Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SEC13_HUMAN

As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed, PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SEC13_HUMAN
GO:0043168 anion binding 29.2308 4 no
GO:0000166 nucleotide binding 27.6923 4 no
GO:0017076 purine nucleotide binding 27.6923 5 no
GO:0032555 purine ribonucleotide binding 27.6923 4 no
GO:0035639 purine ribonucleoside triphosphate binding 26.1538 4 no
GO:0003723 RNA binding 24.6154 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in SEC13_HUMAN
GO:0048522 positive regulation of cellular process 63.0769 4 yes
GO:0006996 organelle organization 55.3846 4 yes
GO:0008104 protein localization 52.3077 4 yes
GO:0048523 negative regulation of cellular process 52.3077 4 yes
GO:0022607 cellular component assembly 49.2308 4 no
GO:0031323 regulation of cellular metabolic process 47.6923 4 no
GO:0051128 regulation of cellular component organization 46.1538 4 no
GO:0010646 regulation of cell communication 41.5385 4 yes
GO:0071705 nitrogen compound transport 41.5385 4 yes
GO:0060255 regulation of macromolecule metabolic process 41.5385 4 no
GO:0080090 regulation of primary metabolic process 41.5385 4 no
GO:0071702 organic substance transport 40.0000 4 yes
GO:0009966 regulation of signal transduction 36.9231 4 yes
GO:0015031 protein transport 35.3846 4 yes
GO:0009889 regulation of biosynthetic process 35.3846 4 no
GO:0060341 regulation of cellular localization 35.3846 4 no
GO:0051049 regulation of transport 33.8462 4 no
GO:0032880 regulation of protein localization 33.8462 5 no
GO:0006886 intracellular protein transport 32.3077 4 yes
GO:0048584 positive regulation of response to stimulus 32.3077 4 yes
GO:0048585 negative regulation of response to stimulus 32.3077 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 32.3077 5 no
GO:0031326 regulation of cellular biosynthetic process 32.3077 5 no
GO:0033043 regulation of organelle organization 30.7692 5 no
GO:0009892 negative regulation of metabolic process 30.7692 4 no
GO:0009893 positive regulation of metabolic process 30.7692 4 no
GO:0036211 protein modification process 29.2308 4 no
GO:0043412 macromolecule modification 29.2308 4 no
GO:0010468 regulation of gene expression 29.2308 6 no
GO:0051246 regulation of protein metabolic process 29.2308 5 no
GO:0010647 positive regulation of cell communication 27.6923 5 yes
GO:0023056 positive regulation of signaling 27.6923 4 yes
GO:0043933 protein-containing complex organization 27.6923 4 no
GO:0031324 negative regulation of cellular metabolic process 27.6923 5 no
GO:0009967 positive regulation of signal transduction 26.1538 5 yes
GO:1902531 regulation of intracellular signal transduction 26.1538 5 yes
GO:0007010 cytoskeleton organization 26.1538 5 no
GO:0044087 regulation of cellular component biogenesis 26.1538 4 no
GO:0010604 positive regulation of macromolecule metabolic process 26.1538 5 no
GO:0010605 negative regulation of macromolecule metabolic process 26.1538 5 no
GO:0031325 positive regulation of cellular metabolic process 26.1538 5 no
GO:0009894 regulation of catabolic process 26.1538 4 no
GO:0009968 negative regulation of signal transduction 24.6154 5 yes
GO:0010648 negative regulation of cell communication 24.6154 5 yes
GO:0023057 negative regulation of signaling 24.6154 4 yes
GO:0051130 positive regulation of cellular component organization 24.6154 5 no
GO:0042981 regulation of apoptotic process 24.6154 5 no
GO:0043067 regulation of programmed cell death 24.6154 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.0769 5 no
GO:0051050 positive regulation of transport 23.0769 4 no
GO:0065003 protein-containing complex assembly 21.5385 5 no
GO:2000026 regulation of multicellular organismal development 21.5385 4 no
GO:0016050 vesicle organization 16.9231 5 yes
GO:0061024 membrane organization 16.9231 4 yes
GO:0033365 protein localization to organelle 15.3846 5 yes
GO:1902533 positive regulation of intracellular signal transduction 15.3846 6 yes
GO:1902532 negative regulation of intracellular signal transduction 13.8462 6 yes
GO:0006913 nucleocytoplasmic transport 10.7692 5 yes
GO:0035459 vesicle cargo loading 10.7692 4 yes
GO:0051169 nuclear transport 10.7692 4 yes
GO:0090110 COPII-coated vesicle cargo loading 9.2308 4 yes
GO:0015931 nucleobase-containing compound transport 7.6923 5 yes
GO:0050657 nucleic acid transport 7.6923 6 yes
GO:0050658 RNA transport 7.6923 4 yes
GO:0072594 establishment of protein localization to organelle 7.6923 4 yes
GO:0034504 protein localization to nucleus 6.1538 6 yes
GO:0051028 mRNA transport 6.1538 5 yes
GO:0006606 protein import into nucleus 4.6154 5 yes
GO:0006900 vesicle budding from membrane 4.6154 5 yes
GO:0032006 regulation of TOR signaling 4.6154 6 yes
GO:0032008 positive regulation of TOR signaling 4.6154 7 yes
GO:0032527 protein exit from endoplasmic reticulum 4.6154 5 yes
GO:0051170 import into nucleus 4.6154 6 yes
GO:1903432 regulation of TORC1 signaling 4.6154 7 yes
GO:1904263 positive regulation of TORC1 signaling 4.6154 8 yes
GO:0032007 negative regulation of TOR signaling 3.0769 7 yes
GO:0090114 COPII-coated vesicle budding 3.0769 6 yes
GO:1904262 negative regulation of TORC1 signaling 3.0769 8 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SC16A_HUMAN [view interactions] Low throughput no yes
NU107_HUMAN [view interactions] Low throughput no no
SEH1_HUMAN [view interactions] Low throughput no no
NUP85_HUMAN [view interactions] Low throughput no yes
SC31A_HUMAN [view entry] [view interactions] Low throughput yes yes
SEC13_HUMAN [view entry] [view interactions] Low throughput yes yes
NUP62_HUMAN [view interactions] Low throughput no yes
SC23A_HUMAN [view entry] [view interactions] Low throughput yes yes
ELYS_HUMAN [view interactions] Low throughput no yes
RB11A_HUMAN [view entry] [view interactions] Low throughput yes yes
STAM2_HUMAN [view interactions] Low throughput no yes
STAM1_HUMAN [view interactions] Low throughput no yes
P53_HUMAN [view interactions] High throughput no no
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
FAF1_HUMAN [view interactions] High throughput no yes
SC23B_HUMAN [view interactions] High throughput no yes
SC24A_HUMAN [view interactions] High throughput no no
SC24B_HUMAN [view interactions] High throughput no yes
SC24D_HUMAN [view interactions] High throughput no yes
HDAC2_HUMAN [view interactions] High throughput no yes
NHLC2_HUMAN [view interactions] High throughput no yes
TIP_HUMAN [view entry] [view interactions] High throughput yes yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
CUL7_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
EMC4_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
NMRL1_HUMAN [view interactions] High throughput no yes
AKT3_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
CIC_HUMAN [view interactions] High throughput no yes
ANDR_HUMAN [view interactions] High throughput no no
SKA3_HUMAN [view interactions] High throughput no no
WDR5_HUMAN [view interactions] High throughput no no
FA83H_HUMAN [view interactions] High throughput no yes
RHG18_HUMAN [view interactions] High throughput no yes
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
ROA2_HUMAN [view entry] [view interactions] High throughput yes yes
TCPE_HUMAN [view entry] [view interactions] High throughput yes yes
TPC1_HUMAN [view interactions] High throughput no yes
GRWD1_HUMAN [view interactions] High throughput no no
PGTA_HUMAN [view interactions] High throughput no yes
MCFD2_HUMAN [view interactions] High throughput no yes
NRBF2_HUMAN [view interactions] High throughput no yes
S23IP_HUMAN [view interactions] High throughput no yes
SAR1A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB14_HUMAN [view entry] [view interactions] High throughput yes yes
MYCN_HUMAN [view interactions] High throughput no no
5HT1A_HUMAN [view interactions] High throughput no yes
E2F4_HUMAN [view interactions] High throughput no no
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
AKIR2_HUMAN [view interactions] High throughput no no
AKIR1_HUMAN [view interactions] High throughput no yes
RNF43_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
ANLN_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
RIT1_HUMAN [view interactions] High throughput no yes
HAPR1_HUMAN [view interactions] High throughput no yes
S12A2_HUMAN [view entry] [view interactions] High throughput yes yes
RPAB1_HUMAN [view interactions] High throughput no yes
PRP19_HUMAN [view interactions] High throughput no yes
PSB1_HUMAN [view interactions] High throughput no yes
AHSA1_HUMAN [view entry] [view interactions] High throughput yes yes
FLNB_HUMAN [view interactions] High throughput no no
PNCB_HUMAN [view interactions] High throughput no no
SYSC_HUMAN [view interactions] High throughput no yes
SPS1_HUMAN [view interactions] High throughput no yes
CLAP2_HUMAN [view entry] [view interactions] High throughput yes no
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
DYLT3_HUMAN [view interactions] High throughput no yes
EF1A1_HUMAN [view entry] [view interactions] High throughput yes yes
ZN276_HUMAN [view interactions] High throughput no yes
CKAP5_HUMAN [view entry] [view interactions] High throughput yes yes
CLAP1_HUMAN [view entry] [view interactions] High throughput yes yes
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
RAGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TPR_HUMAN [view interactions] High throughput no yes
CENPH_HUMAN [view interactions] High throughput no yes
MD1L1_HUMAN [view interactions] High throughput no yes
AAAS_HUMAN [view interactions] High throughput no yes
CENPE_HUMAN [view interactions] High throughput no no
CENPI_HUMAN [view interactions] High throughput no no
EAF6_HUMAN [view interactions] High throughput no no
SGO1_HUMAN [view interactions] High throughput no no
SPAG5_HUMAN [view interactions] High throughput no yes
TPC12_HUMAN [view interactions] High throughput no yes
ZW10_HUMAN [view interactions] High throughput no yes
ZN207_HUMAN [view interactions] High throughput no yes
CAST2_HUMAN [view interactions] High throughput no no
PDPK1_HUMAN [view entry] [view interactions] High throughput yes yes
K1C18_HUMAN [view interactions] High throughput no no
FPPS_HUMAN [view entry] [view interactions] High throughput yes yes
SYDC_HUMAN [view interactions] High throughput no yes
TPD52_HUMAN [view interactions] High throughput no yes
PSME1_HUMAN [view interactions] High throughput no yes
TRI29_HUMAN [view interactions] High throughput no no
WDFY1_HUMAN [view interactions] High throughput no yes
CUL5_HUMAN [view entry] [view interactions] High throughput yes yes
EWS_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
CNOT9_HUMAN [view interactions] High throughput no yes
PTN1_HUMAN [view entry] [view interactions] High throughput yes yes
S2546_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
SAR1B_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
RAD52_HUMAN [view interactions] High throughput no no
FTM_HUMAN [view interactions] High throughput no yes
NANP8_HUMAN [view interactions] High throughput no no
NANOG_HUMAN [view interactions] High throughput no no
NUP98_HUMAN [view interactions] High throughput no no
RBP2_HUMAN [view interactions] High throughput no yes
GORS1_HUMAN [view interactions] High throughput no yes
RBM8A_HUMAN [view interactions] High throughput no yes
AP1S2_HUMAN [view interactions] High throughput no no
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
UBC9_HUMAN [view entry] [view interactions] High throughput yes yes
SC24C_HUMAN [view entry] [view interactions] High throughput yes yes
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
GTSE1_HUMAN [view interactions] High throughput no no
PICAL_HUMAN [view entry] [view interactions] High throughput yes yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
SESN2_HUMAN [view interactions] High throughput no no
USO1_HUMAN [view entry] [view interactions] High throughput yes yes
GAK_HUMAN [view entry] [view interactions] High throughput yes yes
ZBTB5_HUMAN [view interactions] High throughput no yes
BCR_HUMAN [view entry] [view interactions] High throughput yes yes
ACY1_HUMAN [view interactions] High throughput no no
NU160_HUMAN [view interactions] High throughput no no
PR38A_HUMAN [view interactions] High throughput no no
NUP37_HUMAN [view interactions] High throughput no yes
NU133_HUMAN [view interactions] High throughput no yes
PPWD1_HUMAN [view interactions] High throughput no yes
FWCH2_HUMAN [view interactions] High throughput no no
SPDLY_HUMAN [view interactions] High throughput no yes
WDR24_HUMAN [view interactions] High throughput no yes
YJU2_HUMAN [view interactions] High throughput no yes
MIOS_HUMAN [view interactions] High throughput no yes
WDR59_HUMAN [view interactions] High throughput no yes
TFG_HUMAN [view interactions] High throughput no yes
NUP43_HUMAN [view interactions] High throughput no yes
OCRL_HUMAN [view interactions] High throughput no yes
SZT2_HUMAN [view interactions] High throughput no yes
DICER_HUMAN [view entry] [view interactions] High throughput yes yes
MECOM_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
DOCK3_HUMAN [view entry] [view interactions] High throughput yes yes
CUL4A_HUMAN [view interactions] High throughput no no
PKHM1_HUMAN [view interactions] High throughput no yes
SIM26_HUMAN [view interactions] High throughput no no
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
HMGA2_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
BET1_HUMAN [view interactions] High throughput no no
CDK8_HUMAN [view interactions] High throughput no no
EEA1_HUMAN [view entry] [view interactions] High throughput yes yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
SNF5_HUMAN [view interactions] High throughput no yes
ST38L_HUMAN [view entry] [view interactions] High throughput yes yes
TEC_HUMAN [view interactions] High throughput no yes
KC1A_HUMAN [view interactions] High throughput no yes
KC1D_HUMAN [view entry] [view interactions] High throughput yes yes
KC1E_HUMAN [view entry] [view interactions] High throughput yes yes
AURKB_HUMAN [view interactions] High throughput no yes
SCYL1_HUMAN [view interactions] High throughput no yes
ELF4_HUMAN [view interactions] High throughput no no
GATA4_HUMAN [view interactions] High throughput no no
KLF16_HUMAN [view interactions] High throughput no yes
KLF8_HUMAN [view interactions] High throughput no no
SOX5_HUMAN [view interactions] High throughput no no
CRCM_HUMAN [view interactions] High throughput no no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
IF6_HUMAN [view interactions] High throughput no yes
CCNA1_HUMAN [view interactions] High throughput no no
HLAB_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
PKHA7_HUMAN [view interactions] High throughput no yes
LITD1_HUMAN [view interactions] High throughput no no
HDAC4_HUMAN [view interactions] High throughput no yes
BICD1_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
DYR1A_HUMAN [view interactions] High throughput no yes
CE192_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
CLD12_HUMAN [view interactions] High throughput no yes
TRAF5_HUMAN [view interactions] High throughput no yes
NUP42_HUMAN [view interactions] High throughput no no
P121A_HUMAN [view interactions] High throughput no yes
SC16B_HUMAN [view interactions] High throughput no no
LT4R2_HUMAN [view interactions] High throughput no no
TAB2_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
ESR2_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
B9D2_HUMAN [view interactions] High throughput no yes
DYRK2_HUMAN [view interactions] High throughput no yes
ETV6_HUMAN [view interactions] High throughput no no
EPHA8_HUMAN [view interactions] High throughput no no
AGRF5_HUMAN [view interactions] High throughput no no
HPLN2_HUMAN [view entry] [view interactions] High throughput yes no
CFA43_HUMAN [view interactions] High throughput no no
SIR7_HUMAN [view interactions] High throughput no yes
FOXP3_HUMAN [view interactions] High throughput no no
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
MK09_HUMAN [view interactions] High throughput no yes
FUS_HUMAN [view entry] [view interactions] High throughput yes yes
RING2_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
MED4_HUMAN [view interactions] High throughput no yes
QRIC1_HUMAN [view interactions] High throughput no yes
IF16_HUMAN [view interactions] High throughput no no
MCM2_HUMAN [view interactions] High throughput no no
KSR1_HUMAN [view interactions] High throughput no yes
NKX21_HUMAN [view interactions] High throughput no no
WDTC1_HUMAN [view interactions] High throughput no yes
DAA10_HUMAN [view interactions] High throughput no yes
EDEM3_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
KLH12_HUMAN [view interactions] High throughput no no
PDCD6_HUMAN [view interactions] High throughput no no
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RMD5A_HUMAN [view interactions] High throughput no yes
PIHD1_HUMAN [view interactions] High throughput no yes
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIP2_HUMAN [view interactions] High throughput no yes
ARI1_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes