Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ACBG1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed, PubMed, PubMed). Can activate diverse saturated, monosaturated and polyunsaturated fatty acids (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ACBG1_HUMAN
GO:0017076 purine nucleotide binding 40.0000 4 yes
GO:0030554 adenyl nucleotide binding 40.0000 5 yes
GO:0032555 purine ribonucleotide binding 40.0000 4 yes
GO:0032559 adenyl ribonucleotide binding 40.0000 5 yes
GO:0005524 ATP binding 33.3333 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 yes
GO:0046872 metal ion binding 33.3333 4 no
GO:0016790 thiolester hydrolase activity 26.6667 4 no
GO:0042803 protein homodimerization activity 26.6667 4 no
GO:0019900 kinase binding 26.6667 4 no
GO:0019901 protein kinase binding 26.6667 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in ACBG1_HUMAN
GO:0009893 positive regulation of metabolic process 53.3333 4 no
GO:0048522 positive regulation of cellular process 53.3333 4 no
GO:0048523 negative regulation of cellular process 53.3333 4 no
GO:0060255 regulation of macromolecule metabolic process 53.3333 4 no
GO:0031323 regulation of cellular metabolic process 46.6667 4 no
GO:0031325 positive regulation of cellular metabolic process 46.6667 5 no
GO:0080090 regulation of primary metabolic process 46.6667 4 no
GO:0010604 positive regulation of macromolecule metabolic process 46.6667 5 no
GO:0010646 regulation of cell communication 46.6667 4 no
GO:0051049 regulation of transport 46.6667 4 no
GO:0006796 phosphate-containing compound metabolic process 46.6667 4 yes
GO:0014070 response to organic cyclic compound 40.0000 4 yes
GO:0019752 carboxylic acid metabolic process 40.0000 5 yes
GO:0032787 monocarboxylic acid metabolic process 40.0000 6 yes
GO:0043436 oxoacid metabolic process 40.0000 4 yes
GO:0009892 negative regulation of metabolic process 40.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 40.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 40.0000 5 no
GO:0009966 regulation of signal transduction 40.0000 4 no
GO:0019220 regulation of phosphate metabolic process 40.0000 6 no
GO:0031399 regulation of protein modification process 40.0000 6 no
GO:0043085 positive regulation of catalytic activity 40.0000 4 no
GO:0051050 positive regulation of transport 40.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 40.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 40.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 40.0000 5 no
GO:0051246 regulation of protein metabolic process 40.0000 5 no
GO:0051247 positive regulation of protein metabolic process 40.0000 6 no
GO:0051338 regulation of transferase activity 40.0000 4 no
GO:1902531 regulation of intracellular signal transduction 40.0000 5 no
GO:0006631 fatty acid metabolic process 40.0000 4 yes
GO:0016053 organic acid biosynthetic process 33.3333 4 yes
GO:0046394 carboxylic acid biosynthetic process 33.3333 5 yes
GO:0072330 monocarboxylic acid biosynthetic process 33.3333 6 yes
GO:0010468 regulation of gene expression 33.3333 5 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0001934 positive regulation of protein phosphorylation 33.3333 8 no
GO:0010038 response to metal ion 33.3333 4 no
GO:0010243 response to organonitrogen compound 33.3333 4 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0010799 regulation of peptidyl-threonine phosphorylation 33.3333 8 no
GO:0010800 positive regulation of peptidyl-threonine phosphorylation 33.3333 9 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0036211 protein modification process 33.3333 4 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0043269 regulation of ion transport 33.3333 5 no
GO:0043412 macromolecule modification 33.3333 4 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 no
GO:0051099 positive regulation of binding 33.3333 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0051336 regulation of hydrolase activity 33.3333 4 no
GO:0051345 positive regulation of hydrolase activity 33.3333 5 no
GO:0051347 positive regulation of transferase activity 33.3333 5 no
GO:0051726 regulation of cell cycle 33.3333 4 no
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 no
GO:0001676 long-chain fatty acid metabolic process 33.3333 5 yes
GO:0006633 fatty acid biosynthetic process 33.3333 5 yes
GO:0008610 lipid biosynthetic process 33.3333 4 yes
GO:0033993 response to lipid 26.6667 4 yes
GO:0006996 organelle organization 26.6667 4 no
GO:0009889 regulation of biosynthetic process 26.6667 4 no
GO:0016042 lipid catabolic process 26.6667 4 no
GO:0031326 regulation of cellular biosynthetic process 26.6667 5 no
GO:0051241 negative regulation of multicellular organismal process 26.6667 4 no
GO:0080134 regulation of response to stress 26.6667 4 no
GO:0080135 regulation of cellular response to stress 26.6667 4 no
GO:0034097 response to cytokine 26.6667 4 no
GO:0006468 protein phosphorylation 26.6667 5 no
GO:0010563 negative regulation of phosphorus metabolic process 26.6667 6 no
GO:0010564 regulation of cell cycle process 26.6667 5 no
GO:0010921 regulation of phosphatase activity 26.6667 5 no
GO:0016310 phosphorylation 26.6667 5 no
GO:0019722 calcium-mediated signaling 26.6667 5 no
GO:0019932 second-messenger-mediated signaling 26.6667 4 no
GO:0022898 regulation of transmembrane transporter activity 26.6667 4 no
GO:0031400 negative regulation of protein modification process 26.6667 7 no
GO:0032412 regulation of ion transmembrane transporter activity 26.6667 5 no
GO:0033674 positive regulation of kinase activity 26.6667 6 no
GO:0034762 regulation of transmembrane transport 26.6667 4 no
GO:0034765 regulation of ion transmembrane transport 26.6667 5 no
GO:0035303 regulation of dephosphorylation 26.6667 7 no
GO:0035304 regulation of protein dephosphorylation 26.6667 7 no
GO:0043270 positive regulation of ion transport 26.6667 5 no
GO:0043549 regulation of kinase activity 26.6667 5 no
GO:0043666 regulation of phosphoprotein phosphatase activity 26.6667 6 no
GO:0044057 regulation of system process 26.6667 4 no
GO:0045859 regulation of protein kinase activity 26.6667 6 no
GO:0045860 positive regulation of protein kinase activity 26.6667 7 no
GO:0045936 negative regulation of phosphate metabolic process 26.6667 7 no
GO:0050848 regulation of calcium-mediated signaling 26.6667 6 no
GO:0051128 regulation of cellular component organization 26.6667 4 no
GO:0051248 negative regulation of protein metabolic process 26.6667 6 no
GO:0060627 regulation of vesicle-mediated transport 26.6667 4 no
GO:0071900 regulation of protein serine/threonine kinase activity 26.6667 7 no
GO:0071902 positive regulation of protein serine/threonine kinase activity 26.6667 8 no
GO:1903522 regulation of blood circulation 26.6667 5 no
GO:1904062 regulation of cation transmembrane transport 26.6667 6 no
GO:2001257 regulation of cation channel activity 26.6667 6 no
GO:0010628 positive regulation of gene expression 26.6667 6 no
GO:0045595 regulation of cell differentiation 26.6667 4 no
GO:0045596 negative regulation of cell differentiation 26.6667 5 no
GO:0051093 negative regulation of developmental process 26.6667 4 no
GO:0071417 cellular response to organonitrogen compound 26.6667 4 no
GO:1901699 cellular response to nitrogen compound 26.6667 4 no
GO:1901701 cellular response to oxygen-containing compound 26.6667 4 no
GO:0000038 very long-chain fatty acid metabolic process 26.6667 5 yes
GO:0009117 nucleotide metabolic process 20.0000 5 yes
GO:0009150 purine ribonucleotide metabolic process 20.0000 6 yes
GO:0009259 ribonucleotide metabolic process 20.0000 5 yes
GO:0019693 ribose phosphate metabolic process 20.0000 4 yes
GO:0033865 nucleoside bisphosphate metabolic process 20.0000 5 yes
GO:0033875 ribonucleoside bisphosphate metabolic process 20.0000 6 yes
GO:0034032 purine nucleoside bisphosphate metabolic process 20.0000 5 yes
GO:0035337 fatty-acyl-CoA metabolic process 20.0000 5 yes
GO:0043603 cellular amide metabolic process 20.0000 4 yes
GO:0072521 purine-containing compound metabolic process 20.0000 4 yes
GO:1901362 organic cyclic compound biosynthetic process 20.0000 4 yes
GO:1901568 fatty acid derivative metabolic process 20.0000 4 yes
GO:0006163 purine nucleotide metabolic process 20.0000 5 yes
GO:0006637 acyl-CoA metabolic process 20.0000 4 yes
GO:0006753 nucleoside phosphate metabolic process 20.0000 4 yes
GO:0009152 purine ribonucleotide biosynthetic process 13.3333 7 yes
GO:0009165 nucleotide biosynthetic process 13.3333 6 yes
GO:0009260 ribonucleotide biosynthetic process 13.3333 6 yes
GO:0018130 heterocycle biosynthetic process 13.3333 4 yes
GO:0019438 aromatic compound biosynthetic process 13.3333 4 yes
GO:0031960 response to corticosteroid 13.3333 5 yes
GO:0033866 nucleoside bisphosphate biosynthetic process 13.3333 6 yes
GO:0034030 ribonucleoside bisphosphate biosynthetic process 13.3333 7 yes
GO:0034033 purine nucleoside bisphosphate biosynthetic process 13.3333 6 yes
GO:0034654 nucleobase-containing compound biosynthetic process 13.3333 4 yes
GO:0035336 long-chain fatty-acyl-CoA metabolic process 13.3333 6 yes
GO:0042759 long-chain fatty acid biosynthetic process 13.3333 6 yes
GO:0044271 cellular nitrogen compound biosynthetic process 13.3333 4 yes
GO:0046390 ribose phosphate biosynthetic process 13.3333 5 yes
GO:0048545 response to steroid hormone 13.3333 4 yes
GO:0051384 response to glucocorticoid 13.3333 6 yes
GO:0072522 purine-containing compound biosynthetic process 13.3333 5 yes
GO:0090407 organophosphate biosynthetic process 13.3333 4 yes
GO:1901137 carbohydrate derivative biosynthetic process 13.3333 4 yes
GO:1901293 nucleoside phosphate biosynthetic process 13.3333 5 yes
GO:1901566 organonitrogen compound biosynthetic process 13.3333 4 yes
GO:0006164 purine nucleotide biosynthetic process 13.3333 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in ACBG1_HUMAN
DOID:0050700 cardiomyopathy 13.3333 4 no
DOID:0060036 intrinsic cardiomyopathy 13.3333 5 no
DOID:114 heart disease 13.3333 3 no
DOID:2843 long QT syndrome 13.3333 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
KI20A_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
ANR50_HUMAN [view interactions] High throughput no no
NOL11_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
EWS_HUMAN [view interactions] High throughput no yes
BACH_HUMAN [view entry] [view interactions] High throughput yes yes
AHSA1_HUMAN [view entry] [view interactions] High throughput yes yes
ELOV6_HUMAN [view interactions] Computational no yes
ELOV1_HUMAN [view interactions] Computational no yes
ACOX1_HUMAN [view interactions] Computational no yes
THIM_HUMAN [view interactions] Computational no yes
THIK_HUMAN [view entry] [view interactions] Computational yes yes
FAS_HUMAN [view entry] [view interactions] Computational yes no
ACADL_HUMAN [view interactions] Computational no no
ABCD4_HUMAN [view interactions] Computational no yes
S27A2_HUMAN [view interactions] Computational no no
ABCD1_HUMAN [view entry] [view interactions] Computational yes no
FADS2_HUMAN [view interactions] Computational no yes
ABCD3_HUMAN [view entry] [view interactions] Computational yes yes
ABCD2_HUMAN [view interactions] Computational no no
ACOX2_HUMAN [view interactions] Computational no yes