Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CRYAB_HUMAN

GO
G2C
SynGO

May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. [View more on UniProt]

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Download full PS network for entry.
Position Amino acid Mutation Disease Overlap with binding region
120 Arg Gly Myopathy,myofibrillar,2(MFM2) -
109 Asp His Myopathy,myofibrillar,2(MFM2) -
154 Gly Ser Cardiomyopathy,dilated,1II(CMD1II) -
157 Arg His Cardiomyopathy,dilated,1II(CMD1II) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in CRYAB_HUMAN
GO:0043169 cation binding 30.1887 4 yes
GO:0046872 metal ion binding 30.1887 5 yes
GO:0019900 kinase binding 22.6415 4 no
GO:0000166 nucleotide binding 22.6415 4 no
GO:0017076 purine nucleotide binding 22.6415 5 no
GO:0019901 protein kinase binding 20.7547 5 no
GO:0030554 adenyl nucleotide binding 20.7547 6 no
GO:0032555 purine ribonucleotide binding 20.7547 4 no
GO:0043168 anion binding 20.7547 4 no
GO:0015631 tubulin binding 18.8679 4 yes
GO:0042803 protein homodimerization activity 16.9811 4 yes
GO:0008017 microtubule binding 13.2075 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CRYAB_HUMAN
GO:0048523 negative regulation of cellular process 56.6038 4 yes
GO:0048522 positive regulation of cellular process 54.7170 4 no
GO:0060255 regulation of macromolecule metabolic process 49.0566 4 yes
GO:0080090 regulation of primary metabolic process 49.0566 4 yes
GO:0051128 regulation of cellular component organization 47.1698 4 yes
GO:0031323 regulation of cellular metabolic process 47.1698 4 yes
GO:0051049 regulation of transport 41.5094 4 yes
GO:0010646 regulation of cell communication 41.5094 4 no
GO:0051246 regulation of protein metabolic process 39.6226 5 yes
GO:0009893 positive regulation of metabolic process 39.6226 4 no
GO:0006996 organelle organization 35.8491 4 yes
GO:0009889 regulation of biosynthetic process 35.8491 4 yes
GO:0009892 negative regulation of metabolic process 35.8491 4 yes
GO:0010468 regulation of gene expression 35.8491 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 35.8491 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 35.8491 5 yes
GO:0022607 cellular component assembly 35.8491 4 yes
GO:0031326 regulation of cellular biosynthetic process 35.8491 5 yes
GO:0060341 regulation of cellular localization 33.9623 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 33.9623 5 no
GO:0008104 protein localization 33.9623 4 no
GO:0031324 negative regulation of cellular metabolic process 33.9623 5 yes
GO:0009966 regulation of signal transduction 32.0755 4 no
GO:0031325 positive regulation of cellular metabolic process 32.0755 5 no
GO:0051252 regulation of RNA metabolic process 30.1887 5 yes
GO:2001141 regulation of RNA biosynthetic process 30.1887 6 yes
GO:0006355 regulation of DNA-templated transcription 30.1887 7 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.1887 5 yes
GO:0043067 regulation of programmed cell death 30.1887 4 yes
GO:0044087 regulation of cellular component biogenesis 28.3019 4 yes
GO:0048584 positive regulation of response to stimulus 28.3019 4 no
GO:0051130 positive regulation of cellular component organization 28.3019 5 no
GO:0051240 positive regulation of multicellular organismal process 28.3019 4 no
GO:0009894 regulation of catabolic process 28.3019 4 no
GO:0009890 negative regulation of biosynthetic process 28.3019 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 28.3019 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 28.3019 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 26.4151 4 no
GO:0023056 positive regulation of signaling 26.4151 4 no
GO:0032880 regulation of protein localization 26.4151 5 no
GO:0051094 positive regulation of developmental process 26.4151 4 no
GO:0051247 positive regulation of protein metabolic process 26.4151 6 no
GO:0006796 phosphate-containing compound metabolic process 26.4151 4 no
