DICER_HUMAN
Evidence for PS localization
Functions
Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3 overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DICER_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 73.4940 | 4 | yes |
| GO:0003729 | mRNA binding | 33.7349 | 5 | no |
| GO:0000166 | nucleotide binding | 30.1205 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 30.1205 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 30.1205 | 4 | yes |
| GO:0043168 | anion binding | 30.1205 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.9157 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 27.7108 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 27.7108 | 5 | yes |
| GO:0005524 | ATP binding | 26.5060 | 5 | yes |
| GO:0003677 | DNA binding | 20.4819 | 4 | yes |
| GO:0043169 | cation binding | 16.8675 | 4 | yes |
| GO:0046872 | metal ion binding | 16.8675 | 5 | yes |
| GO:0003725 | double-stranded RNA binding | 14.4578 | 5 | yes |
| GO:0061980 | regulatory RNA binding | 9.6386 | 5 | yes |
| GO:0004518 | nuclease activity | 6.0241 | 4 | yes |
| GO:0035197 | siRNA binding | 6.0241 | 6 | yes |
| GO:0004519 | endonuclease activity | 4.8193 | 5 | yes |
| GO:0004520 | DNA endonuclease activity | 3.6145 | 5 | yes |
| GO:0004521 | RNA endonuclease activity | 3.6145 | 5 | yes |
| GO:0004536 | DNA nuclease activity | 3.6145 | 4 | yes |
| GO:0004540 | RNA nuclease activity | 3.6145 | 4 | yes |
| GO:0016891 | RNA endonuclease activity, producing 5-phosphomonoesters | 3.6145 | 6 | yes |
| GO:0016893 | endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5-phosphomonoesters | 3.6145 | 6 | yes |
| GO:0070883 | pre-miRNA binding | 3.6145 | 5 | yes |
| GO:0004525 | ribonuclease III activity | 2.4096 | 6 | yes |
| GO:0004530 | deoxyribonuclease I activity | 2.4096 | 7 | yes |
| GO:0016888 | endodeoxyribonuclease activity, producing 5-phosphomonoesters | 2.4096 | 6 | yes |
| GO:0032296 | double-stranded RNA-specific ribonuclease activity | 2.4096 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DICER_HUMAN |
|---|---|---|---|---|
| GO:0080090 | regulation of primary metabolic process | 63.8554 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 62.6506 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 62.6506 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 57.8313 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 57.8313 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 57.8313 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 56.6265 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 56.6265 | 5 | yes |
| GO:0010468 | regulation of gene expression | 55.4217 | 6 | yes |
| GO:0009892 | negative regulation of metabolic process | 48.1928 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 45.7831 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 45.7831 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 44.5783 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 43.3735 | 5 | no |
| GO:0010646 | regulation of cell communication | 42.1687 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 42.1687 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 42.1687 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 39.7590 | 5 | yes |
| GO:0009059 | macromolecule biosynthetic process | 39.7590 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 38.5542 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 38.5542 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 37.3494 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 37.3494 | 6 | yes |
| GO:0022607 | cellular component assembly | 37.3494 | 4 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 37.3494 | 6 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 36.1446 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 36.1446 | 4 | no |
| GO:0009966 | regulation of signal transduction | 34.9398 | 4 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 34.9398 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 34.9398 | 6 | no |
| GO:0010629 | negative regulation of gene expression | 32.5301 | 7 | yes |
| GO:0016070 | RNA metabolic process | 32.5301 | 5 | yes |
| GO:0006996 | organelle organization | 32.5301 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 31.3253 | 4 | no |
| GO:0010608 | post-transcriptional regulation of gene expression | 31.3253 | 7 | yes |
| GO:0043933 | protein-containing complex organization | 31.3253 | 4 | yes |
| GO:0006396 | RNA processing | 30.1205 | 6 | yes |
| GO:0009894 | regulation of catabolic process | 30.1205 | 4 | no |
| GO:0006412 | translation | 30.1205 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 28.9157 | 6 | no |
| GO:0071702 | organic substance transport | 27.7108 | 4 | no |
| GO:0071705 | nitrogen compound transport | 27.7108 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 27.7108 | 7 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.5060 | 7 | yes |
| GO:0065003 | protein-containing complex assembly | 26.5060 | 5 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 26.5060 | 6 | yes |
| GO:0042981 | regulation of apoptotic process | 26.5060 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 26.5060 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 26.5060 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 25.3012 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.3012 | 5 | no |
| GO:0002181 | cytoplasmic translation | 25.3012 | 5 | no |
| GO:0006417 | regulation of translation | 24.0964 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 22.8916 | 4 | yes |
| GO:0008104 | protein localization | 22.8916 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 22.8916 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.8916 | 4 | no |
| GO:0031399 | regulation of protein modification process | 22.8916 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.8916 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.8916 | 4 | no |
| GO:1903311 | regulation of mRNA metabolic process | 21.6867 | 6 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 21.6867 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 21.6867 | 5 | no |
| GO:0071310 | cellular response to organic substance | 21.6867 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 20.4819 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 20.4819 | 6 | no |
| GO:0043066 | negative regulation of apoptotic process | 20.4819 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 20.4819 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 20.4819 | 5 | no |
| GO:0033043 | regulation of organelle organization | 20.4819 | 5 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 19.2771 | 8 | yes |
| GO:0048585 | negative regulation of response to stimulus | 19.2771 | 4 | yes |
| GO:0051253 | negative regulation of RNA metabolic process | 19.2771 | 6 | yes |
| GO:0051094 | positive regulation of developmental process | 18.0723 | 4 | yes |
| GO:0009057 | macromolecule catabolic process | 16.8675 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 16.8675 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 16.8675 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 16.8675 | 4 | yes |
| GO:0141188 | nucleic acid catabolic process | 16.8675 | 5 | yes |
| GO:0042127 | regulation of cell population proliferation | 15.6627 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 14.4578 | 4 | yes |
| GO:0071826 | protein-RNA complex organization | 14.4578 | 5 | yes |
| GO:0006259 | DNA metabolic process | 13.2530 | 5 | yes |
| GO:0022618 | protein-RNA complex assembly | 13.2530 | 6 | yes |
| GO:0045597 | positive regulation of cell differentiation | 13.2530 | 5 | yes |
| GO:0060284 | regulation of cell development | 13.2530 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 12.0482 | 4 | yes |
| GO:0001817 | regulation of cytokine production | 10.8434 | 4 | yes |
| GO:0030030 | cell projection organization | 10.8434 | 4 | yes |
| GO:0045892 | negative regulation of DNA-templated transcription | 10.8434 | 8 | yes |
| GO:0051093 | negative regulation of developmental process | 10.8434 | 4 | yes |
| GO:1902679 | negative regulation of RNA biosynthetic process | 10.8434 | 7 | yes |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | 9.6386 | 9 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 9.6386 | 5 | yes |
| GO:0010720 | positive regulation of cell development | 9.6386 | 6 | yes |
| GO:0034655 | nucleobase-containing compound catabolic process | 9.6386 | 4 | yes |
| GO:0035196 | miRNA processing | 9.6386 | 8 | yes |
| GO:0045596 | negative regulation of cell differentiation | 9.6386 | 5 | yes |
| GO:0050767 | regulation of neurogenesis | 9.6386 | 6 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 9.6386 | 4 | yes |
| GO:0051960 | regulation of nervous system development | 9.6386 | 5 | yes |
| GO:0070918 | regulatory ncRNA processing | 9.6386 | 7 | yes |
| GO:1901361 | organic cyclic compound catabolic process | 9.6386 | 4 | yes |
| GO:0006401 | RNA catabolic process | 8.4337 | 5 | yes |
| GO:0016441 | post-transcriptional gene silencing | 7.2289 | 8 | yes |
| GO:0050769 | positive regulation of neurogenesis | 7.2289 | 6 | yes |
| GO:0051962 | positive regulation of nervous system development | 7.2289 | 5 | yes |
| GO:0001818 | negative regulation of cytokine production | 6.0241 | 5 | yes |
| GO:0010586 | miRNA metabolic process | 6.0241 | 6 | yes |
| GO:0010721 | negative regulation of cell development | 6.0241 | 6 | yes |
| GO:0014013 | regulation of gliogenesis | 6.0241 | 7 | yes |
| GO:0031054 | pre-miRNA processing | 6.0241 | 9 | yes |
| GO:0070922 | RISC complex assembly | 6.0241 | 7 | yes |
| GO:0001959 | regulation of cytokine-mediated signaling pathway | 4.8193 | 5 | yes |
| GO:0014015 | positive regulation of gliogenesis | 4.8193 | 7 | yes |
| GO:0030422 | siRNA processing | 4.8193 | 8 | yes |
| GO:0045685 | regulation of glial cell differentiation | 4.8193 | 5 | yes |
| GO:0060759 | regulation of response to cytokine stimulus | 4.8193 | 4 | yes |
| GO:0001960 | negative regulation of cytokine-mediated signaling pathway | 3.6145 | 6 | yes |
| GO:0006399 | tRNA metabolic process | 3.6145 | 6 | yes |
| GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway | 3.6145 | 6 | yes |
| GO:0014014 | negative regulation of gliogenesis | 3.6145 | 7 | yes |
| GO:0031641 | regulation of myelination | 3.6145 | 4 | yes |
| GO:0031644 | regulation of nervous system process | 3.6145 | 5 | yes |
| GO:0032680 | regulation of tumor necrosis factor production | 3.6145 | 6 | yes |
| GO:0032720 | negative regulation of tumor necrosis factor production | 3.6145 | 7 | yes |
| GO:0044057 | regulation of system process | 3.6145 | 4 | yes |
| GO:0045687 | positive regulation of glial cell differentiation | 3.6145 | 6 | yes |
| GO:0050768 | negative regulation of neurogenesis | 3.6145 | 6 | yes |
| GO:0051961 | negative regulation of nervous system development | 3.6145 | 5 | yes |
| GO:0060251 | regulation of glial cell proliferation | 3.6145 | 5 | yes |
| GO:0060761 | negative regulation of response to cytokine stimulus | 3.6145 | 5 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 3.6145 | 4 | yes |
| GO:1903555 | regulation of tumor necrosis factor superfamily cytokine production | 3.6145 | 5 | yes |
| GO:1903556 | negative regulation of tumor necrosis factor superfamily cytokine production | 3.6145 | 6 | yes |
| GO:0006308 | DNA catabolic process | 2.4096 | 5 | yes |
| GO:0006309 | apoptotic DNA fragmentation | 2.4096 | 6 | yes |
| GO:0010624 | regulation of Schwann cell proliferation | 2.4096 | 6 | yes |
| GO:0010626 | negative regulation of Schwann cell proliferation | 2.4096 | 7 | yes |
| GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway | 2.4096 | 7 | yes |
| GO:0014038 | regulation of Schwann cell differentiation | 2.4096 | 6 | yes |
| GO:0014040 | positive regulation of Schwann cell differentiation | 2.4096 | 7 | yes |
| GO:0016078 | tRNA decay | 2.4096 | 6 | yes |
| GO:0031643 | positive regulation of myelination | 2.4096 | 5 | yes |
| GO:0031646 | positive regulation of nervous system process | 2.4096 | 5 | yes |
| GO:0032288 | myelin assembly | 2.4096 | 4 | yes |
| GO:0032290 | peripheral nervous system myelin formation | 2.4096 | 5 | yes |
| GO:0048812 | neuron projection morphogenesis | 2.4096 | 5 | yes |
| GO:0060253 | negative regulation of glial cell proliferation | 2.4096 | 6 | yes |
| GO:0098795 | global gene silencing by mRNA cleavage | 2.4096 | 9 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DNJC2_HUMAN | [view interactions] | Low throughput | no | yes |
| AGO2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PIWL4_HUMAN | [view interactions] | Low throughput | no | yes |
| TRBP2_HUMAN | [view interactions] | Low throughput | no | yes |
| TNF12_HUMAN | [view interactions] | Low throughput | no | yes |
| PRKRA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AGO1_HUMAN | [view interactions] | Low throughput | no | no |
| DSRAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AGO3_HUMAN | [view interactions] | Low throughput | no | yes |
| DDX4_HUMAN | [view interactions] | Low throughput | no | no |
| NU153_HUMAN | [view interactions] | Low throughput | no | yes |
| DHX9_HUMAN | [view interactions] | Low throughput | no | yes |
| FUBP2_HUMAN | [view interactions] | Low throughput | no | yes |
| PIWL1_HUMAN | [view interactions] | Low throughput | no | no |
| GEMI4_HUMAN | [view interactions] | Low throughput | no | yes |
| LEUK_HUMAN | [view interactions] | Low throughput | no | no |
| RPB1_HUMAN | [view interactions] | Low throughput | no | no |
| IMB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RBM3_HUMAN | [view interactions] | Low throughput | no | no |
| DICER_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NCOA6_HUMAN | [view interactions] | Low throughput | no | yes |
| LOX5_HUMAN | [view interactions] | Low throughput | no | no |
| AGO4_HUMAN | [view interactions] | Low throughput | no | no |
| PIWL3_HUMAN | [view interactions] | Low throughput | no | no |
| PIWL2_HUMAN | [view interactions] | Low throughput | no | no |
| CACO2_HUMAN | [view interactions] | Low throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | Low throughput | no | no |
| LIN41_HUMAN | [view interactions] | Low throughput | no | no |
| TRI25_HUMAN | [view interactions] | Low throughput | no | yes |
| GHC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RP25L_HUMAN | [view interactions] | High throughput | no | yes |
| RL27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMIL3_HUMAN | [view interactions] | High throughput | no | yes |
| C2C4B_HUMAN | [view interactions] | High throughput | no | no |
| LECT2_HUMAN | [view interactions] | High throughput | no | no |
| PIF1_HUMAN | [view interactions] | High throughput | no | yes |
| NOGG_HUMAN | [view interactions] | High throughput | no | yes |
| ATS13_HUMAN | [view interactions] | High throughput | no | no |
| SOCS1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| PHF1_HUMAN | [view interactions] | High throughput | no | yes |
| HPSE2_HUMAN | [view interactions] | High throughput | no | yes |
| SIX5_HUMAN | [view interactions] | High throughput | no | yes |
| DIK1A_HUMAN | [view interactions] | High throughput | no | yes |
| FGF11_HUMAN | [view interactions] | High throughput | no | no |
| IL17B_HUMAN | [view interactions] | High throughput | no | no |
| RL10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN346_HUMAN | [view interactions] | High throughput | no | yes |
| RL18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZMAT4_HUMAN | [view interactions] | High throughput | no | yes |
| EMID1_HUMAN | [view interactions] | High throughput | no | yes |
| RL36L_HUMAN | [view interactions] | High throughput | no | no |
| RLA0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN363_HUMAN | [view interactions] | High throughput | no | yes |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| ILF3_HUMAN | [view interactions] | High throughput | no | yes |
| MYO9B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRP09_HUMAN | [view interactions] | High throughput | no | no |
| TRI31_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| R113A_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| APC13_HUMAN | [view interactions] | High throughput | no | no |
| ARI1_HUMAN | [view interactions] | High throughput | no | yes |
| CENPM_HUMAN | [view interactions] | High throughput | no | yes |
| MED1_HUMAN | [view interactions] | High throughput | no | no |
| SCYL1_HUMAN | [view interactions] | High throughput | no | yes |
| SC22B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RLA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RLA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MSH6_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF6_HUMAN | [view interactions] | High throughput | no | yes |
| RL27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL10A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| GOGA1_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAKB2_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| MED9_HUMAN | [view interactions] | High throughput | no | no |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| MED29_HUMAN | [view interactions] | High throughput | no | no |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| UBP49_HUMAN | [view interactions] | High throughput | no | yes |
| DHX58_HUMAN | [view interactions] | High throughput | no | yes |
| E2AK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDA11_HUMAN | [view interactions] | High throughput | no | no |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| TIM13_HUMAN | [view interactions] | High throughput | no | yes |
| SGTB_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SORT_HUMAN | [view interactions] | High throughput | no | yes |
| USF1_HUMAN | [view interactions] | High throughput | no | yes |
| ARP5_HUMAN | [view interactions] | High throughput | no | yes |
| RAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRG2_HUMAN | [view interactions] | High throughput | no | no |
| TRM2A_HUMAN | [view interactions] | High throughput | no | yes |
| TRI41_HUMAN | [view interactions] | High throughput | no | yes |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATS4_HUMAN | [view interactions] | High throughput | no | yes |
| RL15_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FX4L6_HUMAN | [view interactions] | High throughput | no | no |
| CBPA6_HUMAN | [view interactions] | High throughput | no | no |
| FXL14_HUMAN | [view interactions] | High throughput | no | yes |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| PRC2A_HUMAN | [view interactions] | High throughput | no | yes |
| NU214_HUMAN | [view interactions] | High throughput | no | no |
| TNR6B_HUMAN | [view interactions] | High throughput | no | yes |
| IF4G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YTDC2_HUMAN | [view interactions] | High throughput | no | no |
| SCAPE_HUMAN | [view interactions] | High throughput | no | yes |
| DHX57_HUMAN | [view interactions] | High throughput | no | no |
| GGYF2_HUMAN | [view interactions] | High throughput | no | yes |
| DHX30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUM1_HUMAN | [view interactions] | High throughput | no | yes |
| RENT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F120A_HUMAN | [view interactions] | High throughput | no | yes |
| ATX2_HUMAN | [view interactions] | High throughput | no | yes |
| UBAP2_HUMAN | [view interactions] | High throughput | no | yes |
| UBP2L_HUMAN | [view interactions] | High throughput | no | yes |
| PUM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX2L_HUMAN | [view interactions] | High throughput | no | no |
| TR150_HUMAN | [view interactions] | High throughput | no | yes |
| NUP98_HUMAN | [view interactions] | High throughput | no | no |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| DHX15_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| NUP88_HUMAN | [view interactions] | High throughput | no | yes |
| DDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CASC3_HUMAN | [view interactions] | High throughput | no | yes |
| SFPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2512_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPR_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PABP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| DDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| FUBP1_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B2_HUMAN | [view interactions] | High throughput | no | yes |
| YTHD3_HUMAN | [view interactions] | High throughput | no | no |
| IF2B3_HUMAN | [view interactions] | High throughput | no | no |
| IF2B1_HUMAN | [view interactions] | High throughput | no | no |
| YTHD2_HUMAN | [view interactions] | High throughput | no | yes |
| FUBP3_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBMX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAHM1_HUMAN | [view interactions] | High throughput | no | yes |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEC13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPC_HUMAN | [view interactions] | High throughput | no | yes |
| ADT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS4X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| TF7L2_HUMAN | [view interactions] | High throughput | no | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| ALBU_HUMAN | [view interactions] | High throughput | no | no |
| DDX20_HUMAN | [view interactions] | High throughput | no | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| LN28A_HUMAN | [view interactions] | High throughput | no | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFA20_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| CEP19_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| RBM47_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| NOS2_HUMAN | [view interactions] | High throughput | no | yes |
| MMS19_HUMAN | [view interactions] | High throughput | no | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMN_HUMAN | [view interactions] | High throughput | no | yes |
| MTFR2_HUMAN | [view interactions] | High throughput | no | no |
| NOG2_HUMAN | [view interactions] | High throughput | no | yes |
| GTPB4_HUMAN | [view interactions] | High throughput | no | yes |
| MTFR1_HUMAN | [view interactions] | High throughput | no | yes |
| MYSM1_HUMAN | [view interactions] | High throughput | no | yes |
| NOC3L_HUMAN | [view interactions] | High throughput | no | no |
| POP1_HUMAN | [view interactions] | High throughput | no | no |
| STAU2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| ZMAT3_HUMAN | [view interactions] | High throughput | no | yes |
| MEMO1_HUMAN | [view interactions] | High throughput | no | yes |
| PNKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SFRP4_HUMAN | [view interactions] | High throughput | no | no |
| ILF2_HUMAN | [view interactions] | High throughput | no | yes |
| AAMP_HUMAN | [view interactions] | High throughput | no | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CRY2_HUMAN | [view interactions] | High throughput | no | yes |
| IFIX_HUMAN | [view interactions] | High throughput | no | no |
| STRBP_HUMAN | [view interactions] | High throughput | no | yes |
| IQCN_HUMAN | [view interactions] | High throughput | no | no |
| IN80B_HUMAN | [view interactions] | High throughput | no | no |
| FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| DUS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DS13A_HUMAN | [view interactions] | High throughput | no | no |
| DUS15_HUMAN | [view interactions] | High throughput | no | no |
| DUS2_HUMAN | [view interactions] | High throughput | no | no |
| DUS26_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| PTPM1_HUMAN | [view interactions] | High throughput | no | yes |
| TPTE2_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| DJC15_HUMAN | [view interactions] | High throughput | no | no |
| TIM14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| SSF1_HUMAN | [view interactions] | High throughput | no | yes |