E2AK2_HUMAN
Evidence for PS localization
Functions
IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Inhibits viral replication via the integrated stress response (ISR): EIF2S1/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4 (PubMed, PubMed, PubMed, PubMed). Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1) (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation: phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11 (PubMed, PubMed, PubMed). In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at Tyr-4 upon DNA damage, facilitating its ubiquitination and proteosomal degradation (PubMed). Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding proinflammatory cytokines and IFNs (PubMed, PubMed, PubMed). Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6 (PubMed, PubMed, PubMed). Can act as both a positive and negative regulator of the insulin signaling pathway (ISP) (PubMed). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at Ser-312 and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2) (PubMed). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes (PubMed). Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in E2AK2_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 58.3333 | 4 | yes |
| GO:0019900 | kinase binding | 21.6667 | 4 | no |
| GO:0017076 | purine nucleotide binding | 20.0000 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 20.0000 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.0000 | 4 | yes |
| GO:0005524 | ATP binding | 18.3333 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 18.3333 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 18.3333 | 5 | yes |
| GO:0003725 | double-stranded RNA binding | 15.0000 | 5 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 6.6667 | 4 | yes |
| GO:0016301 | kinase activity | 6.6667 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 6.6667 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 5.0000 | 4 | yes |
| GO:0004713 | protein tyrosine kinase activity | 5.0000 | 4 | yes |
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity | 5.0000 | 5 | yes |
| GO:0106310 | protein serine kinase activity | 5.0000 | 4 | yes |
| GO:0019888 | protein phosphatase regulator activity | 3.3333 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in E2AK2_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 63.3333 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 61.6667 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 60.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 56.6667 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 56.6667 | 4 | yes |
| GO:0010468 | regulation of gene expression | 53.3333 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 51.6667 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 48.3333 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 48.3333 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 48.3333 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 46.6667 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 43.3333 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 43.3333 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 43.3333 | 5 | yes |
| GO:0010646 | regulation of cell communication | 40.0000 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 40.0000 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 38.3333 | 4 | yes |
| GO:0010941 | regulation of cell death | 38.3333 | 4 | yes |
| GO:0022607 | cellular component assembly | 38.3333 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 36.6667 | 4 | yes |
| GO:0043067 | regulation of programmed cell death | 36.6667 | 5 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 35.0000 | 6 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 35.0000 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 35.0000 | 5 | yes |
| GO:0042981 | regulation of apoptotic process | 35.0000 | 6 | yes |
| GO:0043412 | macromolecule modification | 35.0000 | 4 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 35.0000 | 5 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 35.0000 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 35.0000 | 6 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 35.0000 | 5 | no |
| GO:0036211 | protein modification process | 33.3333 | 4 | yes |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 33.3333 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 33.3333 | 4 | no |
| GO:0009059 | macromolecule biosynthetic process | 31.6667 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 31.6667 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 31.6667 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 30.0000 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 30.0000 | 5 | no |
| GO:0080134 | regulation of response to stress | 28.3333 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 28.3333 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 28.3333 | 6 | no |
| GO:0043603 | cellular amide metabolic process | 26.6667 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 26.6667 | 5 | yes |
| GO:0006996 | organelle organization | 26.6667 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | yes |
| GO:0043604 | amide biosynthetic process | 25.0000 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 25.0000 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0090304 | nucleic acid metabolic process | 25.0000 | 4 | no |
| GO:0006412 | translation | 23.3333 | 4 | yes |
| GO:0006518 | peptide metabolic process | 23.3333 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 23.3333 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 23.3333 | 5 | yes |
| GO:0010628 | positive regulation of gene expression | 23.3333 | 6 | yes |
| GO:0034645 | cellular macromolecule biosynthetic process | 23.3333 | 4 | yes |
| GO:0043043 | peptide biosynthetic process | 23.3333 | 5 | yes |
| GO:0060548 | negative regulation of cell death | 23.3333 | 5 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 23.3333 | 7 | no |
| GO:0043066 | negative regulation of apoptotic process | 21.6667 | 7 | yes |
| GO:0043069 | negative regulation of programmed cell death | 21.6667 | 6 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 21.6667 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 21.6667 | 4 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 21.6667 | 6 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 21.6667 | 5 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 21.6667 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.6667 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 21.6667 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 21.6667 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.6667 | 5 | no |
| GO:0008104 | protein localization | 21.6667 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 21.6667 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 20.0000 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 20.0000 | 6 | yes |
| GO:0010608 | post-transcriptional regulation of gene expression | 20.0000 | 6 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 20.0000 | 6 | yes |
| GO:0045595 | regulation of cell differentiation | 20.0000 | 4 | yes |
| GO:0001817 | regulation of cytokine production | 18.3333 | 4 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 18.3333 | 5 | yes |
| GO:0034097 | response to cytokine | 18.3333 | 4 | yes |
| GO:0080135 | regulation of cellular response to stress | 18.3333 | 4 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 18.3333 | 6 | yes |
| GO:0010629 | negative regulation of gene expression | 16.6667 | 6 | yes |
| GO:2000112 | regulation of cellular macromolecule biosynthetic process | 16.6667 | 6 | yes |
| GO:0006417 | regulation of translation | 15.0000 | 6 | yes |
| GO:0016310 | phosphorylation | 15.0000 | 5 | yes |
| GO:0034248 | regulation of cellular amide metabolic process | 15.0000 | 5 | yes |
| GO:0001819 | positive regulation of cytokine production | 13.3333 | 5 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 13.3333 | 5 | yes |
| GO:0043408 | regulation of MAPK cascade | 13.3333 | 6 | yes |
| GO:0043410 | positive regulation of MAPK cascade | 13.3333 | 7 | yes |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity | 13.3333 | 4 | yes |
| GO:0006468 | protein phosphorylation | 11.6667 | 5 | yes |
| GO:0031667 | response to nutrient levels | 11.6667 | 4 | yes |
| GO:0034976 | response to endoplasmic reticulum stress | 10.0000 | 4 | yes |
| GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 10.0000 | 5 | yes |
| GO:0051607 | defense response to virus | 10.0000 | 4 | yes |
| GO:0140546 | defense response to symbiont | 10.0000 | 4 | yes |
| GO:0009267 | cellular response to starvation | 8.3333 | 4 | yes |
| GO:0017148 | negative regulation of translation | 8.3333 | 7 | yes |
| GO:0031669 | cellular response to nutrient levels | 8.3333 | 4 | yes |
| GO:0032872 | regulation of stress-activated MAPK cascade | 8.3333 | 6 | yes |
| GO:0032874 | positive regulation of stress-activated MAPK cascade | 8.3333 | 7 | yes |
| GO:0034249 | negative regulation of cellular amide metabolic process | 8.3333 | 6 | yes |
| GO:0070302 | regulation of stress-activated protein kinase signaling cascade | 8.3333 | 5 | yes |
| GO:0070304 | positive regulation of stress-activated protein kinase signaling cascade | 8.3333 | 6 | yes |
| GO:2000113 | negative regulation of cellular macromolecule biosynthetic process | 8.3333 | 7 | yes |
| GO:0045069 | regulation of viral genome replication | 6.6667 | 5 | yes |
| GO:0046777 | protein autophosphorylation | 6.6667 | 6 | yes |
| GO:1903900 | regulation of viral life cycle | 6.6667 | 4 | yes |
| GO:0032642 | regulation of chemokine production | 5.0000 | 5 | yes |
| GO:0032722 | positive regulation of chemokine production | 5.0000 | 6 | yes |
| GO:0034198 | cellular response to amino acid starvation | 5.0000 | 5 | yes |
| GO:0035455 | response to interferon-alpha | 5.0000 | 5 | yes |
| GO:0048525 | negative regulation of viral process | 5.0000 | 4 | yes |
| GO:1900225 | regulation of NLRP3 inflammasome complex assembly | 5.0000 | 6 | yes |
| GO:1901222 | regulation of NIK/NF-kappaB signaling | 5.0000 | 6 | yes |
| GO:1901224 | positive regulation of NIK/NF-kappaB signaling | 5.0000 | 7 | yes |
| GO:1990928 | response to amino acid starvation | 5.0000 | 4 | yes |
| GO:2000736 | regulation of stem cell differentiation | 5.0000 | 5 | yes |
| GO:0033688 | regulation of osteoblast proliferation | 3.3333 | 5 | yes |
| GO:0033689 | negative regulation of osteoblast proliferation | 3.3333 | 6 | yes |
| GO:0045071 | negative regulation of viral genome replication | 3.3333 | 5 | yes |
| GO:0072091 | regulation of stem cell proliferation | 3.3333 | 5 | yes |
| GO:1901532 | regulation of hematopoietic progenitor cell differentiation | 3.3333 | 5 | yes |
| GO:1902033 | regulation of hematopoietic stem cell proliferation | 3.3333 | 6 | yes |
| GO:1902036 | regulation of hematopoietic stem cell differentiation | 3.3333 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in E2AK2_HUMAN |
|---|---|---|---|---|
| DOID:0050686 | organ system cancer | 5.0000 | 3 | no |
| DOID:612 | primary immunodeficiency disease | 3.3333 | 3 | no |
| DOID:2531 | hematologic cancer | 3.3333 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ASC_HUMAN | [view interactions] | Low throughput | no | no |
| CDK1_HUMAN | [view interactions] | Low throughput | no | no |
| DNJC3_HUMAN | [view interactions] | Low throughput | no | yes |
| DUS2L_HUMAN | [view interactions] | Low throughput | no | yes |
| FANCC_HUMAN | [view interactions] | Low throughput | no | yes |
| PKRI1_HUMAN | [view interactions] | Low throughput | no | no |
| STAT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| MAP2_HUMAN | [view interactions] | Low throughput | no | yes |
| 2A5A_HUMAN | [view interactions] | Low throughput | no | yes |
| M3K5_HUMAN | [view interactions] | Low throughput | no | yes |
| IKKA_HUMAN | [view interactions] | Low throughput | no | yes |
| IKKB_HUMAN | [view interactions] | Low throughput | no | yes |
| PGFRB_HUMAN | [view interactions] | Low throughput | no | yes |
| STAT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAVS_HUMAN | [view interactions] | Low throughput | no | yes |
| JAK1_HUMAN | [view interactions] | Low throughput | no | yes |
| TYK2_HUMAN | [view interactions] | Low throughput | no | no |
| HS90A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TEBP_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAF5_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAF6_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAF2_HUMAN | [view interactions] | Low throughput | no | yes |
| P52K_HUMAN | [view interactions] | Low throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RL6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RLA0_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RS3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LMNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SUMO2_HUMAN | [view interactions] | Low throughput | no | yes |
| MP2K6_HUMAN | [view interactions] | Low throughput | no | yes |
| DDX58_HUMAN | [view interactions] | Low throughput | no | yes |
| IL24_HUMAN | [view interactions] | Low throughput | no | no |
| SUMO1_HUMAN | [view interactions] | Low throughput | no | yes |
| CAPR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RL18_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PA2G4_HUMAN | [view interactions] | Low throughput | no | yes |
| ILF2_HUMAN | [view interactions] | Low throughput | no | yes |
| H2A2C_HUMAN | [view interactions] | Low throughput | no | yes |
| JAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| H2A1B_HUMAN | [view interactions] | Low throughput | no | yes |
| UBC9_HUMAN | [view interactions] | Low throughput | no | yes |
| PRKRA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRBP2_HUMAN | [view interactions] | Low throughput | no | yes |
| DHX9_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAF3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NLRP3_HUMAN | [view interactions] | Low throughput | no | yes |
| AIM2_HUMAN | [view interactions] | Low throughput | no | no |
| NLRP1_HUMAN | [view interactions] | Low throughput | no | yes |
| NLRC4_HUMAN | [view interactions] | Low throughput | no | no |
| G3BP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| E2AK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IF2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ILF3_HUMAN | [view interactions] | Low throughput | no | yes |
| DSRAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NPM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IRS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| G3BP1_HUMAN | [view interactions] | Low throughput | no | yes |
| EIF2A_HUMAN | [view interactions] | Low throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B3_HUMAN | [view interactions] | High throughput | no | no |
| IF2B2_HUMAN | [view interactions] | High throughput | no | yes |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RED1_HUMAN | [view interactions] | High throughput | no | no |
| HDGF_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| HECW2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| MACD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| IQCF1_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRIP4_HUMAN | [view interactions] | High throughput | no | yes |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| MKRN1_HUMAN | [view interactions] | High throughput | no | no |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| GCH1_HUMAN | [view interactions] | High throughput | no | no |
| RS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KALM_HUMAN | [view interactions] | High throughput | no | no |
| HNRC2_HUMAN | [view interactions] | High throughput | no | no |
| FNDC8_HUMAN | [view interactions] | High throughput | no | no |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TCPQM_HUMAN | [view interactions] | High throughput | no | no |
| RM42_HUMAN | [view interactions] | High throughput | no | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| PSG11_HUMAN | [view interactions] | High throughput | no | no |
| RFXK_HUMAN | [view interactions] | High throughput | no | yes |
| ZC3H3_HUMAN | [view interactions] | High throughput | no | yes |
| H14_HUMAN | [view interactions] | High throughput | no | yes |
| CIA2A_HUMAN | [view interactions] | High throughput | no | yes |
| UBP32_HUMAN | [view interactions] | High throughput | no | yes |
| IFN14_HUMAN | [view interactions] | High throughput | no | no |
| H2A1_HUMAN | [view interactions] | High throughput | no | yes |
| RL19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SENP3_HUMAN | [view interactions] | High throughput | no | yes |
| TRI35_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| ZC11A_HUMAN | [view interactions] | High throughput | no | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IL7RA_HUMAN | [view interactions] | High throughput | no | no |
| VATF_HUMAN | [view interactions] | High throughput | no | yes |
| HELZ2_HUMAN | [view interactions] | High throughput | no | no |
| OAS2_HUMAN | [view interactions] | High throughput | no | yes |
| IFIT3_HUMAN | [view interactions] | High throughput | no | yes |
| PAR14_HUMAN | [view interactions] | High throughput | no | yes |
| TIRAP_HUMAN | [view interactions] | High throughput | no | no |
| TLR3_HUMAN | [view interactions] | High throughput | no | yes |
| ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| TRADD_HUMAN | [view interactions] | High throughput | no | yes |
| GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| MTRFR_HUMAN | [view interactions] | High throughput | no | yes |
| CHCH1_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD2_HUMAN | [view interactions] | High throughput | no | no |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| MTEF3_HUMAN | [view interactions] | High throughput | no | no |
| RF1M_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD4_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
| MK11_HUMAN | [view interactions] | High throughput | no | yes |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX58_HUMAN | [view interactions] | High throughput | no | yes |
| SPB1_HUMAN | [view interactions] | High throughput | no | yes |
| LA_HUMAN | [view interactions] | High throughput | no | yes |
| NOP2_HUMAN | [view interactions] | High throughput | no | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| IFRD1_HUMAN | [view interactions] | High throughput | no | yes |
| EBP2_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPC_HUMAN | [view interactions] | High throughput | no | yes |
| IF6_HUMAN | [view interactions] | High throughput | no | yes |
| PABP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAU2_HUMAN | [view interactions] | High throughput | no | yes |
| NOP53_HUMAN | [view interactions] | High throughput | no | yes |
| GTPB4_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XRN2_HUMAN | [view interactions] | High throughput | no | yes |
| CCNA2_HUMAN | [view interactions] | High throughput | no | no |
| SYFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRC1_HUMAN | [view interactions] | High throughput | no | no |
| NOC3L_HUMAN | [view interactions] | High throughput | no | no |
| DICER_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYAR_HUMAN | [view interactions] | High throughput | no | no |
| KCD17_HUMAN | [view interactions] | High throughput | no | yes |
| CC124_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PURA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EDC4_HUMAN | [view interactions] | High throughput | no | yes |
| SYFA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN346_HUMAN | [view interactions] | High throughput | no | yes |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| CDK3_HUMAN | [view interactions] | High throughput | no | no |
| TOP1_HUMAN | [view interactions] | High throughput | no | yes |
| GNL3_HUMAN | [view interactions] | High throughput | no | yes |
| CDCA5_HUMAN | [view interactions] | High throughput | no | yes |
| RL10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
| KI18B_HUMAN | [view interactions] | High throughput | no | no |
| MDEAS_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MECP2_HUMAN | [view interactions] | High throughput | no | yes |
| GPX7_HUMAN | [view interactions] | High throughput | no | no |
| CP1A1_HUMAN | [view interactions] | High throughput | no | yes |
| RRP1B_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAS1L_HUMAN | [view interactions] | High throughput | no | yes |
| NOC2L_HUMAN | [view interactions] | High throughput | no | yes |
| NOP16_HUMAN | [view interactions] | High throughput | no | yes |
| RRP15_HUMAN | [view interactions] | High throughput | no | yes |
| RALY_HUMAN | [view interactions] | High throughput | no | yes |
| MRT4_HUMAN | [view interactions] | High throughput | no | yes |
| RBM28_HUMAN | [view interactions] | High throughput | no | yes |
| DDX18_HUMAN | [view interactions] | High throughput | no | yes |
| SSF1_HUMAN | [view interactions] | High throughput | no | yes |
| RPF2_HUMAN | [view interactions] | High throughput | no | yes |
| NAT10_HUMAN | [view interactions] | High throughput | no | yes |
| DDX24_HUMAN | [view interactions] | High throughput | no | yes |
| MK67I_HUMAN | [view interactions] | High throughput | no | yes |
| MMTA2_HUMAN | [view interactions] | High throughput | no | yes |
| LLPH_HUMAN | [view interactions] | High throughput | no | no |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| STRBP_HUMAN | [view interactions] | High throughput | no | yes |
| SRPK1_HUMAN | [view interactions] | High throughput | no | yes |
| ZFR_HUMAN | [view interactions] | High throughput | no | yes |
| DDX27_HUMAN | [view interactions] | High throughput | no | no |
| EXOS8_HUMAN | [view interactions] | High throughput | no | yes |
| COG1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX54_HUMAN | [view interactions] | High throughput | no | yes |
| KRI1_HUMAN | [view interactions] | High throughput | no | yes |
| PELP1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRL2_HUMAN | [view interactions] | High throughput | no | yes |
| EXOS7_HUMAN | [view interactions] | High throughput | no | yes |
| RRP5_HUMAN | [view interactions] | High throughput | no | yes |
| URB2_HUMAN | [view interactions] | High throughput | no | no |
| BOP1_HUMAN | [view interactions] | High throughput | no | yes |
| NOG2_HUMAN | [view interactions] | High throughput | no | yes |
| PRP4B_HUMAN | [view interactions] | High throughput | no | yes |
| CEBPZ_HUMAN | [view interactions] | High throughput | no | no |
| EXOSX_HUMAN | [view interactions] | High throughput | no | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX3_HUMAN | [view interactions] | High throughput | no | yes |
| NSA2_HUMAN | [view interactions] | High throughput | no | yes |
| SURF6_HUMAN | [view interactions] | High throughput | no | yes |
| DKC1_HUMAN | [view interactions] | High throughput | no | yes |
| NPA1P_HUMAN | [view interactions] | High throughput | no | yes |
| RRP8_HUMAN | [view interactions] | High throughput | no | yes |
| NKRF_HUMAN | [view interactions] | High throughput | no | no |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| IFI44_HUMAN | [view interactions] | Computational | no | yes |
| PTN2_HUMAN | [view interactions] | Computational | no | yes |
| LY96_HUMAN | [view interactions] | Computational | no | no |
| IFIT1_HUMAN | [view interactions] | Computational | no | no |
| RSAD2_HUMAN | [view interactions] | Computational | no | yes |
| RIPK1_HUMAN | [view interactions] | Computational | no | yes |
| IFT1B_HUMAN | [view interactions] | Computational | no | no |
| UB2L6_HUMAN | [view interactions] | Computational | no | no |
| IF2G_HUMAN | [view interactions] | Computational | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| M4K4_HUMAN | [view interactions] | Computational | no | yes |
| UBP18_HUMAN | [view interactions] | Computational | no | yes |
| IRAK1_HUMAN | [view interactions] | Computational | no | yes |
| MYD88_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FADD_HUMAN | [view interactions] | Computational | no | yes |
| MX1_HUMAN | [view interactions] | Computational | no | yes |
| NF2L2_HUMAN | [view interactions] | Computational | no | yes |
| OAS3_HUMAN | [view interactions] | Computational | no | no |
| CD14_HUMAN | [view interactions] | Computational | no | no |
| TLR4_HUMAN | [view interactions] | Computational | no | yes |
| TRI25_HUMAN | [view interactions] | Computational | no | yes |
| HERC5_HUMAN | [view interactions] | Computational | no | yes |
| ECHP_HUMAN | [view interactions] | Computational | no | no |
| ARI1_HUMAN | [view interactions] | Computational | no | yes |
| IRS2_HUMAN | [view interactions] | Computational | no | yes |
| IF2B_HUMAN | [view interactions] | Computational | no | yes |
| MX2_HUMAN | [view interactions] | Computational | no | yes |
| IF44L_HUMAN | [view interactions] | Computational | no | yes |