Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CDK5_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at Thr-451 and Thr-461 and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CDK5_HUMAN
GO:0043168 anion binding 50.5618 4 yes
GO:0000166 nucleotide binding 49.4382 4 yes
GO:0017076 purine nucleotide binding 49.4382 5 yes
GO:0032555 purine ribonucleotide binding 48.3146 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 48.3146 4 yes
GO:0030554 adenyl nucleotide binding 37.0787 6 yes
GO:0005524 ATP binding 35.9551 5 yes
GO:0032559 adenyl ribonucleotide binding 35.9551 5 yes
GO:0019900 kinase binding 25.8427 4 no
GO:0016462 pyrophosphatase activity 25.8427 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 25.8427 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 25.8427 6 no
GO:0019901 protein kinase binding 22.4719 5 no
GO:0003723 RNA binding 22.4719 4 no
GO:0016301 kinase activity 19.1011 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 19.1011 4 yes
GO:0004674 protein serine/threonine kinase activity 11.2360 4 yes
GO:0106310 protein serine kinase activity 11.2360 4 yes
GO:0048156 tau protein binding 8.9888 4 yes
GO:0051879 Hsp90 protein binding 6.7416 4 yes
GO:0050321 tau-protein kinase activity 4.4944 4 yes
GO:0004693 cyclin-dependent protein serine/threonine kinase activity 3.3708 5 yes
GO:0097472 cyclin-dependent protein kinase activity 3.3708 4 yes
GO:0005176 ErbB-2 class receptor binding 2.2472 4 yes
GO:0030548 acetylcholine receptor regulator activity 2.2472 4 yes
GO:0030549 acetylcholine receptor activator activity 2.2472 4 yes
GO:0043125 ErbB-3 class receptor binding 2.2472 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CDK5_HUMAN
GO:0048522 positive regulation of cellular process 70.7865 4 yes
GO:0051128 regulation of cellular component organization 61.7978 4 yes
GO:0060255 regulation of macromolecule metabolic process 55.0562 4 yes
GO:0080090 regulation of primary metabolic process 55.0562 4 yes
GO:0031323 regulation of cellular metabolic process 52.8090 4 yes
GO:0048523 negative regulation of cellular process 48.3146 4 yes
GO:0031326 regulation of cellular biosynthetic process 43.8202 5 yes
GO:0051130 positive regulation of cellular component organization 43.8202 5 no
GO:0009889 regulation of biosynthetic process 43.8202 4 yes
GO:0010646 regulation of cell communication 43.8202 4 yes
GO:0009893 positive regulation of metabolic process 42.6966 4 no
GO:0010604 positive regulation of macromolecule metabolic process 42.6966 5 no
GO:0010556 regulation of macromolecule biosynthetic process 42.6966 5 yes
GO:0006996 organelle organization 40.4494 4 yes
GO:0051246 regulation of protein metabolic process 39.3258 5 yes
GO:0031325 positive regulation of cellular metabolic process 37.0787 5 no
GO:0060341 regulation of cellular localization 35.9551 4 yes
GO:0022607 cellular component assembly 34.8315 4 yes
GO:0009966 regulation of signal transduction 34.8315 4 no
GO:0032880 regulation of protein localization 33.7079 5 yes
GO:0010468 regulation of gene expression 32.5843 6 yes
GO:0031344 regulation of cell projection organization 31.4607 5 yes
GO:0036211 protein modification process 31.4607 4 yes
GO:0043412 macromolecule modification 31.4607 4 yes
GO:0048584 positive regulation of response to stimulus 31.4607 4 no
GO:0033043 regulation of organelle organization 31.4607 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.3371 5 yes
GO:0031399 regulation of protein modification process 30.3371 6 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 30.3371 6 yes
GO:0042981 regulation of apoptotic process 29.2135 5 yes
GO:0043067 regulation of programmed cell death 29.2135 4 yes
GO:0051049 regulation of transport 29.2135 4 yes
GO:1903829 positive regulation of protein localization 29.2135 5 yes
GO:0023056 positive regulation of signaling 29.2135 4 no
GO:0044087 regulation of cellular component biogenesis 29.2135 4 no
GO:0009892 negative regulation of metabolic process 29.2135 4 yes
GO:0030030 cell projection organization 28.0899 4 yes
GO:0010647 positive regulation of cell communication 28.0899 5 no
GO:0070201 regulation of establishment of protein localization 26.9663 6 yes
GO:0071310 cellular response to organic substance 26.9663 4 yes
GO:0051247 positive regulation of protein metabolic process 26.9663 6 no
GO:0010605 negative regulation of macromolecule metabolic process 26.9663 5 yes
GO:0009891 positive regulation of biosynthetic process 25.8427 5 no
GO:0009967 positive regulation of signal transduction 25.8427 5 no
GO:0031328 positive regulation of cellular biosynthetic process 25.8427 6 no
GO:1902531 regulation of intracellular signal transduction 25.8427 5 no
GO:0019220 regulation of phosphate metabolic process 25.8427 6 no
GO:0051174 regulation of phosphorus metabolic process 25.8427 5 no
GO:0009894 regulation of catabolic process 25.8427 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 24.7191 4 yes
GO:0031324 negative regulation of cellular metabolic process 24.7191 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 24.7191 6 no
GO:0043085 positive regulation of catalytic activity 23.5955 4 no
GO:0043933 protein-containing complex organization 23.5955 4 no
GO:0006796 phosphate-containing compound metabolic process 23.5955 4 yes
GO:0120036 plasma membrane bounded cell projection organization 22.4719 5 yes
GO:1904951 positive regulation of establishment of protein localization 22.4719 6 yes
GO:0010638 positive regulation of organelle organization 22.4719 6 no
GO:0042325 regulation of phosphorylation 22.4719 7 no
GO:0007010 cytoskeleton organization 22.4719 5 yes
GO:0051338 regulation of transferase activity 21.3483 4 no
GO:0001932 regulation of protein phosphorylation 21.3483 7 no
GO:0010975 regulation of neuron projection development 21.3483 7 yes
GO:0034330 cell junction organization 20.2247 4 yes
GO:0045595 regulation of cell differentiation 20.2247 4 yes
GO:0050804 modulation of chemical synaptic transmission 20.2247 5 yes
GO:0051248 negative regulation of protein metabolic process 20.2247 6 yes
GO:0099177 regulation of trans-synaptic signaling 20.2247 4 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 20.2247 5 no
GO:0051240 positive regulation of multicellular organismal process 20.2247 4 no
GO:0031401 positive regulation of protein modification process 20.2247 7 no
GO:0008104 protein localization 20.2247 4 yes
GO:0009890 negative regulation of biosynthetic process 20.2247 5 yes
GO:0016310 phosphorylation 20.2247 5 yes
GO:0050807 regulation of synapse organization 19.1011 5 yes
GO:0030334 regulation of cell migration 17.9775 5 yes
GO:0031327 negative regulation of cellular biosynthetic process 17.9775 6 yes
GO:0051050 positive regulation of transport 17.9775 4 yes
GO:0098657 import into cell 17.9775 4 yes
GO:1901701 cellular response to oxygen-containing compound 17.9775 4 yes
GO:2000145 regulation of cell motility 17.9775 4 yes
GO:0009057 macromolecule catabolic process 17.9775 4 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 17.9775 6 yes
GO:0031175 neuron projection development 16.8539 6 yes
GO:0051129 negative regulation of cellular component organization 16.8539 5 yes
GO:0051252 regulation of RNA metabolic process 16.8539 5 yes
GO:0071702 organic substance transport 16.8539 4 yes
GO:2001141 regulation of RNA biosynthetic process 16.8539 6 yes
GO:0006355 regulation of DNA-templated transcription 16.8539 7 yes
GO:0010243 response to organonitrogen compound 16.8539 4 yes
GO:0031329 regulation of cellular catabolic process 15.7303 5 yes
GO:0050890 cognition 15.7303 4 yes
GO:0060627 regulation of vesicle-mediated transport 15.7303 4 yes
GO:2000026 regulation of multicellular organismal development 15.7303 4 yes
GO:0006915 apoptotic process 15.7303 4 yes
GO:0018193 peptidyl-amino acid modification 14.6067 5 yes
GO:0030162 regulation of proteolysis 14.6067 6 yes
GO:0050808 synapse organization 14.6067 5 yes
GO:0051726 regulation of cell cycle 14.6067 4 yes
GO:0060284 regulation of cell development 14.6067 5 yes
GO:0071417 cellular response to organonitrogen compound 14.6067 4 yes
GO:0099536 synaptic signaling 14.6067 4 yes
GO:0099537 trans-synaptic signaling 14.6067 5 yes
GO:1901699 cellular response to nitrogen compound 14.6067 4 yes
GO:0031400 negative regulation of protein modification process 13.4831 7 yes
GO:0043523 regulation of neuron apoptotic process 13.4831 6 yes
GO:0071705 nitrogen compound transport 13.4831 4 yes
GO:0098916 anterograde trans-synaptic signaling 13.4831 6 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 13.4831 4 yes
GO:0001764 neuron migration 13.4831 4 yes
GO:0006468 protein phosphorylation 13.4831 5 yes
GO:0007268 chemical synaptic transmission 13.4831 7 yes
GO:0007612 learning 13.4831 4 yes
GO:0048812 neuron projection morphogenesis 12.3596 5 yes
GO:0051223 regulation of protein transport 12.3596 5 yes
GO:0010506 regulation of autophagy 12.3596 6 yes
GO:0031396 regulation of protein ubiquitination 11.2360 9 yes
GO:0032386 regulation of intracellular transport 11.2360 5 yes
GO:0034329 cell junction assembly 11.2360 5 yes
GO:0050767 regulation of neurogenesis 11.2360 6 yes
GO:0051046 regulation of secretion 11.2360 5 yes
GO:0051960 regulation of nervous system development 11.2360 5 yes
GO:1901873 regulation of post-translational protein modification 11.2360 7 yes
GO:1903320 regulation of protein modification by small protein conjugation or removal 11.2360 8 yes
GO:1903530 regulation of secretion by cell 11.2360 4 yes
GO:0015031 protein transport 11.2360 4 yes
GO:0030182 neuron differentiation 10.1124 4 yes
GO:0043065 positive regulation of apoptotic process 10.1124 6 yes
GO:0043068 positive regulation of programmed cell death 10.1124 5 yes
GO:0051093 negative regulation of developmental process 10.1124 4 yes
GO:1905475 regulation of protein localization to membrane 10.1124 6 yes
GO:1905477 positive regulation of protein localization to membrane 10.1124 6 yes
GO:0006811 monoatomic ion transport 10.1124 4 yes
GO:0030001 metal ion transport 8.9888 6 yes
GO:0045892 negative regulation of DNA-templated transcription 8.9888 8 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 8.9888 5 yes
GO:0046903 secretion 8.9888 4 yes
GO:0048638 regulation of developmental growth 8.9888 4 yes
GO:0050770 regulation of axonogenesis 8.9888 5 yes
GO:0051051 negative regulation of transport 8.9888 4 yes
GO:0051253 negative regulation of RNA metabolic process 8.9888 6 yes
GO:0051402 neuron apoptotic process 8.9888 5 yes
GO:0072657 protein localization to membrane 8.9888 4 yes
GO:0097485 neuron projection guidance 8.9888 7 yes
GO:1902679 negative regulation of RNA biosynthetic process 8.9888 7 yes
GO:1904645 response to amyloid-beta 8.9888 4 yes
GO:1904646 cellular response to amyloid-beta 8.9888 5 yes
GO:0006812 monoatomic cation transport 8.9888 5 yes
GO:0007411 axon guidance 8.9888 8 yes
GO:0016241 regulation of macroautophagy 8.9888 7 yes
GO:0033157 regulation of intracellular protein transport 7.8652 6 yes
GO:0045596 negative regulation of cell differentiation 7.8652 5 yes
GO:0048488 synaptic vesicle endocytosis 7.8652 5 yes
GO:0048666 neuron development 7.8652 4 yes
GO:0051241 negative regulation of multicellular organismal process 7.8652 4 yes
GO:0099175 regulation of postsynapse organization 7.8652 6 yes
GO:0140238 presynaptic endocytosis 7.8652 4 yes
GO:1903533 regulation of protein targeting 7.8652 7 yes
GO:0001558 regulation of cell growth 7.8652 4 yes
GO:0006886 intracellular protein transport 7.8652 4 yes
GO:0007409 axonogenesis 7.8652 6 yes
GO:0009416 response to light stimulus 7.8652 4 yes
GO:0017157 regulation of exocytosis 7.8652 5 yes
GO:0018209 peptidyl-serine modification 6.7416 6 yes
GO:0018210 peptidyl-threonine modification 6.7416 6 yes
GO:0023061 signal release 6.7416 4 yes
GO:0031345 negative regulation of cell projection organization 6.7416 6 yes
GO:0045861 negative regulation of proteolysis 6.7416 7 yes
GO:0046822 regulation of nucleocytoplasmic transport 6.7416 6 yes
GO:0051047 positive regulation of secretion 6.7416 5 yes
GO:0051650 establishment of vesicle localization 6.7416 4 yes
GO:0099643 signal release from synapse 6.7416 5 yes
GO:1903305 regulation of regulated secretory pathway 6.7416 6 yes
GO:1903532 positive regulation of secretion by cell 6.7416 5 yes
GO:1903828 negative regulation of protein localization 6.7416 5 yes
GO:0007160 cell-matrix adhesion 6.7416 4 yes
GO:0008306 associative learning 6.7416 5 yes
GO:0018105 peptidyl-serine phosphorylation 6.7416 6 yes
GO:0018107 peptidyl-threonine phosphorylation 6.7416 6 yes
GO:0021954 central nervous system neuron development 5.6180 5 yes
GO:0043525 positive regulation of neuron apoptotic process 5.6180 7 yes
GO:0045055 regulated exocytosis 5.6180 4 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 5.6180 6 yes
GO:0090313 regulation of protein targeting to membrane 5.6180 7 yes
GO:0090314 positive regulation of protein targeting to membrane 5.6180 7 yes
GO:0097479 synaptic vesicle localization 5.6180 4 yes
GO:1901874 negative regulation of post-translational protein modification 5.6180 8 yes
GO:1903321 negative regulation of protein modification by small protein conjugation or removal 5.6180 9 yes
GO:1990138 neuron projection extension 5.6180 4 yes
GO:0006816 calcium ion transport 5.6180 7 yes
GO:0010001 glial cell differentiation 5.6180 4 yes
GO:0010721 negative regulation of cell development 5.6180 6 yes
GO:0010977 negative regulation of neuron projection development 5.6180 7 yes
GO:0016079 synaptic vesicle exocytosis 5.6180 4 yes
GO:0030516 regulation of axon extension 4.4944 5 yes
GO:0031397 negative regulation of protein ubiquitination 4.4944 10 yes
GO:0043112 receptor metabolic process 4.4944 4 yes
GO:0045786 negative regulation of cell cycle 4.4944 5 yes
GO:0045921 positive regulation of exocytosis 4.4944 6 yes
GO:0045956 positive regulation of calcium ion-dependent exocytosis 4.4944 8 yes
GO:0048709 oligodendrocyte differentiation 4.4944 5 yes
GO:0050768 negative regulation of neurogenesis 4.4944 6 yes
GO:0051961 negative regulation of nervous system development 4.4944 5 yes
GO:0060537 muscle tissue development 4.4944 4 yes
GO:0061001 regulation of dendritic spine morphogenesis 4.4944 5 yes
GO:0061387 regulation of extent of cell growth 4.4944 5 yes
GO:1903076 regulation of protein localization to plasma membrane 4.4944 7 yes
GO:1903307 positive regulation of regulated secretory pathway 4.4944 7 yes
GO:1904375 regulation of protein localization to cell periphery 4.4944 6 yes
GO:1904950 negative regulation of establishment of protein localization 4.4944 6 yes
GO:0007416 synapse assembly 4.4944 6 yes
GO:0008045 motor neuron axon guidance 4.4944 9 yes
GO:0008542 visual learning 4.4944 4 yes
GO:0017158 regulation of calcium ion-dependent exocytosis 4.4944 7 yes
GO:0021782 glial cell development 3.3708 4 yes
GO:0032801 receptor catabolic process 3.3708 4 yes
GO:0035249 synaptic transmission, glutamatergic 3.3708 8 yes
GO:0035418 protein localization to synapse 3.3708 6 yes
GO:0043113 receptor clustering 3.3708 5 yes
GO:0046825 regulation of protein export from nucleus 3.3708 7 yes
GO:0048148 behavioral response to cocaine 3.3708 4 yes
GO:0048813 dendrite morphogenesis 3.3708 6 yes
GO:0050771 negative regulation of axonogenesis 3.3708 6 yes
GO:0051224 negative regulation of protein transport 3.3708 5 yes
GO:0060078 regulation of postsynaptic membrane potential 3.3708 4 yes
GO:0060079 excitatory postsynaptic potential 3.3708 5 yes
GO:1902414 protein localization to cell junction 3.3708 5 yes
GO:1903421 regulation of synaptic vesicle recycling 3.3708 5 yes
GO:0007519 skeletal muscle tissue development 3.3708 5 yes
GO:0007600 sensory perception 3.3708 4 yes
GO:0019233 sensory perception of pain 2.2472 5 yes
GO:0030308 negative regulation of cell growth 2.2472 5 yes
GO:0030517 negative regulation of axon extension 2.2472 6 yes
GO:0031914 negative regulation of synaptic plasticity 2.2472 4 yes
GO:0032387 negative regulation of intracellular transport 2.2472 5 yes
GO:0045926 negative regulation of growth 2.2472 4 yes
GO:0046823 negative regulation of nucleocytoplasmic transport 2.2472 6 yes
GO:0046826 negative regulation of protein export from nucleus 2.2472 6 yes
GO:0048640 negative regulation of developmental growth 2.2472 5 yes
GO:0048675 axon extension 2.2472 5 yes
GO:0051457 maintenance of protein location in nucleus 2.2472 5 yes
GO:0070509 calcium ion import 2.2472 8 yes
GO:0072595 maintenance of protein localization in organelle 2.2472 4 yes
GO:0090317 negative regulation of intracellular protein transport 2.2472 6 yes
GO:0001963 synaptic transmission, dopaminergic 2.2472 8 yes
GO:0014044 Schwann cell development 2.2472 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SYNJ1_HUMAN [view entry] [view interactions] Low throughput yes yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
DREB_HUMAN [view entry] [view interactions] Low throughput yes yes
CDK1_HUMAN [view interactions] Low throughput no no
LMTK2_HUMAN [view entry] [view interactions] Low throughput yes yes
RL34_HUMAN [view entry] [view interactions] Low throughput yes yes
YBOX3_HUMAN [view interactions] Low throughput no yes
STXB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GAK_HUMAN [view entry] [view interactions] Low throughput yes yes
PAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
P53_HUMAN [view interactions] Low throughput no no
PRKN_HUMAN [view entry] [view interactions] Low throughput yes yes
HDAC4_HUMAN [view interactions] Low throughput no yes
PCNA_HUMAN [view interactions] Low throughput no no
FZR1_HUMAN [view interactions] Low throughput no no
ODFP1_HUMAN [view interactions] Low throughput no no
PURA_HUMAN [view entry] [view interactions] Low throughput yes no
NFH_HUMAN [view entry] [view interactions] Low throughput yes yes
MPIP2_HUMAN [view interactions] Low throughput no no
PPARG_HUMAN [view interactions] Low throughput no yes
CHIP_HUMAN [view entry] [view interactions] Low throughput yes yes
MPIP1_HUMAN [view interactions] Low throughput no no
PER2_HUMAN [view interactions] Low throughput no yes
GSK3B_HUMAN [view entry] [view interactions] Low throughput yes yes
TRI59_HUMAN [view interactions] Low throughput no no
FKBP5_HUMAN [view interactions] Low throughput no yes
FKBP4_HUMAN [view entry] [view interactions] Low throughput yes yes
DNMT1_HUMAN [view interactions] Low throughput no no
SEPT5_HUMAN [view interactions] Low throughput no no
BRCC3_HUMAN [view interactions] Low throughput no no
GRM5_HUMAN [view entry] [view interactions] Low throughput yes no
CK5P2_HUMAN [view interactions] Low throughput no yes
STX1A_HUMAN [view entry] [view interactions] Low throughput yes yes
H11_HUMAN [view interactions] Low throughput no no
NDEL1_HUMAN [view entry] [view interactions] Low throughput yes yes
SDS3_HUMAN [view interactions] Low throughput no yes
TLN1_HUMAN [view entry] [view interactions] Low throughput yes no
H10_HUMAN [view interactions] Low throughput no yes
RB_HUMAN [view interactions] Low throughput no yes
DAB1_HUMAN [view interactions] Low throughput no yes
DYN1_HUMAN [view entry] [view interactions] Low throughput yes yes
KI26B_HUMAN [view interactions] Low throughput no yes
AMPH_HUMAN [view entry] [view interactions] Low throughput yes yes
H15_HUMAN [view interactions] Low throughput no no
MPIP3_HUMAN [view interactions] Low throughput no yes
FYV1_HUMAN [view interactions] Low throughput no no
PI51C_HUMAN [view entry] [view interactions] Low throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
FRPD4_HUMAN [view entry] [view interactions] Low throughput yes no
CCND2_HUMAN [view interactions] Low throughput no yes
CD5R1_HUMAN [view entry] [view interactions] Low throughput yes no
PLXA2_HUMAN [view entry] [view interactions] Low throughput yes yes
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
CDN1B_HUMAN [view interactions] Low throughput no yes
CABL2_HUMAN [view interactions] Low throughput no no
CABL1_HUMAN [view interactions] Low throughput no no
NTRK2_HUMAN [view entry] [view interactions] Low throughput yes yes
LRRK2_HUMAN [view interactions] Low throughput no yes
UCHL1_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
PP1A_HUMAN [view entry] [view interactions] Low throughput yes yes
CDN1A_HUMAN [view interactions] Low throughput no no
CDK16_HUMAN [view interactions] Low throughput no yes
NEST_HUMAN [view interactions] Low throughput no no
LMTK1_HUMAN [view interactions] Low throughput no yes
KCC2A_HUMAN [view entry] [view interactions] Low throughput yes yes
NTRK3_HUMAN [view entry] [view interactions] Low throughput yes yes
ESYT1_HUMAN [view entry] [view interactions] Low throughput yes yes
SYEP_HUMAN [view interactions] Low throughput no yes
DLGP1_HUMAN [view entry] [view interactions] Low throughput yes no
CDC37_HUMAN [view interactions] High throughput no yes
MAST1_HUMAN [view interactions] High throughput no yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
RNF32_HUMAN [view interactions] High throughput no no
SPDYA_HUMAN [view interactions] High throughput no no
PPIA_HUMAN [view entry] [view interactions] High throughput yes yes
TBP_HUMAN [view interactions] High throughput no yes
NUMBL_HUMAN [view entry] [view interactions] High throughput yes yes
ARP3_HUMAN [view entry] [view interactions] High throughput yes yes
HOOK1_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
DHE3_HUMAN [view entry] [view interactions] High throughput yes yes
CDK18_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
CE128_HUMAN [view interactions] High throughput no yes
RASN_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
COPZ1_HUMAN [view interactions] High throughput no no
TCP4_HUMAN [view interactions] High throughput no yes
SARNP_HUMAN [view interactions] High throughput no yes
SCYL2_HUMAN [view interactions] High throughput no yes
RRP44_HUMAN [view interactions] High throughput no yes
SEPT7_HUMAN [view entry] [view interactions] High throughput yes yes
PRCC_HUMAN [view interactions] High throughput no yes
GORS2_HUMAN [view interactions] High throughput no yes
SEP11_HUMAN [view entry] [view interactions] High throughput yes yes
CHRD1_HUMAN [view interactions] High throughput no yes
DRG1_HUMAN [view interactions] High throughput no yes
SHLB1_HUMAN [view interactions] High throughput no yes
BAG6_HUMAN [view entry] [view interactions] High throughput yes yes
MEOX2_HUMAN [view interactions] High throughput no no
CHFR_HUMAN [view interactions] High throughput no no
ECT2_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
CDK5_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
CDK14_HUMAN [view interactions] High throughput no yes
5HT6R_HUMAN [view interactions] High throughput no yes
FBW1B_HUMAN [view interactions] High throughput no yes
MERL_HUMAN [view interactions] High throughput no yes
WDTC1_HUMAN [view interactions] High throughput no yes
RPTOR_HUMAN [view interactions] High throughput no yes
AURKC_HUMAN [view interactions] High throughput no no
UBE2A_HUMAN [view interactions] High throughput no no
HIF1N_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
HEXI1_HUMAN [view interactions] High throughput no yes
LARP7_HUMAN [view interactions] High throughput no yes
DPPA3_HUMAN [view interactions] High throughput no no
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
ANR55_HUMAN [view interactions] High throughput no yes
INS_HUMAN [view interactions] High throughput no no
BRD4_HUMAN [view interactions] High throughput no yes
TULP3_HUMAN [view interactions] High throughput no yes
CCNO_HUMAN [view interactions] High throughput no no
MDGA1_HUMAN [view entry] [view interactions] High throughput yes no
TUSC2_HUMAN [view interactions] High throughput no no
HECD1_HUMAN [view interactions] High throughput no yes
U119B_HUMAN [view interactions] High throughput no yes
CDK2_HUMAN [view interactions] High throughput no yes
RSPRY_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND1_HUMAN [view interactions] High throughput no no
RND2_HUMAN [view interactions] High throughput no no
RND3_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOU_HUMAN [view interactions] High throughput no no
DBLOH_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
CDK7_HUMAN [view interactions] High throughput no yes
PARPT_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
SPDE1_HUMAN [view interactions] High throughput no no
CCNB2_HUMAN [view interactions] High throughput no yes
COX5B_HUMAN [view entry] [view interactions] High throughput yes yes
CKS2_HUMAN [view interactions] High throughput no yes
CCNK_HUMAN [view interactions] High throughput no yes
CKS1_HUMAN [view interactions] High throughput no yes
ENL_HUMAN [view interactions] High throughput no yes
SKP2_HUMAN [view interactions] High throughput no yes
AFF4_HUMAN [view interactions] High throughput no yes
IF2P_HUMAN [view interactions] High throughput no yes
HMGB2_HUMAN [view interactions] High throughput no yes
TRI72_HUMAN [view interactions] High throughput no no
UBE2H_HUMAN [view interactions] High throughput no yes
BRD2_HUMAN [view interactions] High throughput no yes
HMGA1_HUMAN [view interactions] High throughput no yes
NUA4L_HUMAN [view interactions] High throughput no yes
AKT2_HUMAN [view entry] [view interactions] High throughput yes yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
PK3CA_HUMAN [view entry] [view interactions] High throughput yes yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
NED4L_HUMAN [view entry] [view interactions] High throughput yes yes
MBP_HUMAN [view entry] [view interactions] High throughput yes no
HTRA2_HUMAN [view interactions] High throughput no yes
GBP1_HUMAN [view interactions] High throughput no yes
NUBP2_HUMAN [view interactions] High throughput no yes
RPE_HUMAN [view interactions] High throughput no yes
IPP2_HUMAN [view interactions] High throughput no no
IPP2B_HUMAN [view interactions] High throughput no no
WASF1_HUMAN [view entry] [view interactions] High throughput yes yes
SYN1_HUMAN [view entry] [view interactions] High throughput yes no
FSD1_HUMAN [view entry] [view interactions] High throughput yes no
PPR1B_HUMAN [view entry] [view interactions] High throughput yes yes
PTN2_HUMAN [view interactions] High throughput no yes
MIB1_HUMAN [view entry] [view interactions] High throughput yes yes
LZTS2_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
MUC18_HUMAN [view interactions] High throughput no yes
HEM1_HUMAN [view interactions] High throughput no yes
CREL2_HUMAN [view interactions] High throughput no yes
AP2A_HUMAN [view interactions] High throughput no no
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
CCNI_HUMAN [view interactions] High throughput no yes
CCNB1_HUMAN [view interactions] High throughput no no
C2CD5_HUMAN [view interactions] High throughput no yes
TMM94_HUMAN [view interactions] High throughput no yes
CDK3_HUMAN [view interactions] High throughput no no
TCPE_HUMAN [view entry] [view interactions] High throughput yes yes
TCPD_HUMAN [view entry] [view interactions] High throughput yes yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
TCPQ_HUMAN [view entry] [view interactions] High throughput yes yes
FIBP_HUMAN [view entry] [view interactions] High throughput yes yes
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
CCNC_HUMAN [view interactions] High throughput no yes
CCNE1_HUMAN [view interactions] High throughput no no
CDK20_HUMAN [view interactions] High throughput no yes
CNPD1_HUMAN [view interactions] High throughput no no
CCNA2_HUMAN [view interactions] High throughput no no
CCND1_HUMAN [view interactions] High throughput no yes
CCND3_HUMAN [view interactions] High throughput no no
CCNI2_HUMAN [view interactions] High throughput no no
SPDE4_HUMAN [view interactions] High throughput no no
HLAA_HUMAN [view interactions] High throughput no no
G3P_HUMAN [view entry] [view interactions] High throughput yes yes
HMGA2_HUMAN [view interactions] High throughput no yes
CDK6_HUMAN [view interactions] High throughput no yes
FETUA_HUMAN [view interactions] High throughput no no
TCPA_HUMAN [view entry] [view interactions] High throughput yes yes
GDE_HUMAN [view entry] [view interactions] High throughput yes no
FAK1_HUMAN [view entry] [view interactions] High throughput yes yes
POF1B_HUMAN [view interactions] High throughput no no
DCLK3_HUMAN [view interactions] High throughput no no
MK15_HUMAN [view interactions] High throughput no no
HSC20_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
MET_HUMAN [view interactions] High throughput no yes