CDK18_HUMAN
Evidence for PS localization
Functions
May play a role in signal transduction cascades in terminally differentiated cells. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CDK18_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 36.5854 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 36.5854 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 36.5854 | 4 | yes |
| GO:0005524 | ATP binding | 34.1463 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 34.1463 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 34.1463 | 5 | yes |
| GO:0003723 | RNA binding | 34.1463 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 26.8293 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 26.8293 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 26.8293 | 6 | no |
| GO:0016887 | ATP hydrolysis activity | 24.3902 | 7 | no |
| GO:0019900 | kinase binding | 24.3902 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 21.9512 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 21.9512 | 4 | no |
| GO:0019901 | protein kinase binding | 21.9512 | 5 | no |
| GO:0004674 | protein serine/threonine kinase activity | 7.3171 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 7.3171 | 4 | yes |
| GO:0016301 | kinase activity | 7.3171 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 7.3171 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 7.3171 | 4 | yes |
| GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | 4.8780 | 5 | yes |
| GO:0097472 | cyclin-dependent protein kinase activity | 4.8780 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CDK18_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 75.6098 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 70.7317 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 70.7317 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 68.2927 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 63.4146 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 51.2195 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 51.2195 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 48.7805 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 48.7805 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 48.7805 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 48.7805 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 48.7805 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 48.7805 | 5 | no |
| GO:0071702 | organic substance transport | 48.7805 | 4 | no |
| GO:0008104 | protein localization | 46.3415 | 4 | no |
| GO:0071705 | nitrogen compound transport | 46.3415 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 43.9024 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 43.9024 | 5 | no |
| GO:0060341 | regulation of cellular localization | 43.9024 | 4 | no |
| GO:0015031 | protein transport | 43.9024 | 4 | no |
| GO:0032880 | regulation of protein localization | 41.4634 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 39.0244 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 39.0244 | 5 | no |
| GO:0010646 | regulation of cell communication | 39.0244 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 36.5854 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 36.5854 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 36.5854 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 36.5854 | 6 | no |
| GO:0070201 | regulation of establishment of protein localization | 36.5854 | 6 | no |
| GO:0010468 | regulation of gene expression | 34.1463 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 34.1463 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 34.1463 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 34.1463 | 5 | no |
| GO:1903829 | positive regulation of protein localization | 34.1463 | 5 | no |
| GO:1904951 | positive regulation of establishment of protein localization | 34.1463 | 6 | no |
| GO:0006886 | intracellular protein transport | 34.1463 | 4 | no |
| GO:0022607 | cellular component assembly | 31.7073 | 4 | no |
| GO:0009966 | regulation of signal transduction | 31.7073 | 4 | no |
| GO:0031399 | regulation of protein modification process | 29.2683 | 6 | no |
| GO:0033043 | regulation of organelle organization | 29.2683 | 5 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 29.2683 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.8293 | 6 | no |
| GO:0050821 | protein stabilization | 26.8293 | 4 | no |
| GO:0051049 | regulation of transport | 26.8293 | 4 | no |
| GO:0036211 | protein modification process | 24.3902 | 4 | yes |
| GO:0043412 | macromolecule modification | 24.3902 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 24.3902 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 24.3902 | 6 | no |
| GO:0010638 | positive regulation of organelle organization | 24.3902 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 24.3902 | 4 | no |
| GO:0051052 | regulation of DNA metabolic process | 24.3902 | 5 | no |
| GO:0051054 | positive regulation of DNA metabolic process | 24.3902 | 6 | no |
| GO:0051338 | regulation of transferase activity | 24.3902 | 4 | no |
| GO:1900180 | regulation of protein localization to nucleus | 24.3902 | 6 | no |
| GO:2000278 | regulation of DNA biosynthetic process | 24.3902 | 6 | no |
| GO:2000573 | positive regulation of DNA biosynthetic process | 24.3902 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.9512 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.9512 | 5 | no |
| GO:0043933 | protein-containing complex organization | 21.9512 | 4 | no |
| GO:0051347 | positive regulation of transferase activity | 21.9512 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 21.9512 | 5 | no |
| GO:1900182 | positive regulation of protein localization to nucleus | 21.9512 | 6 | no |
| GO:0006605 | protein targeting | 21.9512 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 21.9512 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 19.5122 | 5 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 17.0732 | 6 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 17.0732 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 17.0732 | 6 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 14.6341 | 4 | yes |
| GO:0006468 | protein phosphorylation | 12.1951 | 5 | yes |
| GO:0016310 | phosphorylation | 12.1951 | 5 | yes |
| GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle | 4.8780 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SC23A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SC24D_HUMAN | [view interactions] | Low throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GWL_HUMAN | [view interactions] | High throughput | no | yes |
| TPX2_HUMAN | [view interactions] | High throughput | no | yes |
| FP100_HUMAN | [view interactions] | High throughput | no | yes |
| P3H1_HUMAN | [view interactions] | High throughput | no | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBL4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRPS1_HUMAN | [view interactions] | High throughput | no | no |
| FUBP3_HUMAN | [view interactions] | High throughput | no | yes |
| RL37A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM4_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK1_HUMAN | [view interactions] | High throughput | no | no |
| CHTOP_HUMAN | [view interactions] | High throughput | no | yes |
| RALY_HUMAN | [view interactions] | High throughput | no | yes |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRL2_HUMAN | [view interactions] | High throughput | no | yes |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIM_HUMAN | [view interactions] | High throughput | no | yes |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CO1A2_HUMAN | [view interactions] | High throughput | no | yes |
| CO1A1_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |
| C102B_HUMAN | [view interactions] | High throughput | no | yes |
| CCDB1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI27_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| MTUS2_HUMAN | [view interactions] | High throughput | no | yes |
| K1C40_HUMAN | [view interactions] | High throughput | no | no |
| PNMA1_HUMAN | [view interactions] | High throughput | no | yes |
| MIPO1_HUMAN | [view interactions] | High throughput | no | yes |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| KIFC3_HUMAN | [view interactions] | High throughput | no | no |
| TRI54_HUMAN | [view interactions] | High throughput | no | no |
| TSG10_HUMAN | [view interactions] | High throughput | no | no |
| KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GO45_HUMAN | [view interactions] | High throughput | no | yes |
| CDR2_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| IKZF3_HUMAN | [view interactions] | High throughput | no | no |
| TRAF1_HUMAN | [view interactions] | High throughput | no | no |
| VPS52_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GG6L9_HUMAN | [view interactions] | High throughput | no | no |
| MD1L1_HUMAN | [view interactions] | High throughput | no | yes |
| HMBX1_HUMAN | [view interactions] | High throughput | no | yes |
| HOME3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C15_HUMAN | [view interactions] | High throughput | no | no |
| K2C75_HUMAN | [view interactions] | High throughput | no | no |
| CC125_HUMAN | [view interactions] | High throughput | no | yes |
| RABE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC88B_HUMAN | [view interactions] | High throughput | no | no |
| KRT34_HUMAN | [view interactions] | High throughput | no | no |
| K1C16_HUMAN | [view interactions] | High throughput | no | no |
| LIPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP76_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| KAD8_HUMAN | [view interactions] | High throughput | no | no |
| INCA1_HUMAN | [view interactions] | High throughput | no | no |
| KRT86_HUMAN | [view interactions] | High throughput | no | no |
| TRI50_HUMAN | [view interactions] | High throughput | no | no |
| GORS2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN438_HUMAN | [view interactions] | High throughput | no | no |
| ZN774_HUMAN | [view interactions] | High throughput | no | no |
| ZN426_HUMAN | [view interactions] | High throughput | no | yes |
| CCND3_HUMAN | [view interactions] | High throughput | no | no |
| FSD2_HUMAN | [view interactions] | High throughput | no | no |
| CC85B_HUMAN | [view interactions] | High throughput | no | yes |
| CCNK_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAGD2_HUMAN | [view interactions] | High throughput | no | yes |
| PP2AB_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3I_HUMAN | [view interactions] | High throughput | no | yes |
| NTPCR_HUMAN | [view interactions] | High throughput | no | yes |
| METH_HUMAN | [view interactions] | High throughput | no | yes |
| LAR4B_HUMAN | [view interactions] | High throughput | no | yes |
| KATL1_HUMAN | [view interactions] | High throughput | no | no |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3I_HUMAN | [view interactions] | High throughput | no | no |
| CBY1_HUMAN | [view interactions] | High throughput | no | no |
| EYA2_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM1_HUMAN | [view interactions] | High throughput | no | no |
| PIBF1_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| TTC23_HUMAN | [view interactions] | High throughput | no | yes |
| VPS28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REL_HUMAN | [view interactions] | High throughput | no | yes |
| CBY2_HUMAN | [view interactions] | High throughput | no | no |
| NUTM1_HUMAN | [view interactions] | High throughput | no | no |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CATB_HUMAN | [view interactions] | High throughput | no | yes |
| DUS7_HUMAN | [view interactions] | High throughput | no | yes |
| SFXN2_HUMAN | [view interactions] | High throughput | no | no |
| TTC29_HUMAN | [view interactions] | High throughput | no | no |
| CDK16_HUMAN | [view interactions] | High throughput | no | yes |
| MTA2_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| FGR_HUMAN | [view interactions] | High throughput | no | no |
| CDK15_HUMAN | [view interactions] | High throughput | no | no |
| DNLZ_HUMAN | [view interactions] | High throughput | no | no |
| PSB4_HUMAN | [view interactions] | High throughput | no | yes |
| CAH4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACKR2_HUMAN | [view interactions] | High throughput | no | no |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| REQU_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S100B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDN1A_HUMAN | [view interactions] | High throughput | no | no |
| CDK17_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNA2_HUMAN | [view interactions] | Computational | no | no |