Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ACBG1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed, PubMed, PubMed). Can activate diverse saturated, monosaturated and polyunsaturated fatty acids (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ACBG1_HUMAN
GO:0043169 cation binding 53.8462 4 no
GO:0046872 metal ion binding 53.8462 5 no
GO:0000166 nucleotide binding 38.4615 4 yes
GO:0017076 purine nucleotide binding 38.4615 5 yes
GO:0030554 adenyl nucleotide binding 38.4615 6 yes
GO:0032555 purine ribonucleotide binding 38.4615 4 yes
GO:0032559 adenyl ribonucleotide binding 38.4615 5 yes
GO:0043168 anion binding 38.4615 4 yes
GO:0005524 ATP binding 30.7692 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 30.7692 4 yes
GO:0019900 kinase binding 30.7692 4 no
GO:0019901 protein kinase binding 30.7692 5 no
GO:0005509 calcium ion binding 23.0769 6 no
GO:0010853 cyclase activator activity 23.0769 4 no
GO:0010854 adenylate cyclase regulator activity 23.0769 4 no
GO:0010856 adenylate cyclase activator activity 23.0769 5 no
GO:0019209 kinase activator activity 23.0769 4 no
GO:0019211 phosphatase activator activity 23.0769 4 no
GO:0019887 protein kinase regulator activity 23.0769 4 no
GO:0019888 protein phosphatase regulator activity 23.0769 4 no
GO:0030295 protein kinase activator activity 23.0769 5 no
GO:0031432 titin binding 23.0769 4 no
GO:0043539 protein serine/threonine kinase activator activity 23.0769 6 no
GO:0072542 protein phosphatase activator activity 23.0769 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in ACBG1_HUMAN
GO:0010646 regulation of cell communication 69.2308 4 no
GO:0048522 positive regulation of cellular process 61.5385 4 no
GO:0048523 negative regulation of cellular process 61.5385 4 no
GO:0051049 regulation of transport 61.5385 4 no
GO:0009893 positive regulation of metabolic process 53.8462 4 no
GO:0009966 regulation of signal transduction 53.8462 4 no
GO:0010604 positive regulation of macromolecule metabolic process 53.8462 5 no
GO:0031323 regulation of cellular metabolic process 53.8462 4 no
GO:0031325 positive regulation of cellular metabolic process 53.8462 5 no
GO:0060255 regulation of macromolecule metabolic process 53.8462 4 no
GO:1902531 regulation of intracellular signal transduction 53.8462 5 no
GO:0006796 phosphate-containing compound metabolic process 46.1538 4 yes
GO:0010038 response to metal ion 46.1538 4 no
GO:0019220 regulation of phosphate metabolic process 46.1538 6 no
GO:0031399 regulation of protein modification process 46.1538 6 no
GO:0031401 positive regulation of protein modification process 46.1538 7 no
GO:0051050 positive regulation of transport 46.1538 4 no
GO:0051174 regulation of phosphorus metabolic process 46.1538 5 no
GO:0051246 regulation of protein metabolic process 46.1538 5 no
GO:0051247 positive regulation of protein metabolic process 46.1538 6 no
GO:0051338 regulation of transferase activity 46.1538 4 no
GO:0080090 regulation of primary metabolic process 46.1538 4 no
GO:0014070 response to organic cyclic compound 38.4615 4 yes
GO:0033993 response to lipid 38.4615 4 yes
GO:0001932 regulation of protein phosphorylation 38.4615 7 no
GO:0001934 positive regulation of protein phosphorylation 38.4615 8 no
GO:0009892 negative regulation of metabolic process 38.4615 4 no
GO:0010562 positive regulation of phosphorus metabolic process 38.4615 6 no
GO:0010605 negative regulation of macromolecule metabolic process 38.4615 5 no
GO:0010799 regulation of peptidyl-threonine phosphorylation 38.4615 8 no
GO:0010800 positive regulation of peptidyl-threonine phosphorylation 38.4615 9 no
GO:0031324 negative regulation of cellular metabolic process 38.4615 5 no
GO:0042325 regulation of phosphorylation 38.4615 7 no
GO:0042327 positive regulation of phosphorylation 38.4615 8 no
GO:0043085 positive regulation of catalytic activity 38.4615 4 no
GO:0045937 positive regulation of phosphate metabolic process 38.4615 7 no
GO:0050848 regulation of calcium-mediated signaling 38.4615 6 no
GO:0051726 regulation of cell cycle 38.4615 4 no
GO:0071310 cellular response to organic substance 38.4615 4 no
GO:0141124 intracellular signaling cassette 38.4615 4 no
GO:0036211 protein modification process 38.4615 4 no
GO:0043412 macromolecule modification 38.4615 4 no
GO:0010243 response to organonitrogen compound 38.4615 4 no
GO:0050804 modulation of chemical synaptic transmission 38.4615 5 no
GO:0099177 regulation of trans-synaptic signaling 38.4615 4 no
GO:0000086 G2/M transition of mitotic cell cycle 30.7692 5 no
GO:0010563 negative regulation of phosphorus metabolic process 30.7692 6 no
GO:0010564 regulation of cell cycle process 30.7692 5 no
GO:0010647 positive regulation of cell communication 30.7692 5 no
GO:0010921 regulation of phosphatase activity 30.7692 5 no
GO:0022898 regulation of transmembrane transporter activity 30.7692 4 no
GO:0023056 positive regulation of signaling 30.7692 4 no
GO:0031400 negative regulation of protein modification process 30.7692 7 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 30.7692 5 no
GO:0034097 response to cytokine 30.7692 4 no
GO:0034762 regulation of transmembrane transport 30.7692 4 no
GO:0035303 regulation of dephosphorylation 30.7692 7 no
GO:0035304 regulation of protein dephosphorylation 30.7692 7 no
GO:0043269 regulation of monoatomic ion transport 30.7692 5 no
GO:0043270 positive regulation of monoatomic ion transport 30.7692 5 no
GO:0043549 regulation of kinase activity 30.7692 5 no
GO:0043666 regulation of phosphoprotein phosphatase activity 30.7692 6 no
GO:0044057 regulation of system process 30.7692 4 no
GO:0044772 mitotic cell cycle phase transition 30.7692 4 no
GO:0044839 cell cycle G2/M phase transition 30.7692 4 no
GO:0045859 regulation of protein kinase activity 30.7692 6 no
GO:0045936 negative regulation of phosphate metabolic process 30.7692 7 no
GO:0048584 positive regulation of response to stimulus 30.7692 4 no
GO:0051248 negative regulation of protein metabolic process 30.7692 6 no
GO:0051336 regulation of hydrolase activity 30.7692 4 no
GO:0051345 positive regulation of hydrolase activity 30.7692 5 no
GO:0051347 positive regulation of transferase activity 30.7692 5 no
GO:0051592 response to calcium ion 30.7692 5 no
GO:0009889 regulation of biosynthetic process 30.7692 4 no
GO:0009891 positive regulation of biosynthetic process 30.7692 5 no
GO:0010556 regulation of macromolecule biosynthetic process 30.7692 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 30.7692 6 no
GO:0031326 regulation of cellular biosynthetic process 30.7692 5 no
GO:0031328 positive regulation of cellular biosynthetic process 30.7692 6 no
GO:0045595 regulation of cell differentiation 30.7692 4 no
GO:0045596 negative regulation of cell differentiation 30.7692 5 no
GO:0051093 negative regulation of developmental process 30.7692 4 no
GO:1901701 cellular response to oxygen-containing compound 30.7692 4 no
GO:0050890 cognition 30.7692 4 no
GO:0098657 import into cell 30.7692 4 no
GO:0034654 nucleobase-containing compound biosynthetic process 23.0769 4 yes
GO:1901362 organic cyclic compound biosynthetic process 23.0769 4 yes
GO:0001933 negative regulation of protein phosphorylation 23.0769 8 no
GO:0005513 detection of calcium ion 23.0769 4 no
GO:0006937 regulation of muscle contraction 23.0769 6 no
GO:0006942 regulation of striated muscle contraction 23.0769 7 no
GO:0008016 regulation of heart contraction 23.0769 6 no
GO:0009967 positive regulation of signal transduction 23.0769 5 no
GO:0010649 regulation of cell communication by electrical coupling 23.0769 5 no
GO:0010801 negative regulation of peptidyl-threonine phosphorylation 23.0769 9 no
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 23.0769 6 no
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 23.0769 7 no
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 23.0769 6 no
GO:0010922 positive regulation of phosphatase activity 23.0769 6 no
GO:0010959 regulation of metal ion transport 23.0769 6 no
GO:0019722 calcium-mediated signaling 23.0769 5 no
GO:0021762 substantia nigra development 23.0769 4 no
GO:0031952 regulation of protein autophosphorylation 23.0769 8 no
GO:0031954 positive regulation of protein autophosphorylation 23.0769 9 no
GO:0032410 negative regulation of transporter activity 23.0769 4 no
GO:0032411 positive regulation of transporter activity 23.0769 4 no
GO:0032413 negative regulation of ion transmembrane transporter activity 23.0769 5 no
GO:0032414 positive regulation of ion transmembrane transporter activity 23.0769 5 no
GO:0032465 regulation of cytokinesis 23.0769 5 no
GO:0032516 positive regulation of phosphoprotein phosphatase activity 23.0769 7 no
GO:0033674 positive regulation of kinase activity 23.0769 6 no
GO:0034763 negative regulation of transmembrane transport 23.0769 5 no
GO:0034764 positive regulation of transmembrane transport 23.0769 5 no
GO:0034765 regulation of monoatomic ion transmembrane transport 23.0769 5 no
GO:0034766 negative regulation of monoatomic ion transmembrane transport 23.0769 6 no
GO:0034767 positive regulation of monoatomic ion transmembrane transport 23.0769 6 no
GO:0035306 positive regulation of dephosphorylation 23.0769 8 no
GO:0035307 positive regulation of protein dephosphorylation 23.0769 8 no
GO:0042326 negative regulation of phosphorylation 23.0769 8 no
GO:0043271 negative regulation of monoatomic ion transport 23.0769 5 no
GO:0045860 positive regulation of protein kinase activity 23.0769 7 no
GO:0051051 negative regulation of transport 23.0769 4 no
GO:0051279 regulation of release of sequestered calcium ion into cytosol 23.0769 5 no
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 23.0769 6 no
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 23.0769 6 no
GO:0051282 regulation of sequestering of calcium ion 23.0769 4 no
GO:0051284 positive regulation of sequestering of calcium ion 23.0769 5 no
GO:0051302 regulation of cell division 23.0769 4 no
GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity 23.0769 5 no
GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity 23.0769 6 no
GO:0051924 regulation of calcium ion transport 23.0769 7 no
GO:0051926 negative regulation of calcium ion transport 23.0769 6 no
GO:0051928 positive regulation of calcium ion transport 23.0769 6 no
GO:0055117 regulation of cardiac muscle contraction 23.0769 7 no
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 23.0769 6 no
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 23.0769 7 no
GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity 23.0769 7 no
GO:0071345 cellular response to cytokine stimulus 23.0769 5 no
GO:0071900 regulation of protein serine/threonine kinase activity 23.0769 7 no
GO:0071902 positive regulation of protein serine/threonine kinase activity 23.0769 8 no
GO:0090257 regulation of muscle system process 23.0769 5 no
GO:1901019 regulation of calcium ion transmembrane transporter activity 23.0769 6 no
GO:1901020 negative regulation of calcium ion transmembrane transporter activity 23.0769 6 no
GO:1901021 positive regulation of calcium ion transmembrane transporter activity 23.0769 6 no
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction 23.0769 6 no
GO:1903169 regulation of calcium ion transmembrane transport 23.0769 7 no
GO:1903170 negative regulation of calcium ion transmembrane transport 23.0769 7 no
GO:1903522 regulation of blood circulation 23.0769 5 no
GO:1904062 regulation of monoatomic cation transmembrane transport 23.0769 6 no
GO:1904063 negative regulation of cation transmembrane transport 23.0769 7 no
GO:1904064 positive regulation of cation transmembrane transport 23.0769 7 no
GO:1904427 positive regulation of calcium ion transmembrane transport 23.0769 7 no
GO:1905912 regulation of calcium ion export across plasma membrane 23.0769 8 no
GO:1905913 negative regulation of calcium ion export across plasma membrane 23.0769 8 no
GO:2001257 regulation of cation channel activity 23.0769 6 no
GO:2001258 negative regulation of cation channel activity 23.0769 6 no
GO:2001259 positive regulation of cation channel activity 23.0769 6 no
GO:0006468 protein phosphorylation 23.0769 5 no
GO:0010468 regulation of gene expression 23.0769 6 no
GO:0010628 positive regulation of gene expression 23.0769 7 no
GO:0010648 negative regulation of cell communication 23.0769 5 no
GO:0016310 phosphorylation 23.0769 5 no
GO:0023057 negative regulation of signaling 23.0769 4 no
GO:0045664 regulation of neuron differentiation 23.0769 5 no
GO:0045665 negative regulation of neuron differentiation 23.0769 6 no
GO:0048638 regulation of developmental growth 23.0769 4 no
GO:0051128 regulation of cellular component organization 23.0769 4 no
GO:0051130 positive regulation of cellular component organization 23.0769 5 no
GO:0071417 cellular response to organonitrogen compound 23.0769 4 no
GO:0080134 regulation of response to stress 23.0769 4 no
GO:1901699 cellular response to nitrogen compound 23.0769 4 no
GO:0042127 regulation of cell population proliferation 23.0769 4 no
GO:0001676 long-chain fatty acid metabolic process 15.3846 5 yes
GO:0006163 purine nucleotide metabolic process 15.3846 5 yes
GO:0006164 purine nucleotide biosynthetic process 15.3846 6 yes
GO:0006631 fatty acid metabolic process 15.3846 4 yes
GO:0006633 fatty acid biosynthetic process 15.3846 5 yes
GO:0006753 nucleoside phosphate metabolic process 15.3846 4 yes
GO:0008610 lipid biosynthetic process 15.3846 4 yes
GO:0009117 nucleotide metabolic process 15.3846 5 yes
GO:0009150 purine ribonucleotide metabolic process 15.3846 6 yes
GO:0009152 purine ribonucleotide biosynthetic process 15.3846 7 yes
GO:0009165 nucleotide biosynthetic process 15.3846 6 yes
GO:0009259 ribonucleotide metabolic process 15.3846 5 yes
GO:0009260 ribonucleotide biosynthetic process 15.3846 6 yes
GO:0016053 organic acid biosynthetic process 15.3846 4 yes
GO:0019693 ribose phosphate metabolic process 15.3846 4 yes
GO:0019752 carboxylic acid metabolic process 15.3846 5 yes
GO:0032787 monocarboxylic acid metabolic process 15.3846 6 yes
GO:0033865 nucleoside bisphosphate metabolic process 15.3846 5 yes
GO:0033866 nucleoside bisphosphate biosynthetic process 15.3846 6 yes
GO:0033875 ribonucleoside bisphosphate metabolic process 15.3846 6 yes
GO:0034030 ribonucleoside bisphosphate biosynthetic process 15.3846 7 yes
GO:0034032 purine nucleoside bisphosphate metabolic process 15.3846 5 yes
GO:0034033 purine nucleoside bisphosphate biosynthetic process 15.3846 6 yes
GO:0035336 long-chain fatty-acyl-CoA metabolic process 15.3846 5 yes
GO:0035337 fatty-acyl-CoA metabolic process 15.3846 4 yes
GO:0042552 myelination 15.3846 4 yes
GO:0042759 long-chain fatty acid biosynthetic process 15.3846 6 yes
GO:0043436 oxoacid metabolic process 15.3846 4 yes
GO:0046390 ribose phosphate biosynthetic process 15.3846 5 yes
GO:0046394 carboxylic acid biosynthetic process 15.3846 5 yes
GO:0072330 monocarboxylic acid biosynthetic process 15.3846 6 yes
GO:0072521 purine-containing compound metabolic process 15.3846 4 yes
GO:0072522 purine-containing compound biosynthetic process 15.3846 5 yes
GO:0090407 organophosphate biosynthetic process 15.3846 4 yes
GO:1901137 carbohydrate derivative biosynthetic process 15.3846 4 yes
GO:1901293 nucleoside phosphate biosynthetic process 15.3846 5 yes
GO:1901566 organonitrogen compound biosynthetic process 15.3846 4 yes
GO:1901568 fatty acid derivative metabolic process 15.3846 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
KI20A_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
ANR50_HUMAN [view interactions] High throughput no no
NOL11_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
EWS_HUMAN [view interactions] High throughput no yes
BACH_HUMAN [view entry] [view interactions] High throughput yes yes
AHSA1_HUMAN [view entry] [view interactions] High throughput yes yes
PPP5_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A1_HUMAN [view entry] [view interactions] High throughput yes no