ABI1_HUMAN

G2C

SynGO

SynaptomeDB

May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. [View more on UniProt]

Transmembrane

Phase separation

ELM

Phosphorylation

PFAM

Coiled coil

Anchor

Disordered

Interacting regions

Sequence

LOADING 28%

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

ABI1_HUMAN

ABL1_HUMAN

LOADING 67%

ABI1_HUMAN

SOS1_HUMAN

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ABI1_HUMAN

DYST_HUMAN

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ABI1_HUMAN

HNRPK_HUMAN

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ABI1_HUMAN

K0408_HUMAN

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ABI1_HUMAN

KTN1_HUMAN

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ABI1_HUMAN

SRBS1_HUMAN

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ABI1_HUMAN

TLN1_HUMAN

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ABI1_HUMAN

FYN_HUMAN

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ABI1_HUMAN

LCK_HUMAN

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ABI1_HUMAN

VAV2_HUMAN

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ABI1_HUMAN

YES_HUMAN

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ABI1_HUMAN

HCK_HUMAN

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ABI1_HUMAN

FES_HUMAN

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ABI1_HUMAN

SRC_HUMAN

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ABI1_HUMAN

LYN_HUMAN

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ABI1_HUMAN

PLCG1_HUMAN

LOADING 67%

ABI1_HUMAN

GRB10_HUMAN

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ABI1_HUMAN

ABL2_HUMAN

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ABI1_HUMAN

GRB2_HUMAN

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ABI1_HUMAN

CRKL_HUMAN

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ABI1_HUMAN

CBLB_HUMAN

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ABI1_HUMAN

CRK_HUMAN

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ABI1_HUMAN has binary interactions with 50 proteins

Download full PS network for entry.

Interacting regions

Canonical [ABI1_HUMAN]

Isoform [B6VEX4] alignment

Isoform [B6VEX4] sequence

Isoform [A0A0A0MRT6] alignment

Isoform [A0A0A0MRT6] sequence

Isoform [Q8IZP0-11] alignment

Isoform [Q8IZP0-11] sequence

Isoform [Q8IZP0-10] alignment

Isoform [Q8IZP0-10] sequence

Isoform [Q8IZP0-12] alignment

Isoform [Q8IZP0-12] sequence

Isoform [Q8IZP0-2] alignment

Isoform [Q8IZP0-2] sequence

Isoform [Q8IZP0-3] alignment

Isoform [Q8IZP0-3] sequence

Isoform [Q8IZP0-4] alignment

Isoform [Q8IZP0-4] sequence

Isoform [Q8IZP0-5] alignment

Isoform [Q8IZP0-5] sequence

Isoform [Q8IZP0-6] alignment

Isoform [Q8IZP0-6] sequence

Isoform [Q8IZP0-7] alignment

Isoform [Q8IZP0-7] sequence

Isoform [Q8IZP0-8] alignment

Isoform [Q8IZP0-8] sequence

Isoform [Q8IZP0-9] alignment

Isoform [Q8IZP0-9] sequence

LOADING 7%

No data found.

ELM instance	Name	Type	Start	End	Partner
ELMI000206	LIG_SH3_PxxDY_5	LIG	417	421	-
ELMI000206	LIG_SH3_PxxDY_5	LIG	417	421	-

Molecular function

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Search:

Term	Name	%	Distance from the top of the tree	Annotated in ABI1_HUMAN
GO:0043168	anion binding	31.7460	4	no
GO:0000166	nucleotide binding	27.7778	4	no
GO:0017076	purine nucleotide binding	27.7778	5	no
GO:0032555	purine ribonucleotide binding	27.7778	4	no
GO:0035639	purine ribonucleoside triphosphate binding	27.7778	4	no
GO:0005524	ATP binding	21.4286	5	no
GO:0030554	adenyl nucleotide binding	21.4286	6	no
GO:0032559	adenyl ribonucleotide binding	21.4286	5	no
GO:0045296	cadherin binding	16.6667	4	yes
GO:0017124	SH3 domain binding	13.4921	4	yes
GO:0019887	protein kinase regulator activity	5.5556	4	yes
GO:0019209	kinase activator activity	2.3810	4	yes
GO:0030295	protein kinase activator activity	2.3810	5	yes
GO:0030296	protein tyrosine kinase activator activity	1.5873	6	yes

Showing 1 to 14 of 14 entries

Biological process

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Search:

Term	Name	%	Distance from top the of the tree	Annotated in ABI1_HUMAN
GO:0048522	positive regulation of cellular process	69.8413	4	yes
GO:0051128	regulation of cellular component organization	58.7302	4	no
GO:0010646	regulation of cell communication	54.7619	4	no
GO:0048523	negative regulation of cellular process	52.3810	4	yes
GO:0031323	regulation of cellular metabolic process	49.2063	4	yes
GO:0060255	regulation of macromolecule metabolic process	47.6190	4	yes
GO:0009966	regulation of signal transduction	46.8254	4	no
GO:0080090	regulation of primary metabolic process	42.8571	4	yes
GO:0048584	positive regulation of response to stimulus	40.4762	4	no
GO:0022607	cellular component assembly	40.4762	4	no
GO:0006996	organelle organization	39.6825	4	no
GO:0009889	regulation of biosynthetic process	38.8889	4	no
GO:0010556	regulation of macromolecule biosynthetic process	38.8889	5	no
GO:0031326	regulation of cellular biosynthetic process	38.8889	5	no
GO:0030030	cell projection organization	38.0952	4	yes
GO:0010468	regulation of gene expression	37.3016	6	no
GO:0009893	positive regulation of metabolic process	37.3016	4	yes
GO:0051049	regulation of transport	35.7143	4	no
GO:0051130	positive regulation of cellular component organization	34.9206	5	no
GO:0031325	positive regulation of cellular metabolic process	34.1270	5	yes
GO:1902531	regulation of intracellular signal transduction	34.1270	5	no
GO:0010647	positive regulation of cell communication	34.1270	5	no
GO:0023056	positive regulation of signaling	34.1270	4	no
GO:0010604	positive regulation of macromolecule metabolic process	33.3333	5	yes
GO:0044087	regulation of cellular component biogenesis	33.3333	4	no

Showing 1 to 25 of 107 entries

Disease

No data found.

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Search:

Uniprot ID	Details	Highest evidence	Localizing into PSD	HPA (protein expression in neurons)
1433E_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
1433F_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
1433G_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
1433T_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
1433Z_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
2AAA_HUMAN	[view entry] [view interactions]	High throughput	yes	no
A16L1_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
AAPK1_HUMAN	[view interactions]	High throughput	no	no
AAPK2_HUMAN	[view interactions]	High throughput	no	yes
ABI1_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
ABI2_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
ABL1_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
ABL2_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
ACTB_HUMAN	[view entry] [view interactions]	High throughput	yes	no
ACTC_HUMAN	[view interactions]	High throughput	no	no
ACTG_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
ACTN2_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
ADT2_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
AIMP2_HUMAN	[view interactions]	High throughput	no	yes
AKA12_HUMAN	[view entry] [view interactions]	High throughput	yes	no
AKT1_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
AKT3_HUMAN	[view interactions]	High throughput	no	yes
AMZ1_HUMAN	[view interactions]	High throughput	no	no
APBB1_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
ATX1_HUMAN	[view interactions]	High throughput	no	yes

Showing 1 to 25 of 259 entries

ABI1_HUMAN

Evidence for PS localization

Functions

Protein features

Binary interactions with known binding regions

Network

Isoforms

Disease-causing germline mutations

Linear motifs

Fingerprint

Molecular function

Biological process

Disease

All partners