GO:0071702 organic substance transport 26.4151 4 no
GO:0071705 nitrogen compound transport 26.4151 4 no
GO:0042981 regulation of apoptotic process 26.4151 5 yes
GO:0043933 protein-containing complex organization 26.4151 4 yes
GO:0010647 positive regulation of cell communication 24.5283 5 no
GO:0031344 regulation of cell projection organization 24.5283 5 no
GO:0045595 regulation of cell differentiation 24.5283 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 24.5283 6 no
GO:0014070 response to organic cyclic compound 24.5283 4 yes
GO:0051129 negative regulation of cellular component organization 22.6415 5 yes
GO:0009891 positive regulation of biosynthetic process 22.6415 5 no
GO:0030030 cell projection organization 22.6415 4 no
GO:0031328 positive regulation of cellular biosynthetic process 22.6415 6 no
GO:0042127 regulation of cell population proliferation 22.6415 4 no
GO:0120036 plasma membrane bounded cell projection organization 22.6415 5 no
GO:1902531 regulation of intracellular signal transduction 22.6415 5 no
GO:2000026 regulation of multicellular organismal development 22.6415 4 no
GO:0010243 response to organonitrogen compound 22.6415 4 no
GO:0071310 cellular response to organic substance 22.6415 4 no
GO:0006915 apoptotic process 22.6415 4 yes
GO:0051248 negative regulation of protein metabolic process 20.7547 6 yes
GO:0065003 protein-containing complex assembly 20.7547 5 yes
GO:1902903 regulation of supramolecular fiber organization 20.7547 5 yes
GO:0006357 regulation of transcription by RNA polymerase II 20.7547 8 no
GO:0009967 positive regulation of signal transduction 20.7547 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 20.7547 6 no
GO:0010975 regulation of neuron projection development 20.7547 7 no
GO:0019220 regulation of phosphate metabolic process 20.7547 6 no
GO:0031399 regulation of protein modification process 20.7547 6 no
GO:0032101 regulation of response to external stimulus 20.7547 4 no
GO:0045597 positive regulation of cell differentiation 20.7547 5 no
GO:0048638 regulation of developmental growth 20.7547 4 no
GO:0051174 regulation of phosphorus metabolic process 20.7547 5 no
GO:0060284 regulation of cell development 20.7547 5 no
GO:0015031 protein transport 20.7547 4 no
GO:0050804 modulation of chemical synaptic transmission 20.7547 5 no
GO:0099177 regulation of trans-synaptic signaling 20.7547 4 no
GO:0010629 negative regulation of gene expression 20.7547 7 yes
GO:0043066 negative regulation of apoptotic process 20.7547 6 yes
GO:0043069 negative regulation of programmed cell death 20.7547 5 yes
GO:0043254 regulation of protein-containing complex assembly 20.7547 5 yes
GO:0045892 negative regulation of DNA-templated transcription 18.8679 8 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 18.8679 5 yes
GO:0051253 negative regulation of RNA metabolic process 18.8679 6 yes
GO:1902679 negative regulation of RNA biosynthetic process 18.8679 7 yes
GO:0033993 response to lipid 18.8679 4 yes
GO:0051051 negative regulation of transport 16.9811 4 yes
GO:0141124 intracellular signaling cassette 16.9811 4 yes
GO:0001558 regulation of cell growth 16.9811 4 yes
GO:0007010 cytoskeleton organization 15.0943 5 yes
GO:0006936 muscle contraction 13.2075 4 yes
GO:0032386 regulation of intracellular transport 13.2075 5 yes
GO:1902904 negative regulation of supramolecular fiber organization 11.3208 6 yes
GO:0000165 MAPK cascade 11.3208 5 yes
GO:0032355 response to estradiol 11.3208 4 yes
GO:0036293 response to decreased oxygen levels 11.3208 4 yes
GO:0050821 protein stabilization 9.4340 4 yes
GO:2000377 regulation of reactive oxygen species metabolic process 9.4340 5 yes
GO:0045926 negative regulation of growth 7.5472 4 yes
GO:0007517 muscle organ development 7.5472 4 yes
GO:0030308 negative regulation of cell growth 7.5472 5 yes
GO:0031333 negative regulation of protein-containing complex assembly 7.5472 6 yes
GO:1905906 regulation of amyloid fibril formation 5.6604 6 yes
GO:2000378 negative regulation of reactive oxygen species metabolic process 5.6604 6 yes
GO:0000302 response to reactive oxygen species 5.6604 4 yes
GO:0010212 response to ionizing radiation 5.6604 4 yes
GO:0032387 negative regulation of intracellular transport 5.6604 5 yes
GO:0042542 response to hydrogen peroxide 5.6604 4 yes
GO:0051403 stress-activated MAPK cascade 3.7736 5 yes
GO:0060561 apoptotic process involved in morphogenesis 3.7736 6 yes
GO:0071478 cellular response to radiation 3.7736 4 yes
GO:0071479 cellular response to ionizing radiation 3.7736 5 yes
GO:0071480 cellular response to gamma radiation 3.7736 6 yes
GO:1902742 apoptotic process involved in development 3.7736 5 yes
GO:1905907 negative regulation of amyloid fibril formation 3.7736 7 yes
GO:0007021 tubulin complex assembly 3.7736 6 yes
GO:0010332 response to gamma radiation 3.7736 5 yes
GO:0031098 stress-activated protein kinase signaling cascade 3.7736 4 yes
GO:0031109 microtubule polymerization or depolymerization 3.7736 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PSA3_HUMAN [view interactions] Low throughput no no
LBH_HUMAN [view interactions] Low throughput no yes
DDX20_HUMAN [view interactions] Low throughput no no
SCN5A_HUMAN [view interactions] Low throughput no no
HDAC1_HUMAN [view interactions] Low throughput no no
CCND1_HUMAN [view interactions] Low throughput no yes
FBX4_HUMAN [view interactions] Low throughput no no
P53_HUMAN [view interactions] Low throughput no no
HSP74_HUMAN [view entry] [view interactions] Low throughput yes yes
BCL2_HUMAN [view interactions] Low throughput no no
CD40L_HUMAN [view interactions] Low throughput no no
FCG2A_HUMAN [view interactions] Low throughput no no
ALBU_HUMAN [view interactions] Low throughput no no
VEGFA_HUMAN [view entry] [view interactions] Low throughput yes yes
TITIN_HUMAN [view interactions] Low throughput no no
CAD16_HUMAN [view interactions] Low throughput no no
B2CL1_HUMAN [view interactions] Low throughput no yes
BAX_HUMAN [view interactions] Low throughput no yes
PAR2_HUMAN [view entry] [view interactions] Low throughput yes yes
SMAD4_HUMAN [view interactions] Low throughput no yes
TRI33_HUMAN [view interactions] Low throughput no yes
CASP6_HUMAN [view interactions] Low throughput no no
CASP7_HUMAN [view interactions] Low throughput no no
CRADD_HUMAN [view interactions] Low throughput no yes
PIDD1_HUMAN [view interactions] Low throughput no yes
CASP2_HUMAN [view interactions] Low throughput no yes
NED4L_HUMAN [view entry] [view interactions] Low throughput yes yes
PRKN_HUMAN [view entry] [view interactions] Low throughput yes yes
CLN6_HUMAN [view interactions] Low throughput no no
TM168_HUMAN [view interactions] Low throughput no yes
CISY_HUMAN [view entry] [view interactions] Low throughput yes yes
UB2D1_HUMAN [view interactions] Low throughput no yes
LALBA_HUMAN [view interactions] Low throughput no no
MDHM_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
DESM_HUMAN [view entry] [view interactions] Low throughput yes no
GFAP_HUMAN [view entry] [view interactions] Low throughput yes no
NEU2_HUMAN [view interactions] Low throughput no no
SODC_HUMAN [view interactions] Low throughput no yes
APOC2_HUMAN [view interactions] Low throughput no no
B2MG_HUMAN [view interactions] Low throughput no yes
HBA_HUMAN [view interactions] Low throughput no no
HSPB6_HUMAN [view interactions] Low throughput no no
LYSC_HUMAN [view interactions] Low throughput no no
MIP_HUMAN [view interactions] Low throughput no no
FGF2_HUMAN [view entry] [view interactions] Low throughput yes yes
NGF_HUMAN [view interactions] Low throughput no no
INS_HUMAN [view interactions] Low throughput no no
SQSTM_HUMAN [view interactions] Low throughput no yes
OGA_HUMAN [view interactions] Low throughput no yes
CRGC_HUMAN [view interactions] Low throughput no no
CRBB2_HUMAN [view interactions] Low throughput no no
STAT3_HUMAN [view entry] [view interactions] Low throughput yes yes
HSPB8_HUMAN [view entry] [view interactions] Low throughput yes yes
TM109_HUMAN [view interactions] Low throughput no yes
CRYAA_HUMAN [view interactions] Low throughput no no
CRYAB_HUMAN [view entry] [view interactions] Low throughput yes no
HSPB2_HUMAN [view interactions] Low throughput no yes
HSPB1_HUMAN [view entry] [view interactions] Low throughput yes no
BAG3_HUMAN [view entry] [view interactions] Low throughput yes no
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
CADH1_HUMAN [view entry] [view interactions] Low throughput yes no
CASP3_HUMAN [view entry] [view interactions] Low throughput yes yes
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
CRGD_HUMAN [view interactions] Low throughput no no
CRBA1_HUMAN [view interactions] Low throughput no no
CRYGS_HUMAN [view interactions] Low throughput no no
CRBB1_HUMAN [view interactions] Low throughput no no
MDC1_HUMAN [view interactions] High throughput no yes
AAKG3_HUMAN [view interactions] High throughput no no
BACH_HUMAN [view entry] [view interactions] High throughput yes yes
TNPO2_HUMAN [view interactions] High throughput no yes
RM11_HUMAN [view interactions] High throughput no yes
TPC6A_HUMAN [view interactions] High throughput no yes
KRA81_HUMAN [view interactions] High throughput no no
KR195_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
PSMD4_HUMAN [view interactions] High throughput no yes
DMD_HUMAN [view entry] [view interactions] High throughput yes no
ASB5_HUMAN [view interactions] High throughput no no
CASP8_HUMAN [view interactions] High throughput no yes
CASP9_HUMAN [view interactions] High throughput no yes
CASPC_HUMAN [view interactions] High throughput no no
XIAP_HUMAN [view interactions] High throughput no yes
IQGA3_HUMAN [view interactions] High throughput no no
GOPC_HUMAN [view entry] [view interactions] High throughput yes yes
NFL_HUMAN [view entry] [view interactions] High throughput yes yes
TPC2A_HUMAN [view interactions] High throughput no yes
FBX21_HUMAN [view interactions] High throughput no yes
VP33A_HUMAN [view entry] [view interactions] High throughput yes no
LENG8_HUMAN [view interactions] High throughput no yes
C2D1A_HUMAN [view entry] [view interactions] High throughput yes yes
TPPC9_HUMAN [view entry] [view interactions] High throughput yes no
FA83D_HUMAN [view interactions] High throughput no no
GPBP1_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
G3BP1_HUMAN [view interactions] High throughput no yes
TEDC2_HUMAN [view interactions] High throughput no no
NHLC2_HUMAN [view interactions] High throughput no yes
FBX6_HUMAN [view interactions] High throughput no yes
SIA7F_HUMAN [view interactions] High throughput no yes
FNDC1_HUMAN [view interactions] High throughput no yes
SRRT_HUMAN [view interactions] High throughput no yes
PXL2A_HUMAN [view interactions] High throughput no yes
RSH6A_HUMAN [view interactions] High throughput no no
AMPD2_HUMAN [view entry] [view interactions] High throughput yes yes
PTSS1_HUMAN [view interactions] High throughput no no
STX17_HUMAN [view interactions] High throughput no yes
S2532_HUMAN [view interactions] High throughput no yes
FSTL1_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
ANXA9_HUMAN [view interactions] High throughput no yes
ISCA2_HUMAN [view interactions] High throughput no yes
P2RX6_HUMAN [view entry] [view interactions] High throughput yes no
LATS1_HUMAN [view entry] [view interactions] High throughput yes yes
7B2_HUMAN [view interactions] High throughput no yes
ADT3_HUMAN [view entry] [view interactions] High throughput yes yes
PEMT_HUMAN [view interactions] High throughput no yes
CCR1_HUMAN [view interactions] High throughput no no
IQUB_HUMAN [view interactions] High throughput no no
PLCA_HUMAN [view interactions] High throughput no yes
TMM31_HUMAN [view interactions] High throughput no no
FOXN3_HUMAN [view interactions] High throughput no yes
SSUH2_HUMAN [view interactions] High throughput no no
PLD5_HUMAN [view interactions] High throughput no no
ZC3C1_HUMAN [view interactions] High throughput no yes
CGAT1_HUMAN [view interactions] High throughput no no
ZDH19_HUMAN [view interactions] High throughput no no
FOS_HUMAN [view interactions] High throughput no yes
PHF11_HUMAN [view interactions] High throughput no no
KITH_HUMAN [view interactions] High throughput no yes
TSN33_HUMAN [view interactions] High throughput no no
CR021_HUMAN [view interactions] High throughput no no
THB_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
RN207_HUMAN [view interactions] High throughput no no
S13A1_HUMAN [view interactions] High throughput no no
DHSO_HUMAN [view interactions] High throughput no no
MBP_HUMAN [view entry] [view interactions] High throughput yes no
DYN1_HUMAN [view entry] [view interactions] High throughput yes yes
NSF_HUMAN [view entry] [view interactions] High throughput yes yes
KBTB4_HUMAN [view interactions] High throughput no yes
PLCG2_HUMAN [view interactions] High throughput no yes
ALDOA_HUMAN [view entry] [view interactions] High throughput yes no
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
GLUT4_HUMAN [view interactions] High throughput no no
CE290_HUMAN [view interactions] High throughput no no
FTM_HUMAN [view interactions] High throughput no yes
NPHP4_HUMAN [view interactions] High throughput no yes
MAS_HUMAN [view interactions] High throughput no no
CC85C_HUMAN [view interactions] High throughput no yes
MAP1B_HUMAN [view entry] [view interactions] High throughput yes yes
GEMI4_HUMAN [view interactions] High throughput no yes
CC85B_HUMAN [view interactions] High throughput no yes
HNRL2_HUMAN [view interactions] High throughput no yes
SMCR8_HUMAN [view interactions] High throughput no yes
SEH1_HUMAN [view interactions] High throughput no no
TIRR_HUMAN [view interactions] High throughput no no
NYNRI_HUMAN [view interactions] High throughput no no
CDC23_HUMAN [view interactions] High throughput no yes
PRLD1_HUMAN [view interactions] High throughput no yes
PI4KA_HUMAN [view entry] [view interactions] High throughput yes yes
GMCL1_HUMAN [view interactions] High throughput no yes
FCF1_HUMAN [view interactions] High throughput no yes
OAZ3_HUMAN [view interactions] High throughput no no
RBM24_HUMAN [view interactions] High throughput no yes
TFG_HUMAN [view interactions] High throughput no yes
GDF5_HUMAN [view interactions] High throughput no no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
KPCE_HUMAN [view entry] [view interactions] High throughput yes yes
BMPR2_HUMAN [view entry] [view interactions] High throughput yes yes
TRI54_HUMAN [view interactions] High throughput no no
TEX14_HUMAN [view interactions] High throughput no no
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
CAV3_HUMAN [view interactions] High throughput no no
MYPC3_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
CCL22_HUMAN [view interactions] High throughput no no
KRA61_HUMAN [view interactions] High throughput no no
GORS2_HUMAN [view interactions] High throughput no yes
ANXA4_HUMAN [view interactions] High throughput no no
DPYL1_HUMAN [view entry] [view interactions] High throughput yes yes
PRPS1_HUMAN [view entry] [view interactions] High throughput yes no
EXOC5_HUMAN [view entry] [view interactions] High throughput yes yes
PRUN2_HUMAN [view entry] [view interactions] High throughput yes yes
TLR9_HUMAN [view interactions] High throughput no no
FOXD4_HUMAN [view interactions] High throughput no no
RB40B_HUMAN [view interactions] High throughput no no
IFT22_HUMAN [view interactions] High throughput no yes
CAN3_HUMAN [view interactions] High throughput no no
TIAM1_HUMAN [view entry] [view interactions] High throughput yes yes
RBM11_HUMAN [view interactions] High throughput no no
PCNA_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes