Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GRIN1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

May be involved in neurite outgrowth. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
662 Glu Lys Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomaldominant(NDHMSD) -
217 Arg Trp Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomalrecessive(NDHMSR) -
552 Asp Glu Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomaldominant(NDHMSD) -
557 Pro Arg Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomaldominant(NDHMSD) -
618 Gly Arg Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomaldominant(NDHMSD) -
620 Gly Arg Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomaldominant(NDHMSD) -
647 Tyr Ser Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomaldominant(NDHMSD) -
688 Ser Tyr Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomaldominant(NDHMSD) -
815 Gly Arg Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomaldominant(NDHMSD) -
815 Gly Val Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomaldominant(NDHMSD) -
817 Phe Leu Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomaldominant(NDHMSD) -
827 Gly Arg Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomaldominant(NDHMSD) -
844 Arg Cys Neurodevelopmentaldisorderwithorwithouthyperkineticmovementsandseizures,autosomaldominant(NDHMSD) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GRIN1_HUMAN
GO:0017076 purine nucleotide binding 53.3333 4 no
GO:0032555 purine ribonucleotide binding 53.3333 4 no
GO:0035639 purine ribonucleoside triphosphate binding 53.3333 4 no
GO:0019900 kinase binding 43.3333 4 no
GO:0019901 protein kinase binding 43.3333 5 no
GO:0003924 GTPase activity 36.6667 7 no
GO:0005525 GTP binding 36.6667 5 no
GO:0016462 pyrophosphatase activity 36.6667 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 36.6667 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 36.6667 6 no
GO:0019001 guanyl nucleotide binding 36.6667 5 no
GO:0032561 guanyl ribonucleotide binding 36.6667 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in GRIN1_HUMAN
GO:0048522 positive regulation of cellular process 83.3333 4 no
GO:0051128 regulation of cellular component organization 63.3333 4 no
GO:0060255 regulation of macromolecule metabolic process 63.3333 4 no
GO:0030030 cell projection organization 60.0000 4 yes
GO:0022607 cellular component assembly 60.0000 4 no
GO:0009893 positive regulation of metabolic process 60.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 60.0000 5 no
GO:0010646 regulation of cell communication 60.0000 4 no
GO:0006996 organelle organization 56.6667 4 no
GO:0009966 regulation of signal transduction 56.6667 4 no
GO:0048523 negative regulation of cellular process 56.6667 4 no
GO:0051049 regulation of transport 56.6667 4 no
GO:0080090 regulation of primary metabolic process 56.6667 4 no
GO:0031323 regulation of cellular metabolic process 53.3333 4 no
GO:0051171 regulation of nitrogen compound metabolic process 53.3333 4 no
GO:0120036 plasma membrane bounded cell projection organization 50.0000 5 yes
GO:0048584 positive regulation of response to stimulus 50.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 50.0000 5 no
GO:0051246 regulation of protein metabolic process 46.6667 5 no
GO:0071310 cellular response to organic substance 46.6667 4 no
GO:1902531 regulation of intracellular signal transduction 46.6667 5 no
GO:0008104 protein localization 46.6667 4 no
GO:0010468 regulation of gene expression 43.3333 5 no
GO:0010647 positive regulation of cell communication 43.3333 5 no
GO:0022603 regulation of anatomical structure morphogenesis 43.3333 4 no
GO:0023056 positive regulation of signaling 43.3333 4 no
GO:0031325 positive regulation of cellular metabolic process 43.3333 5 no
GO:0016192 vesicle-mediated transport 43.3333 4 no
GO:0031175 neuron projection development 40.0000 6 yes
GO:0007010 cytoskeleton organization 40.0000 5 no
GO:0030334 regulation of cell migration 40.0000 5 no
GO:0033043 regulation of organelle organization 40.0000 5 no
GO:0051094 positive regulation of developmental process 40.0000 4 no
GO:2000145 regulation of cell motility 40.0000 4 no
GO:0009967 positive regulation of signal transduction 36.6667 5 no
GO:0030155 regulation of cell adhesion 36.6667 4 no
GO:0031344 regulation of cell projection organization 36.6667 5 no
GO:0044087 regulation of cellular component biogenesis 36.6667 4 no
GO:0051247 positive regulation of protein metabolic process 36.6667 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 36.6667 6 no
GO:0051050 positive regulation of transport 36.6667 4 no
GO:0032880 regulation of protein localization 36.6667 5 no
GO:0060341 regulation of cellular localization 36.6667 4 no
GO:0010243 response to organonitrogen compound 33.3333 4 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0042127 regulation of cell population proliferation 33.3333 4 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0043085 positive regulation of catalytic activity 33.3333 4 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0061024 membrane organization 33.3333 4 no
GO:1901701 cellular response to oxygen-containing compound 33.3333 4 no
GO:0071702 organic substance transport 33.3333 4 no
GO:0007015 actin filament organization 30.0000 5 no
GO:0097435 supramolecular fiber organization 30.0000 4 no
GO:0001932 regulation of protein phosphorylation 30.0000 7 no
GO:0007264 small GTPase mediated signal transduction 30.0000 4 no
GO:0009892 negative regulation of metabolic process 30.0000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 30.0000 6 no
GO:0022604 regulation of cell morphogenesis 30.0000 5 no
GO:0031399 regulation of protein modification process 30.0000 6 no
GO:0032956 regulation of actin cytoskeleton organization 30.0000 5 no
GO:0032970 regulation of actin filament-based process 30.0000 4 no
GO:0034330 cell junction organization 30.0000 4 no
GO:0042327 positive regulation of phosphorylation 30.0000 8 no
GO:0045595 regulation of cell differentiation 30.0000 4 no
GO:0045937 positive regulation of phosphate metabolic process 30.0000 7 no
GO:0051240 positive regulation of multicellular organismal process 30.0000 4 no
GO:0051493 regulation of cytoskeleton organization 30.0000 6 no
GO:1902533 positive regulation of intracellular signal transduction 30.0000 6 no
GO:0071705 nitrogen compound transport 30.0000 4 no
GO:0060627 regulation of vesicle-mediated transport 30.0000 4 no
GO:0008284 positive regulation of cell population proliferation 30.0000 5 no
GO:0002684 positive regulation of immune system process 26.6667 4 no
GO:0007265 Ras protein signal transduction 26.6667 5 no
GO:0010628 positive regulation of gene expression 26.6667 6 no
GO:0010941 regulation of cell death 26.6667 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.6667 5 no
GO:0030335 positive regulation of cell migration 26.6667 6 no
GO:0030865 cortical cytoskeleton organization 26.6667 6 no
GO:0040017 positive regulation of locomotion 26.6667 4 no
GO:0044089 positive regulation of cellular component biogenesis 26.6667 5 no
GO:0045597 positive regulation of cell differentiation 26.6667 5 no
GO:0045785 positive regulation of cell adhesion 26.6667 5 no
GO:0051338 regulation of transferase activity 26.6667 4 no
GO:2000147 positive regulation of cell motility 26.6667 5 no
GO:1901699 cellular response to nitrogen compound 26.6667 4 no
GO:0050776 regulation of immune response 26.6667 4 no
GO:1903829 positive regulation of protein localization 26.6667 5 no
GO:0010605 negative regulation of macromolecule metabolic process 26.6667 5 no
GO:0051046 regulation of secretion 26.6667 5 no
GO:1903530 regulation of secretion by cell 26.6667 4 no
GO:0001934 positive regulation of protein phosphorylation 23.3333 8 no
GO:0008360 regulation of cell shape 23.3333 6 no
GO:0009889 regulation of biosynthetic process 23.3333 4 no
GO:0014070 response to organic cyclic compound 23.3333 4 no
GO:0031324 negative regulation of cellular metabolic process 23.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 23.3333 5 no
GO:0031401 positive regulation of protein modification process 23.3333 7 no
GO:0032990 cell part morphogenesis 23.3333 4 no
GO:0034329 cell junction assembly 23.3333 5 no
GO:0042981 regulation of apoptotic process 23.3333 6 no
GO:0043067 regulation of programmed cell death 23.3333 5 no
GO:0048812 neuron projection morphogenesis 23.3333 7 no
GO:0048858 cell projection morphogenesis 23.3333 5 no
GO:0051129 negative regulation of cellular component organization 23.3333 5 no
GO:0051241 negative regulation of multicellular organismal process 23.3333 4 no
GO:0051347 positive regulation of transferase activity 23.3333 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 23.3333 6 no
GO:2000026 regulation of multicellular organismal development 23.3333 4 no
GO:0050804 modulation of chemical synaptic transmission 23.3333 5 no
GO:0099177 regulation of trans-synaptic signaling 23.3333 4 no
GO:0071417 cellular response to organonitrogen compound 23.3333 4 no
GO:1903076 regulation of protein localization to plasma membrane 23.3333 7 no
GO:1904375 regulation of protein localization to cell periphery 23.3333 6 no
GO:1905475 regulation of protein localization to membrane 23.3333 6 no
GO:0051223 regulation of protein transport 23.3333 5 no
GO:0070201 regulation of establishment of protein localization 23.3333 6 no
GO:0030031 cell projection assembly 23.3333 5 no

Disease

Term Name % Distance from top the of the tree Annotated in GRIN1_HUMAN
DOID:0060038 specific developmental disorder 6.6667 3 yes
DOID:0060307 autosomal dominant intellectual developmental disorder 6.6667 5 yes
DOID:1059 intellectual disability 6.6667 4 yes
DOID:0111962 combined immunodeficiency 6.6667 4 no
DOID:612 primary immunodeficiency disease 6.6667 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ACHA7_HUMAN [view entry] [view interactions] Low throughput yes yes
A0A1W2PN81_HUMAN [view entry] [view interactions] Low throughput yes no
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
YETS4_HUMAN [view interactions] High throughput no no
ZN281_HUMAN [view interactions] High throughput no no
S1PR1_HUMAN [view interactions] High throughput no no
CXB7_HUMAN [view interactions] High throughput no no
STALP_HUMAN [view interactions] High throughput no yes
VTNC_HUMAN [view interactions] High throughput no no
T185A_HUMAN [view interactions] High throughput no no
CAB45_HUMAN [view interactions] High throughput no yes
RELL2_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
UFO_HUMAN [view interactions] High throughput no no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
LAMP1_HUMAN [view interactions] High throughput no yes
CTDSL_HUMAN [view interactions] High throughput no no
PTPRG_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
EPHB2_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR1_HUMAN [view interactions] High throughput no yes
FGFR3_HUMAN [view interactions] High throughput no yes
FGFR4_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
CP2S1_HUMAN [view interactions] High throughput no no
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
RN123_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
ACK1_HUMAN [view interactions] High throughput no yes
DX39A_HUMAN [view interactions] High throughput no yes
KCNE3_HUMAN [view interactions] High throughput no yes
TBB4B_HUMAN [view interactions] High throughput no yes
MAGA8_HUMAN [view interactions] High throughput no no
CERS2_HUMAN [view interactions] High throughput no no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOU_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
DCA15_HUMAN [view interactions] High throughput no no
RHDF2_HUMAN [view interactions] High throughput no yes
RET_HUMAN [view interactions] High throughput no yes
PTPRA_HUMAN [view interactions] High throughput no yes
SEC62_HUMAN [view interactions] High throughput no yes
DNJC5_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
CXAR_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
STX4_HUMAN [view entry] [view interactions] High throughput yes no
STX6_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
MECP2_HUMAN [view interactions] Computational no yes