Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NCKPL_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages (PubMed, PubMed). Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells . Within the WAVE2 complex, enables the cortical actin network to restrain excessive degranulation and granule release by T-cells (PubMed). Required for efficient T-lymphocyte and neutrophil migration (PubMed). Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin (PubMed). Also involved in mechanisms WAVE-independent to regulate myosin and actin polymerization during neutrophil chemotaxis (PubMed). In T-cells, required for proper mechanistic target of rapamycin complex 2 (mTORC2)-dependent AKT phosphorylation, cell proliferation and cytokine secretion, including that of IL2 and TNF (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NCKPL_HUMAN
GO:0003779 actin binding 44.4444 4 no
GO:0017076 purine nucleotide binding 33.3333 4 no
GO:0032555 purine ribonucleotide binding 33.3333 4 no
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0017124 SH3 domain binding 22.2222 4 no
GO:0005524 ATP binding 22.2222 5 no
GO:0030554 adenyl nucleotide binding 22.2222 5 no
GO:0032559 adenyl ribonucleotide binding 22.2222 5 no
GO:0019887 protein kinase regulator activity 16.6667 4 yes
GO:0019209 kinase activator activity 11.1111 4 yes
GO:0030295 protein kinase activator activity 11.1111 5 yes
GO:0030695 GTPase regulator activity 11.1111 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NCKPL_HUMAN
GO:0051128 regulation of cellular component organization 88.8889 4 yes
GO:0033043 regulation of organelle organization 83.3333 5 yes
GO:0048522 positive regulation of cellular process 83.3333 4 yes
GO:0051130 positive regulation of cellular component organization 77.7778 5 yes
GO:0051493 regulation of cytoskeleton organization 77.7778 6 yes
GO:0022607 cellular component assembly 72.2222 4 yes
GO:0030030 cell projection organization 72.2222 4 yes
GO:0010638 positive regulation of organelle organization 66.6667 6 yes
GO:0032956 regulation of actin cytoskeleton organization 66.6667 5 yes
GO:0032970 regulation of actin filament-based process 66.6667 4 yes
GO:0006996 organelle organization 61.1111 4 yes
GO:0110053 regulation of actin filament organization 61.1111 6 yes
GO:1902903 regulation of supramolecular fiber organization 61.1111 5 yes
GO:0120036 plasma membrane bounded cell projection organization 55.5556 5 no
GO:0044087 regulation of cellular component biogenesis 55.5556 4 yes
GO:0007015 actin filament organization 50.0000 5 no
GO:0097435 supramolecular fiber organization 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 yes
GO:0044089 positive regulation of cellular component biogenesis 50.0000 5 yes
GO:0048584 positive regulation of response to stimulus 50.0000 4 yes
GO:0051049 regulation of transport 50.0000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 yes
GO:0051495 positive regulation of cytoskeleton organization 50.0000 7 yes
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 yes
GO:0080090 regulation of primary metabolic process 50.0000 4 yes
GO:1902905 positive regulation of supramolecular fiber organization 50.0000 6 yes
GO:0031344 regulation of cell projection organization 44.4444 5 no
GO:0031346 positive regulation of cell projection organization 44.4444 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 44.4444 6 no
GO:0007010 cytoskeleton organization 44.4444 5 yes
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 44.4444 8 no
GO:0009893 positive regulation of metabolic process 44.4444 4 yes
GO:0051125 regulation of actin nucleation 44.4444 7 no
GO:0010468 regulation of gene expression 44.4444 5 yes
GO:0010646 regulation of cell communication 44.4444 4 yes
GO:0023056 positive regulation of signaling 44.4444 4 yes
GO:0030031 cell projection assembly 44.4444 5 yes
GO:0048523 negative regulation of cellular process 44.4444 4 yes
GO:0060627 regulation of vesicle-mediated transport 44.4444 4 yes
GO:0060491 regulation of cell projection assembly 38.8889 5 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 38.8889 6 no
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 38.8889 6 no
GO:0010604 positive regulation of macromolecule metabolic process 38.8889 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 38.8889 5 no
GO:0008154 actin polymerization or depolymerization 38.8889 6 no
GO:0009966 regulation of signal transduction 38.8889 4 yes
GO:0051127 positive regulation of actin nucleation 38.8889 7 no
GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation 38.8889 8 no
GO:0010647 positive regulation of cell communication 38.8889 5 yes
GO:0031325 positive regulation of cellular metabolic process 38.8889 5 yes
GO:0032990 cell part morphogenesis 38.8889 4 yes
GO:0048858 cell projection morphogenesis 38.8889 5 yes
GO:0051246 regulation of protein metabolic process 38.8889 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 38.8889 6 yes
GO:2000145 regulation of cell motility 33.3333 4 yes
GO:0007264 small GTPase mediated signal transduction 33.3333 4 no
GO:0007265 Ras protein signal transduction 33.3333 5 no
GO:0010591 regulation of lamellipodium assembly 33.3333 7 no
GO:0010592 positive regulation of lamellipodium assembly 33.3333 7 no
GO:0016601 Rac protein signal transduction 33.3333 6 no
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 no
GO:1902743 regulation of lamellipodium organization 33.3333 7 no
GO:1902745 positive regulation of lamellipodium organization 33.3333 7 no
GO:0009967 positive regulation of signal transduction 33.3333 5 yes
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:0016192 vesicle-mediated transport 33.3333 4 no
GO:0030334 regulation of cell migration 33.3333 5 yes
GO:0042127 regulation of cell population proliferation 33.3333 4 yes
GO:0043933 protein-containing complex organization 33.3333 4 yes
GO:0051240 positive regulation of multicellular organismal process 33.3333 4 yes
GO:0065003 protein-containing complex assembly 33.3333 5 yes
GO:2000026 regulation of multicellular organismal development 27.7778 4 yes
GO:2000147 positive regulation of cell motility 27.7778 5 yes
GO:0022604 regulation of cell morphogenesis 27.7778 5 no
GO:0060341 regulation of cellular localization 27.7778 4 no
GO:0002684 positive regulation of immune system process 27.7778 4 yes
GO:0002685 regulation of leukocyte migration 27.7778 4 yes
GO:0006915 apoptotic process 27.7778 4 no
GO:0051247 positive regulation of protein metabolic process 27.7778 6 no
GO:0006468 protein phosphorylation 27.7778 5 no
GO:0006796 phosphate-containing compound metabolic process 27.7778 4 no
GO:0016310 phosphorylation 27.7778 5 no
GO:0018193 peptidyl-amino acid modification 27.7778 5 no
GO:0036211 protein modification process 27.7778 4 no
GO:0043412 macromolecule modification 27.7778 4 no
GO:0097581 lamellipodium organization 27.7778 6 no
GO:0008284 positive regulation of cell population proliferation 27.7778 5 yes
GO:0010243 response to organonitrogen compound 27.7778 4 no
GO:0071417 cellular response to organonitrogen compound 27.7778 4 no
GO:0120031 plasma membrane bounded cell projection assembly 27.7778 6 no
GO:1901699 cellular response to nitrogen compound 27.7778 4 no
GO:1901701 cellular response to oxygen-containing compound 27.7778 4 no
GO:0006897 endocytosis 27.7778 5 no
GO:0030041 actin filament polymerization 27.7778 7 no
GO:0051258 protein polymerization 27.7778 6 no
GO:0030100 regulation of endocytosis 27.7778 5 yes
GO:0009891 positive regulation of biosynthetic process 27.7778 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 27.7778 6 no
GO:0030335 positive regulation of cell migration 27.7778 6 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.7778 5 no
GO:0031328 positive regulation of cellular biosynthetic process 27.7778 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 27.7778 6 no
GO:0032271 regulation of protein polymerization 27.7778 6 yes
GO:0040017 positive regulation of locomotion 27.7778 4 yes
GO:0043254 regulation of protein-containing complex assembly 27.7778 5 yes
GO:0045595 regulation of cell differentiation 27.7778 4 yes
GO:0048812 neuron projection morphogenesis 27.7778 7 yes
GO:0051050 positive regulation of transport 27.7778 4 yes
GO:0032386 regulation of intracellular transport 22.2222 5 no
GO:0061024 membrane organization 22.2222 4 no
GO:0002687 positive regulation of leukocyte migration 22.2222 5 yes
GO:0002688 regulation of leukocyte chemotaxis 22.2222 5 yes
GO:0002690 positive regulation of leukocyte chemotaxis 22.2222 6 yes
GO:0043085 positive regulation of catalytic activity 22.2222 4 no
GO:0090287 regulation of cellular response to growth factor stimulus 22.2222 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 22.2222 4 no
GO:0018108 peptidyl-tyrosine phosphorylation 22.2222 6 no
GO:0018212 peptidyl-tyrosine modification 22.2222 6 no
GO:0008064 regulation of actin polymerization or depolymerization 22.2222 6 yes
GO:0010975 regulation of neuron projection development 22.2222 7 no
GO:0034330 cell junction organization 22.2222 4 no
GO:0050807 regulation of synapse organization 22.2222 5 no
GO:0010562 positive regulation of phosphorus metabolic process 22.2222 6 yes
GO:0050804 modulation of chemical synaptic transmission 22.2222 5 no
GO:0050890 cognition 22.2222 4 no
GO:0099177 regulation of trans-synaptic signaling 22.2222 4 no
GO:0019220 regulation of phosphate metabolic process 22.2222 6 yes
GO:0070848 response to growth factor 22.2222 4 no
GO:0006355 regulation of DNA-templated transcription 22.2222 6 no
GO:0006357 regulation of transcription by RNA polymerase II 22.2222 7 no
GO:0014070 response to organic cyclic compound 22.2222 4 no
GO:0030832 regulation of actin filament length 22.2222 5 yes
GO:0030833 regulation of actin filament polymerization 22.2222 7 yes
GO:0045893 positive regulation of DNA-templated transcription 22.2222 7 no
GO:0045944 positive regulation of transcription by RNA polymerase II 22.2222 8 no
GO:0051252 regulation of RNA metabolic process 22.2222 5 no
GO:0051254 positive regulation of RNA metabolic process 22.2222 6 no
GO:0071407 cellular response to organic cyclic compound 22.2222 5 no
GO:0080134 regulation of response to stress 22.2222 4 no
GO:0080135 regulation of cellular response to stress 22.2222 4 no
GO:1902680 positive regulation of RNA biosynthetic process 22.2222 7 no
GO:1903506 regulation of nucleic acid-templated transcription 22.2222 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 22.2222 8 no
GO:2001141 regulation of RNA biosynthetic process 22.2222 6 no
GO:0031399 regulation of protein modification process 22.2222 6 yes
GO:0010628 positive regulation of gene expression 22.2222 6 no
GO:0032101 regulation of response to external stimulus 22.2222 4 yes
GO:0032103 positive regulation of response to external stimulus 22.2222 5 yes
GO:0032535 regulation of cellular component size 22.2222 4 yes
GO:0042325 regulation of phosphorylation 22.2222 7 yes
GO:0042327 positive regulation of phosphorylation 22.2222 8 yes
GO:0045597 positive regulation of cell differentiation 22.2222 5 yes
GO:0045937 positive regulation of phosphate metabolic process 22.2222 7 yes
GO:0050776 regulation of immune response 22.2222 4 yes
GO:0050920 regulation of chemotaxis 22.2222 4 yes
GO:0050921 positive regulation of chemotaxis 22.2222 5 yes
GO:0051094 positive regulation of developmental process 22.2222 4 yes
GO:0051174 regulation of phosphorus metabolic process 22.2222 5 yes
GO:0061515 myeloid cell development 22.2222 4 yes
GO:0070663 regulation of leukocyte proliferation 22.2222 5 yes
GO:0071622 regulation of granulocyte chemotaxis 22.2222 6 yes
GO:1902531 regulation of intracellular signal transduction 22.2222 5 yes
GO:0002429 immune response-activating cell surface receptor signaling pathway 16.6667 4 yes
GO:0002694 regulation of leukocyte activation 16.6667 4 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 16.6667 4 yes
GO:0009892 negative regulation of metabolic process 16.6667 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 16.6667 5 yes
GO:0030155 regulation of cell adhesion 16.6667 4 yes
GO:0030865 cortical cytoskeleton organization 16.6667 6 yes
GO:0031324 negative regulation of cellular metabolic process 16.6667 5 yes
GO:0045807 positive regulation of endocytosis 16.6667 5 yes
GO:0050778 positive regulation of immune response 16.6667 5 yes
GO:0050851 antigen receptor-mediated signaling pathway 16.6667 5 yes
GO:0050853 B cell receptor signaling pathway 16.6667 6 yes
GO:0050863 regulation of T cell activation 16.6667 6 yes
GO:0050865 regulation of cell activation 16.6667 4 yes
GO:0051051 negative regulation of transport 16.6667 4 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 16.6667 5 yes
GO:0051248 negative regulation of protein metabolic process 16.6667 6 yes
GO:0051249 regulation of lymphocyte activation 16.6667 5 yes
GO:0051336 regulation of hydrolase activity 16.6667 4 yes
GO:0070665 positive regulation of leukocyte proliferation 16.6667 6 yes
GO:1902533 positive regulation of intracellular signal transduction 16.6667 6 yes
GO:1903305 regulation of regulated secretory pathway 11.1111 6 yes
GO:1903530 regulation of secretion by cell 11.1111 4 yes
GO:1903706 regulation of hemopoiesis 11.1111 4 yes
GO:0001782 B cell homeostasis 11.1111 4 yes
GO:0001817 regulation of cytokine production 11.1111 4 yes
GO:0002683 negative regulation of immune system process 11.1111 4 yes
GO:0002697 regulation of immune effector process 11.1111 4 yes
GO:0002703 regulation of leukocyte mediated immunity 11.1111 5 yes
GO:0007162 negative regulation of cell adhesion 11.1111 5 yes
GO:0010563 negative regulation of phosphorus metabolic process 11.1111 6 yes
GO:0010941 regulation of cell death 11.1111 4 yes
GO:0017157 regulation of exocytosis 11.1111 5 yes
GO:0022407 regulation of cell-cell adhesion 11.1111 5 yes
GO:0022408 negative regulation of cell-cell adhesion 11.1111 6 yes
GO:0030838 positive regulation of actin filament polymerization 11.1111 7 yes
GO:0030866 cortical actin cytoskeleton organization 11.1111 4 yes
GO:0031334 positive regulation of protein-containing complex assembly 11.1111 6 yes
GO:0031400 negative regulation of protein modification process 11.1111 7 yes
GO:0032273 positive regulation of protein polymerization 11.1111 7 yes
GO:0032944 regulation of mononuclear cell proliferation 11.1111 6 yes
GO:0042129 regulation of T cell proliferation 11.1111 7 yes
GO:0042981 regulation of apoptotic process 11.1111 6 yes
GO:0043066 negative regulation of apoptotic process 11.1111 7 yes
GO:0043067 regulation of programmed cell death 11.1111 5 yes
GO:0043069 negative regulation of programmed cell death 11.1111 6 yes
GO:0043086 negative regulation of catalytic activity 11.1111 4 yes
GO:0043300 regulation of leukocyte degranulation 11.1111 5 yes
GO:0045580 regulation of T cell differentiation 11.1111 7 yes
GO:0045619 regulation of lymphocyte differentiation 11.1111 6 yes
GO:0045785 positive regulation of cell adhesion 11.1111 5 yes
GO:0045936 negative regulation of phosphate metabolic process 11.1111 7 yes
GO:0048585 negative regulation of response to stimulus 11.1111 4 yes
GO:0048872 homeostasis of number of cells 11.1111 4 yes
GO:0050670 regulation of lymphocyte proliferation 11.1111 6 yes
GO:0051046 regulation of secretion 11.1111 5 yes
GO:0051346 negative regulation of hydrolase activity 11.1111 5 yes
GO:0060548 negative regulation of cell death 11.1111 5 yes
GO:0071624 positive regulation of granulocyte chemotaxis 11.1111 7 yes
GO:0090022 regulation of neutrophil chemotaxis 11.1111 6 yes
GO:0090023 positive regulation of neutrophil chemotaxis 11.1111 7 yes
GO:1902105 regulation of leukocyte differentiation 11.1111 5 yes
GO:1902622 regulation of neutrophil migration 11.1111 5 yes
GO:1902624 positive regulation of neutrophil migration 11.1111 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
WASF2_HUMAN [view entry] [view interactions] Low throughput yes yes
RICTR_HUMAN [view interactions] Low throughput no yes
H31T_HUMAN [view interactions] High throughput no yes
GAS7_HUMAN [view entry] [view interactions] High throughput yes yes
DESI1_HUMAN [view interactions] High throughput no yes
NOTC1_HUMAN [view interactions] High throughput no yes
ABI2_HUMAN [view entry] [view interactions] High throughput yes yes
DDX58_HUMAN [view interactions] High throughput no yes
FZR1_HUMAN [view interactions] High throughput no no
BRK1_HUMAN [view interactions] High throughput no no
PR40A_HUMAN [view interactions] High throughput no yes
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
NHLC2_HUMAN [view interactions] High throughput no yes
WASP_HUMAN [view interactions] Computational no yes
NCK1_HUMAN [view interactions] Computational no yes
MK01_HUMAN [view entry] [view interactions] Computational yes yes
RAC2_HUMAN [view entry] [view interactions] Computational yes yes
WASF1_HUMAN [view entry] [view interactions] Computational yes yes
SRA1_HUMAN [view interactions] Computational no yes
MK03_HUMAN [view entry] [view interactions] Computational yes yes
WASF3_HUMAN [view entry] [view interactions] Computational yes yes
NCKP1_HUMAN [view entry] [view interactions] Computational yes yes
ARP2_HUMAN [view entry] [view interactions] Computational yes yes
ABL1_HUMAN [view entry] [view interactions] Computational yes yes
WASL_HUMAN [view entry] [view interactions] Computational yes yes
ARF1_HUMAN [view entry] [view interactions] Computational yes yes