SYFB_HUMAN
Evidence for PS localization
Functions
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SYFB_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 42.1053 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 42.1053 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 42.1053 | 4 | yes |
| GO:0003723 | RNA binding | 34.2105 | 4 | yes |
| GO:0005524 | ATP binding | 31.5789 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 31.5789 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 31.5789 | 5 | yes |
| GO:0019900 | kinase binding | 28.9474 | 4 | no |
| GO:0019901 | protein kinase binding | 23.6842 | 5 | no |
| GO:0046872 | metal ion binding | 15.7895 | 4 | yes |
| GO:0004812 | aminoacyl-tRNA ligase activity | 7.8947 | 4 | yes |
| GO:0004826 | phenylalanine-tRNA ligase activity | 7.8947 | 5 | yes |
| GO:0140101 | catalytic activity, acting on a tRNA | 7.8947 | 4 | yes |
| GO:0000287 | magnesium ion binding | 5.2632 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SYFB_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 65.7895 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 57.8947 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 55.2632 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 52.6316 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 52.6316 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 52.6316 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.3684 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 44.7368 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 44.7368 | 5 | no |
| GO:0010468 | regulation of gene expression | 42.1053 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 42.1053 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 42.1053 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 42.1053 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 42.1053 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 42.1053 | 5 | no |
| GO:0022607 | cellular component assembly | 39.4737 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 39.4737 | 4 | no |
| GO:0010646 | regulation of cell communication | 39.4737 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 39.4737 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 36.8421 | 4 | no |
| GO:0010941 | regulation of cell death | 36.8421 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 36.8421 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 36.8421 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 36.8421 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 34.2105 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 34.2105 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 34.2105 | 4 | no |
| GO:0051049 | regulation of transport | 34.2105 | 4 | no |
| GO:0006996 | organelle organization | 31.5789 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 31.5789 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 31.5789 | 5 | no |
| GO:0071310 | cellular response to organic substance | 31.5789 | 4 | no |
| GO:0043933 | protein-containing complex organization | 28.9474 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 28.9474 | 6 | no |
| GO:0031399 | regulation of protein modification process | 28.9474 | 6 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 28.9474 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 28.9474 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 28.9474 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 28.9474 | 4 | no |
| GO:0080134 | regulation of response to stress | 28.9474 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 28.9474 | 4 | no |
| GO:0009059 | macromolecule biosynthetic process | 26.3158 | 4 | yes |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 26.3158 | 4 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 26.3158 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.3158 | 5 | no |
| GO:0009894 | regulation of catabolic process | 26.3158 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 26.3158 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 26.3158 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 26.3158 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.3158 | 6 | no |
| GO:0023056 | positive regulation of signaling | 26.3158 | 4 | no |
| GO:0023057 | negative regulation of signaling | 26.3158 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 26.3158 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.3158 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 26.3158 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.3158 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 26.3158 | 4 | no |
| GO:0033043 | regulation of organelle organization | 26.3158 | 5 | no |
| GO:0060341 | regulation of cellular localization | 26.3158 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 26.3158 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 23.6842 | 5 | yes |
| GO:0009968 | negative regulation of signal transduction | 23.6842 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.6842 | 6 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 23.6842 | 6 | no |
| GO:0010628 | positive regulation of gene expression | 23.6842 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 23.6842 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.6842 | 6 | no |
| GO:0036211 | protein modification process | 23.6842 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 23.6842 | 7 | no |
| GO:0043412 | macromolecule modification | 23.6842 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 23.6842 | 4 | no |
| GO:0030030 | cell projection organization | 23.6842 | 4 | no |
| GO:0032880 | regulation of protein localization | 23.6842 | 5 | no |
| GO:0014070 | response to organic cyclic compound | 23.6842 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 23.6842 | 4 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 23.6842 | 4 | no |
| GO:0034645 | cellular macromolecule biosynthetic process | 21.0526 | 4 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 21.0526 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 21.0526 | 7 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 21.0526 | 7 | no |
| GO:0010942 | positive regulation of cell death | 21.0526 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 21.0526 | 7 | no |
| GO:0034097 | response to cytokine | 21.0526 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 21.0526 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 21.0526 | 6 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 21.0526 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 21.0526 | 5 | no |
| GO:0080135 | regulation of cellular response to stress | 21.0526 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.0526 | 6 | no |
| GO:0043066 | negative regulation of apoptotic process | 21.0526 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 21.0526 | 6 | no |
| GO:0060548 | negative regulation of cell death | 21.0526 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.0526 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 21.0526 | 4 | no |
| GO:0071407 | cellular response to organic cyclic compound | 21.0526 | 5 | no |
| GO:0051050 | positive regulation of transport | 21.0526 | 4 | no |
| GO:0006412 | translation | 18.4211 | 4 | yes |
| GO:0006518 | peptide metabolic process | 18.4211 | 4 | yes |
| GO:0043043 | peptide biosynthetic process | 18.4211 | 5 | yes |
| GO:0043603 | cellular amide metabolic process | 18.4211 | 4 | yes |
| GO:0043604 | amide biosynthetic process | 18.4211 | 5 | yes |
| GO:0090304 | nucleic acid metabolic process | 15.7895 | 4 | yes |
| GO:0016070 | RNA metabolic process | 13.1579 | 5 | yes |
| GO:0051259 | protein complex oligomerization | 10.5263 | 6 | yes |
| GO:0051262 | protein tetramerization | 10.5263 | 7 | yes |
| GO:0006399 | tRNA metabolic process | 7.8947 | 7 | yes |
| GO:0006418 | tRNA aminoacylation for protein translation | 7.8947 | 6 | yes |
| GO:0006432 | phenylalanyl-tRNA aminoacylation | 7.8947 | 7 | yes |
| GO:0019752 | carboxylic acid metabolic process | 7.8947 | 5 | yes |
| GO:0034660 | ncRNA metabolic process | 7.8947 | 6 | yes |
| GO:0043038 | amino acid activation | 7.8947 | 4 | yes |
| GO:0043039 | tRNA aminoacylation | 7.8947 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 7.8947 | 4 | yes |
| GO:0051290 | protein heterotetramerization | 7.8947 | 8 | yes |
| GO:0051291 | protein heterooligomerization | 7.8947 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SYFB_HUMAN |
|---|---|---|---|---|
| DOID:612 | primary immunodeficiency disease | 5.2632 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MSRA_HUMAN | [view interactions] | Low throughput | no | no |
| SYFB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYFA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MB212_HUMAN | [view interactions] | High throughput | no | no |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| HDGF_HUMAN | [view interactions] | High throughput | no | yes |
| FOXR1_HUMAN | [view interactions] | High throughput | no | no |
| GLI1_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SF3B4_HUMAN | [view interactions] | High throughput | no | yes |
| UBA5_HUMAN | [view interactions] | High throughput | no | yes |
| CD4_HUMAN | [view interactions] | High throughput | no | no |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| DTX3_HUMAN | [view interactions] | High throughput | no | yes |
| TEKT2_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| UBE2A_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| ARI1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTMRE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| BACD3_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
| ANR55_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| SKA3_HUMAN | [view interactions] | High throughput | no | no |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| GHRL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DCAM_HUMAN | [view interactions] | High throughput | no | yes |
| PACE1_HUMAN | [view interactions] | High throughput | no | yes |
| ARSF_HUMAN | [view interactions] | High throughput | no | no |
| CENPM_HUMAN | [view interactions] | High throughput | no | yes |
| MTPN_HUMAN | [view interactions] | High throughput | no | yes |
| ZBTB9_HUMAN | [view interactions] | High throughput | no | no |
| BRK1_HUMAN | [view interactions] | High throughput | no | no |
| PITX1_HUMAN | [view interactions] | High throughput | no | yes |
| HSBP1_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| CLU_HUMAN | [view interactions] | High throughput | no | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| RHBT2_HUMAN | [view interactions] | High throughput | no | no |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| CTBL1_HUMAN | [view interactions] | High throughput | no | yes |
| INT5_HUMAN | [view interactions] | High throughput | no | no |
| LEO1_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| SYIC_HUMAN | [view interactions] | High throughput | no | yes |
| UBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYAC_HUMAN | [view interactions] | High throughput | no | yes |
| FAF1_HUMAN | [view interactions] | High throughput | no | yes |
| GANAB_HUMAN | [view interactions] | High throughput | no | yes |
| PLOD2_HUMAN | [view interactions] | High throughput | no | yes |
| UGPA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| PUR2_HUMAN | [view interactions] | High throughput | no | yes |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RANB3_HUMAN | [view interactions] | High throughput | no | yes |
| RL24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RLA0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RLA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SET_HUMAN | [view interactions] | High throughput | no | yes |
| SF01_HUMAN | [view interactions] | High throughput | no | yes |
| SPT5H_HUMAN | [view interactions] | High throughput | no | yes |
| SWP70_HUMAN | [view interactions] | High throughput | no | no |
| SYTC_HUMAN | [view interactions] | High throughput | no | yes |
| SYTC2_HUMAN | [view interactions] | High throughput | no | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DRG1_HUMAN | [view interactions] | High throughput | no | yes |
| RL19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| DDA1_HUMAN | [view interactions] | High throughput | no | yes |
| E2AK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| WRP73_HUMAN | [view interactions] | High throughput | no | no |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| MAGBA_HUMAN | [view interactions] | High throughput | no | no |
| APBA3_HUMAN | [view interactions] | High throughput | no | yes |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GPX7_HUMAN | [view interactions] | High throughput | no | no |
| UBP47_HUMAN | [view interactions] | High throughput | no | yes |
| PAK4_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| GRN_HUMAN | [view interactions] | High throughput | no | no |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTPRR_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| GATA3_HUMAN | [view interactions] | High throughput | no | no |
| SYDC_HUMAN | [view interactions] | Computational | no | yes |
| SYEP_HUMAN | [view interactions] | Computational | no | yes |
| SYFM_HUMAN | [view interactions] | Computational | no | yes |
| SYK_HUMAN | [view interactions] | Computational | no | yes |
| SYYC_HUMAN | [view interactions] | Computational | no | yes |
| ABCE1_HUMAN | [view interactions] | Computational | no | yes |
| SYWC_HUMAN | [view interactions] | Computational | no | yes |