Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

BACH_HUMAN

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed). Acyl-coenzyme A thioesterase 7/ACOT7 preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (PubMed). May play an important physiological function in brain (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in BACH_HUMAN
GO:0043168 anion binding 40.6780 4 yes
GO:0000166 nucleotide binding 33.8983 4 yes
GO:0017076 purine nucleotide binding 33.8983 5 yes
GO:0003723 RNA binding 33.8983 4 no
GO:0032555 purine ribonucleotide binding 32.2034 4 yes
GO:0030554 adenyl nucleotide binding 28.8136 6 yes
GO:0035639 purine ribonucleoside triphosphate binding 28.8136 4 no
GO:0032559 adenyl ribonucleotide binding 27.1186 5 yes
GO:0043169 cation binding 27.1186 4 no
GO:0046872 metal ion binding 27.1186 5 no
GO:0005524 ATP binding 23.7288 5 no
GO:0042803 protein homodimerization activity 10.1695 4 yes
GO:0052689 carboxylic ester hydrolase activity 5.0847 4 yes
GO:0000062 fatty-acyl-CoA binding 3.3898 4 yes
GO:0036042 long-chain fatty acyl-CoA binding 3.3898 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in BACH_HUMAN
GO:0048522 positive regulation of cellular process 57.6271 4 no
GO:0051128 regulation of cellular component organization 45.7627 4 no
GO:0060255 regulation of macromolecule metabolic process 44.0678 4 no
GO:0080090 regulation of primary metabolic process 42.3729 4 no
GO:0048523 negative regulation of cellular process 40.6780 4 no
GO:0009893 positive regulation of metabolic process 38.9831 4 no
GO:0031323 regulation of cellular metabolic process 38.9831 4 no
GO:0009889 regulation of biosynthetic process 37.2881 4 no
GO:0010556 regulation of macromolecule biosynthetic process 37.2881 5 no
GO:0010604 positive regulation of macromolecule metabolic process 37.2881 5 no
GO:0010646 regulation of cell communication 37.2881 4 no
GO:0031326 regulation of cellular biosynthetic process 37.2881 5 no
GO:0006996 organelle organization 35.5932 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 35.5932 5 no
GO:0010468 regulation of gene expression 32.2034 6 no
GO:0031325 positive regulation of cellular metabolic process 32.2034 5 no
GO:0051130 positive regulation of cellular component organization 32.2034 5 no
GO:0022607 cellular component assembly 30.5085 4 no
GO:0009891 positive regulation of biosynthetic process 28.8136 5 no
GO:0009966 regulation of signal transduction 28.8136 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 28.8136 6 no
GO:0031328 positive regulation of cellular biosynthetic process 28.8136 6 no
GO:0006796 phosphate-containing compound metabolic process 27.1186 4 yes
GO:0033043 regulation of organelle organization 27.1186 5 no
GO:0051049 regulation of transport 27.1186 4 no
GO:0051252 regulation of RNA metabolic process 27.1186 5 no
GO:0023056 positive regulation of signaling 23.7288 4 no
GO:0051246 regulation of protein metabolic process 23.7288 5 no
GO:0043933 protein-containing complex organization 23.7288 4 no
GO:0060341 regulation of cellular localization 23.7288 4 no
GO:0010647 positive regulation of cell communication 22.0339 5 no
GO:0048584 positive regulation of response to stimulus 22.0339 4 no
GO:0006355 regulation of DNA-templated transcription 22.0339 7 no
GO:0010638 positive regulation of organelle organization 22.0339 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 22.0339 5 no
GO:0051129 negative regulation of cellular component organization 22.0339 5 no
GO:2001141 regulation of RNA biosynthetic process 22.0339 6 no
GO:0008104 protein localization 22.0339 4 no
GO:0007010 cytoskeleton organization 20.3390 5 no
GO:0009892 negative regulation of metabolic process 20.3390 4 no
GO:0009967 positive regulation of signal transduction 20.3390 5 no
GO:0010605 negative regulation of macromolecule metabolic process 20.3390 5 no
GO:0031324 negative regulation of cellular metabolic process 20.3390 5 no
GO:0042981 regulation of apoptotic process 20.3390 5 no
GO:0043067 regulation of programmed cell death 20.3390 4 no
GO:0044087 regulation of cellular component biogenesis 20.3390 4 no
GO:0048585 negative regulation of response to stimulus 20.3390 4 no
GO:0071702 organic substance transport 20.3390 4 no
