NTRK2_HUMAN
Evidence for PS localization
Functions
Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity . Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed, PubMed). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 706 | Tyr | Cys | Obesity,hyperphagia,anddevelopmentaldelay(OBHD) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NTRK2_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 24.7619 | 4 | no |
| GO:0019901 | protein kinase binding | 22.8571 | 5 | no |
| GO:0043169 | cation binding | 22.8571 | 4 | no |
| GO:0046872 | metal ion binding | 22.8571 | 5 | no |
| GO:0043168 | anion binding | 21.9048 | 4 | yes |
| GO:0000166 | nucleotide binding | 20.0000 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 20.0000 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 20.0000 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 19.0476 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 18.0952 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 18.0952 | 5 | yes |
| GO:0005524 | ATP binding | 17.1429 | 5 | yes |
| GO:0016301 | kinase activity | 11.4286 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 11.4286 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 7.6190 | 4 | yes |
| GO:0004713 | protein tyrosine kinase activity | 6.6667 | 4 | yes |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | 4.7619 | 5 | yes |
| GO:0019199 | transmembrane receptor protein kinase activity | 4.7619 | 4 | yes |
| GO:0002020 | protease binding | 3.8095 | 4 | yes |
| GO:0043121 | neurotrophin binding | 3.8095 | 4 | yes |
| GO:0048403 | brain-derived neurotrophic factor binding | 1.9048 | 5 | yes |
| GO:0060175 | brain-derived neurotrophic factor receptor activity | 1.9048 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NTRK2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 65.7143 | 4 | yes |
| GO:0010646 | regulation of cell communication | 62.8571 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 53.3333 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 51.4286 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 50.4762 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 49.5238 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 46.6667 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 45.7143 | 4 | yes |
| GO:0051049 | regulation of transport | 43.8095 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 42.8571 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 40.9524 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 40.9524 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 40.9524 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 39.0476 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 39.0476 | 5 | yes |
| GO:0006996 | organelle organization | 39.0476 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 38.0952 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 38.0952 | 5 | yes |
| GO:0008104 | protein localization | 38.0952 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 37.1429 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 37.1429 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 36.1905 | 5 | yes |
| GO:0010468 | regulation of gene expression | 35.2381 | 6 | yes |
| GO:0009892 | negative regulation of metabolic process | 34.2857 | 4 | yes |
| GO:0022607 | cellular component assembly | 34.2857 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 33.3333 | 5 | yes |
| GO:0030030 | cell projection organization | 32.3810 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 31.4286 | 6 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 31.4286 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 31.4286 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 30.4762 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 29.5238 | 6 | yes |
| GO:0032880 | regulation of protein localization | 29.5238 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 28.5714 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.6667 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 26.6667 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 26.6667 | 7 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 26.6667 | 5 | yes |
| GO:0071702 | organic substance transport | 26.6667 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 25.7143 | 7 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.7143 | 6 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 25.7143 | 4 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 24.7619 | 6 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 24.7619 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 24.7619 | 4 | yes |
| GO:0051050 | positive regulation of transport | 24.7619 | 4 | no |
| GO:0071705 | nitrogen compound transport | 23.8095 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 23.8095 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 22.8571 | 7 | yes |
| GO:0042981 | regulation of apoptotic process | 22.8571 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 22.8571 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.8571 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 21.9048 | 6 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.9048 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 21.9048 | 5 | yes |
| GO:0042327 | positive regulation of phosphorylation | 21.9048 | 8 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 21.9048 | 4 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 21.9048 | 7 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 21.9048 | 6 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 20.9524 | 8 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 20.9524 | 4 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 20.9524 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 20.9524 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.9524 | 6 | yes |
| GO:2000026 | regulation of multicellular organismal development | 20.9524 | 4 | yes |
| GO:0141124 | intracellular signaling cassette | 20.9524 | 4 | no |
| GO:0009894 | regulation of catabolic process | 20.9524 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.9524 | 5 | no |
| GO:0071310 | cellular response to organic substance | 20.9524 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 20.0000 | 4 | yes |
| GO:0043412 | macromolecule modification | 20.0000 | 4 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 20.0000 | 6 | yes |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 19.0476 | 5 | yes |
| GO:0036211 | protein modification process | 19.0476 | 4 | yes |
| GO:0010975 | regulation of neuron projection development | 18.0952 | 7 | yes |
| GO:0043408 | regulation of MAPK cascade | 18.0952 | 6 | yes |
| GO:0010628 | positive regulation of gene expression | 17.1429 | 7 | yes |
| GO:0050807 | regulation of synapse organization | 17.1429 | 5 | yes |
| GO:0045595 | regulation of cell differentiation | 16.1905 | 4 | yes |
| GO:0050890 | cognition | 15.2381 | 4 | yes |
| GO:0043066 | negative regulation of apoptotic process | 14.2857 | 6 | yes |
| GO:0043069 | negative regulation of programmed cell death | 14.2857 | 5 | yes |
| GO:0046903 | secretion | 14.2857 | 4 | yes |
| GO:0071363 | cellular response to growth factor stimulus | 14.2857 | 4 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 13.3333 | 5 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 13.3333 | 5 | yes |
| GO:0051336 | regulation of hydrolase activity | 13.3333 | 4 | yes |
| GO:0016310 | phosphorylation | 12.3810 | 5 | yes |
| GO:0031346 | positive regulation of cell projection organization | 12.3810 | 6 | yes |
| GO:0043410 | positive regulation of MAPK cascade | 12.3810 | 7 | yes |
| GO:0099536 | synaptic signaling | 12.3810 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 12.3810 | 5 | yes |
| GO:0007612 | learning | 11.4286 | 4 | yes |
| GO:0060284 | regulation of cell development | 11.4286 | 5 | yes |
| GO:0006468 | protein phosphorylation | 10.4762 | 5 | yes |
| GO:0010976 | positive regulation of neuron projection development | 10.4762 | 7 | yes |
| GO:0045597 | positive regulation of cell differentiation | 9.5238 | 5 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 9.5238 | 5 | yes |
| GO:0051960 | regulation of nervous system development | 9.5238 | 5 | yes |
| GO:0043523 | regulation of neuron apoptotic process | 8.5714 | 6 | yes |
| GO:0051963 | regulation of synapse assembly | 8.5714 | 6 | yes |
| GO:1901888 | regulation of cell junction assembly | 8.5714 | 5 | yes |
| GO:0030182 | neuron differentiation | 7.6190 | 4 | yes |
| GO:0051962 | positive regulation of nervous system development | 7.6190 | 5 | yes |
| GO:0010720 | positive regulation of cell development | 6.6667 | 6 | yes |
| GO:0050767 | regulation of neurogenesis | 6.6667 | 6 | yes |
| GO:1990089 | response to nerve growth factor | 6.6667 | 4 | yes |
| GO:1990090 | cellular response to nerve growth factor stimulus | 6.6667 | 5 | yes |
| GO:0001764 | neuron migration | 5.7143 | 4 | yes |
| GO:0010001 | glial cell differentiation | 5.7143 | 4 | yes |
| GO:0033135 | regulation of peptidyl-serine phosphorylation | 5.7143 | 8 | yes |
| GO:0043524 | negative regulation of neuron apoptotic process | 5.7143 | 7 | yes |
| GO:0050770 | regulation of axonogenesis | 5.7143 | 5 | yes |
| GO:0001508 | action potential | 4.7619 | 4 | yes |
| GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 4.7619 | 9 | yes |
| GO:0042552 | myelination | 4.7619 | 4 | yes |
| GO:0043087 | regulation of GTPase activity | 4.7619 | 5 | yes |
| GO:0046777 | protein autophosphorylation | 4.7619 | 6 | yes |
| GO:0048666 | neuron development | 4.7619 | 4 | yes |
| GO:0050769 | positive regulation of neurogenesis | 4.7619 | 6 | yes |
| GO:0051896 | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 4.7619 | 6 | yes |
| GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 4.7619 | 7 | yes |
| GO:0051965 | positive regulation of synapse assembly | 4.7619 | 6 | yes |
| GO:1901890 | positive regulation of cell junction assembly | 4.7619 | 6 | yes |
| GO:0042461 | photoreceptor cell development | 3.8095 | 5 | yes |
| GO:0042462 | eye photoreceptor cell development | 3.8095 | 6 | yes |
| GO:0043200 | response to amino acid | 3.8095 | 4 | yes |
| GO:0048709 | oligodendrocyte differentiation | 3.8095 | 5 | yes |
| GO:0050772 | positive regulation of axonogenesis | 3.8095 | 6 | yes |
| GO:0060291 | long-term synaptic potentiation | 3.8095 | 4 | yes |
| GO:1902991 | regulation of amyloid precursor protein catabolic process | 3.8095 | 6 | yes |
| GO:0006835 | dicarboxylic acid transport | 2.8571 | 7 | yes |
| GO:0006865 | amino acid transport | 2.8571 | 5 | yes |
| GO:0014047 | glutamate secretion | 2.8571 | 4 | yes |
| GO:0015711 | organic anion transport | 2.8571 | 5 | yes |
| GO:0015800 | acidic amino acid transport | 2.8571 | 6 | yes |
| GO:0015849 | organic acid transport | 2.8571 | 5 | yes |
| GO:0021954 | central nervous system neuron development | 2.8571 | 5 | yes |
| GO:0034248 | regulation of amide metabolic process | 2.8571 | 4 | yes |
| GO:0042490 | mechanoreceptor differentiation | 2.8571 | 5 | yes |
| GO:0046942 | carboxylic acid transport | 2.8571 | 6 | yes |
| GO:0071229 | cellular response to acid chemical | 2.8571 | 4 | yes |
| GO:0071230 | cellular response to amino acid stimulus | 2.8571 | 5 | yes |
| GO:1902992 | negative regulation of amyloid precursor protein catabolic process | 2.8571 | 7 | yes |
| GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus | 2.8571 | 6 | yes |
| GO:0001570 | vasculogenesis | 1.9048 | 4 | yes |
| GO:0019227 | neuronal action potential propagation | 1.9048 | 4 | yes |
| GO:0022011 | myelination in peripheral nervous system | 1.9048 | 5 | yes |
| GO:0031547 | brain-derived neurotrophic factor receptor signaling pathway | 1.9048 | 6 | yes |
| GO:0032292 | peripheral nervous system axon ensheathment | 1.9048 | 4 | yes |
| GO:0034249 | negative regulation of amide metabolic process | 1.9048 | 5 | yes |
| GO:0046548 | retinal rod cell development | 1.9048 | 7 | yes |
| GO:0048935 | peripheral nervous system neuron development | 1.9048 | 5 | yes |
| GO:0098870 | action potential propagation | 1.9048 | 5 | yes |
| GO:0099183 | trans-synaptic signaling by BDNF, modulating synaptic transmission | 1.9048 | 7 | yes |
| GO:0099191 | trans-synaptic signaling by BDNF | 1.9048 | 6 | yes |
| GO:0099538 | synaptic signaling via neuropeptide | 1.9048 | 5 | yes |
| GO:0099540 | trans-synaptic signaling by neuropeptide | 1.9048 | 6 | yes |
| GO:0099550 | trans-synaptic signaling, modulating synaptic transmission | 1.9048 | 6 | yes |
| GO:0099551 | trans-synaptic signaling by neuropeptide, modulating synaptic transmission | 1.9048 | 7 | yes |
| GO:1902003 | regulation of amyloid-beta formation | 1.9048 | 5 | yes |
| GO:1902430 | negative regulation of amyloid-beta formation | 1.9048 | 6 | yes |
| GO:2000209 | regulation of anoikis | 1.9048 | 6 | yes |
| GO:2000811 | negative regulation of anoikis | 1.9048 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NTRK1_HUMAN | [view interactions] | Low throughput | no | yes |
| PTN23_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NTF4_HUMAN | [view interactions] | Low throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SQSTM_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BDNF_HUMAN | [view interactions] | Low throughput | no | yes |
| NTF3_HUMAN | [view interactions] | Low throughput | no | no |
| RANB9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TNR16_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DYLT1_HUMAN | [view interactions] | Low throughput | no | no |
| SOCS2_HUMAN | [view interactions] | Low throughput | no | yes |
| UCHL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NFIP1_HUMAN | [view interactions] | Low throughput | no | yes |
| SLIK5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ERBB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTPA_HUMAN | [view interactions] | Low throughput | no | yes |
| SHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KCNA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRB10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SORC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBP8_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SORL_HUMAN | [view interactions] | Low throughput | no | yes |
| PTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GIPC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NCK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHC3_HUMAN | [view interactions] | Low throughput | no | yes |
| SH2B1_HUMAN | [view interactions] | Low throughput | no | yes |
| PLCG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NCK1_HUMAN | [view interactions] | Low throughput | no | yes |
| TIAM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDK5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FNTA_HUMAN | [view interactions] | Low throughput | no | yes |
| PGTB1_HUMAN | [view interactions] | Low throughput | no | no |
| RGRF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NTRK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FRS2_HUMAN | [view interactions] | Low throughput | no | no |
| SORT_HUMAN | [view interactions] | Low throughput | no | yes |
| PTN11_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KINH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GCR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HGS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GAB1_HUMAN | [view interactions] | Low throughput | no | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPB7_HUMAN | [view interactions] | High throughput | no | yes |
| NMNA1_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFYV9_HUMAN | [view interactions] | High throughput | no | yes |
| PDXD1_HUMAN | [view interactions] | High throughput | no | no |
| GBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S20A2_HUMAN | [view interactions] | High throughput | no | yes |
| CNNM3_HUMAN | [view interactions] | High throughput | no | yes |
| PPIP2_HUMAN | [view interactions] | High throughput | no | no |
| DZIP1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| SPY4_HUMAN | [view interactions] | High throughput | no | yes |
| PLCH1_HUMAN | [view interactions] | High throughput | no | no |
| CBARP_HUMAN | [view interactions] | High throughput | no | no |
| MINK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABLM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PK3CB_HUMAN | [view interactions] | High throughput | no | yes |
| GORS2_HUMAN | [view interactions] | High throughput | no | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PKP2_HUMAN | [view interactions] | High throughput | no | yes |
| DTNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P55G_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGA_HUMAN | [view interactions] | High throughput | no | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHLB3_HUMAN | [view interactions] | High throughput | no | yes |
| UBIA1_HUMAN | [view interactions] | High throughput | no | no |
| M21D2_HUMAN | [view interactions] | High throughput | no | yes |
| STAM2_HUMAN | [view interactions] | High throughput | no | yes |
| PACN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRM7_HUMAN | [view interactions] | High throughput | no | yes |
| RFIP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S53A1_HUMAN | [view interactions] | High throughput | no | yes |
| F171B_HUMAN | [view interactions] | High throughput | no | yes |
| CENPH_HUMAN | [view interactions] | High throughput | no | yes |
| DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F135A_HUMAN | [view interactions] | High throughput | no | yes |
| JPH1_HUMAN | [view interactions] | High throughput | no | no |
| CAPON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STEA3_HUMAN | [view interactions] | High throughput | no | yes |
| KPCI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSC2_HUMAN | [view interactions] | High throughput | no | no |
| S6A15_HUMAN | [view interactions] | High throughput | no | yes |
| GRIN3_HUMAN | [view interactions] | High throughput | no | yes |
| ANR26_HUMAN | [view interactions] | High throughput | no | yes |
| GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E41L5_HUMAN | [view interactions] | High throughput | no | no |
| VANG1_HUMAN | [view interactions] | High throughput | no | no |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRDN_HUMAN | [view interactions] | High throughput | no | no |
| SC23B_HUMAN | [view interactions] | High throughput | no | yes |
| DLG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIPB1_HUMAN | [view interactions] | High throughput | no | yes |
| NOTC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIPB_HUMAN | [view interactions] | High throughput | no | yes |
| NISCH_HUMAN | [view interactions] | High throughput | no | yes |
| RHG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LSR_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA2_HUMAN | [view interactions] | High throughput | no | no |
| CDCA3_HUMAN | [view interactions] | High throughput | no | no |
| TARA_HUMAN | [view interactions] | High throughput | no | yes |
| PEAK1_HUMAN | [view interactions] | High throughput | no | yes |
| US6NL_HUMAN | [view interactions] | High throughput | no | yes |
| S4A7_HUMAN | [view interactions] | High throughput | no | no |
| KDIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC24B_HUMAN | [view interactions] | High throughput | no | yes |
| P85B_HUMAN | [view interactions] | High throughput | no | yes |
| WDR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARK3_HUMAN | [view interactions] | High throughput | no | yes |
| F1712_HUMAN | [view interactions] | High throughput | no | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| L2GL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPRIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F1711_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCP60_HUMAN | [view interactions] | High throughput | no | yes |
| ERBIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN13_HUMAN | [view interactions] | High throughput | no | yes |
| LRBA_HUMAN | [view interactions] | High throughput | no | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DCAF6_HUMAN | [view interactions] | High throughput | no | no |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTPR2_HUMAN | [view interactions] | High throughput | no | yes |
| LRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEPT3_HUMAN | [view interactions] | High throughput | no | no |
| SEP10_HUMAN | [view interactions] | High throughput | no | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGRB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMER2_HUMAN | [view interactions] | High throughput | no | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AQP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DVL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DVL3_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MGLYR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCYB1_HUMAN | [view interactions] | High throughput | no | yes |
| KCNB2_HUMAN | [view interactions] | High throughput | no | no |
| LRRC7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NCAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLPR3_HUMAN | [view interactions] | High throughput | no | no |
| PLPR4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SGIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S4A10_HUMAN | [view interactions] | High throughput | no | yes |
| LAT1_HUMAN | [view interactions] | High throughput | no | yes |
| SNP25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| CD5R1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCN2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| PCH2_HUMAN | [view interactions] | High throughput | no | no |