Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GRIN1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

May be involved in neurite outgrowth. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
662 Glu Lys Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomaldominant(NDHMSD) -
217 Arg Trp Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomalrecessive(NDHMSR) -
552 Asp Glu Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomaldominant(NDHMSD) -
557 Pro Arg Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomaldominant(NDHMSD) -
618 Gly Arg Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomaldominant(NDHMSD) -
620 Gly Arg Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomaldominant(NDHMSD) -
647 Tyr Ser Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomaldominant(NDHMSD) -
688 Ser Tyr Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomaldominant(NDHMSD) -
815 Gly Arg Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomaldominant(NDHMSD) -
815 Gly Val Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomaldominant(NDHMSD) -
817 Phe Leu Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomaldominant(NDHMSD) -
827 Gly Arg Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomaldominant(NDHMSD) -
844 Arg Cys Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomaldominant(NDHMSD) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GRIN1_HUMAN
GO:0000166 nucleotide binding 56.0976 4 no
GO:0017076 purine nucleotide binding 56.0976 5 no
GO:0032555 purine ribonucleotide binding 56.0976 4 no
GO:0035639 purine ribonucleoside triphosphate binding 56.0976 4 no
GO:0043168 anion binding 56.0976 4 no
GO:0016462 pyrophosphatase activity 34.1463 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 34.1463 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 34.1463 6 no
GO:0019900 kinase binding 29.2683 4 no
GO:0019901 protein kinase binding 29.2683 5 no
GO:0003924 GTPase activity 29.2683 7 no
GO:0005525 GTP binding 29.2683 5 no
GO:0019001 guanyl nucleotide binding 29.2683 6 no
GO:0032561 guanyl ribonucleotide binding 29.2683 5 no
GO:0005524 ATP binding 26.8293 5 no
GO:0030554 adenyl nucleotide binding 26.8293 6 no
GO:0032559 adenyl ribonucleotide binding 26.8293 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in GRIN1_HUMAN
GO:0048522 positive regulation of cellular process 85.3659 4 no
GO:0051128 regulation of cellular component organization 75.6098 4 no
GO:0010646 regulation of cell communication 65.8537 4 no
GO:0060255 regulation of macromolecule metabolic process 63.4146 4 no
GO:0009893 positive regulation of metabolic process 60.9756 4 no
GO:0009966 regulation of signal transduction 60.9756 4 no
GO:0010604 positive regulation of macromolecule metabolic process 60.9756 5 no
GO:0048523 negative regulation of cellular process 58.5366 4 no
GO:0031323 regulation of cellular metabolic process 56.0976 4 no
GO:0048584 positive regulation of response to stimulus 56.0976 4 no
GO:0080090 regulation of primary metabolic process 56.0976 4 no
GO:0051049 regulation of transport 53.6585 4 no
GO:0006996 organelle organization 53.6585 4 no
GO:0022607 cellular component assembly 53.6585 4 no
GO:0031325 positive regulation of cellular metabolic process 51.2195 5 no
GO:0051246 regulation of protein metabolic process 51.2195 5 no
GO:0009889 regulation of biosynthetic process 48.7805 4 no
GO:0010468 regulation of gene expression 48.7805 6 no
GO:0010556 regulation of macromolecule biosynthetic process 48.7805 5 no
GO:0010647 positive regulation of cell communication 48.7805 5 no
GO:0023056 positive regulation of signaling 48.7805 4 no
GO:0031326 regulation of cellular biosynthetic process 48.7805 5 no
GO:1902531 regulation of intracellular signal transduction 48.7805 5 no
GO:0030030 cell projection organization 48.7805 4 yes
GO:0031344 regulation of cell projection organization 43.9024 5 no
GO:0051247 positive regulation of protein metabolic process 43.9024 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 43.9024 6 no
GO:0009967 positive regulation of signal transduction 41.4634 5 no
GO:0008104 protein localization 41.4634 4 no
GO:0044087 regulation of cellular component biogenesis 41.4634 4 no
GO:0120036 plasma membrane bounded cell projection organization 41.4634 5 yes
GO:0030334 regulation of cell migration 39.0244 5 no
GO:0031399 regulation of protein modification process 39.0244 6 no
GO:0042127 regulation of cell population proliferation 39.0244 4 no
GO:0051240 positive regulation of multicellular organismal process 39.0244 4 no
GO:2000026 regulation of multicellular organismal development 39.0244 4 no
GO:2000145 regulation of cell motility 39.0244 4 no
GO:0022603 regulation of anatomical structure morphogenesis 39.0244 4 no
GO:0033043 regulation of organelle organization 39.0244 5 no
GO:0009892 negative regulation of metabolic process 36.5854 4 no
GO:0045595 regulation of cell differentiation 36.5854 4 no
GO:0051094 positive regulation of developmental process 36.5854 4 no
GO:0051130 positive regulation of cellular component organization 36.5854 5 no
GO:0141124 intracellular signaling cassette 36.5854 4 no
GO:0001932 regulation of protein phosphorylation 34.1463 7 no
GO:0010605 negative regulation of macromolecule metabolic process 34.1463 5 no
GO:0019220 regulation of phosphate metabolic process 34.1463 6 no
GO:0042325 regulation of phosphorylation 34.1463 7 no
GO:0042981 regulation of apoptotic process 34.1463 5 no
GO:0043067 regulation of programmed cell death 34.1463 4 no
GO:0051174 regulation of phosphorus metabolic process 34.1463 5 no
GO:0060627 regulation of vesicle-mediated transport 34.1463 4 no
GO:0060341 regulation of cellular localization 34.1463 4 no
GO:0009891 positive regulation of biosynthetic process 34.1463 5 no
GO:0031328 positive regulation of cellular biosynthetic process 34.1463 6 no
GO:0031175 neuron projection development 34.1463 6 yes
GO:0002684 positive regulation of immune system process 31.7073 4 no
GO:0008284 positive regulation of cell population proliferation 31.7073 5 no
GO:0030155 regulation of cell adhesion 31.7073 4 no
GO:0031324 negative regulation of cellular metabolic process 31.7073 5 no
GO:0060284 regulation of cell development 31.7073 5 no
GO:0071310 cellular response to organic substance 31.7073 4 no
GO:1902533 positive regulation of intracellular signal transduction 31.7073 6 no
GO:0007010 cytoskeleton organization 31.7073 5 no
GO:0032880 regulation of protein localization 31.7073 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 31.7073 6 no
GO:0051050 positive regulation of transport 31.7073 4 no
GO:0006796 phosphate-containing compound metabolic process 29.2683 4 no
GO:0010975 regulation of neuron projection development 29.2683 7 no
GO:0031401 positive regulation of protein modification process 29.2683 7 no
GO:0032101 regulation of response to external stimulus 29.2683 4 no
GO:0043085 positive regulation of catalytic activity 29.2683 4 no
GO:0071702 organic substance transport 29.2683 4 no
GO:0071705 nitrogen compound transport 29.2683 4 no
GO:0034330 cell junction organization 29.2683 4 no
GO:0050804 modulation of chemical synaptic transmission 29.2683 5 no
GO:0051129 negative regulation of cellular component organization 29.2683 5 no
GO:0099177 regulation of trans-synaptic signaling 29.2683 4 no
GO:0044089 positive regulation of cellular component biogenesis 29.2683 5 no
GO:0061024 membrane organization 29.2683 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.2683 5 no
GO:0097435 supramolecular fiber organization 26.8293 4 no
GO:0001934 positive regulation of protein phosphorylation 26.8293 8 no
GO:0010562 positive regulation of phosphorus metabolic process 26.8293 6 no
GO:0010648 negative regulation of cell communication 26.8293 5 no
GO:0023057 negative regulation of signaling 26.8293 4 no
GO:0030335 positive regulation of cell migration 26.8293 6 no
GO:0040017 positive regulation of locomotion 26.8293 4 no
GO:0042327 positive regulation of phosphorylation 26.8293 8 no
GO:0045597 positive regulation of cell differentiation 26.8293 5 no
GO:0045937 positive regulation of phosphate metabolic process 26.8293 7 no
GO:0051241 negative regulation of multicellular organismal process 26.8293 4 no
GO:2000147 positive regulation of cell motility 26.8293 5 no
GO:0007264 small GTPase-mediated signal transduction 26.8293 5 no
GO:0006355 regulation of DNA-templated transcription 26.8293 7 no
GO:0051252 regulation of RNA metabolic process 26.8293 5 no
GO:2001141 regulation of RNA biosynthetic process 26.8293 6 no
GO:0009968 negative regulation of signal transduction 24.3902 5 no
GO:0032103 positive regulation of response to external stimulus 24.3902 5 no
GO:0048585 negative regulation of response to stimulus 24.3902 4 no
GO:0050776 regulation of immune response 24.3902 4 no
GO:0051338 regulation of transferase activity 24.3902 4 no
GO:0009890 negative regulation of biosynthetic process 24.3902 5 no
GO:0051493 regulation of cytoskeleton organization 24.3902 6 no
GO:1903829 positive regulation of protein localization 24.3902 5 no
GO:0010628 positive regulation of gene expression 24.3902 7 no
GO:0050807 regulation of synapse organization 24.3902 5 no
GO:0001817 regulation of cytokine production 21.9512 4 no
GO:0010243 response to organonitrogen compound 21.9512 4 no
GO:0014070 response to organic cyclic compound 21.9512 4 no
GO:0043408 regulation of MAPK cascade 21.9512 6 no
GO:0045785 positive regulation of cell adhesion 21.9512 5 no
GO:0051046 regulation of secretion 21.9512 5 no
GO:0051248 negative regulation of protein metabolic process 21.9512 6 no
GO:0080134 regulation of response to stress 21.9512 4 no
GO:1901701 cellular response to oxygen-containing compound 21.9512 4 no
GO:1903530 regulation of secretion by cell 21.9512 4 no
GO:0072657 protein localization to membrane 21.9512 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.9512 6 no
GO:0031327 negative regulation of cellular biosynthetic process 21.9512 6 no
GO:1902903 regulation of supramolecular fiber organization 21.9512 5 no
GO:0051726 regulation of cell cycle 21.9512 4 no
GO:0007015 actin filament organization 21.9512 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ACHA7_HUMAN [view entry] [view interactions] Low throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
ARL4C_HUMAN [view interactions] High throughput no yes
AR13B_HUMAN [view interactions] High throughput no yes
ARL14_HUMAN [view interactions] High throughput no no
ARL15_HUMAN [view interactions] High throughput no yes
LRC4C_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK2_HUMAN [view entry] [view interactions] High throughput yes yes
PPP5_HUMAN [view entry] [view interactions] High throughput yes yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
PTK7_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB25_HUMAN [view interactions] High throughput no no
MUC18_HUMAN [view interactions] High throughput no yes
WWTR1_HUMAN [view interactions] High throughput no yes
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
YETS4_HUMAN [view interactions] High throughput no no
ZN281_HUMAN [view interactions] High throughput no no
S1PR1_HUMAN [view interactions] High throughput no no
CXB7_HUMAN [view interactions] High throughput no no
STALP_HUMAN [view interactions] High throughput no yes
VTNC_HUMAN [view interactions] High throughput no no
T185A_HUMAN [view interactions] High throughput no no
CAB45_HUMAN [view interactions] High throughput no no
RELL2_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
UFO_HUMAN [view interactions] High throughput no no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
CTDSL_HUMAN [view interactions] High throughput no no
PTPRG_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
EPHB2_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR3_HUMAN [view interactions] High throughput no yes
FGFR4_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
CP2S1_HUMAN [view interactions] High throughput no no
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
RN123_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
ACK1_HUMAN [view entry] [view interactions] High throughput yes yes
DX39A_HUMAN [view interactions] High throughput no yes
KCNE3_HUMAN [view interactions] High throughput no yes
TBB4B_HUMAN [view interactions] High throughput no yes
MAGA8_HUMAN [view interactions] High throughput no no
CERS2_HUMAN [view interactions] High throughput no no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOU_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
DCA15_HUMAN [view interactions] High throughput no no
RHDF2_HUMAN [view interactions] High throughput no yes
RET_HUMAN [view interactions] High throughput no yes
PTPRA_HUMAN [view interactions] High throughput no yes
SEC62_HUMAN [view interactions] High throughput no yes
DNJC5_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
CXAR_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
STX4_HUMAN [view entry] [view interactions] High throughput yes no
STX6_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes