BACH_HUMAN
Evidence for PS localization
Functions
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed). Acyl-coenzyme A thioesterase 7/ACOT7 preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (PubMed). May play an important physiological function in brain (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in BACH_HUMAN |
|---|---|---|---|---|
| GO:0042803 | protein homodimerization activity | 25.0000 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 20.8333 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 20.8333 | 4 | yes |
| GO:0003723 | RNA binding | 20.8333 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 16.6667 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 16.6667 | 5 | yes |
| GO:0016289 | CoA hydrolase activity | 12.5000 | 5 | yes |
| GO:0016290 | palmitoyl-CoA hydrolase activity | 12.5000 | 7 | yes |
| GO:0016790 | thiolester hydrolase activity | 12.5000 | 4 | yes |
| GO:0047617 | acyl-CoA hydrolase activity | 12.5000 | 6 | yes |
| GO:0102991 | myristoyl-CoA hydrolase activity | 12.5000 | 5 | yes |
| GO:0000062 | fatty-acyl-CoA binding | 8.3333 | 4 | yes |
| GO:0036042 | long-chain fatty acyl-CoA binding | 8.3333 | 5 | yes |
| GO:0052689 | carboxylic ester hydrolase activity | 8.3333 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in BACH_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 62.5000 | 4 | no |
| GO:0010646 | regulation of cell communication | 54.1667 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 54.1667 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 45.8333 | 4 | no |
| GO:0022607 | cellular component assembly | 41.6667 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 41.6667 | 4 | no |
| GO:0009966 | regulation of signal transduction | 41.6667 | 4 | no |
| GO:0051049 | regulation of transport | 37.5000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 37.5000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.5000 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 37.5000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 37.5000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 37.5000 | 4 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0010468 | regulation of gene expression | 33.3333 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
| GO:0008104 | protein localization | 29.1667 | 4 | no |
| GO:0043933 | protein-containing complex organization | 29.1667 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 29.1667 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.1667 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 29.1667 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 29.1667 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 29.1667 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 29.1667 | 5 | no |
| GO:0023056 | positive regulation of signaling | 29.1667 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 29.1667 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 29.1667 | 4 | yes |
| GO:0043412 | macromolecule modification | 25.0000 | 4 | no |
| GO:0044057 | regulation of system process | 25.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.0000 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 25.0000 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 25.0000 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 20.8333 | 4 | no |
| GO:0051050 | positive regulation of transport | 20.8333 | 4 | no |
| GO:0071702 | organic substance transport | 20.8333 | 4 | no |
| GO:0071705 | nitrogen compound transport | 20.8333 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 20.8333 | 6 | no |
| GO:0043269 | regulation of ion transport | 20.8333 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 20.8333 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 20.8333 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 20.8333 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.8333 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 20.8333 | 6 | no |
| GO:0031399 | regulation of protein modification process | 20.8333 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 20.8333 | 7 | no |
| GO:0044087 | regulation of cellular component biogenesis | 20.8333 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 20.8333 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 20.8333 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.8333 | 5 | no |
| GO:0007010 | cytoskeleton organization | 20.8333 | 5 | no |
| GO:0036211 | protein modification process | 20.8333 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.8333 | 5 | no |
| GO:0010941 | regulation of cell death | 20.8333 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 20.8333 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 20.8333 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 20.8333 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.8333 | 4 | no |
| GO:0032880 | regulation of protein localization | 20.8333 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.8333 | 4 | no |
| GO:0031346 | positive regulation of cell projection organization | 20.8333 | 6 | no |
| GO:0019752 | carboxylic acid metabolic process | 20.8333 | 5 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 20.8333 | 6 | yes |
| GO:0043436 | oxoacid metabolic process | 20.8333 | 4 | yes |
| GO:0046394 | carboxylic acid biosynthetic process | 16.6667 | 5 | yes |
| GO:0072330 | monocarboxylic acid biosynthetic process | 16.6667 | 6 | yes |
| GO:0072521 | purine-containing compound metabolic process | 16.6667 | 4 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 16.6667 | 4 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 16.6667 | 4 | yes |
| GO:0006163 | purine nucleotide metabolic process | 16.6667 | 5 | yes |
| GO:0006631 | fatty acid metabolic process | 16.6667 | 4 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 16.6667 | 4 | yes |
| GO:0008610 | lipid biosynthetic process | 16.6667 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 16.6667 | 5 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 16.6667 | 6 | yes |
| GO:0009259 | ribonucleotide metabolic process | 16.6667 | 5 | yes |
| GO:0016053 | organic acid biosynthetic process | 16.6667 | 4 | yes |
| GO:0019693 | ribose phosphate metabolic process | 16.6667 | 4 | yes |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 12.5000 | 4 | yes |
| GO:0046390 | ribose phosphate biosynthetic process | 12.5000 | 5 | yes |
| GO:0072522 | purine-containing compound biosynthetic process | 12.5000 | 5 | yes |
| GO:0090407 | organophosphate biosynthetic process | 12.5000 | 4 | yes |
| GO:1901137 | carbohydrate derivative biosynthetic process | 12.5000 | 4 | yes |
| GO:1901293 | nucleoside phosphate biosynthetic process | 12.5000 | 5 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 12.5000 | 4 | yes |
| GO:1901568 | fatty acid derivative metabolic process | 12.5000 | 4 | yes |
| GO:0001676 | long-chain fatty acid metabolic process | 12.5000 | 5 | yes |
| GO:0006164 | purine nucleotide biosynthetic process | 12.5000 | 6 | yes |
| GO:0006633 | fatty acid biosynthetic process | 12.5000 | 5 | yes |
| GO:0006637 | acyl-CoA metabolic process | 12.5000 | 4 | yes |
| GO:0009152 | purine ribonucleotide biosynthetic process | 12.5000 | 7 | yes |
| GO:0009165 | nucleotide biosynthetic process | 12.5000 | 6 | yes |
| GO:0009260 | ribonucleotide biosynthetic process | 12.5000 | 6 | yes |
| GO:0016042 | lipid catabolic process | 12.5000 | 4 | yes |
| GO:0018130 | heterocycle biosynthetic process | 12.5000 | 4 | yes |
| GO:0019438 | aromatic compound biosynthetic process | 12.5000 | 4 | yes |
| GO:0033865 | nucleoside bisphosphate metabolic process | 12.5000 | 5 | yes |
| GO:0033866 | nucleoside bisphosphate biosynthetic process | 12.5000 | 6 | yes |
| GO:0033875 | ribonucleoside bisphosphate metabolic process | 12.5000 | 6 | yes |
| GO:0034030 | ribonucleoside bisphosphate biosynthetic process | 12.5000 | 7 | yes |
| GO:0034032 | purine nucleoside bisphosphate metabolic process | 12.5000 | 5 | yes |
| GO:0034033 | purine nucleoside bisphosphate biosynthetic process | 12.5000 | 6 | yes |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 12.5000 | 4 | yes |
| GO:0035336 | long-chain fatty-acyl-CoA metabolic process | 12.5000 | 6 | yes |
| GO:0035337 | fatty-acyl-CoA metabolic process | 12.5000 | 5 | yes |
| GO:0042759 | long-chain fatty acid biosynthetic process | 12.5000 | 6 | yes |
| GO:0043603 | cellular amide metabolic process | 12.5000 | 4 | yes |
| GO:0044270 | cellular nitrogen compound catabolic process | 8.3333 | 4 | yes |
| GO:0044273 | sulfur compound catabolic process | 8.3333 | 4 | yes |
| GO:0046434 | organophosphate catabolic process | 8.3333 | 4 | yes |
| GO:0046700 | heterocycle catabolic process | 8.3333 | 4 | yes |
| GO:0051791 | medium-chain fatty acid metabolic process | 8.3333 | 5 | yes |
| GO:0051792 | medium-chain fatty acid biosynthetic process | 8.3333 | 6 | yes |
| GO:0072523 | purine-containing compound catabolic process | 8.3333 | 5 | yes |
| GO:1900533 | palmitic acid metabolic process | 8.3333 | 6 | yes |
| GO:1900535 | palmitic acid biosynthetic process | 8.3333 | 7 | yes |
| GO:1901136 | carbohydrate derivative catabolic process | 8.3333 | 4 | yes |
| GO:1901292 | nucleoside phosphate catabolic process | 8.3333 | 5 | yes |
| GO:1901361 | organic cyclic compound catabolic process | 8.3333 | 4 | yes |
| GO:1901569 | fatty acid derivative catabolic process | 8.3333 | 5 | yes |
| GO:0006195 | purine nucleotide catabolic process | 8.3333 | 6 | yes |
| GO:0009154 | purine ribonucleotide catabolic process | 8.3333 | 6 | yes |
| GO:0009166 | nucleotide catabolic process | 8.3333 | 6 | yes |
| GO:0009261 | ribonucleotide catabolic process | 8.3333 | 5 | yes |
| GO:0015936 | coenzyme A metabolic process | 8.3333 | 6 | yes |
| GO:0015937 | coenzyme A biosynthetic process | 8.3333 | 7 | yes |
| GO:0019439 | aromatic compound catabolic process | 8.3333 | 4 | yes |
| GO:0033869 | nucleoside bisphosphate catabolic process | 8.3333 | 6 | yes |
| GO:0034031 | ribonucleoside bisphosphate catabolic process | 8.3333 | 7 | yes |
| GO:0034034 | purine nucleoside bisphosphate catabolic process | 8.3333 | 6 | yes |
| GO:0034655 | nucleobase-containing compound catabolic process | 8.3333 | 4 | yes |
| GO:0036112 | medium-chain fatty-acyl-CoA metabolic process | 8.3333 | 6 | yes |
| GO:0036114 | medium-chain fatty-acyl-CoA catabolic process | 8.3333 | 6 | yes |
| GO:0036115 | fatty-acyl-CoA catabolic process | 8.3333 | 5 | yes |
| GO:0036116 | long-chain fatty-acyl-CoA catabolic process | 8.3333 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in BACH_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 12.5000 | 3 | no |
| DOID:0050700 | cardiomyopathy | 8.3333 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 8.3333 | 5 | no |
| DOID:0080000 | muscular disease | 8.3333 | 3 | no |
| DOID:12930 | dilated cardiomyopathy | 8.3333 | 6 | no |
| DOID:423 | myopathy | 8.3333 | 5 | no |
| DOID:66 | muscle tissue disease | 8.3333 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| BACH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BRCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| COQ5_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| PHIPL_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHD8_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD3Z_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| MYLK_HUMAN | [view interactions] | High throughput | no | no |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| RHG07_HUMAN | [view interactions] | High throughput | no | no |
| MAGA6_HUMAN | [view interactions] | High throughput | no | no |
| KCC2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THAP1_HUMAN | [view interactions] | High throughput | no | no |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HXA1_HUMAN | [view interactions] | High throughput | no | no |
| FOXI2_HUMAN | [view interactions] | High throughput | no | no |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| TINF2_HUMAN | [view interactions] | High throughput | no | no |
| POTE1_HUMAN | [view interactions] | High throughput | no | no |
| ATX1L_HUMAN | [view interactions] | High throughput | no | no |
| CRYAB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENKD1_HUMAN | [view interactions] | High throughput | no | yes |
| NCOA5_HUMAN | [view interactions] | High throughput | no | yes |
| BAG4_HUMAN | [view interactions] | High throughput | no | yes |
| SPC1L_HUMAN | [view interactions] | High throughput | no | no |
| UBXN1_HUMAN | [view interactions] | High throughput | no | no |
| ACO12_HUMAN | [view interactions] | High throughput | no | no |
| DAZP2_HUMAN | [view interactions] | High throughput | no | no |
| ZN438_HUMAN | [view interactions] | High throughput | no | no |
| PO6F1_HUMAN | [view interactions] | High throughput | no | no |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| MAGA3_HUMAN | [view interactions] | High throughput | no | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| CB39L_HUMAN | [view interactions] | High throughput | no | yes |
| TR19L_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| DUS19_HUMAN | [view interactions] | High throughput | no | yes |
| DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
| PKNX1_HUMAN | [view interactions] | High throughput | no | yes |
| RBG1L_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| UBE3A_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| MGDP1_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| RS4Y1_HUMAN | [view interactions] | High throughput | no | yes |
| KDSR_HUMAN | [view interactions] | High throughput | no | yes |
| CAPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RA51D_HUMAN | [view interactions] | High throughput | no | no |
| RNF41_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| TFIP8_HUMAN | [view interactions] | High throughput | no | no |
| AL9A1_HUMAN | [view interactions] | High throughput | no | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCC2_HUMAN | [view interactions] | High throughput | no | no |
| DHSO_HUMAN | [view interactions] | High throughput | no | no |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| THEM4_HUMAN | [view interactions] | Computational | no | no |
| ACOT1_HUMAN | [view interactions] | Computational | no | yes |
| ACO13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| THEM5_HUMAN | [view interactions] | Computational | no | no |
| TECR_HUMAN | [view interactions] | Computational | no | yes |
| ACOT2_HUMAN | [view interactions] | Computational | no | yes |
| ACOT4_HUMAN | [view interactions] | Computational | no | yes |