DTNB_HUMAN
Evidence for PS localization
Functions
Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids . May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed). May be required for proper maturation and function of a subset of inhibitory synapses . [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 46%
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
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DTNB_HUMAN has binary interactions with 35 proteins
Isoforms
Interacting regions
Canonical [DTNB_HUMAN]
Isoform [E7EVB6] alignment
Isoform [E7ES64] alignment
Isoform [F8WD22] alignment
Isoform [F8W9U0] alignment
Isoform [O60941-2] alignment
Isoform [O60941-3] alignment
Isoform [O60941-4] alignment
Isoform [O60941-5] alignment
Isoform [O60941-6] alignment
Isoform [O60941-7] alignment
Isoform [E9PEY4] alignment
Isoform [E9PE76] alignment
LOADING 15%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DTNB_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 36.1111 | 4 | yes |
| GO:0046872 | metal ion binding | 36.1111 | 5 | yes |
| GO:0000166 | nucleotide binding | 27.7778 | 4 | no |
| GO:0017076 | purine nucleotide binding | 27.7778 | 5 | no |
| GO:0043168 | anion binding | 27.7778 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 25.0000 | 6 | no |
| GO:0003779 | actin binding | 22.2222 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 22.2222 | 4 | no |
| GO:0046914 | transition metal ion binding | 19.4444 | 6 | yes |
| GO:0008270 | zinc ion binding | 16.6667 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DTNB_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 61.1111 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 41.6667 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 41.6667 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 41.6667 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 41.6667 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.1111 | 4 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0051049 | regulation of transport | 33.3333 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.5556 | 4 | no |
| GO:0010646 | regulation of cell communication | 30.5556 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.5556 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 30.5556 | 5 | no |
| GO:0008104 | protein localization | 30.5556 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 27.7778 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.7778 | 5 | no |
| GO:0030030 | cell projection organization | 27.7778 | 4 | no |
| GO:0031399 | regulation of protein modification process | 27.7778 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.7778 | 5 | no |
| GO:0071702 | organic substance transport | 27.7778 | 4 | no |
| GO:0007010 | cytoskeleton organization | 25.0000 | 5 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0036211 | protein modification process | 25.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 25.0000 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ABCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABI3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADA1D_HUMAN | [view interactions] | High throughput | no | no |
| AJUBA_HUMAN | [view interactions] | High throughput | no | yes |
| AMOL2_HUMAN | [view interactions] | High throughput | no | no |
| ASPP1_HUMAN | [view interactions] | High throughput | no | yes |
| BEGIN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CARM1_HUMAN | [view interactions] | High throughput | no | yes |
| CBY2_HUMAN | [view interactions] | High throughput | no | no |
| CC136_HUMAN | [view interactions] | High throughput | no | yes |
| CC85B_HUMAN | [view interactions] | High throughput | no | yes |
| CC88B_HUMAN | [view interactions] | High throughput | no | no |
| CCD96_HUMAN | [view interactions] | High throughput | no | no |
| CCHCR_HUMAN | [view interactions] | High throughput | no | no |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| CEP55_HUMAN | [view interactions] | High throughput | no | yes |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| COG6_HUMAN | [view interactions] | High throughput | no | yes |
| CPNE5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTBP2_HUMAN | [view interactions] | High throughput | no | no |
| CTNL1_HUMAN | [view interactions] | Low throughput | no | no |
| DAG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |