C2D1A_HUMAN
Evidence for PS localization
Functions
Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses . Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in C2D1A_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 34.0426 | 4 | no |
| GO:0000166 | nucleotide binding | 31.9149 | 4 | no |
| GO:0017076 | purine nucleotide binding | 31.9149 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 31.9149 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 31.9149 | 4 | no |
| GO:0043169 | cation binding | 23.4043 | 4 | no |
| GO:0046872 | metal ion binding | 23.4043 | 5 | no |
| GO:0019900 | kinase binding | 21.2766 | 4 | no |
| GO:0045296 | cadherin binding | 8.5106 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in C2D1A_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 63.8298 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 59.5745 | 4 | no |
| GO:0008104 | protein localization | 57.4468 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 53.1915 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 53.1915 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 51.0638 | 4 | yes |
| GO:0006996 | organelle organization | 48.9362 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 44.6809 | 4 | yes |
| GO:0051049 | regulation of transport | 44.6809 | 4 | no |
| GO:0022607 | cellular component assembly | 42.5532 | 4 | no |
| GO:0010646 | regulation of cell communication | 42.5532 | 4 | yes |
| GO:0071702 | organic substance transport | 40.4255 | 4 | no |
| GO:0071705 | nitrogen compound transport | 40.4255 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 40.4255 | 4 | yes |
| GO:0010468 | regulation of gene expression | 40.4255 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.4255 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 40.4255 | 5 | yes |
| GO:0015031 | protein transport | 38.2979 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 36.1702 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 34.0426 | 4 | no |
| GO:0060341 | regulation of cellular localization | 34.0426 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.9149 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 31.9149 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.7872 | 5 | no |
| GO:0009966 | regulation of signal transduction | 29.7872 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 29.7872 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 29.7872 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 27.6596 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.6596 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 25.5319 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 25.5319 | 4 | no |
| GO:0033043 | regulation of organelle organization | 25.5319 | 5 | no |
| GO:0006886 | intracellular protein transport | 25.5319 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.5319 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 23.4043 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 23.4043 | 4 | no |
| GO:0007010 | cytoskeleton organization | 23.4043 | 5 | no |
| GO:0141124 | intracellular signaling cassette | 23.4043 | 4 | no |
| GO:2000145 | regulation of cell motility | 23.4043 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 23.4043 | 4 | no |
| GO:0030030 | cell projection organization | 23.4043 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 23.4043 | 5 | no |
| GO:0032880 | regulation of protein localization | 23.4043 | 5 | no |
| GO:0071310 | cellular response to organic substance | 23.4043 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 23.4043 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.4043 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.4043 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.4043 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 21.2766 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 21.2766 | 5 | no |
| GO:0009894 | regulation of catabolic process | 21.2766 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.2766 | 6 | no |
| GO:0065003 | protein-containing complex assembly | 21.2766 | 5 | no |
| GO:0030334 | regulation of cell migration | 21.2766 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.2766 | 6 | no |
| GO:0051726 | regulation of cell cycle | 21.2766 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 21.2766 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 21.2766 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 21.2766 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 21.2766 | 6 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 21.2766 | 6 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 19.1489 | 6 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 19.1489 | 7 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 14.8936 | 6 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 10.6383 | 8 | yes |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 8.5106 | 5 | yes |
| GO:0045892 | negative regulation of DNA-templated transcription | 6.3830 | 8 | yes |
| GO:0051253 | negative regulation of RNA metabolic process | 6.3830 | 6 | yes |
| GO:1902679 | negative regulation of RNA biosynthetic process | 6.3830 | 7 | yes |
| GO:0043122 | regulation of canonical NF-kappaB signal transduction | 4.2553 | 6 | yes |
| GO:0043123 | positive regulation of canonical NF-kappaB signal transduction | 4.2553 | 7 | yes |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | 4.2553 | 9 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| LRP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| SPICE_HUMAN | [view interactions] | High throughput | no | yes |
| CEP44_HUMAN | [view interactions] | High throughput | no | yes |
| ST38L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| CPEB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| NCOA2_HUMAN | [view interactions] | High throughput | no | no |
| TSN3_HUMAN | [view interactions] | High throughput | no | yes |
| CRYAB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EAA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRAP2_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| BACH1_HUMAN | [view interactions] | High throughput | no | no |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| MTMR4_HUMAN | [view interactions] | High throughput | no | no |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| F184A_HUMAN | [view interactions] | High throughput | no | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| PPAL_HUMAN | [view interactions] | High throughput | no | no |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CRYAA_HUMAN | [view interactions] | High throughput | no | no |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| LDAF1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| RN149_HUMAN | [view interactions] | High throughput | no | no |
| COPT1_HUMAN | [view interactions] | High throughput | no | no |
| TEBP_HUMAN | [view interactions] | High throughput | no | yes |
| HAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD3_HUMAN | [view interactions] | High throughput | no | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| LRWD1_HUMAN | [view interactions] | High throughput | no | no |
| CAVN2_HUMAN | [view interactions] | High throughput | no | no |
| H2AX_HUMAN | [view interactions] | High throughput | no | yes |
| RL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL31_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOLC1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRL2_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF8_HUMAN | [view interactions] | High throughput | no | yes |
| CAVN1_HUMAN | [view interactions] | High throughput | no | no |
| TM10C_HUMAN | [view interactions] | High throughput | no | yes |
| MIER1_HUMAN | [view interactions] | High throughput | no | no |
| H2A1J_HUMAN | [view interactions] | High throughput | no | yes |
| IMUP_HUMAN | [view interactions] | High throughput | no | yes |
| S30BP_HUMAN | [view interactions] | High throughput | no | yes |
| ACINU_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
| TR150_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| Z3H7A_HUMAN | [view interactions] | High throughput | no | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPEB4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTIF_HUMAN | [view interactions] | High throughput | no | yes |
| MEX3B_HUMAN | [view interactions] | High throughput | no | no |
| ENTR1_HUMAN | [view interactions] | High throughput | no | no |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| ZO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| TRI36_HUMAN | [view interactions] | High throughput | no | no |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| ZFY16_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
| ARL10_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4A_HUMAN | [view interactions] | High throughput | no | no |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2B1H_HUMAN | [view interactions] | High throughput | no | yes |
| MEX3C_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| CE162_HUMAN | [view interactions] | High throughput | no | yes |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| CNTRL_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| FBF1_HUMAN | [view interactions] | High throughput | no | no |
| CEP19_HUMAN | [view interactions] | High throughput | no | no |
| CEP89_HUMAN | [view interactions] | High throughput | no | no |
| MKS1_HUMAN | [view interactions] | High throughput | no | no |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| CE104_HUMAN | [view interactions] | High throughput | no | yes |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| CEP43_HUMAN | [view interactions] | High throughput | no | no |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIL_HUMAN | [view interactions] | High throughput | no | no |