PACN2_HUMAN
Evidence for PS localization
Functions
(Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed). Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed). Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PACN2_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 60.0000 | 4 | yes |
| GO:0000166 | nucleotide binding | 56.9231 | 4 | no |
| GO:0017076 | purine nucleotide binding | 55.3846 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 55.3846 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 55.3846 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 32.3077 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 32.3077 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 32.3077 | 6 | no |
| GO:0005524 | ATP binding | 29.2308 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 29.2308 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 29.2308 | 5 | no |
| GO:0005525 | GTP binding | 29.2308 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 29.2308 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 29.2308 | 5 | no |
| GO:0019900 | kinase binding | 24.6154 | 4 | no |
| GO:0019901 | protein kinase binding | 24.6154 | 5 | no |
| GO:0003924 | GTPase activity | 23.0769 | 7 | no |
| GO:0045296 | cadherin binding | 20.0000 | 4 | yes |
| GO:0070300 | phosphatidic acid binding | 3.0769 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PACN2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 72.3077 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 67.6923 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 52.3077 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 52.3077 | 4 | no |
| GO:0006996 | organelle organization | 49.2308 | 4 | yes |
| GO:0022607 | cellular component assembly | 49.2308 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 47.6923 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 46.1538 | 4 | no |
| GO:0010646 | regulation of cell communication | 44.6154 | 4 | yes |
| GO:0030030 | cell projection organization | 44.6154 | 4 | yes |
| GO:0008104 | protein localization | 41.5385 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 41.5385 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 41.5385 | 5 | no |
| GO:0051049 | regulation of transport | 40.0000 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 40.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 40.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 40.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 38.4615 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 36.9231 | 5 | no |
| GO:0009966 | regulation of signal transduction | 35.3846 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 35.3846 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 35.3846 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 35.3846 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 35.3846 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 33.8462 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 33.8462 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 33.8462 | 4 | no |
| GO:0060341 | regulation of cellular localization | 32.3077 | 4 | no |
| GO:0007010 | cytoskeleton organization | 30.7692 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 30.7692 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.7692 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.7692 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.2308 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 27.6923 | 4 | no |
| GO:0032880 | regulation of protein localization | 27.6923 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 26.1538 | 4 | yes |
| GO:0061024 | membrane organization | 26.1538 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 26.1538 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 26.1538 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 26.1538 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.1538 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 26.1538 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 26.1538 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.1538 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.1538 | 5 | no |
| GO:0071310 | cellular response to organic substance | 24.6154 | 4 | no |
| GO:0071702 | organic substance transport | 24.6154 | 4 | no |
| GO:0071705 | nitrogen compound transport | 24.6154 | 4 | no |
| GO:0030334 | regulation of cell migration | 24.6154 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 24.6154 | 4 | no |
| GO:2000145 | regulation of cell motility | 24.6154 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 24.6154 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 24.6154 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 24.6154 | 6 | no |
| GO:0043933 | protein-containing complex organization | 24.6154 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 23.0769 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.0769 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 23.0769 | 4 | no |
| GO:0031175 | neuron projection development | 23.0769 | 6 | no |
| GO:0051094 | positive regulation of developmental process | 23.0769 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 23.0769 | 6 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 21.5385 | 5 | yes |
| GO:0098657 | import into cell | 21.5385 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 21.5385 | 4 | yes |
| GO:0015031 | protein transport | 21.5385 | 4 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 21.5385 | 6 | no |
| GO:0010975 | regulation of neuron projection development | 21.5385 | 7 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 21.5385 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 21.5385 | 7 | no |
| GO:0045595 | regulation of cell differentiation | 21.5385 | 4 | no |
| GO:0051050 | positive regulation of transport | 21.5385 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 21.5385 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.5385 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.5385 | 5 | no |
| GO:0030100 | regulation of endocytosis | 18.4615 | 5 | yes |
| GO:0033365 | protein localization to organelle | 18.4615 | 5 | yes |
| GO:0051051 | negative regulation of transport | 12.3077 | 4 | yes |
| GO:0045806 | negative regulation of endocytosis | 9.2308 | 5 | yes |
| GO:0036010 | protein localization to endosome | 6.1538 | 6 | yes |
| GO:0007009 | plasma membrane organization | 4.6154 | 5 | yes |
| GO:0071709 | membrane assembly | 4.6154 | 5 | yes |
| GO:0097320 | plasma membrane tubulation | 4.6154 | 6 | yes |
| GO:0001765 | membrane raft assembly | 3.0769 | 6 | yes |
| GO:0031579 | membrane raft organization | 3.0769 | 5 | yes |
| GO:0044854 | plasma membrane raft assembly | 3.0769 | 7 | yes |
| GO:0044857 | plasma membrane raft organization | 3.0769 | 6 | yes |
| GO:0070836 | caveola assembly | 3.0769 | 8 | yes |
| GO:0072584 | caveolin-mediated endocytosis | 3.0769 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CNRG_HUMAN | [view interactions] | Low throughput | no | no |
| TNFL6_HUMAN | [view interactions] | Low throughput | no | yes |
| SPN90_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| COBL_HUMAN | [view interactions] | Low throughput | no | yes |
| EHD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EHD4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PACN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PACN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PACN3_HUMAN | [view interactions] | Low throughput | no | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TBG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PICK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERP44_HUMAN | [view interactions] | High throughput | no | yes |
| CHCH2_HUMAN | [view interactions] | High throughput | no | yes |
| 3BP1_HUMAN | [view interactions] | High throughput | no | no |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| JAZF1_HUMAN | [view interactions] | High throughput | no | yes |
| SRF_HUMAN | [view interactions] | High throughput | no | yes |
| SUZ12_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADA17_HUMAN | [view interactions] | High throughput | no | yes |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| ASAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| WASL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSC2_HUMAN | [view interactions] | High throughput | no | no |
| PBX4_HUMAN | [view interactions] | High throughput | no | no |
| TE2IP_HUMAN | [view interactions] | High throughput | no | yes |
| POTE1_HUMAN | [view interactions] | High throughput | no | no |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IRF5_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EPHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA5_HUMAN | [view interactions] | High throughput | no | no |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| SHBG_HUMAN | [view interactions] | High throughput | no | no |
| RIC8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EXOS8_HUMAN | [view interactions] | High throughput | no | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| SYCC_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
| MILK1_HUMAN | [view interactions] | High throughput | no | yes |
| AB1IP_HUMAN | [view interactions] | High throughput | no | no |
| WASP_HUMAN | [view interactions] | High throughput | no | yes |
| WIPF1_HUMAN | [view interactions] | High throughput | no | no |
| SBK1_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| COBL1_HUMAN | [view interactions] | High throughput | no | yes |
| THG1_HUMAN | [view interactions] | High throughput | no | yes |
| WIPF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPRIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| RAI14_HUMAN | [view interactions] | High throughput | no | yes |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYVN1_HUMAN | [view interactions] | High throughput | no | yes |
| T2R31_HUMAN | [view interactions] | High throughput | no | no |
| INSI1_HUMAN | [view interactions] | High throughput | no | no |
| SWP70_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VDR_HUMAN | [view interactions] | High throughput | no | no |
| COQ3_HUMAN | [view interactions] | High throughput | no | no |
| ZBT44_HUMAN | [view interactions] | High throughput | no | yes |
| ABCF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K0408_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PIGF_HUMAN | [view interactions] | High throughput | no | no |
| S35G1_HUMAN | [view interactions] | High throughput | no | no |
| RN145_HUMAN | [view interactions] | High throughput | no | yes |
| SLU7_HUMAN | [view interactions] | High throughput | no | yes |
| PXK_HUMAN | [view interactions] | High throughput | no | yes |
| DIK1A_HUMAN | [view interactions] | High throughput | no | yes |
| RAMP1_HUMAN | [view interactions] | High throughput | no | no |
| ZN75A_HUMAN | [view interactions] | High throughput | no | yes |
| CCD71_HUMAN | [view interactions] | High throughput | no | no |
| CLXN_HUMAN | [view interactions] | High throughput | no | no |
| ZNF10_HUMAN | [view interactions] | High throughput | no | no |
| DDX55_HUMAN | [view interactions] | High throughput | no | yes |
| DIDO1_HUMAN | [view interactions] | High throughput | no | yes |
| STK11_HUMAN | [view interactions] | High throughput | no | yes |
| GARS_HUMAN | [view interactions] | High throughput | no | yes |
| SPB1_HUMAN | [view interactions] | High throughput | no | yes |
| ENTP1_HUMAN | [view interactions] | High throughput | no | yes |
| TARA_HUMAN | [view interactions] | High throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| HELZ2_HUMAN | [view interactions] | High throughput | no | no |
| MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXA1_HUMAN | [view interactions] | High throughput | no | no |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| DYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNJ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITCH_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1A_HUMAN | [view interactions] | High throughput | no | yes |
| CERT_HUMAN | [view interactions] | High throughput | no | yes |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| PLOD2_HUMAN | [view interactions] | High throughput | no | yes |
| PTN12_HUMAN | [view interactions] | High throughput | no | yes |
| UGPA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VASN_HUMAN | [view interactions] | High throughput | no | yes |
| 2A5G_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEBP_HUMAN | [view interactions] | High throughput | no | yes |
| F10A1_HUMAN | [view interactions] | High throughput | no | yes |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| MCFD2_HUMAN | [view interactions] | High throughput | no | yes |
| IMA3_HUMAN | [view interactions] | High throughput | no | yes |
| E41L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRTAP_HUMAN | [view interactions] | High throughput | no | yes |
| ARI2_HUMAN | [view interactions] | High throughput | no | no |
| HNRPC_HUMAN | [view interactions] | High throughput | no | yes |
| TPR_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMCA2_HUMAN | [view interactions] | High throughput | no | yes |
| COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SF3A3_HUMAN | [view interactions] | High throughput | no | yes |
| SAFB2_HUMAN | [view interactions] | High throughput | no | yes |
| RCN1_HUMAN | [view interactions] | High throughput | no | yes |
| CIP4_HUMAN | [view interactions] | High throughput | no | no |
| CCAR2_HUMAN | [view interactions] | High throughput | no | yes |
| COPG1_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFFL_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB8_HUMAN | [view interactions] | High throughput | no | no |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3B_HUMAN | [view interactions] | High throughput | no | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |