CDK5_HUMAN
Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at Thr-451 and Thr-461 and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. [View more on UniProt]
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No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in CDK5_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 46.1538 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 46.1538 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 46.1538 | 4 | yes |
GO:0005524 | ATP binding | 35.5769 | 5 | yes |
GO:0030554 | adenyl nucleotide binding | 35.5769 | 5 | yes |
GO:0032559 | adenyl ribonucleotide binding | 35.5769 | 5 | yes |
GO:0019900 | kinase binding | 29.8077 | 4 | yes |
GO:0019901 | protein kinase binding | 27.8846 | 5 | yes |
GO:0003723 | RNA binding | 22.1154 | 4 | no |
GO:0016462 | pyrophosphatase activity | 22.1154 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 22.1154 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 22.1154 | 6 | no |
GO:0016301 | kinase activity | 21.1538 | 4 | yes |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 21.1538 | 4 | yes |
GO:0004712 | protein serine/threonine/tyrosine kinase activity | 19.2308 | 4 | yes |
GO:0004674 | protein serine/threonine kinase activity | 11.5385 | 4 | yes |
GO:0106310 | protein serine kinase activity | 11.5385 | 4 | yes |
GO:0046875 | ephrin receptor binding | 7.6923 | 4 | yes |
GO:0048156 | tau protein binding | 7.6923 | 4 | yes |
GO:0051879 | Hsp90 protein binding | 6.7308 | 4 | yes |
GO:0050321 | tau-protein kinase activity | 4.8077 | 4 | yes |
GO:0005216 | ion channel activity | 3.8462 | 4 | yes |
GO:0005261 | cation channel activity | 3.8462 | 5 | yes |
GO:0005262 | calcium channel activity | 3.8462 | 6 | yes |
GO:0008324 | cation transmembrane transporter activity | 3.8462 | 4 | yes |
GO:0015085 | calcium ion transmembrane transporter activity | 3.8462 | 6 | yes |
GO:0015267 | channel activity | 3.8462 | 4 | yes |
GO:0022890 | inorganic cation transmembrane transporter activity | 3.8462 | 4 | yes |
GO:0046873 | metal ion transmembrane transporter activity | 3.8462 | 5 | yes |
GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | 2.8846 | 5 | yes |
GO:0005244 | voltage-gated ion channel activity | 2.8846 | 4 | yes |
GO:0022832 | voltage-gated channel activity | 2.8846 | 6 | yes |
GO:0022836 | gated channel activity | 2.8846 | 5 | yes |
GO:0022843 | voltage-gated cation channel activity | 2.8846 | 5 | yes |
GO:0030548 | acetylcholine receptor regulator activity | 2.8846 | 4 | yes |
GO:0030549 | acetylcholine receptor activator activity | 2.8846 | 4 | yes |
GO:0097472 | cyclin-dependent protein kinase activity | 2.8846 | 4 | yes |
GO:0005176 | ErbB-2 class receptor binding | 1.9231 | 4 | yes |
GO:0005245 | voltage-gated calcium channel activity | 1.9231 | 6 | yes |
GO:0043125 | ErbB-3 class receptor binding | 1.9231 | 4 | yes |
GO:0099635 | voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels | 1.9231 | 7 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in CDK5_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 73.0769 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 60.5769 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 58.6538 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 57.6923 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 57.6923 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 57.6923 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 51.9231 | 4 | yes |
GO:0010646 | regulation of cell communication | 50.0000 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 49.0385 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 47.1154 | 5 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 45.1923 | 5 | yes |
GO:0006996 | organelle organization | 44.2308 | 4 | yes |
GO:0051130 | positive regulation of cellular component organization | 43.2692 | 5 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 43.2692 | 5 | yes |
GO:0009966 | regulation of signal transduction | 42.3077 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 41.3462 | 5 | yes |
GO:0033043 | regulation of organelle organization | 38.4615 | 5 | yes |
GO:0009889 | regulation of biosynthetic process | 37.5000 | 4 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 37.5000 | 5 | yes |
GO:0022607 | cellular component assembly | 36.5385 | 4 | yes |
GO:0030030 | cell projection organization | 36.5385 | 4 | yes |
GO:0060341 | regulation of cellular localization | 35.5769 | 4 | yes |
GO:0010468 | regulation of gene expression | 35.5769 | 5 | yes |
GO:0010941 | regulation of cell death | 35.5769 | 4 | yes |
GO:0051174 | regulation of phosphorus metabolic process | 34.6154 | 5 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 34.6154 | 5 | yes |
GO:0019220 | regulation of phosphate metabolic process | 34.6154 | 6 | yes |
GO:0031344 | regulation of cell projection organization | 34.6154 | 5 | yes |
GO:0031399 | regulation of protein modification process | 34.6154 | 6 | yes |
GO:0036211 | protein modification process | 34.6154 | 4 | yes |
GO:0043085 | positive regulation of catalytic activity | 34.6154 | 4 | yes |
GO:0043412 | macromolecule modification | 34.6154 | 4 | yes |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 33.6538 | 6 | yes |
GO:0051049 | regulation of transport | 32.6923 | 4 | yes |
GO:0051247 | positive regulation of protein metabolic process | 32.6923 | 6 | yes |
GO:0051338 | regulation of transferase activity | 32.6923 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 32.6923 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 32.6923 | 5 | yes |
GO:0032880 | regulation of protein localization | 32.6923 | 5 | yes |
GO:0010647 | positive regulation of cell communication | 31.7308 | 5 | no |
GO:0023056 | positive regulation of signaling | 31.7308 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 31.7308 | 5 | no |
GO:0042325 | regulation of phosphorylation | 31.7308 | 7 | yes |
GO:0045595 | regulation of cell differentiation | 31.7308 | 4 | yes |
GO:0042981 | regulation of apoptotic process | 30.7692 | 6 | yes |
GO:0043067 | regulation of programmed cell death | 30.7692 | 5 | yes |
GO:0071310 | cellular response to organic substance | 29.8077 | 4 | yes |
GO:0009892 | negative regulation of metabolic process | 29.8077 | 4 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 29.8077 | 4 | yes |
GO:0009967 | positive regulation of signal transduction | 28.8462 | 5 | no |
GO:0001932 | regulation of protein phosphorylation | 27.8846 | 7 | yes |
GO:0007010 | cytoskeleton organization | 27.8846 | 5 | yes |
GO:1903829 | positive regulation of protein localization | 27.8846 | 5 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 27.8846 | 5 | yes |
GO:0051347 | positive regulation of transferase activity | 26.9231 | 5 | yes |
GO:0070201 | regulation of establishment of protein localization | 26.9231 | 6 | yes |
GO:0120036 | plasma membrane bounded cell projection organization | 26.9231 | 5 | yes |
GO:0006796 | phosphate-containing compound metabolic process | 26.9231 | 4 | yes |
GO:0010562 | positive regulation of phosphorus metabolic process | 26.9231 | 6 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 26.9231 | 5 | yes |
GO:0031401 | positive regulation of protein modification process | 26.9231 | 7 | yes |
GO:0042327 | positive regulation of phosphorylation | 26.9231 | 8 | yes |
GO:0043549 | regulation of kinase activity | 26.9231 | 5 | yes |
GO:0045937 | positive regulation of phosphate metabolic process | 26.9231 | 7 | yes |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.9615 | 5 | yes |
GO:0051094 | positive regulation of developmental process | 25.9615 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 25.9615 | 4 | no |
GO:0051129 | negative regulation of cellular component organization | 25.0000 | 5 | yes |
GO:0060548 | negative regulation of cell death | 25.0000 | 5 | yes |
GO:0008104 | protein localization | 25.0000 | 4 | yes |
GO:2000026 | regulation of multicellular organismal development | 25.0000 | 4 | yes |
GO:0010638 | positive regulation of organelle organization | 25.0000 | 6 | yes |
GO:0010975 | regulation of neuron projection development | 25.0000 | 7 | yes |
GO:0009894 | regulation of catabolic process | 24.0385 | 4 | yes |
GO:0051050 | positive regulation of transport | 23.0769 | 4 | yes |
GO:0051493 | regulation of cytoskeleton organization | 23.0769 | 6 | yes |
GO:0060284 | regulation of cell development | 23.0769 | 5 | yes |
GO:0001934 | positive regulation of protein phosphorylation | 23.0769 | 8 | yes |
GO:1904951 | positive regulation of establishment of protein localization | 23.0769 | 6 | yes |
GO:0043933 | protein-containing complex organization | 23.0769 | 4 | no |
GO:0080134 | regulation of response to stress | 23.0769 | 4 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 23.0769 | 6 | no |
GO:0051336 | regulation of hydrolase activity | 23.0769 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 22.1154 | 5 | no |
GO:0016192 | vesicle-mediated transport | 22.1154 | 4 | yes |
GO:0016310 | phosphorylation | 22.1154 | 5 | yes |
GO:0033674 | positive regulation of kinase activity | 22.1154 | 6 | yes |
GO:0051248 | negative regulation of protein metabolic process | 21.1538 | 6 | yes |
GO:0045597 | positive regulation of cell differentiation | 21.1538 | 5 | no |
GO:0051240 | positive regulation of multicellular organismal process | 21.1538 | 4 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.1538 | 6 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 21.1538 | 6 | no |
GO:0042127 | regulation of cell population proliferation | 21.1538 | 4 | no |
GO:0031329 | regulation of cellular catabolic process | 21.1538 | 5 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 20.1923 | 5 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 20.1923 | 4 | yes |
GO:1901214 | regulation of neuron death | 20.1923 | 5 | yes |
GO:1901701 | cellular response to oxygen-containing compound | 20.1923 | 4 | yes |
GO:0010243 | response to organonitrogen compound | 20.1923 | 4 | yes |
GO:0065003 | protein-containing complex assembly | 20.1923 | 5 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.1923 | 6 | no |
GO:0010648 | negative regulation of cell communication | 20.1923 | 5 | no |
GO:0023057 | negative regulation of signaling | 20.1923 | 4 | no |
GO:0031175 | neuron projection development | 20.1923 | 6 | yes |
GO:0045859 | regulation of protein kinase activity | 20.1923 | 6 | yes |
GO:0051252 | regulation of RNA metabolic process | 19.2308 | 5 | yes |
GO:0071702 | organic substance transport | 19.2308 | 4 | yes |
GO:0006355 | regulation of DNA-templated transcription | 19.2308 | 6 | yes |
GO:0006468 | protein phosphorylation | 19.2308 | 5 | yes |
GO:1903506 | regulation of nucleic acid-templated transcription | 19.2308 | 7 | yes |
GO:2001141 | regulation of RNA biosynthetic process | 19.2308 | 6 | yes |
GO:0030162 | regulation of proteolysis | 19.2308 | 6 | yes |
GO:0048858 | cell projection morphogenesis | 18.2692 | 5 | yes |
GO:0050767 | regulation of neurogenesis | 18.2692 | 6 | yes |
GO:0051223 | regulation of protein transport | 18.2692 | 5 | yes |
GO:0051960 | regulation of nervous system development | 18.2692 | 5 | yes |
GO:0071705 | nitrogen compound transport | 18.2692 | 4 | yes |
GO:0120039 | plasma membrane bounded cell projection morphogenesis | 18.2692 | 6 | yes |
GO:0032990 | cell part morphogenesis | 18.2692 | 4 | yes |
GO:0034330 | cell junction organization | 18.2692 | 4 | yes |
GO:0048812 | neuron projection morphogenesis | 17.3077 | 7 | yes |
GO:0050807 | regulation of synapse organization | 17.3077 | 5 | yes |
GO:0060627 | regulation of vesicle-mediated transport | 17.3077 | 4 | yes |
GO:2000145 | regulation of cell motility | 17.3077 | 4 | yes |
GO:0018193 | peptidyl-amino acid modification | 17.3077 | 5 | yes |
GO:0030334 | regulation of cell migration | 17.3077 | 5 | yes |
GO:0032386 | regulation of intracellular transport | 17.3077 | 5 | yes |
GO:0032956 | regulation of actin cytoskeleton organization | 17.3077 | 5 | yes |
GO:0032970 | regulation of actin filament-based process | 17.3077 | 4 | yes |
GO:0050890 | cognition | 16.3462 | 4 | yes |
GO:0051726 | regulation of cell cycle | 16.3462 | 4 | yes |
GO:0010942 | positive regulation of cell death | 16.3462 | 5 | yes |
GO:0043269 | regulation of ion transport | 16.3462 | 5 | yes |
GO:0045860 | positive regulation of protein kinase activity | 16.3462 | 7 | yes |
GO:0050770 | regulation of axonogenesis | 15.3846 | 5 | yes |
GO:0051093 | negative regulation of developmental process | 15.3846 | 4 | yes |
GO:0051222 | positive regulation of protein transport | 15.3846 | 5 | yes |
GO:0051241 | negative regulation of multicellular organismal process | 15.3846 | 4 | yes |
GO:0009890 | negative regulation of biosynthetic process | 15.3846 | 5 | yes |
GO:0015031 | protein transport | 15.3846 | 4 | yes |
GO:0031345 | negative regulation of cell projection organization | 15.3846 | 6 | yes |
GO:0043523 | regulation of neuron apoptotic process | 15.3846 | 6 | yes |
GO:0071417 | cellular response to organonitrogen compound | 14.4231 | 4 | yes |
GO:0099537 | trans-synaptic signaling | 14.4231 | 4 | yes |
GO:0001558 | regulation of cell growth | 14.4231 | 4 | yes |
GO:0006897 | endocytosis | 14.4231 | 5 | yes |
GO:1901699 | cellular response to nitrogen compound | 14.4231 | 4 | yes |
GO:0031400 | negative regulation of protein modification process | 14.4231 | 7 | yes |
GO:0032388 | positive regulation of intracellular transport | 14.4231 | 5 | yes |
GO:0033157 | regulation of intracellular protein transport | 14.4231 | 6 | yes |
GO:0048638 | regulation of developmental growth | 13.4615 | 4 | yes |
GO:0050808 | synapse organization | 13.4615 | 5 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 13.4615 | 5 | yes |
GO:1901215 | negative regulation of neuron death | 13.4615 | 6 | yes |
GO:0006915 | apoptotic process | 13.4615 | 4 | yes |
GO:0007268 | chemical synaptic transmission | 13.4615 | 6 | yes |
GO:0031327 | negative regulation of cellular biosynthetic process | 13.4615 | 6 | yes |
GO:0045596 | negative regulation of cell differentiation | 13.4615 | 5 | yes |
GO:0090316 | positive regulation of intracellular protein transport | 12.5000 | 6 | yes |
GO:0097485 | neuron projection guidance | 12.5000 | 7 | yes |
GO:1901216 | positive regulation of neuron death | 12.5000 | 6 | yes |
GO:0007411 | axon guidance | 12.5000 | 8 | yes |
GO:0007612 | learning | 12.5000 | 4 | yes |
GO:0009057 | macromolecule catabolic process | 12.5000 | 4 | yes |
GO:0010506 | regulation of autophagy | 12.5000 | 6 | yes |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 12.5000 | 6 | yes |
GO:0010977 | negative regulation of neuron projection development | 12.5000 | 7 | yes |
GO:0043065 | positive regulation of apoptotic process | 12.5000 | 7 | yes |
GO:0043068 | positive regulation of programmed cell death | 12.5000 | 6 | yes |
GO:0051495 | positive regulation of cytoskeleton organization | 11.5385 | 7 | yes |
GO:0001764 | neuron migration | 11.5385 | 4 | yes |
GO:0007409 | axonogenesis | 11.5385 | 8 | yes |
GO:0034762 | regulation of transmembrane transport | 11.5385 | 4 | yes |
GO:0043393 | regulation of protein binding | 11.5385 | 4 | yes |
GO:0046777 | protein autophosphorylation | 11.5385 | 6 | yes |
GO:0051046 | regulation of secretion | 10.5769 | 5 | yes |
GO:0061387 | regulation of extent of cell growth | 10.5769 | 5 | yes |
GO:0099175 | regulation of postsynapse organization | 10.5769 | 6 | yes |
GO:0006811 | ion transport | 10.5769 | 4 | yes |
GO:0006886 | intracellular protein transport | 10.5769 | 4 | yes |
GO:1901652 | response to peptide | 10.5769 | 4 | yes |
GO:1903320 | regulation of protein modification by small protein conjugation or removal | 10.5769 | 7 | yes |
GO:1903530 | regulation of secretion by cell | 10.5769 | 4 | yes |
GO:0034765 | regulation of ion transmembrane transport | 10.5769 | 5 | yes |
GO:0051099 | positive regulation of binding | 9.6154 | 4 | yes |
GO:0051253 | negative regulation of RNA metabolic process | 9.6154 | 6 | yes |
GO:0006812 | cation transport | 9.6154 | 5 | yes |
GO:1901653 | cellular response to peptide | 9.6154 | 5 | yes |
GO:1902679 | negative regulation of RNA biosynthetic process | 9.6154 | 7 | yes |
GO:1903507 | negative regulation of nucleic acid-templated transcription | 9.6154 | 8 | yes |
GO:0022411 | cellular component disassembly | 9.6154 | 4 | yes |
GO:0030516 | regulation of axon extension | 9.6154 | 5 | yes |
GO:0030865 | cortical cytoskeleton organization | 9.6154 | 6 | yes |
GO:0031396 | regulation of protein ubiquitination | 9.6154 | 8 | yes |
GO:0034329 | cell junction assembly | 9.6154 | 5 | yes |
GO:0045892 | negative regulation of DNA-templated transcription | 9.6154 | 7 | yes |
GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 9.6154 | 6 | yes |
GO:0046903 | secretion | 8.6538 | 4 | yes |
GO:0072657 | protein localization to membrane | 8.6538 | 4 | yes |
GO:0007005 | mitochondrion organization | 8.6538 | 5 | yes |
GO:1904062 | regulation of cation transmembrane transport | 8.6538 | 6 | yes |
GO:1904645 | response to amyloid-beta | 8.6538 | 5 | yes |
GO:1904646 | cellular response to amyloid-beta | 8.6538 | 6 | yes |
GO:1905475 | regulation of protein localization to membrane | 8.6538 | 6 | yes |
GO:1905477 | positive regulation of protein localization to membrane | 8.6538 | 6 | yes |
GO:0010721 | negative regulation of cell development | 8.6538 | 6 | yes |
GO:0010959 | regulation of metal ion transport | 8.6538 | 6 | yes |
GO:0016241 | regulation of macroautophagy | 8.6538 | 7 | yes |
GO:0030001 | metal ion transport | 8.6538 | 6 | yes |
GO:0043525 | positive regulation of neuron apoptotic process | 8.6538 | 7 | yes |
GO:0048666 | neuron development | 7.6923 | 4 | yes |
GO:0050768 | negative regulation of neurogenesis | 7.6923 | 6 | yes |
GO:0051051 | negative regulation of transport | 7.6923 | 4 | yes |
GO:0051924 | regulation of calcium ion transport | 7.6923 | 7 | yes |
GO:0051961 | negative regulation of nervous system development | 7.6923 | 5 | yes |
GO:0099003 | vesicle-mediated transport in synapse | 7.6923 | 5 | yes |
GO:1903533 | regulation of protein targeting | 7.6923 | 7 | yes |
GO:0017157 | regulation of exocytosis | 7.6923 | 5 | yes |
GO:0018105 | peptidyl-serine phosphorylation | 7.6923 | 6 | yes |
GO:0018209 | peptidyl-serine modification | 7.6923 | 6 | yes |
GO:0022898 | regulation of transmembrane transporter activity | 7.6923 | 4 | yes |
GO:0030182 | neuron differentiation | 7.6923 | 4 | yes |
GO:0032092 | positive regulation of protein binding | 7.6923 | 5 | yes |
GO:0032412 | regulation of ion transmembrane transporter activity | 7.6923 | 5 | yes |
GO:0045861 | negative regulation of proteolysis | 7.6923 | 7 | yes |
GO:0046822 | regulation of nucleocytoplasmic transport | 7.6923 | 6 | yes |
GO:0048488 | synaptic vesicle endocytosis | 6.7308 | 5 | yes |
GO:0140238 | presynaptic endocytosis | 6.7308 | 4 | yes |
GO:1903305 | regulation of regulated secretory pathway | 6.7308 | 6 | yes |
GO:1903321 | negative regulation of protein modification by small protein conjugation or removal | 6.7308 | 8 | yes |
GO:0008306 | associative learning | 6.7308 | 5 | yes |
GO:0009416 | response to light stimulus | 6.7308 | 4 | yes |
GO:1990138 | neuron projection extension | 6.7308 | 4 | yes |
GO:0043270 | positive regulation of ion transport | 6.7308 | 5 | yes |
GO:0050771 | negative regulation of axonogenesis | 5.7692 | 6 | yes |
GO:0051047 | positive regulation of secretion | 5.7692 | 5 | yes |
GO:0051402 | neuron apoptotic process | 5.7692 | 4 | yes |
GO:0051650 | establishment of vesicle localization | 5.7692 | 4 | yes |
GO:0061001 | regulation of dendritic spine morphogenesis | 5.7692 | 5 | yes |
GO:0099643 | signal release from synapse | 5.7692 | 5 | yes |
GO:0006816 | calcium ion transport | 5.7692 | 7 | yes |
GO:0006887 | exocytosis | 5.7692 | 4 | yes |
GO:0007160 | cell-matrix adhesion | 5.7692 | 4 | yes |
GO:0008045 | motor neuron axon guidance | 5.7692 | 9 | yes |
GO:1903532 | positive regulation of secretion by cell | 5.7692 | 5 | yes |
GO:1903828 | negative regulation of protein localization | 5.7692 | 5 | yes |
GO:0010001 | glial cell differentiation | 5.7692 | 4 | yes |
GO:0018107 | peptidyl-threonine phosphorylation | 5.7692 | 6 | yes |
GO:0018210 | peptidyl-threonine modification | 5.7692 | 6 | yes |
GO:0023061 | signal release | 5.7692 | 4 | yes |
GO:0031397 | negative regulation of protein ubiquitination | 5.7692 | 9 | yes |
GO:0046825 | regulation of protein export from nucleus | 4.8077 | 7 | yes |
GO:0051966 | regulation of synaptic transmission, glutamatergic | 4.8077 | 6 | yes |
GO:0090313 | regulation of protein targeting to membrane | 4.8077 | 7 | yes |
GO:0090314 | positive regulation of protein targeting to membrane | 4.8077 | 7 | yes |
GO:0097479 | synaptic vesicle localization | 4.8077 | 4 | yes |
GO:1903169 | regulation of calcium ion transmembrane transport | 4.8077 | 7 | yes |
GO:2000249 | regulation of actin cytoskeleton reorganization | 4.8077 | 6 | yes |
GO:2000251 | positive regulation of actin cytoskeleton reorganization | 4.8077 | 7 | yes |
GO:2001257 | regulation of cation channel activity | 4.8077 | 6 | yes |
GO:0016079 | synaptic vesicle exocytosis | 4.8077 | 4 | yes |
GO:0021954 | central nervous system neuron development | 4.8077 | 5 | yes |
GO:0034764 | positive regulation of transmembrane transport | 4.8077 | 5 | yes |
GO:0043112 | receptor metabolic process | 4.8077 | 4 | yes |
GO:0045055 | regulated exocytosis | 4.8077 | 5 | yes |
GO:0045786 | negative regulation of cell cycle | 4.8077 | 5 | yes |
GO:0048489 | synaptic vesicle transport | 3.8462 | 4 | yes |
GO:0048640 | negative regulation of developmental growth | 3.8462 | 5 | yes |
GO:0048675 | axon extension | 3.8462 | 5 | yes |
GO:0051169 | nuclear transport | 3.8462 | 4 | yes |
GO:0051928 | positive regulation of calcium ion transport | 3.8462 | 6 | yes |
GO:0060078 | regulation of postsynaptic membrane potential | 3.8462 | 4 | yes |
GO:0060079 | excitatory postsynaptic potential | 3.8462 | 5 | yes |
GO:0060537 | muscle tissue development | 3.8462 | 4 | yes |
GO:0006913 | nucleocytoplasmic transport | 3.8462 | 5 | yes |
GO:1903076 | regulation of protein localization to plasma membrane | 3.8462 | 7 | yes |
GO:1903307 | positive regulation of regulated secretory pathway | 3.8462 | 7 | yes |
GO:0007416 | synapse assembly | 3.8462 | 6 | yes |
GO:0007600 | sensory perception | 3.8462 | 4 | yes |
GO:0008542 | visual learning | 3.8462 | 4 | yes |
GO:1904375 | regulation of protein localization to cell periphery | 3.8462 | 6 | yes |
GO:1904950 | negative regulation of establishment of protein localization | 3.8462 | 6 | yes |
GO:0017158 | regulation of calcium ion-dependent exocytosis | 3.8462 | 7 | yes |
GO:0030308 | negative regulation of cell growth | 3.8462 | 5 | yes |
GO:0032801 | receptor catabolic process | 3.8462 | 4 | yes |
GO:0034767 | positive regulation of ion transmembrane transport | 3.8462 | 6 | yes |
GO:0045921 | positive regulation of exocytosis | 3.8462 | 6 | yes |
GO:0045926 | negative regulation of growth | 3.8462 | 4 | yes |
GO:0045956 | positive regulation of calcium ion-dependent exocytosis | 3.8462 | 8 | yes |
GO:0048148 | behavioral response to cocaine | 2.8846 | 4 | yes |
GO:0048709 | oligodendrocyte differentiation | 2.8846 | 5 | yes |
GO:0048813 | dendrite morphogenesis | 2.8846 | 8 | yes |
GO:0051224 | negative regulation of protein transport | 2.8846 | 5 | yes |
GO:0098883 | synapse pruning | 2.8846 | 6 | yes |
GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle | 2.8846 | 4 | yes |
GO:0150146 | cell junction disassembly | 2.8846 | 5 | yes |
GO:1901019 | regulation of calcium ion transmembrane transporter activity | 2.8846 | 6 | yes |
GO:1902414 | protein localization to cell junction | 2.8846 | 5 | yes |
GO:0007519 | skeletal muscle tissue development | 2.8846 | 5 | yes |
GO:1904064 | positive regulation of cation transmembrane transport | 2.8846 | 7 | yes |
GO:1904427 | positive regulation of calcium ion transmembrane transport | 2.8846 | 7 | yes |
GO:0019233 | sensory perception of pain | 2.8846 | 5 | yes |
GO:0021782 | glial cell development | 2.8846 | 4 | yes |
GO:0030517 | negative regulation of axon extension | 2.8846 | 6 | yes |
GO:0030866 | cortical actin cytoskeleton organization | 2.8846 | 4 | yes |
GO:0035249 | synaptic transmission, glutamatergic | 2.8846 | 7 | yes |
GO:0035418 | protein localization to synapse | 2.8846 | 6 | yes |
GO:0042501 | serine phosphorylation of STAT protein | 2.8846 | 7 | yes |
GO:0043113 | receptor clustering | 2.8846 | 5 | yes |
GO:0046826 | negative regulation of protein export from nucleus | 1.9231 | 6 | yes |
GO:0051457 | maintenance of protein location in nucleus | 1.9231 | 5 | yes |
GO:0070509 | calcium ion import | 1.9231 | 8 | yes |
GO:0072595 | maintenance of protein localization in organelle | 1.9231 | 4 | yes |
GO:0090317 | negative regulation of intracellular protein transport | 1.9231 | 6 | yes |
GO:0001963 | synaptic transmission, dopaminergic | 1.9231 | 7 | yes |
GO:1901021 | positive regulation of calcium ion transmembrane transporter activity | 1.9231 | 6 | yes |
GO:1901385 | regulation of voltage-gated calcium channel activity | 1.9231 | 7 | yes |
GO:1901387 | positive regulation of voltage-gated calcium channel activity | 1.9231 | 7 | yes |
GO:1903421 | regulation of synaptic vesicle recycling | 1.9231 | 5 | yes |
GO:2001259 | positive regulation of cation channel activity | 1.9231 | 6 | yes |
GO:0014044 | Schwann cell development | 1.9231 | 5 | yes |
GO:0031914 | negative regulation of synaptic plasticity | 1.9231 | 4 | yes |
GO:0032387 | negative regulation of intracellular transport | 1.9231 | 5 | yes |
GO:0032411 | positive regulation of transporter activity | 1.9231 | 4 | yes |
GO:0032414 | positive regulation of ion transmembrane transporter activity | 1.9231 | 5 | yes |
GO:0034350 | regulation of glial cell apoptotic process | 1.9231 | 7 | yes |
GO:0034352 | positive regulation of glial cell apoptotic process | 1.9231 | 8 | yes |
GO:0046823 | negative regulation of nucleocytoplasmic transport | 1.9231 | 6 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in CDK5_HUMAN |
---|---|---|---|---|
DOID:331 | central nervous system disease | 4.8077 | 3 | no |
DOID:936 | brain disease | 2.8846 | 4 | no |
DOID:0060038 | specific developmental disorder | 1.9231 | 3 | no |
DOID:0060307 | autosomal dominant intellectual developmental disorder | 1.9231 | 5 | no |
DOID:1059 | intellectual disability | 1.9231 | 4 | no |
DOID:0050890 | synucleinopathy | 1.9231 | 5 | no |
DOID:0060894 | early-onset Parkinsons disease | 1.9231 | 7 | no |
DOID:1289 | neurodegenerative disease | 1.9231 | 4 | no |
DOID:14330 | Parkinsons disease | 1.9231 | 6 | no |
DOID:0050701 | electroclinical syndrome | 1.9231 | 6 | no |
DOID:0112202 | developmental and epileptic encephalopathy | 1.9231 | 7 | no |
DOID:1826 | epilepsy | 1.9231 | 5 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FRPD4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CCND2_HUMAN | [view interactions] | Low throughput | no | yes |
CD5R1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
PLXA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CABL1_HUMAN | [view interactions] | Low throughput | no | no |
CABL2_HUMAN | [view interactions] | Low throughput | no | no |
CDN1B_HUMAN | [view interactions] | Low throughput | no | yes |
NTRK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
UCHL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ACTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CDN1A_HUMAN | [view interactions] | Low throughput | no | no |
CDK16_HUMAN | [view interactions] | Low throughput | no | yes |
NEST_HUMAN | [view interactions] | Low throughput | no | no |
LMTK1_HUMAN | [view interactions] | Low throughput | no | yes |
KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NTRK3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ESYT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SYEP_HUMAN | [view interactions] | Low throughput | no | yes |
DLGP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SYNJ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DREB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CDK1_HUMAN | [view interactions] | Low throughput | no | no |
LMTK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RL34_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
YBOX3_HUMAN | [view interactions] | Low throughput | no | yes |
STXB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GAK_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
P53_HUMAN | [view interactions] | Low throughput | no | no |
PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HDAC4_HUMAN | [view interactions] | Low throughput | no | yes |
PCNA_HUMAN | [view interactions] | Low throughput | no | no |
FZR1_HUMAN | [view interactions] | Low throughput | no | no |
ODFP1_HUMAN | [view interactions] | Low throughput | no | no |
PURA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
NFH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MPIP2_HUMAN | [view interactions] | Low throughput | no | no |
PPARG_HUMAN | [view interactions] | Low throughput | no | yes |
CHIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MPIP1_HUMAN | [view interactions] | Low throughput | no | no |
PER2_HUMAN | [view interactions] | Low throughput | no | yes |
GSK3B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TRI59_HUMAN | [view interactions] | Low throughput | no | no |
FKBP5_HUMAN | [view interactions] | Low throughput | no | yes |
FKBP4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DNMT1_HUMAN | [view interactions] | Low throughput | no | no |
SEPT5_HUMAN | [view interactions] | Low throughput | no | no |
BRCC3_HUMAN | [view interactions] | Low throughput | no | no |
GRM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CK5P2_HUMAN | [view interactions] | Low throughput | no | yes |
STX1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
H11_HUMAN | [view interactions] | Low throughput | no | no |
NDEL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SDS3_HUMAN | [view interactions] | Low throughput | no | yes |
TLN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
H10_HUMAN | [view interactions] | Low throughput | no | yes |
RB_HUMAN | [view interactions] | Low throughput | no | yes |
DAB1_HUMAN | [view interactions] | Low throughput | no | yes |
DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KI26B_HUMAN | [view interactions] | Low throughput | no | yes |
AMPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
H15_HUMAN | [view interactions] | Low throughput | no | no |
MPIP3_HUMAN | [view interactions] | Low throughput | no | yes |
FYV1_HUMAN | [view interactions] | Low throughput | no | no |
PI51C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RPE_HUMAN | [view interactions] | High throughput | no | yes |
IPP2B_HUMAN | [view interactions] | High throughput | no | no |
IPP2_HUMAN | [view interactions] | High throughput | no | no |
WASF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FSD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PPR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTN2_HUMAN | [view interactions] | High throughput | no | yes |
MIB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LZTS2_HUMAN | [view interactions] | High throughput | no | no |
HEM1_HUMAN | [view interactions] | High throughput | no | yes |
CREL2_HUMAN | [view interactions] | High throughput | no | yes |
AP2A_HUMAN | [view interactions] | High throughput | no | no |
CCNC_HUMAN | [view interactions] | High throughput | no | yes |
CCNB1_HUMAN | [view interactions] | High throughput | no | no |
TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FIBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDK3_HUMAN | [view interactions] | High throughput | no | no |
TMM94_HUMAN | [view interactions] | High throughput | no | yes |
C2CD5_HUMAN | [view interactions] | High throughput | no | yes |
CCNI_HUMAN | [view interactions] | High throughput | no | yes |
TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDK20_HUMAN | [view interactions] | High throughput | no | yes |
CCNE1_HUMAN | [view interactions] | High throughput | no | no |
CNPD1_HUMAN | [view interactions] | High throughput | no | no |
CCNA2_HUMAN | [view interactions] | High throughput | no | no |
CCND1_HUMAN | [view interactions] | High throughput | no | yes |
CCND3_HUMAN | [view interactions] | High throughput | no | no |
CCNI2_HUMAN | [view interactions] | High throughput | no | no |
SPDE4_HUMAN | [view interactions] | High throughput | no | no |
G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
DCLK3_HUMAN | [view interactions] | High throughput | no | no |
POF1B_HUMAN | [view interactions] | High throughput | no | no |
FAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GDE_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FETUA_HUMAN | [view interactions] | High throughput | no | no |
CDK6_HUMAN | [view interactions] | High throughput | no | yes |
MK15_HUMAN | [view interactions] | High throughput | no | no |
HSC20_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
MET_HUMAN | [view interactions] | High throughput | no | yes |
CDC37_HUMAN | [view interactions] | High throughput | no | yes |
MAST1_HUMAN | [view interactions] | High throughput | no | yes |
PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RNF32_HUMAN | [view interactions] | High throughput | no | no |
SPDYA_HUMAN | [view interactions] | High throughput | no | no |
HOOK1_HUMAN | [view interactions] | High throughput | no | no |
ARP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUMBL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBP_HUMAN | [view interactions] | High throughput | no | yes |
PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDK18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DHE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CE128_HUMAN | [view interactions] | High throughput | no | yes |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
COPZ1_HUMAN | [view interactions] | High throughput | no | no |
TCP4_HUMAN | [view interactions] | High throughput | no | yes |
SARNP_HUMAN | [view interactions] | High throughput | no | yes |
RRP44_HUMAN | [view interactions] | High throughput | no | yes |
SCYL2_HUMAN | [view interactions] | High throughput | no | yes |
SEPT7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRCC_HUMAN | [view interactions] | High throughput | no | yes |
GORS2_HUMAN | [view interactions] | High throughput | no | yes |
SEP11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHRD1_HUMAN | [view interactions] | High throughput | no | yes |
DRG1_HUMAN | [view interactions] | High throughput | no | yes |
SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MEOX2_HUMAN | [view interactions] | High throughput | no | no |
CHFR_HUMAN | [view interactions] | High throughput | no | no |
ECT2_HUMAN | [view interactions] | High throughput | no | no |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDK5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
CDK14_HUMAN | [view interactions] | High throughput | no | yes |
5HT6R_HUMAN | [view interactions] | High throughput | no | yes |
FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
MERL_HUMAN | [view interactions] | High throughput | no | yes |
WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
AURKC_HUMAN | [view interactions] | High throughput | no | no |
UBE2A_HUMAN | [view interactions] | High throughput | no | no |
HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
LARP7_HUMAN | [view interactions] | High throughput | no | yes |
DPPA3_HUMAN | [view interactions] | High throughput | no | no |
PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
ANR55_HUMAN | [view interactions] | High throughput | no | yes |
INS_HUMAN | [view interactions] | High throughput | no | no |
BRD4_HUMAN | [view interactions] | High throughput | no | yes |
TULP3_HUMAN | [view interactions] | High throughput | no | yes |
CCNO_HUMAN | [view interactions] | High throughput | no | no |
MDGA1_HUMAN | [view interactions] | High throughput | no | no |
TUSC2_HUMAN | [view interactions] | High throughput | no | no |
HECD1_HUMAN | [view interactions] | High throughput | no | yes |
U119B_HUMAN | [view interactions] | High throughput | no | yes |
CDK2_HUMAN | [view interactions] | High throughput | no | yes |
RSPRY_HUMAN | [view interactions] | High throughput | no | yes |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOD_HUMAN | [view interactions] | High throughput | no | no |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
RHOH_HUMAN | [view interactions] | High throughput | no | yes |
RND1_HUMAN | [view interactions] | High throughput | no | no |
RND2_HUMAN | [view interactions] | High throughput | no | no |
RND3_HUMAN | [view interactions] | High throughput | no | no |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOU_HUMAN | [view interactions] | High throughput | no | no |
BRD2_HUMAN | [view interactions] | High throughput | no | yes |
HMGA1_HUMAN | [view interactions] | High throughput | no | yes |
NUA4L_HUMAN | [view interactions] | High throughput | no | yes |
AKT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PK3CA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NED4L_HUMAN | [view interactions] | High throughput | no | yes |
MBP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
GBP1_HUMAN | [view interactions] | High throughput | no | yes |
NUBP2_HUMAN | [view interactions] | High throughput | no | yes |
GCR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EPHA4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KC1D_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EPHA7_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CCNB2_HUMAN | [view interactions] | Computational | no | yes |
1433E_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PRDX1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
DPYL2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
JUN_HUMAN | [view interactions] | Computational | no | yes |
ABL1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PSA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EGR1_HUMAN | [view interactions] | Computational | no | yes |
LMNA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CDK4_HUMAN | [view interactions] | Computational | no | no |
MP2K1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EFNA5_HUMAN | [view interactions] | Computational | no | yes |
LMNB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CDK7_HUMAN | [view interactions] | Computational | no | yes |
FOSB_HUMAN | [view interactions] | Computational | no | no |
CCNG1_HUMAN | [view interactions] | Computational | no | yes |
1433S_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EPHA3_HUMAN | [view interactions] | Computational | no | yes |
NMDE2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CDK8_HUMAN | [view interactions] | Computational | no | no |
CAN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
FOXO3_HUMAN | [view interactions] | Computational | no | yes |
DPYL1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ICAL_HUMAN | [view interactions] | Computational | no | yes |
JUND_HUMAN | [view interactions] | Computational | no | yes |
CD5R2_HUMAN | [view interactions] | Computational | no | no |
PRDX2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
BDNF_HUMAN | [view interactions] | Computational | no | yes |
LIS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |