Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

WASF2_HUMAN

Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. [View more on UniProt]

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ELM instance Name Type Start End Partner
ELMI001661 LIG_Actin_WH2_1 LIG 437 453 -

Molecular function

Term Name % Distance from the top of the tree Annotated in WASF2_HUMAN
GO:0017076 purine nucleotide binding 43.9394 4 no
GO:0032555 purine ribonucleotide binding 42.4242 4 no
GO:0035639 purine ribonucleoside triphosphate binding 42.4242 4 no
GO:0003779 actin binding 34.8485 4 yes
GO:0030554 adenyl nucleotide binding 27.2727 5 no
GO:0005524 ATP binding 25.7576 5 no
GO:0032559 adenyl ribonucleotide binding 25.7576 5 no
GO:0019900 kinase binding 22.7273 4 no
GO:0019901 protein kinase binding 21.2121 5 no
GO:0045296 cadherin binding 13.6364 4 yes
GO:0017124 SH3 domain binding 12.1212 4 yes
GO:0034237 protein kinase A regulatory subunit binding 7.5758 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in WASF2_HUMAN
GO:0051128 regulation of cellular component organization 75.7576 4 yes
GO:0048522 positive regulation of cellular process 74.2424 4 yes
GO:0033043 regulation of organelle organization 57.5758 5 yes
GO:0048523 negative regulation of cellular process 57.5758 4 yes
GO:0022607 cellular component assembly 54.5455 4 yes
GO:0051493 regulation of cytoskeleton organization 54.5455 6 yes
GO:0044087 regulation of cellular component biogenesis 53.0303 4 yes
GO:0031323 regulation of cellular metabolic process 53.0303 4 no
GO:0030030 cell projection organization 51.5152 4 yes
GO:0032956 regulation of actin cytoskeleton organization 50.0000 5 yes
GO:0032970 regulation of actin filament-based process 50.0000 4 yes
GO:0051130 positive regulation of cellular component organization 50.0000 5 yes
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0006996 organelle organization 48.4848 4 yes
GO:0010646 regulation of cell communication 48.4848 4 no
GO:0051171 regulation of nitrogen compound metabolic process 46.9697 4 no
GO:0080090 regulation of primary metabolic process 46.9697 4 no
GO:0031344 regulation of cell projection organization 45.4545 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 45.4545 6 yes
GO:0120036 plasma membrane bounded cell projection organization 45.4545 5 yes
GO:0009966 regulation of signal transduction 45.4545 4 no
GO:0009893 positive regulation of metabolic process 42.4242 4 no
GO:0008104 protein localization 40.9091 4 no
GO:0110053 regulation of actin filament organization 39.3939 6 yes
GO:1902903 regulation of supramolecular fiber organization 39.3939 5 yes
GO:0097435 supramolecular fiber organization 39.3939 4 no
GO:0010604 positive regulation of macromolecule metabolic process 37.8788 5 no
GO:0031325 positive regulation of cellular metabolic process 37.8788 5 no
GO:0010468 regulation of gene expression 37.8788 5 no
GO:0051049 regulation of transport 37.8788 4 no
GO:0051246 regulation of protein metabolic process 36.3636 5 no
GO:0071310 cellular response to organic substance 36.3636 4 no
GO:2000145 regulation of cell motility 36.3636 4 no
GO:0007015 actin filament organization 36.3636 5 no
GO:0007010 cytoskeleton organization 34.8485 5 yes
GO:0030334 regulation of cell migration 34.8485 5 no
GO:0045595 regulation of cell differentiation 34.8485 4 no
GO:0048584 positive regulation of response to stimulus 34.8485 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 34.8485 5 no
GO:0010638 positive regulation of organelle organization 33.3333 6 yes
GO:0031346 positive regulation of cell projection organization 33.3333 6 yes
GO:0016192 vesicle-mediated transport 31.8182 4 yes
GO:0044089 positive regulation of cellular component biogenesis 31.8182 5 yes
GO:0019220 regulation of phosphate metabolic process 31.8182 6 no
GO:0022603 regulation of anatomical structure morphogenesis 31.8182 4 no
GO:0051174 regulation of phosphorus metabolic process 31.8182 5 no
GO:0051495 positive regulation of cytoskeleton organization 30.3030 7 yes
GO:0010647 positive regulation of cell communication 30.3030 5 no
GO:0023056 positive regulation of signaling 30.3030 4 no
GO:0042325 regulation of phosphorylation 30.3030 7 no
GO:1902531 regulation of intracellular signal transduction 30.3030 5 no
GO:0031399 regulation of protein modification process 28.7879 6 no
GO:0051094 positive regulation of developmental process 28.7879 4 no
GO:1901701 cellular response to oxygen-containing compound 28.7879 4 no
GO:0032535 regulation of cellular component size 28.7879 4 no
GO:0030031 cell projection assembly 27.2727 5 yes
GO:1902905 positive regulation of supramolecular fiber organization 27.2727 6 yes
GO:0010975 regulation of neuron projection development 27.2727 7 no
GO:0030335 positive regulation of cell migration 27.2727 6 no
GO:0040017 positive regulation of locomotion 27.2727 4 no
GO:0060284 regulation of cell development 27.2727 5 no
GO:2000147 positive regulation of cell motility 27.2727 5 no
GO:0043254 regulation of protein-containing complex assembly 27.2727 5 no
GO:0071702 organic substance transport 27.2727 4 no
GO:0060491 regulation of cell projection assembly 25.7576 5 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 25.7576 6 yes
GO:0001932 regulation of protein phosphorylation 25.7576 7 no
GO:0009892 negative regulation of metabolic process 25.7576 4 no
GO:0009967 positive regulation of signal transduction 25.7576 5 no
GO:0010605 negative regulation of macromolecule metabolic process 25.7576 5 no
GO:0030155 regulation of cell adhesion 25.7576 4 no
GO:0042127 regulation of cell population proliferation 25.7576 4 no
GO:0051240 positive regulation of multicellular organismal process 25.7576 4 no
GO:0051338 regulation of transferase activity 25.7576 4 no
GO:2000026 regulation of multicellular organismal development 25.7576 4 no
GO:0032271 regulation of protein polymerization 25.7576 6 no
GO:0009889 regulation of biosynthetic process 25.7576 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.7576 5 no
GO:0031326 regulation of cellular biosynthetic process 25.7576 5 no
GO:0071705 nitrogen compound transport 25.7576 4 no
GO:0032990 cell part morphogenesis 24.2424 4 yes
GO:0048858 cell projection morphogenesis 24.2424 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 24.2424 6 yes
GO:0008284 positive regulation of cell population proliferation 24.2424 5 no
GO:0010243 response to organonitrogen compound 24.2424 4 no
GO:0010562 positive regulation of phosphorus metabolic process 24.2424 6 no
GO:0031175 neuron projection development 24.2424 6 no
GO:0034330 cell junction organization 24.2424 4 no
GO:0036211 protein modification process 24.2424 4 no
GO:0042327 positive regulation of phosphorylation 24.2424 8 no
GO:0043412 macromolecule modification 24.2424 4 no
GO:0045937 positive regulation of phosphate metabolic process 24.2424 7 no
GO:0051247 positive regulation of protein metabolic process 24.2424 6 no
GO:0080134 regulation of response to stress 24.2424 4 no
GO:0060341 regulation of cellular localization 24.2424 4 no
GO:0015031 protein transport 24.2424 4 no
GO:0051129 negative regulation of cellular component organization 22.7273 5 yes
GO:0006796 phosphate-containing compound metabolic process 22.7273 4 no
GO:0022604 regulation of cell morphogenesis 22.7273 5 no
GO:0043085 positive regulation of catalytic activity 22.7273 4 no
GO:0043549 regulation of kinase activity 22.7273 5 no
GO:0045597 positive regulation of cell differentiation 22.7273 5 no
GO:0071417 cellular response to organonitrogen compound 22.7273 4 no
GO:1901699 cellular response to nitrogen compound 22.7273 4 no
GO:0008064 regulation of actin polymerization or depolymerization 22.7273 6 no
GO:0010941 regulation of cell death 22.7273 4 no
GO:0030832 regulation of actin filament length 22.7273 5 no
GO:0030833 regulation of actin filament polymerization 22.7273 7 no
GO:0051050 positive regulation of transport 22.7273 4 no
GO:0060627 regulation of vesicle-mediated transport 22.7273 4 no
GO:0010556 regulation of macromolecule biosynthetic process 22.7273 5 no
GO:0007264 small GTPase mediated signal transduction 21.2121 4 yes
GO:0120031 plasma membrane bounded cell projection assembly 21.2121 6 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 21.2121 4 no
GO:0010648 negative regulation of cell communication 21.2121 5 no
GO:0016310 phosphorylation 21.2121 5 no
GO:0023057 negative regulation of signaling 21.2121 4 no
GO:0048585 negative regulation of response to stimulus 21.2121 4 no
GO:0048812 neuron projection morphogenesis 21.2121 7 no
GO:0050804 modulation of chemical synaptic transmission 21.2121 5 no
GO:0050807 regulation of synapse organization 21.2121 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 21.2121 5 no
GO:0080135 regulation of cellular response to stress 21.2121 4 no
GO:0099177 regulation of trans-synaptic signaling 21.2121 4 no
GO:0032880 regulation of protein localization 21.2121 5 no
GO:0043933 protein-containing complex organization 21.2121 4 no
GO:0065003 protein-containing complex assembly 21.2121 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.2121 6 no
GO:0006897 endocytosis 19.6970 5 yes
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 19.6970 6 yes
GO:0007265 Ras protein signal transduction 18.1818 5 yes
GO:0010591 regulation of lamellipodium assembly 16.6667 7 yes
GO:1902743 regulation of lamellipodium organization 16.6667 7 yes
GO:0010592 positive regulation of lamellipodium assembly 15.1515 7 yes
GO:1902745 positive regulation of lamellipodium organization 15.1515 7 yes
GO:0097581 lamellipodium organization 13.6364 6 yes
GO:0032231 regulation of actin filament bundle assembly 12.1212 5 yes
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 12.1212 8 yes
GO:0051125 regulation of actin nucleation 12.1212 7 yes
GO:0016601 Rac protein signal transduction 10.6061 6 yes
GO:0051127 positive regulation of actin nucleation 10.6061 7 yes
GO:0051492 regulation of stress fiber assembly 10.6061 6 yes
GO:0110020 regulation of actomyosin structure organization 10.6061 6 yes
GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation 10.6061 8 yes
GO:0030032 lamellipodium assembly 9.0909 7 yes
GO:0010639 negative regulation of organelle organization 7.5758 6 yes
GO:0001667 ameboidal-type cell migration 6.0606 4 yes
GO:0051494 negative regulation of cytoskeleton organization 6.0606 7 yes
GO:0032232 negative regulation of actin filament bundle assembly 4.5455 6 yes
GO:0061515 myeloid cell development 4.5455 4 yes
GO:0072673 lamellipodium morphogenesis 4.5455 7 yes
GO:1902904 negative regulation of supramolecular fiber organization 4.5455 6 yes
GO:0035855 megakaryocyte development 3.0303 5 yes
GO:0051497 negative regulation of stress fiber assembly 3.0303 7 yes
GO:0098751 bone cell development 3.0303 4 yes
GO:0098974 postsynaptic actin cytoskeleton organization 3.0303 4 yes
GO:0099188 postsynaptic cytoskeleton organization 3.0303 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in WASF2_HUMAN
DOID:0050686 organ system cancer 3.0303 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NCKPL_HUMAN [view entry] [view interactions] Low throughput yes yes
PR40A_HUMAN [view interactions] Low throughput no yes
ARP3_HUMAN [view entry] [view interactions] Low throughput yes yes
DTBP1_HUMAN [view entry] [view interactions] Low throughput yes yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
BAIP2_HUMAN [view entry] [view interactions] Low throughput yes yes
ABI1_HUMAN [view entry] [view interactions] Low throughput yes yes
NCKP1_HUMAN [view entry] [view interactions] Low throughput yes yes
CYFP1_HUMAN [view entry] [view interactions] Low throughput yes yes
ABI2_HUMAN [view entry] [view interactions] Low throughput yes yes
ABI3_HUMAN [view entry] [view interactions] Low throughput yes no
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
VINEX_HUMAN [view interactions] Low throughput no no
SRC8_HUMAN [view entry] [view interactions] Low throughput yes yes
KANK1_HUMAN [view interactions] Low throughput no yes
ZN511_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
TIM50_HUMAN [view entry] [view interactions] High throughput yes yes
HOME3_HUMAN [view entry] [view interactions] High throughput yes yes
EVL_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
HDAC4_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
WWP2_HUMAN [view interactions] High throughput no no
BACD3_HUMAN [view interactions] High throughput no yes
DDX58_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
CNGA4_HUMAN [view interactions] High throughput no no
RHG12_HUMAN [view interactions] High throughput no yes
ES8L1_HUMAN [view interactions] High throughput no no
K1522_HUMAN [view interactions] High throughput no yes
SPTCS_HUMAN [view interactions] High throughput no yes
NTNG1_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RHOD_HUMAN [view interactions] High throughput no no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
KC1G3_HUMAN [view interactions] High throughput no yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
COPT1_HUMAN [view interactions] High throughput no no
NHSL1_HUMAN [view interactions] High throughput no yes
ANR26_HUMAN [view interactions] High throughput no yes
WASF3_HUMAN [view entry] [view interactions] High throughput yes yes
WASF1_HUMAN [view entry] [view interactions] High throughput yes yes
MECR_HUMAN [view entry] [view interactions] High throughput yes yes
VP33B_HUMAN [view interactions] High throughput no yes
SPE39_HUMAN [view interactions] High throughput no yes
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
HSBP1_HUMAN [view interactions] High throughput no no
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
TCRG1_HUMAN [view interactions] High throughput no yes
APBB1_HUMAN [view interactions] High throughput no yes
WASL_HUMAN [view entry] [view interactions] High throughput yes yes
KLF16_HUMAN [view interactions] High throughput no yes
DPOD1_HUMAN [view interactions] High throughput no yes
AB1IP_HUMAN [view interactions] High throughput no no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
ACTC_HUMAN [view interactions] High throughput no no
BICD1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
HOOK3_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
OCLN_HUMAN [view interactions] High throughput no no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
VASP_HUMAN [view interactions] High throughput no yes
ZFPL1_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
CEP55_HUMAN [view interactions] High throughput no yes
SMC2_HUMAN [view interactions] High throughput no yes
GCC2_HUMAN [view interactions] High throughput no yes
BRK1_HUMAN [view interactions] High throughput no no
PLIN3_HUMAN [view interactions] High throughput no yes
YIF1B_HUMAN [view interactions] High throughput no yes
CP250_HUMAN [view interactions] High throughput no no
CRLF3_HUMAN [view interactions] High throughput no yes
CHM1B_HUMAN [view interactions] High throughput no yes
GOGA4_HUMAN [view interactions] High throughput no yes
T2EB_HUMAN [view interactions] High throughput no yes
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
CXB7_HUMAN [view interactions] High throughput no no
WASC3_HUMAN [view interactions] High throughput no yes
CBLC_HUMAN [view interactions] High throughput no yes
LHX4_HUMAN [view interactions] High throughput no no
NHSL2_HUMAN [view interactions] High throughput no yes
AMZ1_HUMAN [view interactions] High throughput no no
CCD27_HUMAN [view interactions] High throughput no no
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
GAS7_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
ZDH17_HUMAN [view interactions] High throughput no yes
SPRE1_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
ITF2_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
TMM17_HUMAN [view interactions] High throughput no yes
CEP19_HUMAN [view interactions] High throughput no no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
EPHA4_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
EPHB2_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR1_HUMAN [view interactions] High throughput no yes
FGFR4_HUMAN [view interactions] High throughput no no
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
ITSN2_HUMAN [view entry] [view interactions] High throughput yes yes
RYK_HUMAN [view interactions] High throughput no no
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
ARP3B_HUMAN [view entry] [view interactions] Computational yes yes
ARPC5_HUMAN [view interactions] Computational no yes
ARP5L_HUMAN [view entry] [view interactions] Computational yes yes
WASP_HUMAN [view interactions] Computational no yes
AKT1_HUMAN [view entry] [view interactions] Computational yes yes
CDC42_HUMAN [view entry] [view interactions] Computational yes yes
ARPC4_HUMAN [view entry] [view interactions] Computational yes no
WIPF1_HUMAN [view interactions] Computational no no
PSA7_HUMAN [view interactions] Computational no yes
DIAP3_HUMAN [view interactions] Computational no no
VINC_HUMAN [view entry] [view interactions] Computational yes no
ARPC3_HUMAN [view entry] [view interactions] Computational yes yes
MK01_HUMAN [view entry] [view interactions] Computational yes yes
ABL2_HUMAN [view entry] [view interactions] Computational yes yes
ARC1A_HUMAN [view entry] [view interactions] Computational yes yes
ARC1B_HUMAN [view interactions] Computational no no
MK03_HUMAN [view entry] [view interactions] Computational yes yes
ARP3C_HUMAN [view interactions] Computational no no
SRA1_HUMAN [view interactions] Computational no yes
ARF1_HUMAN [view entry] [view interactions] Computational yes yes
PIR_HUMAN [view interactions] Computational no no
ARP2_HUMAN [view entry] [view interactions] Computational yes yes
ARPC2_HUMAN [view entry] [view interactions] Computational yes yes
ACTS_HUMAN [view interactions] Computational no no