Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AHSA1_HUMAN

Acts as a co-chaperone of HSP90AA1 (PubMed). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in AHSA1_HUMAN
GO:0003723 RNA binding 49.5798 4 no
GO:0017076 purine nucleotide binding 34.4538 4 no
GO:0032555 purine ribonucleotide binding 34.4538 4 no
GO:0035639 purine ribonucleoside triphosphate binding 33.6134 4 no
GO:0030554 adenyl nucleotide binding 29.4118 5 no
GO:0032559 adenyl ribonucleotide binding 29.4118 5 no
GO:0005524 ATP binding 28.5714 5 no
GO:0016462 pyrophosphatase activity 21.0084 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 21.0084 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 21.0084 6 no
GO:0045296 cadherin binding 19.3277 4 yes
GO:0051879 Hsp90 protein binding 5.8824 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AHSA1_HUMAN
GO:0060255 regulation of macromolecule metabolic process 56.3025 4 no
GO:0080090 regulation of primary metabolic process 56.3025 4 no
GO:0051171 regulation of nitrogen compound metabolic process 55.4622 4 no
GO:0031323 regulation of cellular metabolic process 52.9412 4 no
GO:0048522 positive regulation of cellular process 52.1008 4 no
GO:0010468 regulation of gene expression 45.3782 5 no
GO:0009889 regulation of biosynthetic process 42.8571 4 no
GO:0048523 negative regulation of cellular process 42.0168 4 no
GO:0010556 regulation of macromolecule biosynthetic process 42.0168 5 no
GO:0031326 regulation of cellular biosynthetic process 42.0168 5 no
GO:0009893 positive regulation of metabolic process 39.4958 4 no
GO:0010604 positive regulation of macromolecule metabolic process 39.4958 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 38.6555 5 no
GO:0051246 regulation of protein metabolic process 37.8151 5 no
GO:0010646 regulation of cell communication 36.1345 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 36.1345 5 no
GO:0031325 positive regulation of cellular metabolic process 33.6134 5 no
GO:0009892 negative regulation of metabolic process 32.7731 4 no
GO:0009966 regulation of signal transduction 32.7731 4 no
GO:0022607 cellular component assembly 32.7731 4 no
GO:0044271 cellular nitrogen compound biosynthetic process 31.9328 4 no
GO:0051252 regulation of RNA metabolic process 31.9328 5 no
GO:0051128 regulation of cellular component organization 31.9328 4 no
GO:0031324 negative regulation of cellular metabolic process 31.0924 5 no
GO:0010605 negative regulation of macromolecule metabolic process 30.2521 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 30.2521 5 no
GO:1902531 regulation of intracellular signal transduction 30.2521 5 no
GO:0009059 macromolecule biosynthetic process 29.4118 4 no
GO:1903506 regulation of nucleic acid-templated transcription 27.7311 7 no
GO:2001141 regulation of RNA biosynthetic process 27.7311 6 no
GO:0010941 regulation of cell death 27.7311 4 no
GO:0006355 regulation of DNA-templated transcription 27.7311 6 no
GO:0071310 cellular response to organic substance 26.8908 4 no
GO:0006996 organelle organization 26.8908 4 no
GO:0043933 protein-containing complex organization 26.8908 4 no
GO:1901566 organonitrogen compound biosynthetic process 26.0504 4 no
GO:0043067 regulation of programmed cell death 26.0504 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 26.0504 6 no
GO:0043603 cellular amide metabolic process 25.2101 4 no
GO:0042981 regulation of apoptotic process 25.2101 6 no
GO:0034645 cellular macromolecule biosynthetic process 24.3697 4 no
GO:0043604 amide biosynthetic process 24.3697 5 no
GO:0009891 positive regulation of biosynthetic process 24.3697 5 no
GO:0051247 positive regulation of protein metabolic process 24.3697 6 no
GO:0065003 protein-containing complex assembly 24.3697 5 no
GO:0031399 regulation of protein modification process 23.5294 6 no
GO:0048584 positive regulation of response to stimulus 23.5294 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 23.5294 6 no
GO:0031328 positive regulation of cellular biosynthetic process 23.5294 6 no
GO:0006518 peptide metabolic process 22.6891 4 no
GO:0090304 nucleic acid metabolic process 22.6891 4 no
GO:0006412 translation 21.8487 4 no
GO:0008104 protein localization 21.8487 4 no
GO:0010628 positive regulation of gene expression 21.8487 6 no
GO:0043043 peptide biosynthetic process 21.8487 5 no
GO:0009967 positive regulation of signal transduction 21.0084 5 no
GO:0010647 positive regulation of cell communication 21.0084 5 no
GO:0023056 positive regulation of signaling 21.0084 4 no
GO:0051338 regulation of transferase activity 21.0084 4 no
GO:0071702 organic substance transport 21.0084 4 no
GO:0033043 regulation of organelle organization 21.0084 5 no
GO:0002181 cytoplasmic translation 21.0084 5 no
GO:0071705 nitrogen compound transport 20.1681 4 no
GO:0051130 positive regulation of cellular component organization 20.1681 5 no
GO:0032781 positive regulation of ATP-dependent activity 2.5210 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in AHSA1_HUMAN
DOID:1289 neurodegenerative disease 1.6807 4 no
DOID:331 central nervous system disease 1.6807 3 no
DOID:612 primary immunodeficiency disease 1.6807 3 no
DOID:0050686 organ system cancer 1.6807 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CLCN1_HUMAN [view interactions] Low throughput no no
CDK20_HUMAN [view interactions] Low throughput no yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
HS90A_HUMAN [view entry] [view interactions] Low throughput yes yes
GCH1_HUMAN [view interactions] Low throughput no no
HS90B_HUMAN [view entry] [view interactions] Low throughput yes yes
CFTR_HUMAN [view interactions] Low throughput no no
PRDX6_HUMAN [view entry] [view interactions] High throughput yes yes
AT1A1_HUMAN [view entry] [view interactions] High throughput yes no
P121A_HUMAN [view interactions] High throughput no yes
UFL1_HUMAN [view interactions] High throughput no yes
UBF1_HUMAN [view interactions] High throughput no yes
PLK1_HUMAN [view interactions] High throughput no yes
RL6_HUMAN [view entry] [view interactions] High throughput yes yes
CKAP5_HUMAN [view entry] [view interactions] High throughput yes yes
DPOD3_HUMAN [view interactions] High throughput no yes
ZCCHV_HUMAN [view interactions] High throughput no yes
TF3C2_HUMAN [view interactions] High throughput no no
CKAP2_HUMAN [view interactions] High throughput no yes
ARHG1_HUMAN [view interactions] High throughput no no
UHRF1_HUMAN [view interactions] High throughput no yes
PRP19_HUMAN [view interactions] High throughput no yes
MYH2_HUMAN [view interactions] High throughput no yes
TEBP_HUMAN [view interactions] High throughput no yes
DNJA1_HUMAN [view entry] [view interactions] High throughput yes yes
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
PKN2_HUMAN [view interactions] High throughput no yes
SRPK1_HUMAN [view interactions] High throughput no yes
PPM1G_HUMAN [view interactions] High throughput no no
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
TOP2A_HUMAN [view interactions] High throughput no no
XRCC5_HUMAN [view interactions] High throughput no yes
XRCC6_HUMAN [view interactions] High throughput no yes
RACK1_HUMAN [view interactions] High throughput no yes
ATOH1_HUMAN [view interactions] High throughput no no
DPF3_HUMAN [view interactions] High throughput no yes
ZN746_HUMAN [view interactions] High throughput no no
FLCN_HUMAN [view interactions] High throughput no yes
P85A_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
TES_HUMAN [view interactions] High throughput no yes
CDK9_HUMAN [view interactions] High throughput no yes
KC1A_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
LAP2A_HUMAN [view interactions] High throughput no yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
SNAI1_HUMAN [view interactions] High throughput no yes
WWOX_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
CCND1_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
FA20C_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
FZR1_HUMAN [view interactions] High throughput no no
WDR5_HUMAN [view interactions] High throughput no no
SPRTN_HUMAN [view interactions] High throughput no yes
CRBN_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
OBI1_HUMAN [view interactions] High throughput no yes
RICTR_HUMAN [view interactions] High throughput no yes
APLP2_HUMAN [view interactions] High throughput no yes
GDAP2_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
AP2M1_HUMAN [view entry] [view interactions] High throughput yes yes
ENPL_HUMAN [view entry] [view interactions] High throughput yes yes
TOM40_HUMAN [view interactions] High throughput no yes
BAG4_HUMAN [view interactions] High throughput no yes
DJC17_HUMAN [view interactions] High throughput no yes
DNJC2_HUMAN [view interactions] High throughput no yes
ITPR3_HUMAN [view interactions] High throughput no yes
PA24A_HUMAN [view entry] [view interactions] High throughput yes yes
PTSS2_HUMAN [view interactions] High throughput no yes
S35B2_HUMAN [view interactions] High throughput no no
STIM1_HUMAN [view interactions] High throughput no yes
STX12_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
DNJB4_HUMAN [view entry] [view interactions] High throughput yes yes
IF4E_HUMAN [view entry] [view interactions] High throughput yes yes
PLPHP_HUMAN [view interactions] High throughput no yes
DX39A_HUMAN [view interactions] High throughput no yes
IF4H_HUMAN [view interactions] High throughput no yes
PSF2_HUMAN [view interactions] High throughput no no
GSHR_HUMAN [view interactions] High throughput no yes
6PGD_HUMAN [view entry] [view interactions] High throughput yes no
ACADM_HUMAN [view interactions] High throughput no yes
ARF1_HUMAN [view entry] [view interactions] High throughput yes yes
CLH2_HUMAN [view interactions] High throughput no no
PRS6B_HUMAN [view interactions] High throughput no yes
MSS4_HUMAN [view interactions] High throughput no yes
ASNS_HUMAN [view interactions] High throughput no yes
ATPG_HUMAN [view interactions] High throughput no yes
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
TCPW_HUMAN [view entry] [view interactions] High throughput yes yes
DX39B_HUMAN [view interactions] High throughput no no
DNJA4_HUMAN [view interactions] High throughput no yes
SYEP_HUMAN [view interactions] High throughput no yes
GALE_HUMAN [view interactions] High throughput no no
GFPT1_HUMAN [view interactions] High throughput no no
GFPT2_HUMAN [view interactions] High throughput no yes
DHB12_HUMAN [view entry] [view interactions] High throughput yes yes
CH10_HUMAN [view interactions] High throughput no yes
SYIC_HUMAN [view interactions] High throughput no yes
IDH3G_HUMAN [view entry] [view interactions] High throughput yes yes
IMA3_HUMAN [view interactions] High throughput no yes
NMD3_HUMAN [view interactions] High throughput no no
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB1B_HUMAN [view entry] [view interactions] High throughput yes yes
RD23B_HUMAN [view interactions] High throughput no yes
MLP3B_HUMAN [view interactions] High throughput no yes
SEC13_HUMAN [view entry] [view interactions] High throughput yes yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
STAT1_HUMAN [view entry] [view interactions] High throughput yes no
FKBP5_HUMAN [view interactions] High throughput no yes
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP4_HUMAN [view entry] [view interactions] High throughput yes yes
UBA1_HUMAN [view entry] [view interactions] High throughput yes yes
CHRD1_HUMAN [view interactions] High throughput no yes
ZYX_HUMAN [view interactions] High throughput no no
TOM34_HUMAN [view entry] [view interactions] High throughput yes yes
ACBG1_HUMAN [view entry] [view interactions] High throughput yes yes
PPP5_HUMAN [view entry] [view interactions] High throughput yes yes
HS105_HUMAN [view entry] [view interactions] High throughput yes yes
SYTM_HUMAN [view interactions] High throughput no yes
CYBP_HUMAN [view entry] [view interactions] High throughput yes yes
PPID_HUMAN [view entry] [view interactions] High throughput yes yes
LRC40_HUMAN [view entry] [view interactions] High throughput yes yes
EWS_HUMAN [view interactions] High throughput no yes
CDC37_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
FKBPL_HUMAN [view interactions] High throughput no yes
TRI14_HUMAN [view interactions] High throughput no yes
TTC4_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
UN45B_HUMAN [view interactions] High throughput no no
COIL_HUMAN [view interactions] High throughput no yes
OTUB1_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
LRRK2_HUMAN [view interactions] High throughput no yes
PML_HUMAN [view interactions] High throughput no yes
KAP0_HUMAN [view entry] [view interactions] High throughput yes yes
MOT11_HUMAN [view interactions] High throughput no no
DNM1L_HUMAN [view entry] [view interactions] High throughput yes yes
H2B2E_HUMAN [view interactions] High throughput no yes
AICDA_HUMAN [view interactions] High throughput no no
CD3Z_HUMAN [view interactions] High throughput no no
TRI63_HUMAN [view interactions] High throughput no no
MP2K7_HUMAN [view entry] [view interactions] High throughput yes yes
M3K7_HUMAN [view interactions] High throughput no yes
GRK6_HUMAN [view interactions] High throughput no yes
RIPK4_HUMAN [view interactions] High throughput no no
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
COQ8A_HUMAN [view interactions] High throughput no no
NEK7_HUMAN [view interactions] High throughput no yes
TESK2_HUMAN [view interactions] High throughput no yes
LATS2_HUMAN [view interactions] High throughput no yes
AAKG3_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
PHLA3_HUMAN [view interactions] High throughput no yes
TP4A3_HUMAN [view interactions] High throughput no no
IF6_HUMAN [view interactions] High throughput no yes
NEK6_HUMAN [view interactions] High throughput no yes
TRM7_HUMAN [view interactions] High throughput no yes
STK24_HUMAN [view interactions] High throughput no yes
HLAB_HUMAN [view interactions] High throughput no yes
GSTK1_HUMAN [view entry] [view interactions] High throughput yes yes
RCAF1_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
PKHA7_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
CUL5_HUMAN [view entry] [view interactions] High throughput yes yes
NFKB1_HUMAN [view interactions] High throughput no yes
SCHI1_HUMAN [view interactions] High throughput no yes
EF1D_HUMAN [view entry] [view interactions] High throughput yes yes
BET1_HUMAN [view interactions] High throughput no no
EPHA1_HUMAN [view interactions] High throughput no yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
FGFR3_HUMAN [view interactions] High throughput no yes
VGFR3_HUMAN [view interactions] High throughput no yes
LMTK3_HUMAN [view entry] [view interactions] High throughput yes yes
MERTK_HUMAN [view interactions] High throughput no yes
PGFRB_HUMAN [view interactions] High throughput no yes
FBX6_HUMAN [view interactions] High throughput no yes
PLCB1_HUMAN [view entry] [view interactions] High throughput yes yes
HUWE1_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
RL23_HUMAN [view entry] [view interactions] High throughput yes yes
RL17_HUMAN [view entry] [view interactions] High throughput yes yes
RS3A_HUMAN [view entry] [view interactions] High throughput yes yes
PRP31_HUMAN [view interactions] High throughput no yes
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
PAIRB_HUMAN [view interactions] High throughput no yes
EIF3G_HUMAN [view interactions] High throughput no yes
RBMX_HUMAN [view entry] [view interactions] High throughput yes yes
DDX3X_HUMAN [view entry] [view interactions] High throughput yes yes
TCPD_HUMAN [view entry] [view interactions] High throughput yes yes
IF4B_HUMAN [view entry] [view interactions] High throughput yes yes
SFPQ_HUMAN [view entry] [view interactions] High throughput yes yes
RS30_HUMAN [view interactions] High throughput no yes
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
RS14_HUMAN [view entry] [view interactions] High throughput yes yes
ALDOA_HUMAN [view entry] [view interactions] High throughput yes no
RL31_HUMAN [view entry] [view interactions] High throughput yes yes
TR150_HUMAN [view interactions] High throughput no yes
RS3_HUMAN [view entry] [view interactions] High throughput yes yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
ROA1_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPU_HUMAN [view interactions] High throughput no yes
LDHA_HUMAN [view entry] [view interactions] High throughput yes yes
RS15A_HUMAN [view entry] [view interactions] High throughput yes yes
EF1A1_HUMAN [view entry] [view interactions] High throughput yes yes
RS23_HUMAN [view entry] [view interactions] High throughput yes yes
MCM7_HUMAN [view interactions] High throughput no no
RS4X_HUMAN [view entry] [view interactions] High throughput yes yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
ACLY_HUMAN [view entry] [view interactions] High throughput yes yes
RBM10_HUMAN [view interactions] High throughput no yes
RS20_HUMAN [view entry] [view interactions] High throughput yes yes
RS2_HUMAN [view entry] [view interactions] High throughput yes yes
ADT3_HUMAN [view entry] [view interactions] High throughput yes yes
RS7_HUMAN [view entry] [view interactions] High throughput yes yes
ANM5_HUMAN [view entry] [view interactions] High throughput yes yes
TBB2A_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3L_HUMAN [view interactions] High throughput no yes
RS15_HUMAN [view entry] [view interactions] High throughput yes yes
RL11_HUMAN [view entry] [view interactions] High throughput yes yes
RS18_HUMAN [view entry] [view interactions] High throughput yes yes
RL9_HUMAN [view entry] [view interactions] High throughput yes yes
RS13_HUMAN [view entry] [view interactions] High throughput yes yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
TCPQ_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
RS10_HUMAN [view entry] [view interactions] High throughput yes yes
CIRBP_HUMAN [view interactions] High throughput no no
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3A_HUMAN [view entry] [view interactions] High throughput yes yes
RL22_HUMAN [view entry] [view interactions] High throughput yes no
EIF3B_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
LDHB_HUMAN [view entry] [view interactions] High throughput yes yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
IMB1_HUMAN [view entry] [view interactions] High throughput yes yes
RS16_HUMAN [view entry] [view interactions] High throughput yes yes
TIF1B_HUMAN [view interactions] High throughput no yes
RS11_HUMAN [view entry] [view interactions] High throughput yes yes
U5S1_HUMAN [view interactions] High throughput no yes
RS25_HUMAN [view entry] [view interactions] High throughput yes yes
ROA2_HUMAN [view entry] [view interactions] High throughput yes yes
BCLF1_HUMAN [view interactions] High throughput no yes
RBM39_HUMAN [view interactions] High throughput no yes
IMDH2_HUMAN [view interactions] High throughput no yes
DCD_HUMAN [view interactions] High throughput no no
MCM2_HUMAN [view interactions] High throughput no no
TFR1_HUMAN [view interactions] High throughput no yes
PSMD3_HUMAN [view interactions] High throughput no yes
RL13_HUMAN [view entry] [view interactions] High throughput yes yes
LS14A_HUMAN [view interactions] High throughput no yes
RL38_HUMAN [view entry] [view interactions] High throughput yes yes
PSMD2_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
GDE_HUMAN [view entry] [view interactions] High throughput yes no
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
HPBP1_HUMAN [view interactions] Computational no yes
HSP74_HUMAN [view entry] [view interactions] Computational yes yes
DNJB1_HUMAN [view entry] [view interactions] Computational yes yes
EDF1_HUMAN [view interactions] Computational no yes
TRAP1_HUMAN [view entry] [view interactions] Computational yes yes
SGT1_HUMAN [view interactions] Computational no no
HS74L_HUMAN [view entry] [view interactions] Computational yes no