Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NTRK2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity . Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed, PubMed). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
706 Tyr Cys Obesity,hyperphagia,anddevelopmentaldelay(OBHD) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NTRK2_HUMAN
GO:0019900 kinase binding 33.7079 4 no
GO:0019901 protein kinase binding 32.5843 5 no
GO:0017076 purine nucleotide binding 29.2135 4 yes
GO:0032555 purine ribonucleotide binding 29.2135 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 29.2135 4 yes
GO:0046872 metal ion binding 24.7191 4 no
GO:0005524 ATP binding 19.1011 5 yes
GO:0030554 adenyl nucleotide binding 19.1011 5 yes
GO:0032559 adenyl ribonucleotide binding 19.1011 5 yes
GO:0016301 kinase activity 13.4831 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 13.4831 4 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 12.3596 4 yes
GO:0042803 protein homodimerization activity 11.2360 4 yes
GO:0004713 protein tyrosine kinase activity 8.9888 4 yes
GO:0004714 transmembrane receptor protein tyrosine kinase activity 5.6180 5 yes
GO:0019199 transmembrane receptor protein kinase activity 5.6180 4 yes
GO:0043121 neurotrophin binding 4.4944 4 yes
GO:0002020 protease binding 3.3708 4 yes
GO:0048403 brain-derived neurotrophic factor binding 2.2472 5 yes
GO:0060175 brain-derived neurotrophic factor receptor activity 2.2472 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NTRK2_HUMAN
GO:0010646 regulation of cell communication 75.2809 4 yes
GO:0048522 positive regulation of cellular process 74.1573 4 yes
GO:0009966 regulation of signal transduction 68.5393 4 yes
GO:0048523 negative regulation of cellular process 65.1685 4 yes
GO:0060255 regulation of macromolecule metabolic process 62.9213 4 yes
GO:0031323 regulation of cellular metabolic process 60.6742 4 yes
GO:0080090 regulation of primary metabolic process 59.5506 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 57.3034 4 yes
GO:0009893 positive regulation of metabolic process 55.0562 4 yes
GO:0010647 positive regulation of cell communication 51.6854 5 yes
GO:0023056 positive regulation of signaling 51.6854 4 yes
GO:0051049 regulation of transport 51.6854 4 no
GO:0010604 positive regulation of macromolecule metabolic process 50.5618 5 yes
GO:0048584 positive regulation of response to stimulus 50.5618 4 yes
GO:0051246 regulation of protein metabolic process 50.5618 5 yes
GO:0009967 positive regulation of signal transduction 48.3146 5 yes
GO:0031325 positive regulation of cellular metabolic process 48.3146 5 yes
GO:0010468 regulation of gene expression 47.1910 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 46.0674 5 yes
GO:0051128 regulation of cellular component organization 44.9438 4 yes
GO:1902531 regulation of intracellular signal transduction 44.9438 5 yes
GO:0071310 cellular response to organic substance 42.6966 4 yes
GO:0051247 positive regulation of protein metabolic process 41.5730 6 yes
GO:0019220 regulation of phosphate metabolic process 40.4494 6 yes
GO:0042325 regulation of phosphorylation 40.4494 7 yes
GO:0051174 regulation of phosphorus metabolic process 40.4494 5 yes
GO:0009889 regulation of biosynthetic process 39.3258 4 no
GO:0031326 regulation of cellular biosynthetic process 39.3258 5 no
GO:0009892 negative regulation of metabolic process 38.2022 4 yes
GO:0031399 regulation of protein modification process 38.2022 6 yes
GO:0022607 cellular component assembly 38.2022 4 no
GO:0006996 organelle organization 38.2022 4 no
GO:0060341 regulation of cellular localization 38.2022 4 no
GO:0010605 negative regulation of macromolecule metabolic process 37.0787 5 yes
GO:0043085 positive regulation of catalytic activity 37.0787 4 yes
GO:0001932 regulation of protein phosphorylation 35.9551 7 yes
GO:0008104 protein localization 35.9551 4 no
GO:0032880 regulation of protein localization 35.9551 5 no
GO:0010941 regulation of cell death 34.8315 4 yes
GO:0042127 regulation of cell population proliferation 33.7079 4 yes
GO:1902533 positive regulation of intracellular signal transduction 33.7079 6 yes
GO:0010562 positive regulation of phosphorus metabolic process 32.5843 6 yes
GO:0042327 positive regulation of phosphorylation 32.5843 8 yes
GO:0045937 positive regulation of phosphate metabolic process 32.5843 7 yes
GO:0051130 positive regulation of cellular component organization 32.5843 5 yes
GO:0051050 positive regulation of transport 32.5843 4 no
GO:0010556 regulation of macromolecule biosynthetic process 32.5843 5 no
GO:0010648 negative regulation of cell communication 32.5843 5 no
GO:0023057 negative regulation of signaling 32.5843 4 no
GO:0031401 positive regulation of protein modification process 31.4607 7 yes
GO:0051338 regulation of transferase activity 31.4607 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 30.3371 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 30.3371 4 yes
GO:0031324 negative regulation of cellular metabolic process 30.3371 5 yes
GO:0043549 regulation of kinase activity 30.3371 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 30.3371 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.3371 5 no
GO:0048585 negative regulation of response to stimulus 30.3371 4 no
GO:0001934 positive regulation of protein phosphorylation 29.2135 8 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 29.2135 5 yes
GO:0010243 response to organonitrogen compound 29.2135 4 yes
GO:0043067 regulation of programmed cell death 29.2135 5 yes
GO:0045595 regulation of cell differentiation 29.2135 4 yes
GO:0051094 positive regulation of developmental process 29.2135 4 yes
GO:0030030 cell projection organization 29.2135 4 no
GO:0042981 regulation of apoptotic process 28.0899 6 yes
GO:0051240 positive regulation of multicellular organismal process 28.0899 4 yes
GO:0051336 regulation of hydrolase activity 28.0899 4 yes
GO:0009891 positive regulation of biosynthetic process 28.0899 5 no
GO:0008284 positive regulation of cell population proliferation 26.9663 5 yes
GO:0031344 regulation of cell projection organization 26.9663 5 yes
GO:1901701 cellular response to oxygen-containing compound 26.9663 4 yes
GO:2000026 regulation of multicellular organismal development 26.9663 4 yes
GO:0006355 regulation of DNA-templated transcription 26.9663 6 no
GO:0031328 positive regulation of cellular biosynthetic process 26.9663 6 no
GO:0051252 regulation of RNA metabolic process 26.9663 5 no
GO:1903506 regulation of nucleic acid-templated transcription 26.9663 7 no
GO:2001141 regulation of RNA biosynthetic process 26.9663 6 no
GO:0043408 regulation of MAPK cascade 25.8427 6 yes
GO:0050804 modulation of chemical synaptic transmission 25.8427 5 yes
GO:0051347 positive regulation of transferase activity 25.8427 5 yes
GO:0071702 organic substance transport 25.8427 4 yes
GO:0071705 nitrogen compound transport 25.8427 4 yes
GO:0099177 regulation of trans-synaptic signaling 25.8427 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.8427 6 yes
GO:0009968 negative regulation of signal transduction 25.8427 5 no
GO:0033674 positive regulation of kinase activity 24.7191 6 yes
GO:0044087 regulation of cellular component biogenesis 24.7191 4 yes
GO:0034762 regulation of transmembrane transport 24.7191 4 no
GO:0045859 regulation of protein kinase activity 24.7191 6 no
GO:2000145 regulation of cell motility 24.7191 4 no
GO:0016192 vesicle-mediated transport 24.7191 4 no
GO:0043412 macromolecule modification 23.5955 4 yes
GO:0051248 negative regulation of protein metabolic process 23.5955 6 yes
GO:0060548 negative regulation of cell death 23.5955 5 yes
GO:0120036 plasma membrane bounded cell projection organization 23.5955 5 no
GO:0030334 regulation of cell migration 23.5955 5 no
GO:0007010 cytoskeleton organization 23.5955 5 no
GO:0006796 phosphate-containing compound metabolic process 22.4719 4 yes
GO:0010628 positive regulation of gene expression 22.4719 6 yes
GO:0036211 protein modification process 22.4719 4 yes
GO:0043410 positive regulation of MAPK cascade 22.4719 7 yes
GO:0070848 response to growth factor 22.4719 4 yes
GO:0071363 cellular response to growth factor stimulus 22.4719 5 yes
GO:0071417 cellular response to organonitrogen compound 22.4719 4 yes
GO:1901699 cellular response to nitrogen compound 22.4719 4 yes
GO:0015031 protein transport 22.4719 4 no
GO:0009894 regulation of catabolic process 22.4719 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.4719 6 no
GO:0033043 regulation of organelle organization 22.4719 5 no
GO:0060627 regulation of vesicle-mediated transport 22.4719 4 no
GO:0043269 regulation of ion transport 21.3483 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.3483 6 no
GO:0051726 regulation of cell cycle 21.3483 4 no
GO:0080134 regulation of response to stress 21.3483 4 no
GO:0051051 negative regulation of transport 21.3483 4 no
GO:0051345 positive regulation of hydrolase activity 21.3483 5 no
GO:0034330 cell junction organization 21.3483 4 no
GO:0045597 positive regulation of cell differentiation 20.2247 5 yes
GO:0043933 protein-containing complex organization 20.2247 4 no
GO:1903829 positive regulation of protein localization 20.2247 5 no
GO:0051241 negative regulation of multicellular organismal process 20.2247 4 no
GO:0060284 regulation of cell development 19.1011 5 yes
GO:0010975 regulation of neuron projection development 17.9775 7 yes
GO:0044089 positive regulation of cellular component biogenesis 17.9775 5 yes
GO:0050807 regulation of synapse organization 17.9775 5 yes
GO:1901214 regulation of neuron death 17.9775 5 yes
GO:0016310 phosphorylation 16.8539 5 yes
GO:0031346 positive regulation of cell projection organization 16.8539 6 yes
GO:0043066 negative regulation of apoptotic process 16.8539 7 yes
GO:0043069 negative regulation of programmed cell death 16.8539 6 yes
GO:0006468 protein phosphorylation 15.7303 5 yes
GO:0043523 regulation of neuron apoptotic process 14.6067 6 yes
GO:0006811 ion transport 13.4831 4 yes
GO:0010720 positive regulation of cell development 13.4831 6 yes
GO:0051960 regulation of nervous system development 13.4831 5 yes
GO:1901888 regulation of cell junction assembly 13.4831 5 yes
GO:0050767 regulation of neurogenesis 12.3596 6 yes
GO:0050890 cognition 12.3596 4 yes
GO:0099537 trans-synaptic signaling 12.3596 4 yes
GO:1901215 negative regulation of neuron death 12.3596 6 yes
GO:0001764 neuron migration 11.2360 4 yes
GO:0046777 protein autophosphorylation 11.2360 6 yes
GO:0046903 secretion 11.2360 4 yes
GO:0007612 learning 10.1124 4 yes
GO:0010001 glial cell differentiation 10.1124 4 yes
GO:0030182 neuron differentiation 10.1124 4 yes
GO:0043087 regulation of GTPase activity 10.1124 5 yes
GO:0010976 positive regulation of neuron projection development 8.9888 7 yes
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 8.9888 6 yes
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 8.9888 7 yes
GO:0033135 regulation of peptidyl-serine phosphorylation 8.9888 8 yes
GO:0034248 regulation of cellular amide metabolic process 8.9888 5 yes
GO:0050770 regulation of axonogenesis 8.9888 5 yes
GO:0051896 regulation of protein kinase B signaling 8.9888 6 yes
GO:0051962 positive regulation of nervous system development 8.9888 5 yes
GO:0033138 positive regulation of peptidyl-serine phosphorylation 7.8652 9 yes
GO:0043524 negative regulation of neuron apoptotic process 7.8652 7 yes
GO:0050769 positive regulation of neurogenesis 7.8652 6 yes
GO:0050806 positive regulation of synaptic transmission 7.8652 5 yes
GO:0051963 regulation of synapse assembly 7.8652 6 yes
GO:1990090 cellular response to nerve growth factor stimulus 7.8652 4 yes
GO:0048666 neuron development 6.7416 4 yes
GO:1902991 regulation of amyloid precursor protein catabolic process 6.7416 6 yes
GO:0050772 positive regulation of axonogenesis 5.6180 6 yes
GO:1901890 positive regulation of cell junction assembly 5.6180 6 yes
GO:0043200 response to amino acid 4.4944 4 yes
GO:0048709 oligodendrocyte differentiation 4.4944 5 yes
GO:0060291 long-term synaptic potentiation 4.4944 4 yes
GO:1902992 negative regulation of amyloid precursor protein catabolic process 4.4944 7 yes
GO:0001570 vasculogenesis 3.3708 4 yes
GO:0006820 anion transport 3.3708 5 yes
GO:0006835 dicarboxylic acid transport 3.3708 7 yes
GO:0006865 amino acid transport 3.3708 5 yes
GO:0014047 glutamate secretion 3.3708 4 yes
GO:0015711 organic anion transport 3.3708 5 yes
GO:0015800 acidic amino acid transport 3.3708 6 yes
GO:0015849 organic acid transport 3.3708 5 yes
GO:0021954 central nervous system neuron development 3.3708 5 yes
GO:0034249 negative regulation of cellular amide metabolic process 3.3708 6 yes
GO:0042461 photoreceptor cell development 3.3708 5 yes
GO:0042462 eye photoreceptor cell development 3.3708 6 yes
GO:0042490 mechanoreceptor differentiation 3.3708 5 yes
GO:0042552 myelination 3.3708 4 yes
GO:0046942 carboxylic acid transport 3.3708 6 yes
GO:0051965 positive regulation of synapse assembly 3.3708 6 yes
GO:0071229 cellular response to acid chemical 3.3708 4 yes
GO:0071230 cellular response to amino acid stimulus 3.3708 5 yes
GO:1902003 regulation of amyloid-beta formation 3.3708 6 yes
GO:1902430 negative regulation of amyloid-beta formation 3.3708 7 yes
GO:2000209 regulation of anoikis 3.3708 7 yes
GO:2000811 negative regulation of anoikis 3.3708 8 yes
GO:0001508 action potential 2.2472 4 yes
GO:0019227 neuronal action potential propagation 2.2472 4 yes
GO:0022011 myelination in peripheral nervous system 2.2472 5 yes
GO:0031547 brain-derived neurotrophic factor receptor signaling pathway 2.2472 6 yes
GO:0032292 peripheral nervous system axon ensheathment 2.2472 4 yes
GO:0046548 retinal rod cell development 2.2472 7 yes
GO:0048935 peripheral nervous system neuron development 2.2472 5 yes
GO:0098870 action potential propagation 2.2472 5 yes
GO:0099183 trans-synaptic signaling by BDNF, modulating synaptic transmission 2.2472 6 yes
GO:0099191 trans-synaptic signaling by BDNF 2.2472 5 yes
GO:0099538 synaptic signaling via neuropeptide 2.2472 4 yes
GO:0099540 trans-synaptic signaling by neuropeptide 2.2472 5 yes
GO:0099550 trans-synaptic signaling, modulating synaptic transmission 2.2472 5 yes
GO:0099551 trans-synaptic signaling by neuropeptide, modulating synaptic transmission 2.2472 6 yes
GO:1990416 cellular response to brain-derived neurotrophic factor stimulus 2.2472 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in NTRK2_HUMAN
DOID:331 central nervous system disease 6.7416 3 yes
DOID:0050700 cardiomyopathy 3.3708 4 no
DOID:0060036 intrinsic cardiomyopathy 3.3708 5 no
DOID:114 heart disease 3.3708 3 no
DOID:1289 neurodegenerative disease 3.3708 4 no
DOID:0050701 electroclinical syndrome 2.2472 6 yes
DOID:0080285 developmental and epileptic encephalopathy 58 2.2472 8 yes
DOID:0112202 developmental and epileptic encephalopathy 2.2472 7 yes
DOID:1826 epilepsy 2.2472 5 yes
DOID:936 brain disease 2.2472 4 yes
DOID:2843 long QT syndrome 2.2472 6 no
DOID:231 motor neuron disease 2.2472 5 no
DOID:332 amyotrophic lateral sclerosis 2.2472 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SHC3_HUMAN [view interactions] Low throughput no yes
SH2B1_HUMAN [view interactions] Low throughput no yes
NCK2_HUMAN [view entry] [view interactions] Low throughput yes yes
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
SQSTM_HUMAN [view interactions] Low throughput no yes
TRAF6_HUMAN [view interactions] Low throughput no yes
BDNF_HUMAN [view interactions] Low throughput no yes
NTF3_HUMAN [view interactions] Low throughput no no
RANB9_HUMAN [view entry] [view interactions] Low throughput yes yes
ACK1_HUMAN [view interactions] Low throughput no yes
TNR16_HUMAN [view entry] [view interactions] Low throughput yes no
DYLT1_HUMAN [view interactions] Low throughput no no
SOCS2_HUMAN [view interactions] Low throughput no yes
UCHL1_HUMAN [view entry] [view interactions] Low throughput yes yes
NFIP1_HUMAN [view interactions] Low throughput no yes
SLIK5_HUMAN [view interactions] Low throughput no no
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
ERBB4_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPA_HUMAN [view interactions] Low throughput no yes
SHC1_HUMAN [view entry] [view interactions] Low throughput yes yes
SHC4_HUMAN [view entry] [view interactions] Low throughput yes no
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
KCNA3_HUMAN [view entry] [view interactions] Low throughput yes no
GRB10_HUMAN [view entry] [view interactions] Low throughput yes yes
SORC2_HUMAN [view entry] [view interactions] Low throughput yes no
UBP8_HUMAN [view entry] [view interactions] Low throughput yes no
SORL_HUMAN [view interactions] Low throughput no yes
PTN1_HUMAN [view interactions] Low throughput no yes
RB11A_HUMAN [view entry] [view interactions] Low throughput yes yes
GIPC1_HUMAN [view entry] [view interactions] Low throughput yes yes
TIAM1_HUMAN [view entry] [view interactions] Low throughput yes yes
CDK5_HUMAN [view entry] [view interactions] Low throughput yes yes
FNTA_HUMAN [view interactions] Low throughput no yes
PGTB1_HUMAN [view interactions] Low throughput no no
RGRF1_HUMAN [view interactions] Low throughput no yes
NTRK2_HUMAN [view entry] [view interactions] Low throughput yes yes
PLCG1_HUMAN [view entry] [view interactions] Low throughput yes yes
FRS2_HUMAN [view interactions] Low throughput no no
SORT_HUMAN [view interactions] Low throughput no yes
PTN11_HUMAN [view entry] [view interactions] Low throughput yes yes
KINH_HUMAN [view entry] [view interactions] Low throughput yes no
GCR_HUMAN [view entry] [view interactions] Low throughput yes yes
HGS_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
GAB1_HUMAN [view interactions] Low throughput no yes
NTRK1_HUMAN [view interactions] Low throughput no yes
NTF4_HUMAN [view interactions] Low throughput no no
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
P85A_HUMAN [view interactions] Low throughput no yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
PTPR2_HUMAN [view interactions] High throughput no yes
LRP1_HUMAN [view entry] [view interactions] High throughput yes yes
VPS35_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
CDC37_HUMAN [view interactions] High throughput no yes
GNAI3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
CD5R1_HUMAN [view entry] [view interactions] High throughput yes no
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
KPYM_HUMAN [view interactions] High throughput no yes
PCH2_HUMAN [view interactions] High throughput no no
AP1B1_HUMAN [view entry] [view interactions] High throughput yes yes
RPB7_HUMAN [view interactions] High throughput no yes
NMNA1_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
GRDN_HUMAN [view interactions] High throughput no no
ANR26_HUMAN [view interactions] High throughput no yes
CENPH_HUMAN [view interactions] High throughput no yes
DZIP1_HUMAN [view interactions] High throughput no yes
US6NL_HUMAN [view interactions] High throughput no yes
M21D2_HUMAN [view interactions] High throughput no yes
OCLN_HUMAN [view interactions] High throughput no no
LRBA_HUMAN [view interactions] High throughput no yes
PTN13_HUMAN [view interactions] High throughput no yes
ERBIN_HUMAN [view entry] [view interactions] High throughput yes yes
GCP60_HUMAN [view interactions] High throughput no yes
DYST_HUMAN [view entry] [view interactions] High throughput yes yes
F1711_HUMAN [view entry] [view interactions] High throughput yes yes
MPRIP_HUMAN [view entry] [view interactions] High throughput yes yes
L2GL1_HUMAN [view entry] [view interactions] High throughput yes yes
PARD3_HUMAN [view interactions] High throughput no yes
F1712_HUMAN [view interactions] High throughput no no
MARK3_HUMAN [view interactions] High throughput no yes
WDR6_HUMAN [view entry] [view interactions] High throughput yes yes
P85B_HUMAN [view interactions] High throughput no yes
SC24B_HUMAN [view interactions] High throughput no yes
KDIS_HUMAN [view interactions] High throughput no yes
S4A7_HUMAN [view interactions] High throughput no no
PEAK1_HUMAN [view interactions] High throughput no yes
TARA_HUMAN [view interactions] High throughput no yes
CDCA3_HUMAN [view interactions] High throughput no no
EPHA2_HUMAN [view interactions] High throughput no no
LSR_HUMAN [view interactions] High throughput no yes
AT2B1_HUMAN [view entry] [view interactions] High throughput yes yes
RHG32_HUMAN [view entry] [view interactions] High throughput yes yes
NISCH_HUMAN [view interactions] High throughput no yes
TRIPB_HUMAN [view interactions] High throughput no yes
NOTC2_HUMAN [view interactions] High throughput no yes
LIPB1_HUMAN [view interactions] High throughput no yes
NCK1_HUMAN [view interactions] High throughput no yes
DLG5_HUMAN [view entry] [view interactions] High throughput yes no
SC23B_HUMAN [view interactions] High throughput no yes
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
VANG1_HUMAN [view interactions] High throughput no no
E41L5_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
GOPC_HUMAN [view entry] [view interactions] High throughput yes yes
GRIN3_HUMAN [view interactions] High throughput no yes
S6A15_HUMAN [view interactions] High throughput no yes
DSC2_HUMAN [view interactions] High throughput no no
FLOT2_HUMAN [view entry] [view interactions] High throughput yes yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
AGRL2_HUMAN [view entry] [view interactions] High throughput yes no
KPCI_HUMAN [view entry] [view interactions] High throughput yes yes
STEA3_HUMAN [view interactions] High throughput no yes
CAPON_HUMAN [view entry] [view interactions] High throughput yes yes
JPH1_HUMAN [view interactions] High throughput no no
F135A_HUMAN [view interactions] High throughput no yes
DP13A_HUMAN [view entry] [view interactions] High throughput yes yes
F171B_HUMAN [view interactions] High throughput no yes
XPR1_HUMAN [view interactions] High throughput no yes
LIPA1_HUMAN [view entry] [view interactions] High throughput yes yes
RFIP5_HUMAN [view entry] [view interactions] High throughput yes yes
TRM7_HUMAN [view interactions] High throughput no yes
PACN2_HUMAN [view entry] [view interactions] High throughput yes no
STAM2_HUMAN [view interactions] High throughput no yes
UBIA1_HUMAN [view interactions] High throughput no no
PHLB3_HUMAN [view interactions] High throughput no yes
VAPB_HUMAN [view entry] [view interactions] High throughput yes yes
ARHGA_HUMAN [view interactions] High throughput no yes
P55G_HUMAN [view interactions] High throughput no yes
DTNA_HUMAN [view entry] [view interactions] High throughput yes yes
PKP2_HUMAN [view interactions] High throughput no yes
GORS2_HUMAN [view interactions] High throughput no yes
PK3CB_HUMAN [view interactions] High throughput no yes
ABLM1_HUMAN [view entry] [view interactions] High throughput yes yes
MINK1_HUMAN [view entry] [view interactions] High throughput yes yes
CBARP_HUMAN [view interactions] High throughput no no
PLCH1_HUMAN [view interactions] High throughput no no
SPY4_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
PPIP2_HUMAN [view interactions] High throughput no no
CNNM3_HUMAN [view interactions] High throughput no yes
S20A2_HUMAN [view interactions] High throughput no yes
GBB1_HUMAN [view entry] [view interactions] High throughput yes yes
PDXD1_HUMAN [view interactions] High throughput no no
ZFYV9_HUMAN [view interactions] High throughput no yes
AIP_HUMAN [view entry] [view interactions] High throughput yes yes
NGF_HUMAN [view interactions] Computational no no
SHC2_HUMAN [view interactions] Computational no yes
CDC42_HUMAN [view entry] [view interactions] Computational yes yes
FRS3_HUMAN [view interactions] Computational no no
IGF1_HUMAN [view entry] [view interactions] Computational yes no
FGF2_HUMAN [view entry] [view interactions] Computational yes yes
RAC1_HUMAN [view entry] [view interactions] Computational yes no
NMDE2_HUMAN [view entry] [view interactions] Computational yes no
CRKL_HUMAN [view entry] [view interactions] Computational yes yes
MATK_HUMAN [view interactions] Computational no yes
RASN_HUMAN [view entry] [view interactions] Computational yes no
CTND1_HUMAN [view entry] [view interactions] Computational yes no
ABL1_HUMAN [view entry] [view interactions] Computational yes yes
CTNB1_HUMAN [view entry] [view interactions] Computational yes yes
RASH_HUMAN [view entry] [view interactions] Computational yes no
CTNA1_HUMAN [view entry] [view interactions] Computational yes yes
CADH2_HUMAN [view entry] [view interactions] Computational yes no
EGF_HUMAN [view interactions] Computational no no
RAP1B_HUMAN [view entry] [view interactions] Computational yes no
DOK5_HUMAN [view interactions] Computational no no
RB27A_HUMAN [view interactions] Computational no yes
SRC_HUMAN [view entry] [view interactions] Computational yes no
IRS1_HUMAN [view entry] [view interactions] Computational yes yes
RASA1_HUMAN [view interactions] Computational no yes
CNR1_HUMAN [view interactions] Computational no yes
RASK_HUMAN [view entry] [view interactions] Computational yes no
PLCG2_HUMAN [view interactions] Computational no yes
RAP1A_HUMAN [view entry] [view interactions] Computational yes no
RIT2_HUMAN [view interactions] Computational no yes
SH2B3_HUMAN [view interactions] Computational no yes
SH2B2_HUMAN [view interactions] Computational no no
STAT3_HUMAN [view entry] [view interactions] Computational yes yes
RIT1_HUMAN [view interactions] Computational no yes
EFNA5_HUMAN [view interactions] Computational no yes
CRK_HUMAN [view entry] [view interactions] Computational yes no
EHD4_HUMAN [view entry] [view interactions] Computational yes no