DTNB_HUMAN
Evidence for PS localization
Functions
Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids . May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed). May be required for proper maturation and function of a subset of inhibitory synapses . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DTNB_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 36.1111 | 4 | yes |
| GO:0046872 | metal ion binding | 36.1111 | 5 | yes |
| GO:0000166 | nucleotide binding | 27.7778 | 4 | no |
| GO:0017076 | purine nucleotide binding | 27.7778 | 5 | no |
| GO:0043168 | anion binding | 27.7778 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 25.0000 | 6 | no |
| GO:0003779 | actin binding | 22.2222 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 22.2222 | 4 | no |
| GO:0046914 | transition metal ion binding | 19.4444 | 6 | yes |
| GO:0008270 | zinc ion binding | 16.6667 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DTNB_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 61.1111 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 41.6667 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 41.6667 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 41.6667 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 41.6667 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.1111 | 4 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0051049 | regulation of transport | 33.3333 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.5556 | 4 | no |
| GO:0010646 | regulation of cell communication | 30.5556 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.5556 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 30.5556 | 5 | no |
| GO:0008104 | protein localization | 30.5556 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 27.7778 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.7778 | 5 | no |
| GO:0030030 | cell projection organization | 27.7778 | 4 | no |
| GO:0031399 | regulation of protein modification process | 27.7778 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.7778 | 5 | no |
| GO:0071702 | organic substance transport | 27.7778 | 4 | no |
| GO:0007010 | cytoskeleton organization | 25.0000 | 5 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0036211 | protein modification process | 25.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 25.0000 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
| GO:0099536 | synaptic signaling | 22.2222 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 22.2222 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 22.2222 | 5 | no |
| GO:0009966 | regulation of signal transduction | 22.2222 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 22.2222 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.2222 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 22.2222 | 7 | no |
| GO:0031344 | regulation of cell projection organization | 22.2222 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 22.2222 | 7 | no |
| GO:0051050 | positive regulation of transport | 22.2222 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 22.2222 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.2222 | 5 | no |
| GO:0032880 | regulation of protein localization | 22.2222 | 5 | no |
| GO:0015031 | protein transport | 22.2222 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 22.2222 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 22.2222 | 4 | no |
| GO:0030182 | neuron differentiation | 5.5556 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CTNL1_HUMAN | [view interactions] | Low throughput | no | no |
| DMD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UTRN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNTB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KINH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ABCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| HM20A_HUMAN | [view interactions] | Low throughput | no | yes |
| SNTA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SNTG2_HUMAN | [view interactions] | Low throughput | no | no |
| SNTG1_HUMAN | [view interactions] | Low throughput | no | no |
| KIF5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TENS1_HUMAN | [view interactions] | High throughput | no | no |
| DAG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TENS2_HUMAN | [view interactions] | High throughput | no | no |
| CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP55_HUMAN | [view interactions] | High throughput | no | yes |
| NUP62_HUMAN | [view interactions] | High throughput | no | yes |
| TXLNA_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| LIPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| MTUS2_HUMAN | [view interactions] | High throughput | no | yes |
| K1C40_HUMAN | [view interactions] | High throughput | no | no |
| USBP1_HUMAN | [view interactions] | High throughput | no | no |
| ZBTB9_HUMAN | [view interactions] | High throughput | no | no |
| SPZ1_HUMAN | [view interactions] | High throughput | no | no |
| NDEL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABI3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GGA1_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DTNB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SKA1_HUMAN | [view interactions] | High throughput | no | yes |
| TSACC_HUMAN | [view interactions] | High throughput | no | no |
| CC85B_HUMAN | [view interactions] | High throughput | no | yes |
| PRDC1_HUMAN | [view interactions] | High throughput | no | yes |
| BEGIN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIPB2_HUMAN | [view interactions] | High throughput | no | yes |
| ADA1D_HUMAN | [view interactions] | High throughput | no | no |
| ZGPAT_HUMAN | [view interactions] | High throughput | no | no |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| ASPP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFP11_HUMAN | [view interactions] | High throughput | no | no |
| PICK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PO6F2_HUMAN | [view interactions] | High throughput | no | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMOL2_HUMAN | [view interactions] | High throughput | no | no |
| CC136_HUMAN | [view interactions] | High throughput | no | yes |
| KT33B_HUMAN | [view interactions] | High throughput | no | no |
| COG6_HUMAN | [view interactions] | High throughput | no | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI54_HUMAN | [view interactions] | High throughput | no | no |
| F167A_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP3_HUMAN | [view interactions] | High throughput | no | no |
| DEUP1_HUMAN | [view interactions] | High throughput | no | no |
| CC88B_HUMAN | [view interactions] | High throughput | no | no |
| K1C15_HUMAN | [view interactions] | High throughput | no | no |
| LURA1_HUMAN | [view interactions] | High throughput | no | yes |
| KRT38_HUMAN | [view interactions] | High throughput | no | no |
| K1C27_HUMAN | [view interactions] | High throughput | no | no |
| CBY2_HUMAN | [view interactions] | High throughput | no | no |
| CTBP2_HUMAN | [view interactions] | High throughput | no | no |
| M21D2_HUMAN | [view interactions] | High throughput | no | yes |
| FSD2_HUMAN | [view interactions] | High throughput | no | no |
| KAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KRT35_HUMAN | [view interactions] | High throughput | no | no |
| CCHCR_HUMAN | [view interactions] | High throughput | no | no |
| TRI27_HUMAN | [view interactions] | High throughput | no | yes |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS52_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MLC1_HUMAN | [view interactions] | High throughput | no | no |
| SGF29_HUMAN | [view interactions] | High throughput | no | yes |
| CPNE5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHPN1_HUMAN | [view interactions] | High throughput | no | yes |
| NOE2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
| DTNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNTB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CARM1_HUMAN | [view interactions] | High throughput | no | yes |
| TAGAP_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA2_HUMAN | [view interactions] | High throughput | no | no |
| KCNA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AJUBA_HUMAN | [view interactions] | High throughput | no | yes |
| PMF1_HUMAN | [view interactions] | High throughput | no | no |
| CCD96_HUMAN | [view interactions] | High throughput | no | no |
| NOS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FYCO1_HUMAN | [view interactions] | High throughput | no | no |
| IFT74_HUMAN | [view interactions] | High throughput | no | yes |
| PNMA2_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA4_HUMAN | [view interactions] | High throughput | no | yes |
| LIN7B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SEGN_HUMAN | [view interactions] | High throughput | no | no |
| MARK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARK3_HUMAN | [view interactions] | High throughput | no | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAF1_HUMAN | [view interactions] | High throughput | no | no |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| ZMYM1_HUMAN | [view interactions] | High throughput | no | no |
| TIPIN_HUMAN | [view interactions] | High throughput | no | no |
| TENS3_HUMAN | [view interactions] | High throughput | no | no |