC | 283 | 286 | - |
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in DTBP1_HUMAN |
---|---|---|---|---|
GO:0043169 | cation binding | 25.0000 | 4 | no |
GO:0046872 | metal ion binding | 25.0000 | 5 | no |
GO:0043168 | anion binding | 23.5294 | 4 | no |
GO:0003723 | RNA binding | 20.5882 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in DTBP1_HUMAN |
---|---|---|---|---|
GO:0006996 | organelle organization | 48.5294 | 4 | yes |
GO:0008104 | protein localization | 48.5294 | 4 | no |
GO:0048522 | positive regulation of cellular process | 47.0588 | 4 | yes |
GO:0071702 | organic substance transport | 44.1176 | 4 | no |
GO:0071705 | nitrogen compound transport | 44.1176 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 38.2353 | 4 | yes |
GO:0015031 | protein transport | 38.2353 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 33.8235 | 4 | yes |
GO:0010646 | regulation of cell communication | 32.3529 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 32.3529 | 4 | yes |
GO:0022607 | cellular component assembly | 32.3529 | 4 | no |
GO:0048523 | negative regulation of cellular process | 30.8824 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 30.8824 | 4 | yes |
GO:0009966 | regulation of signal transduction | 27.9412 | 4 | yes |
GO:0030030 | cell projection organization | 26.4706 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | yes |
GO:0051049 | regulation of transport | 25.0000 | 4 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 23.5294 | 5 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 23.5294 | 5 | yes |
GO:0051246 | regulation of protein metabolic process | 23.5294 | 5 | yes |
GO:0120036 | plasma membrane bounded cell projection organization | 23.5294 | 5 | yes |
GO:0010468 | regulation of gene expression | 22.0588 | 6 | yes |
GO:0006886 | intracellular protein transport | 22.0588 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 22.0588 | 4 | no |
GO:0030705 | cytoskeleton-dependent intracellular transport | 20.5882 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 20.5882 | 5 | yes |
GO:0051130 | positive regulation of cellular component organization | 20.5882 | 5 | yes |
GO:0051650 | establishment of vesicle localization | 20.5882 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 19.1176 | 5 | yes |
GO:0007010 | cytoskeleton organization | 17.6471 | 5 | yes |
GO:0010647 | positive regulation of cell communication | 17.6471 | 5 | yes |
GO:0010970 | transport along microtubule | 17.6471 | 4 | yes |
GO:0023056 | positive regulation of signaling | 17.6471 | 4 | yes |
GO:0099111 | microtubule-based transport | 17.6471 | 4 | yes |
GO:0099518 | vesicle cytoskeletal trafficking | 17.6471 | 5 | yes |
GO:0008088 | axo-dendritic transport | 16.1765 | 5 | yes |
GO:0016050 | vesicle organization | 16.1765 | 5 | yes |
GO:0072384 | organelle transport along microtubule | 16.1765 | 4 | yes |
GO:0098930 | axonal transport | 16.1765 | 6 | yes |
GO:0008089 | anterograde axonal transport | 14.7059 | 7 | yes |
GO:0019220 | regulation of phosphate metabolic process | 14.7059 | 6 | yes |
GO:0031344 | regulation of cell projection organization | 14.7059 | 5 | yes |
GO:0047496 | vesicle transport along microtubule | 14.7059 | 5 | yes |
GO:0051174 | regulation of phosphorus metabolic process | 14.7059 | 5 | yes |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 14.7059 | 6 | yes |
GO:0009891 | positive regulation of biosynthetic process | 13.2353 | 5 | yes |
GO:0051247 | positive regulation of protein metabolic process | 13.2353 | 6 | yes |
GO:0097479 | synaptic vesicle localization | 13.2353 | 4 | yes |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 11.7647 | 6 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 11.7647 | 4 | yes |
GO:0031175 | neuron projection development | 11.7647 | 6 | yes |
GO:0031328 | positive regulation of cellular biosynthetic process | 11.7647 | 6 | yes |
GO:0042325 | regulation of phosphorylation | 11.7647 | 7 | yes |
GO:0051050 | positive regulation of transport | 11.7647 | 4 | yes |
GO:0051129 | negative regulation of cellular component organization | 11.7647 | 5 | yes |
GO:0001932 | regulation of protein phosphorylation | 10.2941 | 7 | yes |
GO:0031399 | regulation of protein modification process | 10.2941 | 6 | yes |
GO:0048490 | anterograde synaptic vesicle transport | 10.2941 | 5 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 10.2941 | 5 | yes |
GO:0060627 | regulation of vesicle-mediated transport | 10.2941 | 4 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 10.2941 | 4 | yes |
GO:0099517 | synaptic vesicle transport along microtubule | 10.2941 | 4 | yes |
GO:0010975 | regulation of neuron projection development | 8.8235 | 7 | yes |
GO:0032438 | melanosome organization | 8.8235 | 7 | yes |
GO:0033363 | secretory granule organization | 8.8235 | 6 | yes |
GO:0048753 | pigment granule organization | 8.8235 | 6 | yes |
GO:0060155 | platelet dense granule organization | 8.8235 | 7 | yes |
GO:0010628 | positive regulation of gene expression | 7.3529 | 7 | yes |
GO:0030100 | regulation of endocytosis | 7.3529 | 5 | yes |
GO:0050807 | regulation of synapse organization | 7.3529 | 5 | yes |
GO:0051093 | negative regulation of developmental process | 7.3529 | 4 | yes |
GO:0120039 | plasma membrane bounded cell projection morphogenesis | 7.3529 | 4 | yes |
GO:0002090 | regulation of receptor internalization | 5.8824 | 7 | yes |
GO:0010562 | positive regulation of phosphorus metabolic process | 5.8824 | 6 | yes |
GO:0017157 | regulation of exocytosis | 5.8824 | 5 | yes |
GO:0031401 | positive regulation of protein modification process | 5.8824 | 7 | yes |
GO:0042327 | positive regulation of phosphorylation | 5.8824 | 8 | yes |
GO:0045937 | positive regulation of phosphate metabolic process | 5.8824 | 7 | yes |
GO:0048259 | regulation of receptor-mediated endocytosis | 5.8824 | 6 | yes |
GO:0048812 | neuron projection morphogenesis | 5.8824 | 5 | yes |
GO:0051046 | regulation of secretion | 5.8824 | 5 | yes |
GO:1903530 | regulation of secretion by cell | 5.8824 | 4 | yes |
GO:0001934 | positive regulation of protein phosphorylation | 4.4118 | 8 | yes |
GO:0046928 | regulation of neurotransmitter secretion | 4.4118 | 5 | yes |
GO:0051588 | regulation of neurotransmitter transport | 4.4118 | 5 | yes |
GO:0099175 | regulation of postsynapse organization | 4.4118 | 6 | yes |
GO:0007599 | hemostasis | 2.9412 | 4 | yes |
GO:0014059 | regulation of dopamine secretion | 2.9412 | 6 | yes |
GO:0031345 | negative regulation of cell projection organization | 2.9412 | 6 | yes |
GO:0045807 | positive regulation of endocytosis | 2.9412 | 5 | yes |
GO:0048260 | positive regulation of receptor-mediated endocytosis | 2.9412 | 6 | yes |
GO:0048813 | dendrite morphogenesis | 2.9412 | 6 | yes |
GO:0050433 | regulation of catecholamine secretion | 2.9412 | 5 | yes |
GO:0050806 | positive regulation of synaptic transmission | 2.9412 | 5 | yes |
GO:0051047 | positive regulation of secretion | 2.9412 | 5 | yes |
GO:0051590 | positive regulation of neurotransmitter transport | 2.9412 | 5 | yes |
GO:0051952 | regulation of amine transport | 2.9412 | 5 | yes |
GO:0060998 | regulation of dendritic spine development | 2.9412 | 4 | yes |
GO:0061000 | negative regulation of dendritic spine development | 2.9412 | 5 | yes |
GO:0061001 | regulation of dendritic spine morphogenesis | 2.9412 | 5 | yes |
GO:1903305 | regulation of regulated secretory pathway | 2.9412 | 6 | yes |
GO:1903532 | positive regulation of secretion by cell | 2.9412 | 5 | yes |
GO:2000300 | regulation of synaptic vesicle exocytosis | 2.9412 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
BL1S6_HUMAN | [view interactions] | Low throughput | no | yes |
BL1S5_HUMAN | [view interactions] | Low throughput | no | yes |
SNAPN_HUMAN | [view interactions] | Low throughput | no | yes |
DTNB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
DTNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CMYA5_HUMAN | [view interactions] | Low throughput | no | no |
XRCC6_HUMAN | [view interactions] | Low throughput | no | yes |
XRCC5_HUMAN | [view interactions] | Low throughput | no | yes |
ATP7A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DOPO_HUMAN | [view interactions] | Low throughput | no | no |
ACM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
BL1S2_HUMAN | [view interactions] | Low throughput | no | yes |
BL1S1_HUMAN | [view interactions] | Low throughput | no | yes |
DMD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
NECD_HUMAN | [view interactions] | Low throughput | no | no |
CCND3_HUMAN | [view interactions] | Low throughput | no | no |
TRI32_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
THIO_HUMAN | [view interactions] | Low throughput | no | yes |
CCND2_HUMAN | [view interactions] | Low throughput | no | yes |
CCND1_HUMAN | [view interactions] | Low throughput | no | yes |
TIF1A_HUMAN | [view interactions] | Low throughput | no | yes |
RN151_HUMAN | [view interactions] | Low throughput | no | no |
VRK2_HUMAN | [view interactions] | Low throughput | no | no |
TNKS1_HUMAN | [view interactions] | High throughput | no | yes |
NCK1_HUMAN | [view interactions] | High throughput | no | yes |
P85A_HUMAN | [view interactions] | High throughput | no | yes |
PLCG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WASF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AKAP6_HUMAN | [view interactions] | High throughput | no | no |
TF3B_HUMAN | [view interactions] | High throughput | no | yes |
SFR1_HUMAN | [view interactions] | High throughput | no | no |
CCNA2_HUMAN | [view interactions] | High throughput | no | no |
SYBU_HUMAN | [view interactions] | High throughput | no | yes |
BICRL_HUMAN | [view interactions] | High throughput | no | yes |
K0408_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MACF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NBEA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSME3_HUMAN | [view interactions] | High throughput | no | yes |
RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IPO5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EXOC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RBNS5_HUMAN | [view interactions] | High throughput | no | yes |
ZN490_HUMAN | [view interactions] | High throughput | no | no |
OSBL9_HUMAN | [view interactions] | High throughput | no | yes |
TXLNB_HUMAN | [view interactions] | High throughput | no | no |
PTPRM_HUMAN | [view interactions] | High throughput | no | yes |
BL1S3_HUMAN | [view interactions] | High throughput | no | no |
BL1S4_HUMAN | [view interactions] | High throughput | no | yes |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRKDC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP3B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATPA_HUMAN | [view interactions] | High throughput | no | yes |
BIG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRCRL_HUMAN | [view interactions] | High throughput | no | yes |
KANL1_HUMAN | [view interactions] | High throughput | no | yes |
SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI27_HUMAN | [view interactions] | High throughput | no | yes |
CC153_HUMAN | [view interactions] | High throughput | no | no |
P4HA3_HUMAN | [view interactions] | High throughput | no | no |
IFT20_HUMAN | [view interactions] | High throughput | no | yes |
BRK1_HUMAN | [view interactions] | High throughput | no | no |
HAUS1_HUMAN | [view interactions] | High throughput | no | yes |
ELOV7_HUMAN | [view interactions] | High throughput | no | no |
KIFC3_HUMAN | [view interactions] | High throughput | no | no |
SHFL_HUMAN | [view interactions] | High throughput | no | yes |
WASC3_HUMAN | [view interactions] | High throughput | no | yes |
K2C75_HUMAN | [view interactions] | High throughput | no | no |
MS18B_HUMAN | [view interactions] | High throughput | no | no |
ABI3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ARFP2_HUMAN | [view interactions] | High throughput | no | no |
DGC6L_HUMAN | [view interactions] | High throughput | no | no |
MIPT3_HUMAN | [view interactions] | High throughput | no | yes |
TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EXOC7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DYST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYNE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUF2_HUMAN | [view interactions] | High throughput | no | no |
KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRGP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRIM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ASAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CCHCR_HUMAN | [view interactions] | High throughput | no | no |
CC146_HUMAN | [view interactions] | High throughput | no | yes |
NECA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TEX35_HUMAN | [view interactions] | High throughput | no | no |
TRI74_HUMAN | [view interactions] | High throughput | no | no |
BBLN_HUMAN | [view interactions] | High throughput | no | yes |
VPS53_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP3M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IQGA2_HUMAN | [view interactions] | High throughput | no | yes |
EXOC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ASPM_HUMAN | [view interactions] | High throughput | no | no |
PCNT_HUMAN | [view interactions] | High throughput | no | yes |
COG6_HUMAN | [view interactions] | High throughput | no | yes |
AP3D1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DCAF1_HUMAN | [view interactions] | High throughput | no | yes |
TACC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BRCA2_HUMAN | [view interactions] | High throughput | no | no |
SNTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VPS50_HUMAN | [view interactions] | High throughput | no | yes |
KIF5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LAMC2_HUMAN | [view interactions] | High throughput | no | no |
CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VPS51_HUMAN | [view interactions] | High throughput | no | yes |
AP3B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NAV1_HUMAN | [view interactions] | High throughput | no | yes |
STX5_HUMAN | [view interactions] | High throughput | no | yes |
CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
KLC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KLC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CETN3_HUMAN | [view interactions] | High throughput | no | yes |
COG5_HUMAN | [view interactions] | High throughput | no | yes |
ALMS1_HUMAN | [view interactions] | High throughput | no | no |
CE290_HUMAN | [view interactions] | High throughput | no | no |
GDC_HUMAN | [view interactions] | High throughput | no | no |
EXOC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EXOC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPAG5_HUMAN | [view interactions] | High throughput | no | yes |
FA83H_HUMAN | [view interactions] | High throughput | no | yes |
BCAS4_HUMAN | [view interactions] | High throughput | no | yes |
BORC8_HUMAN | [view interactions] | High throughput | no | yes |
CCD22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AP3S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BORC6_HUMAN | [view interactions] | High throughput | no | yes |
COG7_HUMAN | [view interactions] | High throughput | no | yes |
STX8_HUMAN | [view interactions] | High throughput | no | yes |
ENTR1_HUMAN | [view interactions] | High throughput | no | no |
EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VAMP8_HUMAN | [view interactions] | High throughput | no | no |
KXDL1_HUMAN | [view interactions] | High throughput | no | yes |
VTI1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EIPR1_HUMAN | [view interactions] | High throughput | no | yes |
ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRAF7_HUMAN | [view interactions] | High throughput | no | yes |
EXC6B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP3S2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SNX7_HUMAN | [view interactions] | High throughput | no | yes |
TRI69_HUMAN | [view interactions] | High throughput | no | no |
TSKS_HUMAN | [view interactions] | High throughput | no | no |
GGA1_HUMAN | [view interactions] | High throughput | no | yes |
AKND1_HUMAN | [view interactions] | High throughput | no | no |
TRAK2_HUMAN | [view interactions] | High throughput | no | yes |
TRIMM_HUMAN | [view interactions] | High throughput | no | no |
MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
ANGP4_HUMAN | [view interactions] | High throughput | no | no |
KLC3_HUMAN | [view interactions] | High throughput | no | no |
K1C27_HUMAN | [view interactions] | High throughput | no | no |
PWP2_HUMAN | [view interactions] | High throughput | no | no |
TTC27_HUMAN | [view interactions] | High throughput | no | yes |
LYG2_HUMAN | [view interactions] | High throughput | no | no |
DUS14_HUMAN | [view interactions] | High throughput | no | yes |
IF1AX_HUMAN | [view interactions] | High throughput | no | yes |
LRC15_HUMAN | [view interactions] | High throughput | no | no |
DSG4_HUMAN | [view interactions] | High throughput | no | no |
VSIG8_HUMAN | [view interactions] | High throughput | no | no |
SNH28_HUMAN | [view interactions] | High throughput | no | no |
HPHL1_HUMAN | [view interactions] | High throughput | no | no |
PP2AA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SBP1_HUMAN | [view interactions] | High throughput | no | no |
PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COPZ1_HUMAN | [view interactions] | High throughput | no | no |
COPE_HUMAN | [view interactions] | High throughput | no | yes |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNR6_HUMAN | [view interactions] | High throughput | no | no |