SWP70_HUMAN
Evidence for PS localization
Functions
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SWP70_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 51.4286 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 51.4286 | 5 | yes |
| GO:0043168 | anion binding | 51.4286 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 48.5714 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 45.7143 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 37.1429 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 34.2857 | 5 | yes |
| GO:0019900 | kinase binding | 34.2857 | 4 | no |
| GO:0019901 | protein kinase binding | 34.2857 | 5 | no |
| GO:0005524 | ATP binding | 31.4286 | 5 | yes |
| GO:0043169 | cation binding | 28.5714 | 4 | yes |
| GO:0046872 | metal ion binding | 28.5714 | 5 | yes |
| GO:0003723 | RNA binding | 28.5714 | 4 | no |
| GO:0045296 | cadherin binding | 25.7143 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 25.7143 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 25.7143 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 25.7143 | 6 | no |
| GO:0005509 | calcium ion binding | 17.1429 | 6 | yes |
| GO:0003677 | DNA binding | 8.5714 | 4 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 8.5714 | 5 | yes |
| GO:0030695 | GTPase regulator activity | 8.5714 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SWP70_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 65.7143 | 4 | yes |
| GO:0022607 | cellular component assembly | 60.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 60.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 54.2857 | 4 | yes |
| GO:0008104 | protein localization | 54.2857 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 51.4286 | 4 | yes |
| GO:0006996 | organelle organization | 51.4286 | 4 | no |
| GO:0010646 | regulation of cell communication | 48.5714 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 48.5714 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 45.7143 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 42.8571 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | yes |
| GO:0030030 | cell projection organization | 40.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 37.1429 | 4 | yes |
| GO:0032880 | regulation of protein localization | 37.1429 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 37.1429 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 37.1429 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 37.1429 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 37.1429 | 4 | no |
| GO:0010468 | regulation of gene expression | 37.1429 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 37.1429 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.1429 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 37.1429 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 37.1429 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 34.2857 | 4 | yes |
| GO:0051049 | regulation of transport | 34.2857 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 31.4286 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.4286 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 31.4286 | 5 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 31.4286 | 6 | yes |
| GO:0097435 | supramolecular fiber organization | 31.4286 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 31.4286 | 5 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 31.4286 | 5 | no |
| GO:0071702 | organic substance transport | 31.4286 | 4 | no |
| GO:0071705 | nitrogen compound transport | 31.4286 | 4 | no |
| GO:0009894 | regulation of catabolic process | 31.4286 | 4 | no |
| GO:0031399 | regulation of protein modification process | 28.5714 | 6 | yes |
| GO:0051130 | positive regulation of cellular component organization | 28.5714 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 28.5714 | 4 | no |
| GO:0015031 | protein transport | 28.5714 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 28.5714 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 28.5714 | 4 | no |
| GO:0071310 | cellular response to organic substance | 28.5714 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 28.5714 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 28.5714 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 28.5714 | 6 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 28.5714 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 28.5714 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 28.5714 | 6 | no |
| GO:0051094 | positive regulation of developmental process | 28.5714 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 28.5714 | 7 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.5714 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 28.5714 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 28.5714 | 6 | no |
| GO:0002684 | positive regulation of immune system process | 25.7143 | 4 | yes |
| GO:0007015 | actin filament organization | 25.7143 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 25.7143 | 6 | yes |
| GO:0030155 | regulation of cell adhesion | 25.7143 | 4 | yes |
| GO:0032101 | regulation of response to external stimulus | 25.7143 | 4 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 25.7143 | 5 | yes |
| GO:0007010 | cytoskeleton organization | 25.7143 | 5 | no |
| GO:0014070 | response to organic cyclic compound | 25.7143 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 25.7143 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 25.7143 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 25.7143 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.7143 | 6 | no |
| GO:0080134 | regulation of response to stress | 25.7143 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.7143 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 25.7143 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.7143 | 4 | no |
| GO:0030334 | regulation of cell migration | 22.8571 | 5 | yes |
| GO:0090304 | nucleic acid metabolic process | 22.8571 | 4 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 22.8571 | 5 | yes |
| GO:2000145 | regulation of cell motility | 22.8571 | 4 | yes |
