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DTBP1_HUMAN

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway. [View more on UniProt]

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No data found.

ELM instance Name Type Start End Partner
ELMI004855 DOC_PP2B_LxvP_1 DOC 283 286 -
ELMI004855 DOC_PP2B_LxvP_1 DOC 283 286 -

Molecular function

Term Name % Distance from the top of the tree Annotated in DTBP1_HUMAN
GO:0043169 cation binding 25.0000 4 no
GO:0046872 metal ion binding 25.0000 5 no
GO:0043168 anion binding 23.5294 4 no
GO:0003723 RNA binding 20.5882 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in DTBP1_HUMAN
GO:0006996 organelle organization 48.5294 4 yes
GO:0008104 protein localization 48.5294 4 no
GO:0048522 positive regulation of cellular process 47.0588 4 yes
GO:0071702 organic substance transport 44.1176 4 no
GO:0071705 nitrogen compound transport 44.1176 4 no
GO:0031323 regulation of cellular metabolic process 38.2353 4 yes
GO:0015031 protein transport 38.2353 4 no
GO:0060255 regulation of macromolecule metabolic process 33.8235 4 yes
GO:0010646 regulation of cell communication 32.3529 4 yes
GO:0051128 regulation of cellular component organization 32.3529 4 yes
GO:0022607 cellular component assembly 32.3529 4 no
GO:0048523 negative regulation of cellular process 30.8824 4 yes
GO:0080090 regulation of primary metabolic process 30.8824 4 yes
GO:0009966 regulation of signal transduction 27.9412 4 yes
GO:0030030 cell projection organization 26.4706 4 yes
GO:0009889 regulation of biosynthetic process 25.0000 4 yes
GO:0009893 positive regulation of metabolic process 25.0000 4 yes
GO:0051049 regulation of transport 25.0000 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 23.5294 5 yes
GO:0031326 regulation of cellular biosynthetic process 23.5294 5 yes
GO:0051246 regulation of protein metabolic process 23.5294 5 yes
GO:0120036 plasma membrane bounded cell projection organization 23.5294 5 yes
GO:0010468 regulation of gene expression 22.0588 6 yes
GO:0006886 intracellular protein transport 22.0588 4 no
GO:0048584 positive regulation of response to stimulus 22.0588 4 no
GO:0030705 cytoskeleton-dependent intracellular transport 20.5882 4 yes
GO:0031325 positive regulation of cellular metabolic process 20.5882 5 yes
GO:0051130 positive regulation of cellular component organization 20.5882 5 yes
GO:0051650 establishment of vesicle localization 20.5882 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 19.1176 5 yes
GO:0007010 cytoskeleton organization 17.6471 5 yes
GO:0010647 positive regulation of cell communication 17.6471 5 yes
GO:0010970 transport along microtubule 17.6471 4 yes
GO:0023056 positive regulation of signaling 17.6471 4 yes
GO:0099111 microtubule-based transport 17.6471 4 yes
GO:0099518 vesicle cytoskeletal trafficking 17.6471 5 yes
GO:0008088 axo-dendritic transport 16.1765 5 yes
GO:0016050 vesicle organization 16.1765 5 yes
GO:0072384 organelle transport along microtubule 16.1765 4 yes
GO:0098930 axonal transport 16.1765 6 yes
GO:0008089 anterograde axonal transport 14.7059 7 yes
GO:0019220 regulation of phosphate metabolic process 14.7059 6 yes
GO:0031344 regulation of cell projection organization 14.7059 5 yes
GO:0047496 vesicle transport along microtubule 14.7059 5 yes
GO:0051174 regulation of phosphorus metabolic process 14.7059 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 14.7059 6 yes
GO:0009891 positive regulation of biosynthetic process 13.2353 5 yes
GO:0051247 positive regulation of protein metabolic process 13.2353 6 yes
GO:0097479 synaptic vesicle localization 13.2353 4 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 11.7647 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 11.7647 4 yes
GO:0031175 neuron projection development 11.7647 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 11.7647 6 yes
GO:0042325 regulation of phosphorylation 11.7647 7 yes
GO:0051050 positive regulation of transport 11.7647 4 yes
GO:0051129 negative regulation of cellular component organization 11.7647 5 yes
GO:0001932 regulation of protein phosphorylation 10.2941 7 yes
GO:0031399 regulation of protein modification process 10.2941 6 yes
GO:0048490 anterograde synaptic vesicle transport 10.2941 5 yes
GO:0050804 modulation of chemical synaptic transmission 10.2941 5 yes
GO:0060627 regulation of vesicle-mediated transport 10.2941 4 yes
GO:0099177 regulation of trans-synaptic signaling 10.2941 4 yes
GO:0099517 synaptic vesicle transport along microtubule 10.2941 4 yes
GO:0010975 regulation of neuron projection development 8.8235 7 yes
GO:0032438 melanosome organization 8.8235 7 yes
GO:0033363 secretory granule organization 8.8235 6 yes
GO:0048753 pigment granule organization 8.8235 6 yes
GO:0060155 platelet dense granule organization 8.8235 7 yes
GO:0010628 positive regulation of gene expression 7.3529 7 yes
GO:0030100 regulation of endocytosis 7.3529 5 yes
GO:0050807 regulation of synapse organization 7.3529 5 yes
GO:0051093 negative regulation of developmental process 7.3529 4 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 7.3529 4 yes
GO:0002090 regulation of receptor internalization 5.8824 7 yes
GO:0010562 positive regulation of phosphorus metabolic process 5.8824 6 yes
GO:0017157 regulation of exocytosis 5.8824 5 yes
GO:0031401 positive regulation of protein modification process 5.8824 7 yes
GO:0042327 positive regulation of phosphorylation 5.8824 8 yes
GO:0045937 positive regulation of phosphate metabolic process 5.8824 7 yes
GO:0048259 regulation of receptor-mediated endocytosis 5.8824 6 yes
GO:0048812 neuron projection morphogenesis 5.8824 5 yes
GO:0051046 regulation of secretion 5.8824 5 yes
GO:1903530 regulation of secretion by cell 5.8824 4 yes
GO:0001934 positive regulation of protein phosphorylation 4.4118 8 yes
GO:0046928 regulation of neurotransmitter secretion 4.4118 5 yes
GO:0051588 regulation of neurotransmitter transport 4.4118 5 yes
GO:0099175 regulation of postsynapse organization 4.4118 6 yes
GO:0007599 hemostasis 2.9412 4 yes
GO:0014059 regulation of dopamine secretion 2.9412 6 yes
GO:0031345 negative regulation of cell projection organization 2.9412 6 yes
GO:0045807 positive regulation of endocytosis 2.9412 5 yes
GO:0048260 positive regulation of receptor-mediated endocytosis 2.9412 6 yes
GO:0048813 dendrite morphogenesis 2.9412 6 yes
GO:0050433 regulation of catecholamine secretion 2.9412 5 yes
GO:0050806 positive regulation of synaptic transmission 2.9412 5 yes
GO:0051047 positive regulation of secretion 2.9412 5 yes
GO:0051590 positive regulation of neurotransmitter transport 2.9412 5 yes
GO:0051952 regulation of amine transport 2.9412 5 yes
GO:0060998 regulation of dendritic spine development 2.9412 4 yes
GO:0061000 negative regulation of dendritic spine development 2.9412 5 yes
GO:0061001 regulation of dendritic spine morphogenesis 2.9412 5 yes
GO:1903305 regulation of regulated secretory pathway 2.9412 6 yes
GO:1903532 positive regulation of secretion by cell 2.9412 5 yes
GO:2000300 regulation of synaptic vesicle exocytosis 2.9412 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
BL1S6_HUMAN [view interactions] Low throughput no yes
BL1S5_HUMAN [view interactions] Low throughput no yes
SNAPN_HUMAN [view interactions] Low throughput no yes
DTNB_HUMAN [view entry] [view interactions] Low throughput yes no
DTNA_HUMAN [view entry] [view interactions] Low throughput yes yes
CMYA5_HUMAN [view interactions] Low throughput no no
XRCC6_HUMAN [view interactions] Low throughput no yes
XRCC5_HUMAN [view interactions] Low throughput no yes
ATP7A_HUMAN [view entry] [view interactions] Low throughput yes yes
DOPO_HUMAN [view interactions] Low throughput no no
ACM5_HUMAN [view entry] [view interactions] Low throughput yes no
BL1S2_HUMAN [view interactions] Low throughput no yes
BL1S1_HUMAN [view interactions] Low throughput no yes
DMD_HUMAN [view entry] [view interactions] Low throughput yes no
NECD_HUMAN [view interactions] Low throughput no no
CCND3_HUMAN [view interactions] Low throughput no no
TRI32_HUMAN [view entry] [view interactions] Low throughput yes yes
THIO_HUMAN [view interactions] Low throughput no yes
CCND2_HUMAN [view interactions] Low throughput no yes
CCND1_HUMAN [view interactions] Low throughput no yes
TIF1A_HUMAN [view interactions] Low throughput no yes
RN151_HUMAN [view interactions] Low throughput no no
VRK2_HUMAN [view interactions] Low throughput no no
TNKS1_HUMAN [view interactions] High throughput no yes
NCK1_HUMAN [view interactions] High throughput no yes
P85A_HUMAN [view interactions] High throughput no yes
PLCG1_HUMAN [view entry] [view interactions] High throughput yes yes
WASF2_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP6_HUMAN [view interactions] High throughput no no
TF3B_HUMAN [view interactions] High throughput no yes
SFR1_HUMAN [view interactions] High throughput no no
CCNA2_HUMAN [view interactions] High throughput no no
SYBU_HUMAN [view interactions] High throughput no yes
BICRL_HUMAN [view interactions] High throughput no yes
K0408_HUMAN [view entry] [view interactions] High throughput yes no
MACF1_HUMAN [view entry] [view interactions] High throughput yes yes
NBEA_HUMAN [view entry] [view interactions] High throughput yes yes
PSME3_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
IPO5_HUMAN [view entry] [view interactions] High throughput yes yes
EXOC4_HUMAN [view entry] [view interactions] High throughput yes yes
RBNS5_HUMAN [view interactions] High throughput no yes
ZN490_HUMAN [view interactions] High throughput no no
OSBL9_HUMAN [view interactions] High throughput no yes
TXLNB_HUMAN [view interactions] High throughput no no
PTPRM_HUMAN [view interactions] High throughput no yes
BL1S3_HUMAN [view interactions] High throughput no no
BL1S4_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
AP3B2_HUMAN [view entry] [view interactions] High throughput yes yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
LPPRC_HUMAN [view entry] [view interactions] High throughput yes yes
AT2A2_HUMAN [view entry] [view interactions] High throughput yes yes
ATPA_HUMAN [view interactions] High throughput no yes
BIG2_HUMAN [view entry] [view interactions] High throughput yes yes
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
DAPK1_HUMAN [view entry] [view interactions] High throughput yes yes
ADT1_HUMAN [view entry] [view interactions] High throughput yes yes
SRCRL_HUMAN [view interactions] High throughput no yes
KANL1_HUMAN [view interactions] High throughput no yes
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
TRI27_HUMAN [view interactions] High throughput no yes
CC153_HUMAN [view interactions] High throughput no no
P4HA3_HUMAN [view interactions] High throughput no no
IFT20_HUMAN [view interactions] High throughput no yes
BRK1_HUMAN [view interactions] High throughput no no
HAUS1_HUMAN [view interactions] High throughput no yes
ELOV7_HUMAN [view interactions] High throughput no no
KIFC3_HUMAN [view interactions] High throughput no no
SHFL_HUMAN [view interactions] High throughput no yes
WASC3_HUMAN [view interactions] High throughput no yes
K2C75_HUMAN [view interactions] High throughput no no
MS18B_HUMAN [view interactions] High throughput no no
ABI3_HUMAN [view entry] [view interactions] High throughput yes no
ARFP2_HUMAN [view interactions] High throughput no no
DGC6L_HUMAN [view interactions] High throughput no no
MIPT3_HUMAN [view interactions] High throughput no yes
TRIM9_HUMAN [view entry] [view interactions] High throughput yes no
EXOC7_HUMAN [view entry] [view interactions] High throughput yes yes
DYST_HUMAN [view entry] [view interactions] High throughput yes yes
SYNE1_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
NUF2_HUMAN [view interactions] High throughput no no
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
SRGP3_HUMAN [view entry] [view interactions] High throughput yes yes
TRIM2_HUMAN [view entry] [view interactions] High throughput yes yes
ASAP1_HUMAN [view entry] [view interactions] High throughput yes yes
CCHCR_HUMAN [view interactions] High throughput no no
CC146_HUMAN [view interactions] High throughput no yes
NECA2_HUMAN [view entry] [view interactions] High throughput yes yes
TEX35_HUMAN [view interactions] High throughput no no
TRI74_HUMAN [view interactions] High throughput no no
BBLN_HUMAN [view interactions] High throughput no yes
VPS53_HUMAN [view entry] [view interactions] High throughput yes yes
AP3M1_HUMAN [view entry] [view interactions] High throughput yes yes
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA2_HUMAN [view interactions] High throughput no yes
EXOC3_HUMAN [view entry] [view interactions] High throughput yes no
ASPM_HUMAN [view interactions] High throughput no no
PCNT_HUMAN [view interactions] High throughput no yes
COG6_HUMAN [view interactions] High throughput no yes
AP3D1_HUMAN [view entry] [view interactions] High throughput yes no
DCAF1_HUMAN [view interactions] High throughput no yes
TACC1_HUMAN [view entry] [view interactions] High throughput yes yes
BRCA2_HUMAN [view interactions] High throughput no no
SNTB2_HUMAN [view entry] [view interactions] High throughput yes no
KTN1_HUMAN [view entry] [view interactions] High throughput yes yes
MYO5A_HUMAN [view entry] [view interactions] High throughput yes yes
MYO5C_HUMAN [view entry] [view interactions] High throughput yes yes
VPS50_HUMAN [view interactions] High throughput no yes
KIF5A_HUMAN [view entry] [view interactions] High throughput yes yes
KINH_HUMAN [view entry] [view interactions] High throughput yes no
LAMC2_HUMAN [view interactions] High throughput no no
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
KIF3A_HUMAN [view entry] [view interactions] High throughput yes yes
VPS51_HUMAN [view interactions] High throughput no yes
AP3B1_HUMAN [view entry] [view interactions] High throughput yes yes
NAV1_HUMAN [view interactions] High throughput no yes
STX5_HUMAN [view interactions] High throughput no yes
CK5P2_HUMAN [view interactions] High throughput no yes
KLC2_HUMAN [view entry] [view interactions] High throughput yes yes
KLC1_HUMAN [view entry] [view interactions] High throughput yes no
CETN3_HUMAN [view interactions] High throughput no yes
COG5_HUMAN [view interactions] High throughput no yes
ALMS1_HUMAN [view interactions] High throughput no no
CE290_HUMAN [view interactions] High throughput no no
GDC_HUMAN [view interactions] High throughput no no
EXOC5_HUMAN [view entry] [view interactions] High throughput yes yes
EXOC6_HUMAN [view entry] [view interactions] High throughput yes yes
SPAG5_HUMAN [view interactions] High throughput no yes
FA83H_HUMAN [view interactions] High throughput no yes
BCAS4_HUMAN [view interactions] High throughput no yes
BORC8_HUMAN [view interactions] High throughput no yes
CCD22_HUMAN [view entry] [view interactions] High throughput yes no
AP3S1_HUMAN [view entry] [view interactions] High throughput yes no
BORC6_HUMAN [view interactions] High throughput no yes
COG7_HUMAN [view interactions] High throughput no yes
STX8_HUMAN [view interactions] High throughput no yes
ENTR1_HUMAN [view interactions] High throughput no no
EXOC1_HUMAN [view entry] [view interactions] High throughput yes yes
VAMP8_HUMAN [view interactions] High throughput no no
KXDL1_HUMAN [view interactions] High throughput no yes
VTI1B_HUMAN [view entry] [view interactions] High throughput yes yes
EIPR1_HUMAN [view interactions] High throughput no yes
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
TRAF7_HUMAN [view interactions] High throughput no yes
EXC6B_HUMAN [view entry] [view interactions] High throughput yes yes
AP3S2_HUMAN [view entry] [view interactions] High throughput yes no
SNX7_HUMAN [view interactions] High throughput no yes
TRI69_HUMAN [view interactions] High throughput no no
TSKS_HUMAN [view interactions] High throughput no no
GGA1_HUMAN [view interactions] High throughput no yes
AKND1_HUMAN [view interactions] High throughput no no
TRAK2_HUMAN [view interactions] High throughput no yes
TRIMM_HUMAN [view interactions] High throughput no no
MKRN2_HUMAN [view interactions] High throughput no yes
ANGP4_HUMAN [view interactions] High throughput no no
KLC3_HUMAN [view interactions] High throughput no no
K1C27_HUMAN [view interactions] High throughput no no
PWP2_HUMAN [view interactions] High throughput no no
TTC27_HUMAN [view interactions] High throughput no yes
LYG2_HUMAN [view interactions] High throughput no no
DUS14_HUMAN [view interactions] High throughput no yes
IF1AX_HUMAN [view interactions] High throughput no yes
LRC15_HUMAN [view interactions] High throughput no no
DSG4_HUMAN [view interactions] High throughput no no
VSIG8_HUMAN [view interactions] High throughput no no
SNH28_HUMAN [view interactions] High throughput no no
HPHL1_HUMAN [view interactions] High throughput no no
PP2AA_HUMAN [view entry] [view interactions] High throughput yes yes
SBP1_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
COPZ1_HUMAN [view interactions] High throughput no no
COPE_HUMAN [view interactions] High throughput no yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
TNR6_HUMAN [view interactions] High throughput no no