HAP1_HUMAN
Evidence for PS localization
Functions
Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to facilitate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptors to synapses; the function is dependent on kinesin motor protein KIF5 and is disrupted by HTT with expanded polyglutamine repeat. Involved in regulation of autophagosome motility by promoting efficient retrograde axonal transport. Seems to be involved in regulation of membrane receptor recycling and degradation, and respective signal transduction, including GABA(A) receptors, tyrosine kinase receptors, EGFR, IP3 receptor and androgen receptor. Among others suggested to be involved in control of feeding behavior (involving hypothalamic GABA(A) receptors), cerebellar and brainstem development (involving AHI1 and NTRK1/TrkA), postnatal neurogenesis (involving hypothalamic NTRK2/TrkB), and ITPR1/InsP3R1-mediated Ca(2+) release (involving HTT and possibly the effect of mutant HTT). Via association with DCTN1/dynactin p150-glued and HTT/huntingtin involved in cytoplasmic retention of REST in neurons. May be involved in ciliogenesis. Involved in regulation of exocytosis. Seems to be involved in formation of cytoplasmic inclusion bodies (STBs). In case of anomalous expression of TBP, can sequester a subset of TBP into STBs; sequestration is enhanced by an expanded polyglutamine repeat within TBP. HAP1-containing STBs have been proposed to play a protective role against neurodegeneration in Huntigton disease (HD) and spinocerebellar ataxia 17 (SCA17). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in HAP1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 29.3103 | 4 | no |
| GO:0000166 | nucleotide binding | 27.5862 | 4 | no |
| GO:0017076 | purine nucleotide binding | 27.5862 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 25.8621 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 25.8621 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.8621 | 4 | no |
| GO:0003723 | RNA binding | 25.8621 | 4 | no |
| GO:0005524 | ATP binding | 24.1379 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 24.1379 | 5 | no |
| GO:0017022 | myosin binding | 3.4483 | 4 | yes |
| GO:0043121 | neurotrophin binding | 3.4483 | 4 | yes |
| GO:0048403 | brain-derived neurotrophic factor binding | 3.4483 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in HAP1_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 44.8276 | 4 | yes |
| GO:0006996 | organelle organization | 44.8276 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 44.8276 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 41.3793 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 39.6552 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 34.4828 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 32.7586 | 4 | no |
| GO:0010468 | regulation of gene expression | 32.7586 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 32.7586 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 32.7586 | 5 | no |
| GO:0008104 | protein localization | 32.7586 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 31.0345 | 5 | yes |
| GO:0010646 | regulation of cell communication | 31.0345 | 4 | yes |
| GO:0051049 | regulation of transport | 31.0345 | 4 | yes |
| GO:0022607 | cellular component assembly | 27.5862 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 27.5862 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.5862 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 25.8621 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.8621 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 25.8621 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 24.1379 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 24.1379 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 24.1379 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 24.1379 | 6 | no |
| GO:0071702 | organic substance transport | 24.1379 | 4 | no |
| GO:0071705 | nitrogen compound transport | 24.1379 | 4 | no |
| GO:0009966 | regulation of signal transduction | 24.1379 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 22.4138 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.4138 | 5 | no |
| GO:0015031 | protein transport | 22.4138 | 4 | no |
| GO:0009894 | regulation of catabolic process | 20.6897 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 20.6897 | 7 | no |
| GO:0071310 | cellular response to organic substance | 20.6897 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.6897 | 4 | yes |
| GO:0051050 | positive regulation of transport | 20.6897 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 18.9655 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 18.9655 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 18.9655 | 5 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 17.2414 | 6 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 17.2414 | 4 | yes |
| GO:1903530 | regulation of secretion by cell | 17.2414 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 17.2414 | 5 | yes |
| GO:0030030 | cell projection organization | 17.2414 | 4 | yes |
| GO:0051046 | regulation of secretion | 17.2414 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 17.2414 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 15.5172 | 4 | yes |
| GO:0010638 | positive regulation of organelle organization | 15.5172 | 6 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 15.5172 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 15.5172 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 15.5172 | 4 | yes |
| GO:0051650 | establishment of vesicle localization | 13.7931 | 4 | yes |
| GO:0060284 | regulation of cell development | 13.7931 | 5 | yes |
| GO:0007005 | mitochondrion organization | 13.7931 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 13.7931 | 5 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 13.7931 | 4 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 13.7931 | 5 | yes |
| GO:0099111 | microtubule-based transport | 12.0690 | 4 | yes |
| GO:0010970 | transport along microtubule | 12.0690 | 4 | yes |
| GO:0017157 | regulation of exocytosis | 12.0690 | 5 | yes |
| GO:0051094 | positive regulation of developmental process | 12.0690 | 4 | yes |
| GO:0072384 | organelle transport along microtubule | 10.3448 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 10.3448 | 4 | yes |
| GO:0099518 | vesicle cytoskeletal trafficking | 10.3448 | 5 | yes |
| GO:0032886 | regulation of microtubule-based process | 10.3448 | 4 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 10.3448 | 5 | yes |
| GO:0045597 | positive regulation of cell differentiation | 10.3448 | 5 | yes |
| GO:0047496 | vesicle transport along microtubule | 10.3448 | 5 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 10.3448 | 5 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 8.6207 | 6 | yes |
| GO:0098930 | axonal transport | 8.6207 | 6 | yes |
| GO:0099536 | synaptic signaling | 8.6207 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 8.6207 | 5 | yes |
| GO:1902115 | regulation of organelle assembly | 8.6207 | 5 | yes |
| GO:0006605 | protein targeting | 8.6207 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 8.6207 | 7 | yes |
| GO:0008088 | axo-dendritic transport | 8.6207 | 5 | yes |
| GO:0008089 | anterograde axonal transport | 8.6207 | 7 | yes |
| GO:0010959 | regulation of metal ion transport | 8.6207 | 6 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 8.6207 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 8.6207 | 5 | yes |
| GO:0032386 | regulation of intracellular transport | 8.6207 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 8.6207 | 4 | yes |
| GO:0043270 | positive regulation of monoatomic ion transport | 8.6207 | 5 | yes |
| GO:0051282 | regulation of sequestering of calcium ion | 6.8966 | 4 | yes |
| GO:0051924 | regulation of calcium ion transport | 6.8966 | 7 | yes |
| GO:0051960 | regulation of nervous system development | 6.8966 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 6.8966 | 6 | yes |
| GO:1901019 | regulation of calcium ion transmembrane transporter activity | 6.8966 | 6 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 6.8966 | 7 | yes |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 6.8966 | 6 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 6.8966 | 4 | yes |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 6.8966 | 5 | yes |
| GO:0008090 | retrograde axonal transport | 6.8966 | 7 | yes |
| GO:0010720 | positive regulation of cell development | 6.8966 | 6 | yes |
| GO:0031346 | positive regulation of cell projection organization | 6.8966 | 6 | yes |
| GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 6.8966 | 5 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 6.8966 | 5 | yes |
| GO:0046903 | secretion | 6.8966 | 4 | yes |
| GO:0050767 | regulation of neurogenesis | 6.8966 | 6 | yes |
| GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 5.1724 | 5 | yes |
| GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | 5.1724 | 6 | yes |
| GO:0051654 | establishment of mitochondrion localization | 5.1724 | 4 | yes |
| GO:0051928 | positive regulation of calcium ion transport | 5.1724 | 6 | yes |
| GO:0060491 | regulation of cell projection assembly | 5.1724 | 5 | yes |
| GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 5.1724 | 6 | yes |
| GO:0120034 | positive regulation of plasma membrane bounded cell projection assembly | 5.1724 | 6 | yes |
| GO:1901021 | positive regulation of calcium ion transmembrane transporter activity | 5.1724 | 6 | yes |
| GO:1902017 | regulation of cilium assembly | 5.1724 | 6 | yes |
| GO:1902117 | positive regulation of organelle assembly | 5.1724 | 6 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 5.1724 | 7 | yes |
| GO:1904427 | positive regulation of calcium ion transmembrane transport | 5.1724 | 7 | yes |
| GO:2001257 | regulation of cation channel activity | 5.1724 | 6 | yes |
| GO:2001259 | positive regulation of cation channel activity | 5.1724 | 6 | yes |
| GO:0007420 | brain development | 5.1724 | 4 | yes |
| GO:0022008 | neurogenesis | 5.1724 | 4 | yes |
| GO:0031585 | regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity | 5.1724 | 6 | yes |
| GO:0031587 | positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity | 5.1724 | 6 | yes |
| GO:0032228 | regulation of synaptic transmission, GABAergic | 5.1724 | 6 | yes |
| GO:0032230 | positive regulation of synaptic transmission, GABAergic | 5.1724 | 6 | yes |
| GO:0032411 | positive regulation of transporter activity | 5.1724 | 4 | yes |
| GO:0032414 | positive regulation of ion transmembrane transporter activity | 5.1724 | 5 | yes |
| GO:0034643 | establishment of mitochondrion localization, microtubule-mediated | 5.1724 | 4 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 5.1724 | 5 | yes |
| GO:0034767 | positive regulation of monoatomic ion transmembrane transport | 5.1724 | 6 | yes |
| GO:0045724 | positive regulation of cilium assembly | 5.1724 | 7 | yes |
| GO:0047497 | mitochondrion transport along microtubule | 5.1724 | 5 | yes |
| GO:0048311 | mitochondrion distribution | 5.1724 | 4 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 5.1724 | 5 | yes |
| GO:0051962 | positive regulation of nervous system development | 3.4483 | 5 | yes |
| GO:0060632 | regulation of microtubule-based movement | 3.4483 | 5 | yes |
| GO:0098957 | anterograde axonal transport of mitochondrion | 3.4483 | 7 | yes |
| GO:1901184 | regulation of ERBB signaling pathway | 3.4483 | 5 | yes |
| GO:1901186 | positive regulation of ERBB signaling pathway | 3.4483 | 6 | yes |
| GO:1902003 | regulation of amyloid-beta formation | 3.4483 | 5 | yes |
| GO:1902430 | negative regulation of amyloid-beta formation | 3.4483 | 6 | yes |
| GO:1902513 | regulation of organelle transport along microtubule | 3.4483 | 6 | yes |
| GO:1902855 | regulation of non-motile cilium assembly | 3.4483 | 7 | yes |
| GO:1902857 | positive regulation of non-motile cilium assembly | 3.4483 | 8 | yes |
| GO:1902991 | regulation of amyloid precursor protein catabolic process | 3.4483 | 6 | yes |
| GO:1902992 | negative regulation of amyloid precursor protein catabolic process | 3.4483 | 7 | yes |
| GO:0019896 | axonal transport of mitochondrion | 3.4483 | 6 | yes |
| GO:0021979 | hypothalamus cell differentiation | 3.4483 | 4 | yes |
| GO:0032899 | regulation of neurotrophin production | 3.4483 | 4 | yes |
| GO:0032901 | positive regulation of neurotrophin production | 3.4483 | 5 | yes |
| GO:0034248 | regulation of amide metabolic process | 3.4483 | 4 | yes |
| GO:0034249 | negative regulation of amide metabolic process | 3.4483 | 5 | yes |
| GO:0038179 | neurotrophin signaling pathway | 3.4483 | 4 | yes |
| GO:0042058 | regulation of epidermal growth factor receptor signaling pathway | 3.4483 | 6 | yes |
| GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway | 3.4483 | 7 | yes |
| GO:0048011 | neurotrophin TRK receptor signaling pathway | 3.4483 | 5 | yes |
| GO:0050769 | positive regulation of neurogenesis | 3.4483 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GRIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PCM1_HUMAN | [view interactions] | Low throughput | no | yes |
| NFM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIF5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HGS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KALRN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AHI1_HUMAN | [view interactions] | Low throughput | no | yes |
| ATX3_HUMAN | [view interactions] | Low throughput | no | yes |
| KINH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KLC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KIF5C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITPR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KLC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBRB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DC1I1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SORT_HUMAN | [view interactions] | Low throughput | no | yes |
| NDF1_HUMAN | [view interactions] | Low throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CLCB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BDNF_HUMAN | [view interactions] | Low throughput | no | yes |
| HSP74_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BARD1_HUMAN | [view interactions] | High throughput | no | yes |
| LRIF1_HUMAN | [view interactions] | High throughput | no | yes |
| CE126_HUMAN | [view interactions] | High throughput | no | no |
| ZN33B_HUMAN | [view interactions] | High throughput | no | no |
| TBP_HUMAN | [view interactions] | High throughput | no | yes |
| CG025_HUMAN | [view interactions] | High throughput | no | yes |
| CH033_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAF1D_HUMAN | [view interactions] | High throughput | no | yes |
| TNNT1_HUMAN | [view interactions] | High throughput | no | no |
| MECP2_HUMAN | [view interactions] | High throughput | no | yes |
| ZMAT2_HUMAN | [view interactions] | High throughput | no | yes |
| CDK18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FA50B_HUMAN | [view interactions] | High throughput | no | yes |
| ZN490_HUMAN | [view interactions] | High throughput | no | no |
| CTSRT_HUMAN | [view interactions] | High throughput | no | no |
| ZN124_HUMAN | [view interactions] | High throughput | no | no |
| PRP31_HUMAN | [view interactions] | High throughput | no | yes |
| CA216_HUMAN | [view interactions] | High throughput | no | yes |
| PKN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN648_HUMAN | [view interactions] | High throughput | no | no |
| SCNM1_HUMAN | [view interactions] | High throughput | no | no |
| ZFP1_HUMAN | [view interactions] | High throughput | no | no |
| PPR18_HUMAN | [view interactions] | High throughput | no | no |
| ZN575_HUMAN | [view interactions] | High throughput | no | no |
| CCD13_HUMAN | [view interactions] | High throughput | no | no |
| ZN572_HUMAN | [view interactions] | High throughput | no | yes |
| MSGN1_HUMAN | [view interactions] | High throughput | no | no |
| RHPN1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN835_HUMAN | [view interactions] | High throughput | no | no |
| HXB5_HUMAN | [view interactions] | High throughput | no | no |
| ATPK_HUMAN | [view interactions] | High throughput | no | yes |
| CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
| NDUB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFD1_HUMAN | [view interactions] | High throughput | no | yes |
| PSD11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNAPN_HUMAN | [view interactions] | High throughput | no | yes |
| STX5_HUMAN | [view interactions] | High throughput | no | yes |
| TNNT3_HUMAN | [view interactions] | High throughput | no | no |
| TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNF24_HUMAN | [view interactions] | High throughput | no | yes |
| CBX8_HUMAN | [view interactions] | High throughput | no | yes |
| CO9A2_HUMAN | [view interactions] | High throughput | no | no |
| CRIP1_HUMAN | [view interactions] | High throughput | no | yes |
| KTBL1_HUMAN | [view interactions] | High throughput | no | no |
| CC113_HUMAN | [view interactions] | High throughput | no | no |
| OGA_HUMAN | [view interactions] | High throughput | no | yes |
| ANKMT_HUMAN | [view interactions] | High throughput | no | yes |
| MPP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NP1L5_HUMAN | [view interactions] | High throughput | no | yes |
| NPS3A_HUMAN | [view interactions] | High throughput | no | yes |
| PDCD7_HUMAN | [view interactions] | High throughput | no | no |
| PPID_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPOX_HUMAN | [view interactions] | High throughput | no | no |
| RER1_HUMAN | [view interactions] | High throughput | no | yes |
| SAS10_HUMAN | [view interactions] | High throughput | no | yes |
| ZNF20_HUMAN | [view interactions] | High throughput | no | no |
| DDX49_HUMAN | [view interactions] | High throughput | no | no |
| EIF3E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOP53_HUMAN | [view interactions] | High throughput | no | yes |
| ZN691_HUMAN | [view interactions] | High throughput | no | yes |
| RT09_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF4_HUMAN | [view interactions] | High throughput | no | yes |
| TI17A_HUMAN | [view interactions] | High throughput | no | yes |
| TSYL1_HUMAN | [view interactions] | High throughput | no | yes |
| APLP1_HUMAN | [view interactions] | High throughput | no | yes |
| LC7L2_HUMAN | [view interactions] | High throughput | no | yes |
| FEZ1_HUMAN | [view interactions] | High throughput | no | no |
| GA45G_HUMAN | [view interactions] | High throughput | no | yes |
| GIT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAT7_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB7_HUMAN | [view interactions] | High throughput | no | yes |
| ING5_HUMAN | [view interactions] | High throughput | no | yes |
| GASP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| KAT5_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| NOD2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| AEN_HUMAN | [view interactions] | High throughput | no | no |
| PNKP_HUMAN | [view interactions] | High throughput | no | yes |
| RPB1_HUMAN | [view interactions] | High throughput | no | no |
| SYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| ARGI1_HUMAN | [view interactions] | High throughput | no | no |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRPS2_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TXLNG_HUMAN | [view interactions] | High throughput | no | no |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMPCT_HUMAN | [view interactions] | High throughput | no | yes |
| MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MKLN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| NOSIP_HUMAN | [view interactions] | High throughput | no | yes |
| TXLNA_HUMAN | [view interactions] | High throughput | no | yes |
| CCD96_HUMAN | [view interactions] | High throughput | no | no |
| ASPP2_HUMAN | [view interactions] | High throughput | no | yes |
| C2D1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P52K_HUMAN | [view interactions] | High throughput | no | yes |