| GO:0031175 | neuron projection development | 22.8571 | 6 | no |
| GO:0071407 | cellular response to organic cyclic compound | 22.8571 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 22.8571 | 4 | no |
| GO:0009896 | positive regulation of catabolic process | 22.8571 | 5 | no |
| GO:0010629 | negative regulation of gene expression | 22.8571 | 7 | no |
| GO:1903829 | positive regulation of protein localization | 22.8571 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 22.8571 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 22.8571 | 4 | no |
| GO:0010638 | positive regulation of organelle organization | 20.0000 | 6 | yes |
| GO:0032103 | positive regulation of response to external stimulus | 20.0000 | 5 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 20.0000 | 5 | yes |
| GO:0010639 | negative regulation of organelle organization | 17.1429 | 6 | yes |
| GO:0031400 | negative regulation of protein modification process | 17.1429 | 7 | yes |
| GO:0032535 | regulation of cellular component size | 17.1429 | 4 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 17.1429 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 17.1429 | 4 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 17.1429 | 6 | yes |
| GO:0002685 | regulation of leukocyte migration | 14.2857 | 4 | yes |
| GO:0010563 | negative regulation of phosphorus metabolic process | 14.2857 | 6 | yes |
| GO:0030335 | positive regulation of cell migration | 14.2857 | 6 | yes |
| GO:0040017 | positive regulation of locomotion | 14.2857 | 4 | yes |
| GO:0045936 | negative regulation of phosphate metabolic process | 14.2857 | 7 | yes |
| GO:0050920 | regulation of chemotaxis | 14.2857 | 4 | yes |
| GO:0051017 | actin filament bundle assembly | 14.2857 | 5 | yes |
| GO:0051495 | positive regulation of cytoskeleton organization | 14.2857 | 7 | yes |
| GO:0061572 | actin filament bundle organization | 14.2857 | 6 | yes |
| GO:0110053 | regulation of actin filament organization | 14.2857 | 6 | yes |
| GO:1902905 | positive regulation of supramolecular fiber organization | 14.2857 | 6 | yes |
| GO:2000147 | positive regulation of cell motility | 14.2857 | 5 | yes |
| GO:0002687 | positive regulation of leukocyte migration | 11.4286 | 5 | yes |
| GO:0002688 | regulation of leukocyte chemotaxis | 11.4286 | 5 | yes |
| GO:0002690 | positive regulation of leukocyte chemotaxis | 11.4286 | 6 | yes |
| GO:0022407 | regulation of cell-cell adhesion | 11.4286 | 5 | yes |
| GO:0050921 | positive regulation of chemotaxis | 11.4286 | 5 | yes |
| GO:0051494 | negative regulation of cytoskeleton organization | 11.4286 | 7 | yes |
| GO:1902904 | negative regulation of supramolecular fiber organization | 11.4286 | 6 | yes |
| GO:0006259 | DNA metabolic process | 8.5714 | 5 | yes |
| GO:0007162 | negative regulation of cell adhesion | 8.5714 | 5 | yes |
| GO:0022408 | negative regulation of cell-cell adhesion | 8.5714 | 6 | yes |
| GO:0032231 | regulation of actin filament bundle assembly | 8.5714 | 5 | yes |
| GO:0033628 | regulation of cell adhesion mediated by integrin | 8.5714 | 5 | yes |
| GO:0035303 | regulation of dephosphorylation | 8.5714 | 7 | yes |
| GO:0035304 | regulation of protein dephosphorylation | 8.5714 | 7 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 8.5714 | 6 | yes |
| GO:0008064 | regulation of actin polymerization or depolymerization | 5.7143 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 5.7143 | 5 | yes |
| GO:0032233 | positive regulation of actin filament bundle assembly | 5.7143 | 6 | yes |
| GO:0035305 | negative regulation of dephosphorylation | 5.7143 | 8 | yes |
| GO:0035308 | negative regulation of protein dephosphorylation | 5.7143 | 8 | yes |
| GO:0060753 | regulation of mast cell chemotaxis | 5.7143 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NPM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NUCL_HUMAN | [view interactions] | Low throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CELR3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| ZBTB5_HUMAN | [view interactions] | High throughput | no | yes |
| RPGF4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYSC_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SCLT1_HUMAN | [view interactions] | High throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PACN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TM263_HUMAN | [view interactions] | High throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RMC1_HUMAN | [view interactions] | High throughput | no | no |
| RANB3_HUMAN | [view interactions] | High throughput | no | yes |
| SPT5H_HUMAN | [view interactions] | High throughput | no | yes |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INT13_HUMAN | [view interactions] | High throughput | no | no |
| COR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DPYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| FAF1_HUMAN | [view interactions] | High throughput | no | yes |
| SYFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GANAB_HUMAN | [view interactions] | High throughput | no | yes |
| PUR2_HUMAN | [view interactions] | High throughput | no | yes |
| JMJD6_HUMAN | [view interactions] | High throughput | no | yes |
| OSBP1_HUMAN | [view interactions] | High throughput | no | yes |
| OTU6B_HUMAN | [view interactions] | High throughput | no | yes |
| PUR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLOD2_HUMAN | [view interactions] | High throughput | no | yes |
| 2A5G_HUMAN | [view interactions] | High throughput | no | yes |
| SET_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAB2_HUMAN | [view interactions] | High throughput | no | yes |
| NAA20_HUMAN | [view interactions] | High throughput | no | no |
| TTC5_HUMAN | [view interactions] | High throughput | no | yes |
| ZCHC3_HUMAN | [view interactions] | High throughput | no | no |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VASP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHLP1_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB25_HUMAN | [view interactions] | High throughput | no | no |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |