Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

WASF2_HUMAN

Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. [View more on UniProt]

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No data found.

ELM instance Name Type Start End Partner
ELMI001661 LIG_Actin_WH2_1 LIG 437 453 -
ELMI001661 LIG_Actin_WH2_1 LIG 437 453 -

Molecular function

Term Name % Distance from the top of the tree Annotated in WASF2_HUMAN
GO:0043168 anion binding 39.1304 4 no
GO:0000166 nucleotide binding 37.6812 4 no
GO:0017076 purine nucleotide binding 37.6812 5 no
GO:0032555 purine ribonucleotide binding 37.6812 4 no
GO:0035639 purine ribonucleoside triphosphate binding 37.6812 4 no
GO:0003779 actin binding 24.6377 4 yes
GO:0005524 ATP binding 24.6377 5 no
GO:0030554 adenyl nucleotide binding 24.6377 6 no
GO:0032559 adenyl ribonucleotide binding 24.6377 5 no
GO:0019900 kinase binding 20.2899 4 no
GO:0045296 cadherin binding 15.9420 4 yes
GO:0017124 SH3 domain binding 13.0435 4 yes
GO:0034237 protein kinase A regulatory subunit binding 7.2464 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in WASF2_HUMAN
GO:0048522 positive regulation of cellular process 76.8116 4 yes
GO:0051128 regulation of cellular component organization 68.1159 4 yes
GO:0048523 negative regulation of cellular process 60.8696 4 yes
GO:0031323 regulation of cellular metabolic process 56.5217 4 no
GO:0030030 cell projection organization 55.0725 4 yes
GO:0060255 regulation of macromolecule metabolic process 52.1739 4 no
GO:0022607 cellular component assembly 50.7246 4 yes
GO:0080090 regulation of primary metabolic process 47.8261 4 no
GO:0010646 regulation of cell communication 47.8261 4 no
GO:0009893 positive regulation of metabolic process 44.9275 4 no
GO:0031325 positive regulation of cellular metabolic process 43.4783 5 no
GO:0031326 regulation of cellular biosynthetic process 43.4783 5 no
GO:0031344 regulation of cell projection organization 43.4783 5 yes
GO:0044087 regulation of cellular component biogenesis 43.4783 4 yes
GO:0051130 positive regulation of cellular component organization 43.4783 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 43.4783 6 yes
GO:0120036 plasma membrane bounded cell projection organization 43.4783 5 yes
GO:0009889 regulation of biosynthetic process 43.4783 4 no
GO:0009966 regulation of signal transduction 43.4783 4 no
GO:0006996 organelle organization 42.0290 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 42.0290 5 no
GO:0033043 regulation of organelle organization 40.5797 5 yes
GO:0010468 regulation of gene expression 40.5797 6 no
GO:0010604 positive regulation of macromolecule metabolic process 39.1304 5 no
GO:0051246 regulation of protein metabolic process 37.6812 5 no
GO:0008104 protein localization 36.2319 4 no
GO:0051049 regulation of transport 34.7826 4 no
GO:0051493 regulation of cytoskeleton organization 33.3333 6 yes
GO:0030334 regulation of cell migration 31.8841 5 no
GO:1902531 regulation of intracellular signal transduction 31.8841 5 no
GO:2000145 regulation of cell motility 31.8841 4 no
GO:0097435 supramolecular fiber organization 31.8841 4 no
GO:0007010 cytoskeleton organization 31.8841 5 yes
GO:0032956 regulation of actin cytoskeleton organization 31.8841 5 yes
GO:0032970 regulation of actin filament-based process 31.8841 4 yes
GO:0048584 positive regulation of response to stimulus 30.4348 4 no
GO:0009891 positive regulation of biosynthetic process 30.4348 5 no
GO:0031328 positive regulation of cellular biosynthetic process 30.4348 6 no
GO:0031324 negative regulation of cellular metabolic process 28.9855 5 no
GO:0045595 regulation of cell differentiation 28.9855 4 no
GO:0051174 regulation of phosphorus metabolic process 28.9855 5 no
GO:0022603 regulation of anatomical structure morphogenesis 28.9855 4 no
GO:0031346 positive regulation of cell projection organization 28.9855 6 yes
GO:0044089 positive regulation of cellular component biogenesis 28.9855 5 yes
GO:0110053 regulation of actin filament organization 28.9855 6 yes
GO:1902903 regulation of supramolecular fiber organization 28.9855 5 yes
GO:0009892 negative regulation of metabolic process 28.9855 4 no
GO:0010647 positive regulation of cell communication 28.9855 5 no
GO:0019220 regulation of phosphate metabolic process 28.9855 6 no
GO:0023056 positive regulation of signaling 28.9855 4 no
GO:0031399 regulation of protein modification process 27.5362 6 no
GO:0051240 positive regulation of multicellular organismal process 27.5362 4 no
GO:0007015 actin filament organization 27.5362 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 27.5362 6 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 27.5362 4 yes
GO:0010975 regulation of neuron projection development 27.5362 7 no
GO:0031175 neuron projection development 26.0870 6 no
GO:0042325 regulation of phosphorylation 26.0870 7 no
GO:2000026 regulation of multicellular organismal development 26.0870 4 no
GO:0141124 intracellular signaling cassette 26.0870 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 26.0870 5 no
GO:0042127 regulation of cell population proliferation 24.6377 4 no
GO:0051247 positive regulation of protein metabolic process 24.6377 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 24.6377 5 no
GO:0032535 regulation of cellular component size 24.6377 4 no
GO:0048812 neuron projection morphogenesis 24.6377 5 no
GO:0051129 negative regulation of cellular component organization 24.6377 5 yes
GO:0001932 regulation of protein phosphorylation 24.6377 7 no
GO:0009967 positive regulation of signal transduction 24.6377 5 no
GO:0030335 positive regulation of cell migration 23.1884 6 no
GO:0040017 positive regulation of locomotion 23.1884 4 no
GO:0043067 regulation of programmed cell death 23.1884 4 no
GO:0051094 positive regulation of developmental process 23.1884 4 no
GO:0060284 regulation of cell development 23.1884 5 no
GO:2000147 positive regulation of cell motility 23.1884 5 no
GO:0032880 regulation of protein localization 23.1884 5 no
GO:0060341 regulation of cellular localization 23.1884 4 no
GO:0010638 positive regulation of organelle organization 23.1884 6 yes
GO:0030031 cell projection assembly 23.1884 5 yes
GO:0051495 positive regulation of cytoskeleton organization 23.1884 7 yes
GO:1902905 positive regulation of supramolecular fiber organization 23.1884 6 yes
GO:0030155 regulation of cell adhesion 23.1884 4 no
GO:0042981 regulation of apoptotic process 21.7391 5 no
GO:0048585 negative regulation of response to stimulus 21.7391 4 no
GO:0071702 organic substance transport 21.7391 4 no
GO:0071705 nitrogen compound transport 21.7391 4 no
GO:0006355 regulation of DNA-templated transcription 21.7391 7 no
GO:0051252 regulation of RNA metabolic process 21.7391 5 no
GO:2001141 regulation of RNA biosynthetic process 21.7391 6 no
GO:0050804 modulation of chemical synaptic transmission 21.7391 5 no
GO:0099177 regulation of trans-synaptic signaling 21.7391 4 no
GO:0060491 regulation of cell projection assembly 21.7391 5 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 21.7391 6 yes
GO:0008284 positive regulation of cell population proliferation 21.7391 5 no
GO:0051241 negative regulation of multicellular organismal process 20.2899 4 no
GO:0071310 cellular response to organic substance 20.2899 4 no
GO:0043254 regulation of protein-containing complex assembly 20.2899 5 no
GO:0043933 protein-containing complex organization 20.2899 4 no
GO:0050807 regulation of synapse organization 20.2899 5 no
GO:0034330 cell junction organization 20.2899 4 no
GO:0015031 protein transport 20.2899 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 20.2899 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 20.2899 5 no
GO:0007264 small GTPase-mediated signal transduction 18.8406 5 yes
GO:0120031 plasma membrane bounded cell projection assembly 14.4928 6 yes
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 14.4928 6 yes
GO:0010591 regulation of lamellipodium assembly 11.5942 7 yes
GO:0016601 Rac protein signal transduction 11.5942 6 yes
GO:0097581 lamellipodium organization 11.5942 6 yes
GO:1902743 regulation of lamellipodium organization 11.5942 7 yes
GO:0010592 positive regulation of lamellipodium assembly 10.1449 7 yes
GO:0032231 regulation of actin filament bundle assembly 10.1449 5 yes
GO:0098657 import into cell 10.1449 4 yes
GO:1902745 positive regulation of lamellipodium organization 10.1449 7 yes
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 8.6957 8 yes
GO:0051125 regulation of actin nucleation 8.6957 7 yes
GO:0051127 positive regulation of actin nucleation 8.6957 7 yes
GO:0051492 regulation of stress fiber assembly 8.6957 6 yes
GO:0110020 regulation of actomyosin structure organization 8.6957 6 yes
GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation 8.6957 8 yes
GO:0010639 negative regulation of organelle organization 7.2464 6 yes
GO:0030032 lamellipodium assembly 7.2464 7 yes
GO:0051494 negative regulation of cytoskeleton organization 7.2464 7 yes
GO:0098974 postsynaptic actin cytoskeleton organization 5.7971 4 yes
GO:0099188 postsynaptic cytoskeleton organization 5.7971 6 yes
GO:1902904 negative regulation of supramolecular fiber organization 5.7971 6 yes
GO:0030097 hemopoiesis 4.3478 4 yes
GO:0032232 negative regulation of actin filament bundle assembly 4.3478 6 yes
GO:0061515 myeloid cell development 4.3478 5 yes
GO:0072673 lamellipodium morphogenesis 4.3478 5 yes
GO:0001667 ameboidal-type cell migration 2.8986 4 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 2.8986 4 yes
GO:0035855 megakaryocyte development 2.8986 6 yes
GO:0051497 negative regulation of stress fiber assembly 2.8986 7 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
BAIP2_HUMAN [view entry] [view interactions] Low throughput yes yes
ABI1_HUMAN [view entry] [view interactions] Low throughput yes yes
CYFP1_HUMAN [view entry] [view interactions] Low throughput yes yes
NCKP1_HUMAN [view entry] [view interactions] Low throughput yes yes
ABI3_HUMAN [view entry] [view interactions] Low throughput yes no
ABI2_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
VINEX_HUMAN [view interactions] Low throughput no no
SRC8_HUMAN [view entry] [view interactions] Low throughput yes yes
KANK1_HUMAN [view interactions] Low throughput no yes
NCKPL_HUMAN [view entry] [view interactions] Low throughput yes yes
PR40A_HUMAN [view interactions] Low throughput no no
ARP3_HUMAN [view entry] [view interactions] Low throughput yes yes
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
SMC2_HUMAN [view interactions] High throughput no yes
GCC2_HUMAN [view interactions] High throughput no yes
BRK1_HUMAN [view interactions] High throughput no no
PLIN3_HUMAN [view interactions] High throughput no yes
YIF1B_HUMAN [view interactions] High throughput no yes
DTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
CP250_HUMAN [view interactions] High throughput no no
CRLF3_HUMAN [view interactions] High throughput no yes
CHM1B_HUMAN [view interactions] High throughput no yes
GOGA4_HUMAN [view interactions] High throughput no yes
T2EB_HUMAN [view interactions] High throughput no yes
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
CXB7_HUMAN [view interactions] High throughput no no
WASC3_HUMAN [view interactions] High throughput no yes
CBLC_HUMAN [view interactions] High throughput no yes
LHX4_HUMAN [view interactions] High throughput no no
NHSL2_HUMAN [view interactions] High throughput no yes
AMZ1_HUMAN [view interactions] High throughput no no
CCD27_HUMAN [view interactions] High throughput no no
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
SRBS2_HUMAN [view entry] [view interactions] High throughput yes no
GAS7_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
ZDH17_HUMAN [view entry] [view interactions] High throughput yes yes
SPRE1_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
ITF2_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
TMM17_HUMAN [view interactions] High throughput no yes
CEP19_HUMAN [view interactions] High throughput no no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
EPHA4_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
EPHB2_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR4_HUMAN [view interactions] High throughput no no
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
ITSN2_HUMAN [view entry] [view interactions] High throughput yes yes
RYK_HUMAN [view entry] [view interactions] High throughput yes no
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
ZN511_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
TIM50_HUMAN [view entry] [view interactions] High throughput yes yes
HOME3_HUMAN [view entry] [view interactions] High throughput yes yes
EVL_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
HDAC4_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
WWP2_HUMAN [view interactions] High throughput no no
BACD3_HUMAN [view interactions] High throughput no yes
RIGI_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
CNGA4_HUMAN [view interactions] High throughput no no
RHG12_HUMAN [view entry] [view interactions] High throughput yes yes
ES8L1_HUMAN [view interactions] High throughput no no
NHSL3_HUMAN [view interactions] High throughput no yes
SPTCS_HUMAN [view interactions] High throughput no yes
NTNG1_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RHOD_HUMAN [view interactions] High throughput no no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
KC1G3_HUMAN [view interactions] High throughput no yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
COPT1_HUMAN [view interactions] High throughput no no
NHSL1_HUMAN [view interactions] High throughput no yes
ANR26_HUMAN [view interactions] High throughput no yes
WASF3_HUMAN [view entry] [view interactions] High throughput yes yes
WASF1_HUMAN [view entry] [view interactions] High throughput yes yes
MECR_HUMAN [view entry] [view interactions] High throughput yes yes
VP33B_HUMAN [view interactions] High throughput no yes
SPE39_HUMAN [view interactions] High throughput no yes
HSBP1_HUMAN [view interactions] High throughput no no
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
TLS1_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
TCRG1_HUMAN [view interactions] High throughput no yes
APBB1_HUMAN [view entry] [view interactions] High throughput yes yes
WASL_HUMAN [view entry] [view interactions] High throughput yes yes
KLF16_HUMAN [view interactions] High throughput no yes
DPOD1_HUMAN [view interactions] High throughput no yes
AB1IP_HUMAN [view interactions] High throughput no no
ATG7_HUMAN [view interactions] High throughput no yes
DPOLA_HUMAN [view interactions] High throughput no yes
ACPH_HUMAN [view interactions] High throughput no yes
PRS6A_HUMAN [view entry] [view interactions] High throughput yes yes
PRS6B_HUMAN [view interactions] High throughput no yes
UTRN_HUMAN [view entry] [view interactions] High throughput yes yes
PRS8_HUMAN [view interactions] High throughput no yes
IF4G1_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
DPOA2_HUMAN [view interactions] High throughput no yes
DDX46_HUMAN [view interactions] High throughput no yes
CCAR1_HUMAN [view interactions] High throughput no yes
PP4R1_HUMAN [view interactions] High throughput no yes
HS105_HUMAN [view entry] [view interactions] High throughput yes yes
PSMD1_HUMAN [view entry] [view interactions] High throughput yes yes
SLK_HUMAN [view entry] [view interactions] High throughput yes yes
GOPC_HUMAN [view entry] [view interactions] High throughput yes yes
WDR6_HUMAN [view entry] [view interactions] High throughput yes yes
DBLOH_HUMAN [view interactions] High throughput no no
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
LRRF2_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
ACTC_HUMAN [view interactions] High throughput no no
BICD1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
HOOK3_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
OCLN_HUMAN [view interactions] High throughput no no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
VASP_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
ARL4C_HUMAN [view interactions] High throughput no yes
MUC18_HUMAN [view interactions] High throughput no yes