GO:0031344 regulation of cell projection organization 20.3390 5 no
GO:0006163 purine nucleotide metabolic process 18.6441 5 yes
GO:0006753 nucleoside phosphate metabolic process 18.6441 4 yes
GO:0009117 nucleotide metabolic process 18.6441 5 yes
GO:0019693 ribose phosphate metabolic process 18.6441 4 yes
GO:0072521 purine-containing compound metabolic process 18.6441 4 yes
GO:0009150 purine ribonucleotide metabolic process 16.9492 6 yes
GO:0009259 ribonucleotide metabolic process 16.9492 5 yes
GO:1901565 organonitrogen compound catabolic process 16.9492 4 yes
GO:1901566 organonitrogen compound biosynthetic process 16.9492 4 yes
GO:1901362 organic cyclic compound biosynthetic process 15.2542 4 yes
GO:0019752 carboxylic acid metabolic process 13.5593 5 yes
GO:0034654 nucleobase-containing compound biosynthetic process 13.5593 4 yes
GO:0043436 oxoacid metabolic process 13.5593 4 yes
GO:0006164 purine nucleotide biosynthetic process 10.1695 6 yes
GO:0009165 nucleotide biosynthetic process 10.1695 6 yes
GO:0016053 organic acid biosynthetic process 10.1695 4 yes
GO:0046394 carboxylic acid biosynthetic process 10.1695 5 yes
GO:0072522 purine-containing compound biosynthetic process 10.1695 5 yes
GO:0090407 organophosphate biosynthetic process 10.1695 4 yes
GO:1901137 carbohydrate derivative biosynthetic process 10.1695 4 yes
GO:1901293 nucleoside phosphate biosynthetic process 10.1695 5 yes
GO:1901361 organic cyclic compound catabolic process 10.1695 4 yes
GO:0009152 purine ribonucleotide biosynthetic process 8.4746 7 yes
GO:0009260 ribonucleotide biosynthetic process 8.4746 6 yes
GO:0032787 monocarboxylic acid metabolic process 8.4746 6 yes
GO:0034655 nucleobase-containing compound catabolic process 8.4746 4 yes
GO:0046390 ribose phosphate biosynthetic process 8.4746 5 yes
GO:0006631 fatty acid metabolic process 6.7797 4 yes
GO:0008610 lipid biosynthetic process 6.7797 4 yes
GO:0016042 lipid catabolic process 6.7797 4 yes
GO:0046434 organophosphate catabolic process 6.7797 4 yes
GO:0072330 monocarboxylic acid biosynthetic process 6.7797 6 yes
GO:0001676 long-chain fatty acid metabolic process 5.0847 5 yes
GO:0006195 purine nucleotide catabolic process 5.0847 6 yes
GO:0006633 fatty acid biosynthetic process 5.0847 5 yes
GO:0009154 purine ribonucleotide catabolic process 5.0847 6 yes
GO:0009166 nucleotide catabolic process 5.0847 6 yes
GO:0009261 ribonucleotide catabolic process 5.0847 5 yes
GO:0033865 nucleoside bisphosphate metabolic process 5.0847 5 yes
GO:0033866 nucleoside bisphosphate biosynthetic process 5.0847 6 yes
GO:0033875 ribonucleoside bisphosphate metabolic process 5.0847 6 yes
GO:0034030 ribonucleoside bisphosphate biosynthetic process 5.0847 7 yes
GO:0034032 purine nucleoside bisphosphate metabolic process 5.0847 5 yes
GO:0034033 purine nucleoside bisphosphate biosynthetic process 5.0847 6 yes
GO:0035336 long-chain fatty-acyl-CoA metabolic process 5.0847 5 yes
GO:0035337 fatty-acyl-CoA metabolic process 5.0847 4 yes
GO:0042759 long-chain fatty acid biosynthetic process 5.0847 6 yes
GO:0072523 purine-containing compound catabolic process 5.0847 5 yes
GO:1901136 carbohydrate derivative catabolic process 5.0847 4 yes
GO:1901292 nucleoside phosphate catabolic process 5.0847 5 yes
GO:1901568 fatty acid derivative metabolic process 5.0847 4 yes
GO:0015936 coenzyme A metabolic process 3.3898 6 yes
GO:0015937 coenzyme A biosynthetic process 3.3898 7 yes
GO:0033869 nucleoside bisphosphate catabolic process 3.3898 6 yes
GO:0034031 ribonucleoside bisphosphate catabolic process 3.3898 7 yes
GO:0034034 purine nucleoside bisphosphate catabolic process 3.3898 6 yes
GO:0036112 medium-chain fatty-acyl-CoA metabolic process 3.3898 5 yes
GO:0036114 medium-chain fatty-acyl-CoA catabolic process 3.3898 6 yes
GO:0036115 fatty-acyl-CoA catabolic process 3.3898 5 yes
GO:0036116 long-chain fatty-acyl-CoA catabolic process 3.3898 6 yes
GO:0044273 sulfur compound catabolic process 3.3898 4 yes
GO:0051791 medium-chain fatty acid metabolic process 3.3898 5 yes
GO:0051792 medium-chain fatty acid biosynthetic process 3.3898 6 yes
GO:1900533 palmitic acid metabolic process 3.3898 6 yes
GO:1900535 palmitic acid biosynthetic process 3.3898 7 yes
GO:1901569 fatty acid derivative catabolic process 3.3898 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
BACH_HUMAN [view entry] [view interactions] Low throughput yes yes
BRCA1_HUMAN [view interactions] Low throughput no yes
RRBP1_HUMAN [view entry] [view interactions] High throughput yes yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
SI1L1_HUMAN [view entry] [view interactions] High throughput yes yes
SRP72_HUMAN [view interactions] High throughput no yes
LA_HUMAN [view interactions] High throughput no yes
TALDO_HUMAN [view entry] [view interactions] High throughput yes no
TBCA_HUMAN [view interactions] High throughput no yes
TBL2_HUMAN [view interactions] High throughput no no
TCOF_HUMAN [view interactions] High throughput no yes
UBP48_HUMAN [view interactions] High throughput no yes
YTHD2_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
PARPT_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
EZH2_HUMAN [view interactions] High throughput no no
SPOP_HUMAN [view interactions] High throughput no no
UBE2H_HUMAN [view interactions] High throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
GDIA_HUMAN [view entry] [view interactions] High throughput yes yes
NDRG1_HUMAN [view entry] [view interactions] High throughput yes yes
NHLC2_HUMAN [view interactions] High throughput no yes
TFIP8_HUMAN [view interactions] High throughput no no
AL9A1_HUMAN [view interactions] High throughput no yes
G3P_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA3_HUMAN [view entry] [view interactions] High throughput yes yes
RCC2_HUMAN [view interactions] High throughput no no
DHSO_HUMAN [view interactions] High throughput no no
PCBP1_HUMAN [view entry] [view interactions] High throughput yes yes
ACBG1_HUMAN [view entry] [view interactions] High throughput yes yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
MPRI_HUMAN [view interactions] High throughput no yes
NDKB_HUMAN [view entry] [view interactions] High throughput yes yes
DEST_HUMAN [view entry] [view interactions] High throughput yes yes
RAN_HUMAN [view entry] [view interactions] High throughput yes no
PPIA_HUMAN [view entry] [view interactions] High throughput yes yes
KGUA_HUMAN [view entry] [view interactions] High throughput yes yes
COF2_HUMAN [view entry] [view interactions] High throughput yes yes
AGR2_HUMAN [view interactions] High throughput no no
NECD_HUMAN [view interactions] High throughput no no
COIL_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
OTUB1_HUMAN [view interactions] High throughput no yes
COQ5_HUMAN [view interactions] High throughput no yes
NDUS3_HUMAN [view entry] [view interactions] High throughput yes yes
COQ9_HUMAN [view interactions] High throughput no yes
ATPA_HUMAN [view interactions] High throughput no yes
PHIPL_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
LRRK2_HUMAN [view interactions] High throughput no yes
SH2D3_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
SODC_HUMAN [view interactions] High throughput no yes
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
CHD8_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
CD3Z_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
M3K7_HUMAN [view interactions] High throughput no yes
MYLK_HUMAN [view entry] [view interactions] High throughput yes no
KPCD2_HUMAN [view interactions] High throughput no yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
DYR1A_HUMAN [view interactions] High throughput no yes
RHG07_HUMAN [view interactions] High throughput no no
MAGA6_HUMAN [view interactions] High throughput no no
KCC2B_HUMAN [view entry] [view interactions] High throughput yes yes
THAP1_HUMAN [view interactions] High throughput no no
UBQL1_HUMAN [view interactions] High throughput no yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
HXA1_HUMAN [view interactions] High throughput no no
FOXI2_HUMAN [view interactions] High throughput no no
TERF1_HUMAN [view interactions] High throughput no no
TINF2_HUMAN [view interactions] High throughput no no
POTE1_HUMAN [view interactions] High throughput no no
ATX1L_HUMAN [view interactions] High throughput no no
CRYAB_HUMAN [view entry] [view interactions] High throughput yes no
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
ENKD1_HUMAN [view interactions] High throughput no yes
NCOA5_HUMAN [view interactions] High throughput no yes
BAG4_HUMAN [view interactions] High throughput no yes
SPC1L_HUMAN [view interactions] High throughput no no
UBXN1_HUMAN [view interactions] High throughput no no
ACO12_HUMAN [view interactions] High throughput no no
DAZP2_HUMAN [view interactions] High throughput no no
ZN438_HUMAN [view interactions] High throughput no no
PO6F1_HUMAN [view interactions] High throughput no no
UBQL2_HUMAN [view interactions] High throughput no yes
MAGA3_HUMAN [view interactions] High throughput no no
CDK2_HUMAN [view interactions] High throughput no yes
CB39L_HUMAN [view interactions] High throughput no yes
TR19L_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
DUS19_HUMAN [view interactions] High throughput no yes
DUS4_HUMAN [view entry] [view interactions] High throughput yes no
FBW1A_HUMAN [view interactions] High throughput no yes
PKNX1_HUMAN [view interactions] High throughput no yes
RBG1L_HUMAN [view interactions] High throughput no yes
HDAC4_HUMAN [view interactions] High throughput no yes
UBE3A_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
TIA1_HUMAN [view interactions] High throughput no no
MGDP1_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
RS4Y1_HUMAN [view interactions] High throughput no yes
KDSR_HUMAN [view interactions] High throughput no yes
CAPS1_HUMAN [view entry] [view interactions] High throughput yes yes
RA51D_HUMAN [view interactions] High throughput no no
RNF41_HUMAN [view interactions] High throughput no yes
SAR1B_HUMAN [view interactions] High throughput no yes
C102A_HUMAN [view interactions] High throughput no yes
DESP_HUMAN [view entry] [view interactions] High throughput yes no
K1C14_HUMAN [view interactions] High throughput no no
PNM8A_HUMAN [view interactions] High throughput no yes
PSMD1_HUMAN [view entry] [view interactions] High throughput yes yes
RETST_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RS14_HUMAN [view entry] [view interactions] High throughput yes yes
SART3_HUMAN [view interactions] High throughput no yes
ABCE1_HUMAN [view interactions] High throughput no yes
ACON_HUMAN [view entry] [view interactions] High throughput yes yes
KAD2_HUMAN [view interactions] High throughput no no
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
ANXA5_HUMAN [view entry] [view interactions] High throughput yes no
GDIR2_HUMAN [view interactions] High throughput no no
AT5F1_HUMAN [view interactions] High throughput no yes
CU058_HUMAN [view interactions] High throughput no no
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
TCPD_HUMAN [view entry] [view interactions] High throughput yes yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
COPB_HUMAN [view interactions] High throughput no yes
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
ECH1_HUMAN [view interactions] High throughput no yes
ERF1_HUMAN [view interactions] High throughput no yes
EXOS6_HUMAN [view interactions] High throughput no no
SYFA_HUMAN [view entry] [view interactions] High throughput yes yes
FNBP1_HUMAN [view interactions] High throughput no yes
FUBP1_HUMAN [view interactions] High throughput no yes
GANAB_HUMAN [view interactions] High throughput no yes
EFGM_HUMAN [view interactions] High throughput no yes
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
AATM_HUMAN [view entry] [view interactions] High throughput yes yes
ITB5_HUMAN [view interactions] High throughput no yes
SYK_HUMAN [view interactions] High throughput no yes
KDM7A_HUMAN [view interactions] High throughput no yes
COX2_HUMAN [view entry] [view interactions] High throughput yes yes
NASP_HUMAN [view interactions] High throughput no yes
CPSF5_HUMAN [view interactions] High throughput no yes
OLA1_HUMAN [view entry] [view interactions] High throughput yes yes
PCNP_HUMAN [view interactions] High throughput no yes
PLCG2_HUMAN [view interactions] High throughput no yes
IPYR_HUMAN [view interactions] High throughput no yes
PPIF_HUMAN [view interactions] High throughput no no
PRDX6_HUMAN [view entry] [view interactions] High throughput yes yes
PSA1_HUMAN [view interactions] High throughput no yes
PSMD4_HUMAN [view interactions] High throughput no yes
RD23B_HUMAN [view interactions] High throughput no yes
RPN1_HUMAN [view entry] [view interactions] High throughput yes yes