ABI3_HUMAN
Evidence for PS localization
Functions
May inhibit tumor metastasis . In vitro, reduces cell motility. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ABI3_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 28.5714 | 4 | yes |
| GO:0017124 | SH3 domain binding | 25.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ABI3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 64.2857 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 60.7143 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 46.4286 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 46.4286 | 4 | yes |
| GO:0022607 | cellular component assembly | 46.4286 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 42.8571 | 5 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 42.8571 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 42.8571 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 42.8571 | 5 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 42.8571 | 6 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 42.8571 | 6 | yes |
| GO:0051130 | positive regulation of cellular component organization | 39.2857 | 5 | no |
| GO:0006996 | organelle organization | 35.7143 | 4 | no |
| GO:0110053 | regulation of actin filament organization | 35.7143 | 6 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 35.7143 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 32.1429 | 4 | yes |
| GO:0010975 | regulation of neuron projection development | 32.1429 | 7 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 32.1429 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 32.1429 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 32.1429 | 5 | no |
| GO:0023056 | positive regulation of signaling | 32.1429 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 32.1429 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.5714 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 28.5714 | 5 | no |
| GO:0007010 | cytoskeleton organization | 28.5714 | 5 | no |
| GO:0010638 | positive regulation of organelle organization | 28.5714 | 6 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 28.5714 | 5 | no |
| GO:0051495 | positive regulation of cytoskeleton organization | 28.5714 | 7 | no |
| GO:1902905 | positive regulation of supramolecular fiber organization | 28.5714 | 6 | no |
| GO:0030030 | cell projection organization | 28.5714 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 28.5714 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.5714 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 25.0000 | 5 | yes |
| GO:0008104 | protein localization | 25.0000 | 4 | no |
| GO:0043933 | protein-containing complex organization | 25.0000 | 4 | no |
| GO:0051049 | regulation of transport | 25.0000 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 25.0000 | 5 | no |
| GO:0007015 | actin filament organization | 25.0000 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 25.0000 | 4 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 25.0000 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 25.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:0050807 | regulation of synapse organization | 21.4286 | 5 | yes |
| GO:0060491 | regulation of cell projection assembly | 21.4286 | 5 | yes |
| GO:0099175 | regulation of postsynapse organization | 21.4286 | 6 | yes |
| GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 21.4286 | 6 | yes |
| GO:0016192 | vesicle-mediated transport | 21.4286 | 4 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 21.4286 | 4 | no |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 21.4286 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.4286 | 5 | no |
| GO:0032271 | regulation of protein polymerization | 21.4286 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.4286 | 5 | no |
| GO:0032990 | cell part morphogenesis | 21.4286 | 4 | no |
| GO:0048858 | cell projection morphogenesis | 21.4286 | 5 | no |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 21.4286 | 6 | no |
| GO:0030334 | regulation of cell migration | 17.8571 | 5 | yes |
| GO:0031345 | negative regulation of cell projection organization | 17.8571 | 6 | yes |
| GO:0032880 | regulation of protein localization | 17.8571 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 17.8571 | 4 | yes |
| GO:0061001 | regulation of dendritic spine morphogenesis | 17.8571 | 5 | yes |
| GO:2000145 | regulation of cell motility | 17.8571 | 4 | yes |
| GO:0010591 | regulation of lamellipodium assembly | 14.2857 | 7 | yes |
| GO:1900027 | regulation of ruffle assembly | 14.2857 | 7 | yes |
| GO:1902743 | regulation of lamellipodium organization | 14.2857 | 7 | yes |
| GO:0120033 | negative regulation of plasma membrane bounded cell projection assembly | 10.7143 | 7 | yes |
| GO:1900028 | negative regulation of ruffle assembly | 10.7143 | 8 | yes |
| GO:2000249 | regulation of actin cytoskeleton reorganization | 10.7143 | 6 | yes |
| GO:0002357 | defense response to tumor cell | 7.1429 | 4 | yes |
| GO:0010593 | negative regulation of lamellipodium assembly | 7.1429 | 8 | yes |
| GO:0051963 | regulation of synapse assembly | 7.1429 | 6 | yes |
| GO:0099150 | regulation of postsynaptic specialization assembly | 7.1429 | 6 | yes |
| GO:0099151 | regulation of postsynaptic density assembly | 7.1429 | 7 | yes |
| GO:1901888 | regulation of cell junction assembly | 7.1429 | 5 | yes |
| GO:1902115 | regulation of organelle assembly | 7.1429 | 5 | yes |
| GO:1902744 | negative regulation of lamellipodium organization | 7.1429 | 7 | yes |
| GO:1903076 | regulation of protein localization to plasma membrane | 7.1429 | 7 | yes |
| GO:1903077 | negative regulation of protein localization to plasma membrane | 7.1429 | 7 | yes |
| GO:1903828 | negative regulation of protein localization | 7.1429 | 5 | yes |
| GO:1904375 | regulation of protein localization to cell periphery | 7.1429 | 6 | yes |
| GO:1904376 | negative regulation of protein localization to cell periphery | 7.1429 | 6 | yes |
| GO:1904889 | regulation of excitatory synapse assembly | 7.1429 | 7 | yes |
| GO:1905475 | regulation of protein localization to membrane | 7.1429 | 6 | yes |
| GO:1905476 | negative regulation of protein localization to membrane | 7.1429 | 6 | yes |
| GO:1905874 | regulation of postsynaptic density organization | 7.1429 | 6 | yes |
| GO:2000772 | regulation of cellular senescence | 7.1429 | 5 | yes |
| GO:2000774 | positive regulation of cellular senescence | 7.1429 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ENAH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WASF2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TARSH_HUMAN | [view interactions] | Low throughput | no | no |
| PAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NUP58_HUMAN | [view interactions] | High throughput | no | yes |
| WASP_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3H_HUMAN | [view interactions] | High throughput | no | yes |
| HOME3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DTNB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| VASP_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLC3_HUMAN | [view interactions] | High throughput | no | no |
| MR1L1_HUMAN | [view interactions] | High throughput | no | no |
| ARMC7_HUMAN | [view interactions] | High throughput | no | yes |
| KLC4_HUMAN | [view interactions] | High throughput | no | yes |
| CEP44_HUMAN | [view interactions] | High throughput | no | yes |
| MAGAC_HUMAN | [view interactions] | High throughput | no | no |
| EVL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYFA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABI3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| THIOM_HUMAN | [view interactions] | High throughput | no | yes |
| SUFU_HUMAN | [view interactions] | High throughput | no | yes |
| BFSP2_HUMAN | [view interactions] | High throughput | no | no |
| SYVM_HUMAN | [view interactions] | High throughput | no | yes |
| IHO1_HUMAN | [view interactions] | High throughput | no | no |
| GBG13_HUMAN | [view interactions] | High throughput | no | no |
| 3BP1_HUMAN | [view interactions] | High throughput | no | no |
| RHG09_HUMAN | [view interactions] | High throughput | no | no |
| STX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| KRT38_HUMAN | [view interactions] | High throughput | no | no |
| TRAF4_HUMAN | [view interactions] | High throughput | no | yes |
| KRT35_HUMAN | [view interactions] | High throughput | no | no |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMRD1_HUMAN | [view interactions] | High throughput | no | yes |
| NDEL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOFA1_HUMAN | [view interactions] | High throughput | no | yes |
| DESI1_HUMAN | [view interactions] | High throughput | no | yes |
| RUFY3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C24_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K1C28_HUMAN | [view interactions] | High throughput | no | no |
| K0408_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NHSL2_HUMAN | [view interactions] | High throughput | no | yes |
| K1C14_HUMAN | [view interactions] | High throughput | no | no |
| WASF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MS18B_HUMAN | [view interactions] | High throughput | no | no |
| MED29_HUMAN | [view interactions] | High throughput | no | no |
| MS18A_HUMAN | [view interactions] | High throughput | no | yes |
| CENPQ_HUMAN | [view interactions] | High throughput | no | yes |
| BL1S5_HUMAN | [view interactions] | High throughput | no | yes |
| GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3M_HUMAN | [view interactions] | High throughput | no | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTG8_HUMAN | [view interactions] | High throughput | no | yes |
| TM147_HUMAN | [view interactions] | High throughput | no | no |
| SNP23_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K1C15_HUMAN | [view interactions] | High throughput | no | no |
| C170L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGTR1_HUMAN | [view interactions] | High throughput | no | no |
| ACTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K1C13_HUMAN | [view interactions] | High throughput | no | no |
| FBF1_HUMAN | [view interactions] | High throughput | no | no |
| HOME2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFT20_HUMAN | [view interactions] | High throughput | no | yes |
| STX2_HUMAN | [view interactions] | High throughput | no | no |
| F124B_HUMAN | [view interactions] | High throughput | no | yes |
| KRT36_HUMAN | [view interactions] | High throughput | no | no |
| BI2L2_HUMAN | [view interactions] | High throughput | no | yes |
| EMIL1_HUMAN | [view interactions] | High throughput | no | no |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIFC3_HUMAN | [view interactions] | High throughput | no | no |
| WASH1_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP2_HUMAN | [view interactions] | High throughput | no | no |
| BAIP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| BRK1_HUMAN | [view interactions] | Computational | no | no |