Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NCKPL_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages (PubMed, PubMed). Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells . Within the WAVE2 complex, enables the cortical actin network to restrain excessive degranulation and granule release by T-cells (PubMed). Required for efficient T-lymphocyte and neutrophil migration (PubMed). Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin (PubMed). Also involved in mechanisms WAVE-independent to regulate myosin and actin polymerization during neutrophil chemotaxis (PubMed). In T-cells, required for proper mechanistic target of rapamycin complex 2 (mTORC2)-dependent AKT phosphorylation, cell proliferation and cytokine secretion, including that of IL2 and TNF (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NCKPL_HUMAN
GO:0045296 cadherin binding 33.3333 4 no
GO:0017124 SH3 domain binding 33.3333 4 no
GO:0003779 actin binding 33.3333 4 no
GO:0019209 kinase activator activity 22.2222 4 yes
GO:0019887 protein kinase regulator activity 22.2222 4 yes
GO:0030295 protein kinase activator activity 22.2222 5 yes
GO:0031267 small GTPase binding 22.2222 5 no
GO:0051020 GTPase binding 22.2222 4 no
GO:0003723 RNA binding 22.2222 4 no
GO:0005509 calcium ion binding 22.2222 6 no
GO:0043169 cation binding 22.2222 4 no
GO:0046872 metal ion binding 22.2222 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in NCKPL_HUMAN
GO:0048522 positive regulation of cellular process 88.8889 4 yes
GO:0022607 cellular component assembly 88.8889 4 yes
GO:0051128 regulation of cellular component organization 77.7778 4 yes
GO:0030030 cell projection organization 77.7778 4 yes
GO:0044087 regulation of cellular component biogenesis 66.6667 4 yes
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 yes
GO:0080090 regulation of primary metabolic process 66.6667 4 yes
GO:0033043 regulation of organelle organization 66.6667 5 yes
GO:0048523 negative regulation of cellular process 55.5556 4 yes
GO:0051130 positive regulation of cellular component organization 55.5556 5 yes
GO:0051246 regulation of protein metabolic process 55.5556 5 yes
GO:0051493 regulation of cytoskeleton organization 55.5556 6 yes
GO:0110053 regulation of actin filament organization 55.5556 6 yes
GO:1902903 regulation of supramolecular fiber organization 55.5556 5 yes
GO:0120036 plasma membrane bounded cell projection organization 55.5556 5 no
GO:0006996 organelle organization 55.5556 4 yes
GO:0009893 positive regulation of metabolic process 55.5556 4 yes
GO:0010638 positive regulation of organelle organization 55.5556 6 yes
GO:0023056 positive regulation of signaling 55.5556 4 yes
GO:0030031 cell projection assembly 55.5556 5 yes
GO:0031323 regulation of cellular metabolic process 55.5556 4 yes
GO:0032956 regulation of actin cytoskeleton organization 55.5556 5 yes
GO:0032970 regulation of actin filament-based process 55.5556 4 yes
GO:0044089 positive regulation of cellular component biogenesis 44.4444 5 yes
GO:0045595 regulation of cell differentiation 44.4444 4 yes
GO:0048584 positive regulation of response to stimulus 44.4444 4 yes
GO:0051049 regulation of transport 44.4444 4 yes
GO:0051051 negative regulation of transport 44.4444 4 yes
GO:0051240 positive regulation of multicellular organismal process 44.4444 4 yes
GO:0051495 positive regulation of cytoskeleton organization 44.4444 7 yes
GO:0060284 regulation of cell development 44.4444 5 yes
GO:0061515 myeloid cell development 44.4444 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 44.4444 4 yes
GO:1902905 positive regulation of supramolecular fiber organization 44.4444 6 yes
GO:2000026 regulation of multicellular organismal development 44.4444 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 44.4444 5 no
GO:0097435 supramolecular fiber organization 44.4444 4 no
GO:0009889 regulation of biosynthetic process 44.4444 4 yes
GO:0009966 regulation of signal transduction 44.4444 4 yes
GO:0009967 positive regulation of signal transduction 44.4444 5 yes
GO:0010468 regulation of gene expression 44.4444 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 44.4444 5 yes
GO:0010646 regulation of cell communication 44.4444 4 yes
GO:0010647 positive regulation of cell communication 44.4444 5 yes
GO:0030097 hemopoiesis 44.4444 4 yes
GO:0031325 positive regulation of cellular metabolic process 44.4444 5 yes
GO:0031326 regulation of cellular biosynthetic process 44.4444 5 yes
GO:0045597 positive regulation of cell differentiation 33.3333 5 yes
GO:0048585 negative regulation of response to stimulus 33.3333 4 yes
GO:0048812 neuron projection morphogenesis 33.3333 5 yes
GO:0051046 regulation of secretion 33.3333 5 yes
GO:0051094 positive regulation of developmental process 33.3333 4 yes
GO:0051241 negative regulation of multicellular organismal process 33.3333 4 yes
GO:0060627 regulation of vesicle-mediated transport 33.3333 4 yes
GO:1903530 regulation of secretion by cell 33.3333 4 yes
GO:0007411 axon guidance 33.3333 8 no
GO:0031175 neuron projection development 33.3333 6 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0090287 regulation of cellular response to growth factor stimulus 33.3333 4 no
GO:0097485 neuron projection guidance 33.3333 7 no
GO:0050767 regulation of neurogenesis 33.3333 6 no
GO:0051129 negative regulation of cellular component organization 33.3333 5 no
GO:0051960 regulation of nervous system development 33.3333 5 no
GO:0007010 cytoskeleton organization 33.3333 5 yes
GO:0008064 regulation of actin polymerization or depolymerization 33.3333 6 yes
GO:0007015 actin filament organization 33.3333 5 no
GO:0009892 negative regulation of metabolic process 33.3333 4 yes
GO:0008154 actin polymerization or depolymerization 33.3333 6 no
GO:0097581 lamellipodium organization 33.3333 6 no
GO:0007264 small GTPase-mediated signal transduction 33.3333 5 no
GO:0010591 regulation of lamellipodium assembly 33.3333 7 no
GO:0010592 positive regulation of lamellipodium assembly 33.3333 7 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 yes
GO:0016601 Rac protein signal transduction 33.3333 6 no
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 no
GO:0031344 regulation of cell projection organization 33.3333 5 no
GO:0031346 positive regulation of cell projection organization 33.3333 6 no
GO:0010720 positive regulation of cell development 33.3333 6 yes
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 33.3333 8 no
GO:0017157 regulation of exocytosis 33.3333 5 yes
GO:0051125 regulation of actin nucleation 33.3333 7 no
GO:0051127 positive regulation of actin nucleation 33.3333 7 no
GO:0060491 regulation of cell projection assembly 33.3333 5 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 33.3333 6 no
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 33.3333 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 no
GO:0141124 intracellular signaling cassette 33.3333 4 no
GO:1902743 regulation of lamellipodium organization 33.3333 7 no
GO:1902745 positive regulation of lamellipodium organization 33.3333 7 no
GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation 33.3333 8 no
GO:0030832 regulation of actin filament length 33.3333 5 yes
GO:0030833 regulation of actin filament polymerization 33.3333 7 yes
GO:0120031 plasma membrane bounded cell projection assembly 33.3333 6 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 yes
GO:0032101 regulation of response to external stimulus 33.3333 4 yes
GO:0032271 regulation of protein polymerization 33.3333 6 yes
GO:0032535 regulation of cellular component size 33.3333 4 yes
GO:0042127 regulation of cell population proliferation 33.3333 4 yes
GO:0043254 regulation of protein-containing complex assembly 33.3333 5 yes
GO:0043933 protein-containing complex organization 22.2222 4 yes
GO:0045807 positive regulation of endocytosis 22.2222 5 yes
GO:0045920 negative regulation of exocytosis 22.2222 6 yes
GO:0045937 positive regulation of phosphate metabolic process 22.2222 7 yes
GO:0050920 regulation of chemotaxis 22.2222 4 yes
GO:0051048 negative regulation of secretion 22.2222 5 yes
GO:0051050 positive regulation of transport 22.2222 4 yes
GO:0051174 regulation of phosphorus metabolic process 22.2222 5 yes
GO:0051248 negative regulation of protein metabolic process 22.2222 6 yes
GO:0051336 regulation of hydrolase activity 22.2222 4 yes
GO:0065003 protein-containing complex assembly 22.2222 5 yes
GO:1902531 regulation of intracellular signal transduction 22.2222 5 yes
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 yes
GO:1903305 regulation of regulated secretory pathway 22.2222 6 yes
GO:1903306 negative regulation of regulated secretory pathway 22.2222 7 yes
GO:1903531 negative regulation of secretion by cell 22.2222 5 yes
GO:2000145 regulation of cell motility 22.2222 4 yes
GO:2000147 positive regulation of cell motility 22.2222 5 yes
GO:0006915 apoptotic process 22.2222 4 no
GO:0030162 regulation of proteolysis 22.2222 6 no
GO:0043085 positive regulation of catalytic activity 22.2222 4 no
GO:0045862 positive regulation of proteolysis 22.2222 7 no
GO:0051386 regulation of neurotrophin TRK receptor signaling pathway 22.2222 5 no
GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway 22.2222 6 no
GO:0097484 dendrite extension 22.2222 5 no
GO:1990138 neuron projection extension 22.2222 4 no
GO:0006351 DNA-templated transcription 22.2222 6 no
GO:0006355 regulation of DNA-templated transcription 22.2222 7 no
GO:0006357 regulation of transcription by RNA polymerase II 22.2222 8 no
GO:0006366 transcription by RNA polymerase II 22.2222 7 no
GO:0009059 macromolecule biosynthetic process 22.2222 4 no
GO:0009891 positive regulation of biosynthetic process 22.2222 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0010628 positive regulation of gene expression 22.2222 7 no
GO:0016070 RNA metabolic process 22.2222 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0031328 positive regulation of cellular biosynthetic process 22.2222 6 no
GO:0032102 negative regulation of response to external stimulus 22.2222 5 no
GO:0032774 RNA biosynthetic process 22.2222 5 no
GO:0034654 nucleobase-containing compound biosynthetic process 22.2222 4 no
GO:0045893 positive regulation of DNA-templated transcription 22.2222 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0045944 positive regulation of transcription by RNA polymerase II 22.2222 9 no
GO:0051252 regulation of RNA metabolic process 22.2222 5 no
GO:0051254 positive regulation of RNA metabolic process 22.2222 6 no
GO:0090304 nucleic acid metabolic process 22.2222 4 no
GO:0141187 nucleic acid biosynthetic process 22.2222 5 no
GO:1901362 organic cyclic compound biosynthetic process 22.2222 4 no
GO:0008284 positive regulation of cell population proliferation 22.2222 5 yes
GO:1902680 positive regulation of RNA biosynthetic process 22.2222 7 no
GO:2001141 regulation of RNA biosynthetic process 22.2222 6 no
GO:0009890 negative regulation of biosynthetic process 22.2222 5 yes
GO:0008285 negative regulation of cell population proliferation 22.2222 5 no
GO:0009952 anterior/posterior pattern specification 22.2222 4 no
GO:0035855 megakaryocyte development 22.2222 6 no
GO:0072673 lamellipodium morphogenesis 22.2222 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 22.2222 6 yes
GO:0010562 positive regulation of phosphorus metabolic process 22.2222 6 yes
GO:0010975 regulation of neuron projection development 22.2222 7 no
GO:0010629 negative regulation of gene expression 22.2222 7 yes
GO:0034330 cell junction organization 22.2222 4 no
GO:0050807 regulation of synapse organization 22.2222 5 no
GO:0019220 regulation of phosphate metabolic process 22.2222 6 yes
GO:0022407 regulation of cell-cell adhesion 22.2222 5 yes
GO:0030100 regulation of endocytosis 22.2222 5 yes
GO:0030155 regulation of cell adhesion 22.2222 4 yes
GO:0010243 response to organonitrogen compound 22.2222 4 no
GO:0030334 regulation of cell migration 22.2222 5 yes
GO:0030032 lamellipodium assembly 22.2222 7 no
GO:0030335 positive regulation of cell migration 22.2222 6 yes
GO:0032870 cellular response to hormone stimulus 22.2222 4 no
GO:0045927 positive regulation of growth 22.2222 4 no
GO:0048638 regulation of developmental growth 22.2222 4 no
GO:0048639 positive regulation of developmental growth 22.2222 5 no
GO:0050769 positive regulation of neurogenesis 22.2222 6 no
GO:0051962 positive regulation of nervous system development 22.2222 5 no
GO:0071310 cellular response to organic substance 22.2222 4 no
GO:0031327 negative regulation of cellular biosynthetic process 22.2222 6 yes
GO:0031399 regulation of protein modification process 22.2222 6 yes
GO:0040017 positive regulation of locomotion 22.2222 4 yes
GO:0042325 regulation of phosphorylation 22.2222 7 yes
GO:0042327 positive regulation of phosphorylation 22.2222 8 yes
GO:0042981 regulation of apoptotic process 22.2222 5 yes
GO:0043066 negative regulation of apoptotic process 22.2222 6 yes
GO:0043067 regulation of programmed cell death 22.2222 4 yes
GO:0043069 negative regulation of programmed cell death 22.2222 5 yes
GO:0043086 negative regulation of catalytic activity 22.2222 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
WASF2_HUMAN [view entry] [view interactions] Low throughput yes yes
RICTR_HUMAN [view interactions] Low throughput no yes
H31T_HUMAN [view interactions] High throughput no yes
GAS7_HUMAN [view entry] [view interactions] High throughput yes yes
DESI1_HUMAN [view interactions] High throughput no yes
NOTC1_HUMAN [view entry] [view interactions] High throughput yes yes
ABI2_HUMAN [view entry] [view interactions] High throughput yes yes
RIGI_HUMAN [view interactions] High throughput no yes
FZR1_HUMAN [view interactions] High throughput no no
BRK1_HUMAN [view interactions] High throughput no no
PR40A_HUMAN [view interactions] High throughput no no
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
NHLC2_HUMAN [view interactions] High throughput no yes