Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

C2D1A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses . Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in C2D1A_HUMAN
GO:0017076 purine nucleotide binding 29.7297 4 no
GO:0032555 purine ribonucleotide binding 29.7297 4 no
GO:0035639 purine ribonucleoside triphosphate binding 29.7297 4 no
GO:0046872 metal ion binding 27.0270 4 no
GO:0019900 kinase binding 27.0270 4 no
GO:0019901 protein kinase binding 27.0270 5 no
GO:0045296 cadherin binding 10.8108 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in C2D1A_HUMAN
GO:0048522 positive regulation of cellular process 67.5676 4 yes
GO:0051128 regulation of cellular component organization 62.1622 4 no
GO:0008104 protein localization 59.4595 4 no
GO:0060255 regulation of macromolecule metabolic process 56.7568 4 yes
GO:0031323 regulation of cellular metabolic process 54.0541 4 yes
GO:0006996 organelle organization 54.0541 4 no
GO:0051049 regulation of transport 54.0541 4 no
GO:0048523 negative regulation of cellular process 51.3514 4 yes
GO:0080090 regulation of primary metabolic process 51.3514 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 48.6486 4 yes
GO:0016192 vesicle-mediated transport 45.9459 4 no
GO:0022607 cellular component assembly 43.2432 4 no
GO:0071702 organic substance transport 43.2432 4 no
GO:0071705 nitrogen compound transport 43.2432 4 no
GO:0010646 regulation of cell communication 40.5405 4 yes
GO:0015031 protein transport 40.5405 4 no
GO:0051246 regulation of protein metabolic process 40.5405 5 no
GO:0010468 regulation of gene expression 37.8378 5 yes
GO:1901701 cellular response to oxygen-containing compound 35.1351 4 no
GO:0009893 positive regulation of metabolic process 35.1351 4 no
GO:0010604 positive regulation of macromolecule metabolic process 35.1351 5 no
GO:0071310 cellular response to organic substance 35.1351 4 no
GO:0010243 response to organonitrogen compound 32.4324 4 no
GO:0060341 regulation of cellular localization 32.4324 4 no
GO:0009966 regulation of signal transduction 29.7297 4 yes
GO:0048584 positive regulation of response to stimulus 29.7297 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 29.7297 5 no
GO:0071417 cellular response to organonitrogen compound 29.7297 4 no
GO:1901699 cellular response to nitrogen compound 29.7297 4 no
GO:0006886 intracellular protein transport 29.7297 4 no
GO:0009889 regulation of biosynthetic process 27.0270 4 yes
GO:0009892 negative regulation of metabolic process 27.0270 4 yes
GO:0010647 positive regulation of cell communication 27.0270 5 yes
GO:0023056 positive regulation of signaling 27.0270 4 yes
GO:0031326 regulation of cellular biosynthetic process 27.0270 5 yes
GO:0031325 positive regulation of cellular metabolic process 27.0270 5 no
GO:0007010 cytoskeleton organization 27.0270 5 no
GO:0033043 regulation of organelle organization 27.0270 5 no
GO:0060627 regulation of vesicle-mediated transport 27.0270 4 no
GO:0010556 regulation of macromolecule biosynthetic process 24.3243 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 24.3243 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 24.3243 5 yes
GO:0043933 protein-containing complex organization 24.3243 4 no
GO:0032880 regulation of protein localization 24.3243 5 no
GO:0044087 regulation of cellular component biogenesis 24.3243 4 no
GO:0051050 positive regulation of transport 24.3243 4 no
GO:0051726 regulation of cell cycle 24.3243 4 no
GO:0009967 positive regulation of signal transduction 21.6216 5 yes
GO:0051252 regulation of RNA metabolic process 21.6216 5 yes
GO:0010941 regulation of cell death 21.6216 4 no
GO:0050804 modulation of chemical synaptic transmission 21.6216 5 no
GO:0099177 regulation of trans-synaptic signaling 21.6216 4 no
GO:0065003 protein-containing complex assembly 21.6216 5 no
GO:0045595 regulation of cell differentiation 21.6216 4 no
GO:0030030 cell projection organization 21.6216 4 no
GO:0030334 regulation of cell migration 21.6216 5 no
GO:0051493 regulation of cytoskeleton organization 21.6216 6 no
GO:2000145 regulation of cell motility 21.6216 4 no
GO:0016050 vesicle organization 21.6216 5 no
GO:0031344 regulation of cell projection organization 21.6216 5 no
GO:0051130 positive regulation of cellular component organization 21.6216 5 no
GO:0031324 negative regulation of cellular metabolic process 18.9189 5 yes
GO:0006355 regulation of DNA-templated transcription 16.2162 6 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 16.2162 5 yes
GO:1902531 regulation of intracellular signal transduction 16.2162 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 16.2162 7 yes
GO:2001141 regulation of RNA biosynthetic process 16.2162 6 yes
GO:1902533 positive regulation of intracellular signal transduction 13.5135 6 yes
GO:0009890 negative regulation of biosynthetic process 10.8108 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 10.8108 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 10.8108 6 yes
GO:0006357 regulation of transcription by RNA polymerase II 5.4054 7 yes
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 5.4054 6 yes
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 5.4054 7 yes
GO:0045892 negative regulation of DNA-templated transcription 5.4054 7 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 5.4054 6 yes
GO:0051253 negative regulation of RNA metabolic process 5.4054 6 yes
GO:1902679 negative regulation of RNA biosynthetic process 5.4054 7 yes
GO:1903507 negative regulation of nucleic acid-templated transcription 5.4054 8 yes

Disease

Term Name % Distance from top the of the tree Annotated in C2D1A_HUMAN
DOID:37 skin disease 5.4054 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
LRP1_HUMAN [view entry] [view interactions] Low throughput yes yes
MLP3A_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
CDC37_HUMAN [view interactions] High throughput no yes
CHM4A_HUMAN [view interactions] High throughput no no
CHM4C_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
MIC60_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
H2B1H_HUMAN [view interactions] High throughput no yes
MEX3C_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
JUN_HUMAN [view interactions] High throughput no yes
OFD1_HUMAN [view interactions] High throughput no yes
PCM1_HUMAN [view interactions] High throughput no yes
CE170_HUMAN [view interactions] High throughput no yes
CE162_HUMAN [view interactions] High throughput no yes
CE128_HUMAN [view interactions] High throughput no yes
CNTRL_HUMAN [view interactions] High throughput no yes
NIN_HUMAN [view interactions] High throughput no no
FBF1_HUMAN [view interactions] High throughput no no
CEP19_HUMAN [view interactions] High throughput no no
CEP89_HUMAN [view interactions] High throughput no no
MKS1_HUMAN [view interactions] High throughput no no
NINL_HUMAN [view interactions] High throughput no yes
CE104_HUMAN [view interactions] High throughput no yes
CE152_HUMAN [view interactions] High throughput no yes
CEP43_HUMAN [view interactions] High throughput no no
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
STIL_HUMAN [view interactions] High throughput no no
CP135_HUMAN [view interactions] High throughput no no
SPICE_HUMAN [view interactions] High throughput no yes
CEP44_HUMAN [view interactions] High throughput no yes
ST38L_HUMAN [view entry] [view interactions] High throughput yes yes
NECD_HUMAN [view interactions] High throughput no no
CPEB1_HUMAN [view entry] [view interactions] High throughput yes no
FGFR1_HUMAN [view interactions] High throughput no yes
FGFR4_HUMAN [view interactions] High throughput no no
LMTK1_HUMAN [view interactions] High throughput no yes
NCOA2_HUMAN [view interactions] High throughput no no
TSN3_HUMAN [view interactions] High throughput no yes
CRYAB_HUMAN [view entry] [view interactions] High throughput yes no
EAA3_HUMAN [view entry] [view interactions] High throughput yes yes
MRAP2_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
BACH1_HUMAN [view interactions] High throughput no no
APEX1_HUMAN [view interactions] High throughput no yes
MTMR4_HUMAN [view interactions] High throughput no no
CSN5_HUMAN [view interactions] High throughput no yes
F184A_HUMAN [view interactions] High throughput no no
DDX58_HUMAN [view interactions] High throughput no yes
UBQL2_HUMAN [view interactions] High throughput no yes
PPAL_HUMAN [view interactions] High throughput no no
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
CRYAA_HUMAN [view interactions] High throughput no no
FRIL_HUMAN [view interactions] High throughput no yes
LDAF1_HUMAN [view interactions] High throughput no yes
CAV1_HUMAN [view interactions] High throughput no no
RN149_HUMAN [view interactions] High throughput no no
COPT1_HUMAN [view interactions] High throughput no no
TEBP_HUMAN [view interactions] High throughput no yes
HAP1_HUMAN [view entry] [view interactions] High throughput yes yes
BRD3_HUMAN [view interactions] High throughput no yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
LRWD1_HUMAN [view interactions] High throughput no no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
Z3H7A_HUMAN [view interactions] High throughput no no
BICD1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
HOOK1_HUMAN [view interactions] High throughput no no
HOOK3_HUMAN [view entry] [view interactions] High throughput yes yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
CPEB4_HUMAN [view entry] [view interactions] High throughput yes no
CTIF_HUMAN [view interactions] High throughput no yes
MEX3B_HUMAN [view interactions] High throughput no no
ENTR1_HUMAN [view interactions] High throughput no no
UNK_HUMAN [view interactions] High throughput no yes
DNJC1_HUMAN [view interactions] High throughput no yes
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
ANFY1_HUMAN [view entry] [view interactions] High throughput yes yes
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
RCAS1_HUMAN [view interactions] High throughput no yes
EMD_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
IMDH2_HUMAN [view interactions] High throughput no yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
PARD3_HUMAN [view interactions] High throughput no yes
PEX14_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
SQSTM_HUMAN [view interactions] High throughput no yes
STX4_HUMAN [view entry] [view interactions] High throughput yes no
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
SYNE3_HUMAN [view interactions] High throughput no no
ZO2_HUMAN [view entry] [view interactions] High throughput yes no
LAP2A_HUMAN [view interactions] High throughput no yes
TRI36_HUMAN [view interactions] High throughput no no
VIME_HUMAN [view entry] [view interactions] High throughput yes no
NAA40_HUMAN [view interactions] High throughput no no
IFM1_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no