ACK1_HUMAN
Evidence for PS localization
Functions
Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on Tyr-176. Phosphorylates AR on Tyr-267 and Tyr-363 thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on Tyr-287. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACK1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 37.2549 | 5 | yes |
| GO:0000166 | nucleotide binding | 37.2549 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 36.2745 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 36.2745 | 4 | yes |
| GO:0043168 | anion binding | 36.2745 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 35.2941 | 6 | yes |
| GO:0005524 | ATP binding | 34.3137 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 34.3137 | 5 | yes |
| GO:0003723 | RNA binding | 27.4510 | 4 | no |
| GO:0045296 | cadherin binding | 24.5098 | 4 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 19.6078 | 4 | yes |
| GO:0016301 | kinase activity | 18.6275 | 4 | yes |
| GO:0031625 | ubiquitin protein ligase binding | 18.6275 | 5 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 17.6471 | 4 | yes |
| GO:0004713 | protein tyrosine kinase activity | 11.7647 | 4 | yes |
| GO:0043169 | cation binding | 10.7843 | 4 | yes |
| GO:0046872 | metal ion binding | 10.7843 | 5 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 8.8235 | 4 | yes |
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity | 7.8431 | 5 | yes |
| GO:0106310 | protein serine kinase activity | 7.8431 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 5.8824 | 4 | yes |
| GO:0070851 | growth factor receptor binding | 4.9020 | 4 | yes |
| GO:0005154 | epidermal growth factor receptor binding | 2.9412 | 5 | yes |
| GO:0050699 | WW domain binding | 2.9412 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 2.9412 | 4 | yes |
| GO:0005095 | GTPase inhibitor activity | 1.9608 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ACK1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 63.7255 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 53.9216 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 52.9412 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 52.9412 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 49.0196 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 47.0588 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 45.0980 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 41.1765 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 41.1765 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 41.1765 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 41.1765 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 41.1765 | 5 | yes |
| GO:0022607 | cellular component assembly | 39.2157 | 4 | no |
| GO:0010646 | regulation of cell communication | 39.2157 | 4 | no |
| GO:0006996 | organelle organization | 38.2353 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 35.2941 | 5 | no |
| GO:0009966 | regulation of signal transduction | 34.3137 | 4 | no |
| GO:0033043 | regulation of organelle organization | 32.3529 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 31.3725 | 5 | yes |
| GO:0010468 | regulation of gene expression | 31.3725 | 6 | no |
| GO:0051049 | regulation of transport | 29.4118 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.4118 | 5 | no |
| GO:0060341 | regulation of cellular localization | 28.4314 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 28.4314 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 28.4314 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 27.4510 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 27.4510 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 27.4510 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.4706 | 6 | yes |
| GO:0048584 | positive regulation of response to stimulus | 26.4706 | 4 | no |
| GO:0032880 | regulation of protein localization | 25.4902 | 5 | no |
| GO:0008104 | protein localization | 25.4902 | 4 | no |
| GO:0031399 | regulation of protein modification process | 24.5098 | 6 | yes |
| GO:0031344 | regulation of cell projection organization | 24.5098 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.5098 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.5098 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 24.5098 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 22.5490 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 22.5490 | 4 | no |
| GO:0071702 | organic substance transport | 22.5490 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.5490 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 22.5490 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.5686 | 5 | yes |
| GO:0007010 | cytoskeleton organization | 21.5686 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 21.5686 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 21.5686 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.5686 | 4 | no |
| GO:0010638 | positive regulation of organelle organization | 21.5686 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.5686 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.5686 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 20.5882 | 7 | yes |
| GO:0010975 | regulation of neuron projection development | 20.5882 | 7 | no |
| GO:0036211 | protein modification process | 20.5882 | 4 | no |
| GO:0043412 | macromolecule modification | 20.5882 | 4 | no |
| GO:0030030 | cell projection organization | 20.5882 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 20.5882 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 20.5882 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 20.5882 | 7 | yes |
| GO:0031401 | positive regulation of protein modification process | 19.6078 | 7 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 18.6275 | 7 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 18.6275 | 6 | yes |
| GO:0016310 | phosphorylation | 18.6275 | 5 | yes |
| GO:0042327 | positive regulation of phosphorylation | 17.6471 | 8 | yes |
| GO:0098657 | import into cell | 17.6471 | 4 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 17.6471 | 8 | yes |
| GO:0141124 | intracellular signaling cassette | 12.7451 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 10.7843 | 4 | yes |
| GO:0030100 | regulation of endocytosis | 9.8039 | 5 | yes |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 8.8235 | 8 | yes |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 8.8235 | 9 | yes |
| GO:0007264 | small GTPase-mediated signal transduction | 5.8824 | 5 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 2.9412 | 6 | yes |
| GO:2000369 | regulation of clathrin-dependent endocytosis | 1.9608 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| HS90A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BCAR1_HUMAN | [view interactions] | Low throughput | no | yes |
| ACK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYNJ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| CRK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| HSH2D_HUMAN | [view interactions] | Low throughput | no | no |
| PAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NPHP1_HUMAN | [view interactions] | Low throughput | no | yes |
| P55G_HUMAN | [view interactions] | Low throughput | no | yes |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| P85B_HUMAN | [view interactions] | Low throughput | no | yes |
| FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MCF2_HUMAN | [view interactions] | Low throughput | no | no |
| NEDD4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CLCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AMPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FABP4_HUMAN | [view interactions] | Low throughput | no | no |
| NED4L_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KAT8_HUMAN | [view interactions] | Low throughput | no | no |
| KAT5_HUMAN | [view interactions] | Low throughput | no | yes |
| PGFRB_HUMAN | [view interactions] | Low throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WWOX_HUMAN | [view interactions] | Low throughput | no | yes |
| MERTK_HUMAN | [view interactions] | Low throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WASP_HUMAN | [view interactions] | Low throughput | no | yes |
| ZBT16_HUMAN | [view interactions] | Low throughput | no | yes |
| EP300_HUMAN | [view interactions] | Low throughput | no | yes |
| P73_HUMAN | [view interactions] | Low throughput | no | no |
| LYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SRC8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SIAH2_HUMAN | [view interactions] | Low throughput | no | no |
| A16L1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | Low throughput | no | yes |
| TRI50_HUMAN | [view interactions] | Low throughput | no | no |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| NTRK1_HUMAN | [view interactions] | Low throughput | no | yes |
| NTRK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KDM3A_HUMAN | [view interactions] | Low throughput | no | no |
| AKT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PDK1_HUMAN | [view interactions] | Low throughput | no | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LCP2_HUMAN | [view interactions] | Low throughput | no | yes |
| CDN1B_HUMAN | [view interactions] | Low throughput | no | yes |
| ATPA_HUMAN | [view interactions] | Low throughput | no | yes |
| WWP2_HUMAN | [view interactions] | Low throughput | no | no |
| HCK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KCNA5_HUMAN | [view interactions] | Low throughput | no | no |
| EEA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NBR1_HUMAN | [view interactions] | Low throughput | no | yes |
| YES_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNX9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NCK1_HUMAN | [view interactions] | Low throughput | no | yes |
| SIAH1_HUMAN | [view interactions] | Low throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANDR_HUMAN | [view interactions] | Low throughput | no | no |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H90B3_HUMAN | [view interactions] | High throughput | no | no |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H90B2_HUMAN | [view interactions] | High throughput | no | no |
| TCPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHIP1_HUMAN | [view interactions] | High throughput | no | no |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DCLK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZW10_HUMAN | [view interactions] | High throughput | no | yes |
| MCM3_HUMAN | [view interactions] | High throughput | no | no |
| ATPK_HUMAN | [view interactions] | High throughput | no | yes |
| MTA1_HUMAN | [view interactions] | High throughput | no | yes |
| TSR1_HUMAN | [view interactions] | High throughput | no | no |
| NUF2_HUMAN | [view interactions] | High throughput | no | no |
| EIF3L_HUMAN | [view interactions] | High throughput | no | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SOCS4_HUMAN | [view interactions] | High throughput | no | yes |
| SH21A_HUMAN | [view interactions] | High throughput | no | no |
| GALT_HUMAN | [view interactions] | High throughput | no | yes |
| AQP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NT2NA_HUMAN | [view interactions] | High throughput | no | no |
| NEK6_HUMAN | [view interactions] | High throughput | no | yes |
| ARSL_HUMAN | [view interactions] | High throughput | no | no |
| ITFG2_HUMAN | [view interactions] | High throughput | no | yes |
| RGF1C_HUMAN | [view interactions] | High throughput | no | yes |
| RL18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEZ6_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF5_HUMAN | [view interactions] | High throughput | no | yes |
| VTI1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRC_HUMAN | [view interactions] | High throughput | no | no |
| PTPRJ_HUMAN | [view interactions] | High throughput | no | yes |
| PTN12_HUMAN | [view interactions] | High throughput | no | yes |
| KR103_HUMAN | [view interactions] | High throughput | no | no |
| DPH2_HUMAN | [view interactions] | High throughput | no | no |
| CRTP1_HUMAN | [view interactions] | High throughput | no | yes |
| SH21B_HUMAN | [view interactions] | High throughput | no | no |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| LTK_HUMAN | [view interactions] | High throughput | no | no |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD6_HUMAN | [view interactions] | High throughput | no | yes |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| CRKL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIMC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADDB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPRIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHG23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NFM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| CTNA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMER2_HUMAN | [view interactions] | High throughput | no | yes |
| CRACD_HUMAN | [view interactions] | High throughput | no | yes |
| AJM1_HUMAN | [view interactions] | High throughput | no | no |
| MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFAP1_HUMAN | [view interactions] | High throughput | no | yes |
| ENAH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDHD1_HUMAN | [view interactions] | High throughput | no | no |
| KI21B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FRM4A_HUMAN | [view interactions] | High throughput | no | no |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| CAMP3_HUMAN | [view interactions] | High throughput | no | no |
| DEN2A_HUMAN | [view interactions] | High throughput | no | no |
| SMRC2_HUMAN | [view interactions] | High throughput | no | yes |
| SRBS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAOK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRL2_HUMAN | [view interactions] | High throughput | no | yes |
| FBX41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LEO1_HUMAN | [view interactions] | High throughput | no | yes |
| SH2D7_HUMAN | [view interactions] | High throughput | no | no |
| MICA3_HUMAN | [view interactions] | High throughput | no | yes |
| MTCL3_HUMAN | [view interactions] | High throughput | no | no |
| RAI14_HUMAN | [view interactions] | High throughput | no | yes |
| AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRC7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NLGN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SVIL_HUMAN | [view interactions] | High throughput | no | yes |
| FAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAD10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPR18_HUMAN | [view interactions] | High throughput | no | no |
| MAP9_HUMAN | [view interactions] | High throughput | no | no |
| ARVC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNM3A_HUMAN | [view interactions] | High throughput | no | yes |
| MYPT2_HUMAN | [view interactions] | High throughput | no | no |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP6R2_HUMAN | [view interactions] | High throughput | no | no |
| TMX1_HUMAN | [view interactions] | High throughput | no | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2ABD_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| HECW1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAGI3_HUMAN | [view interactions] | High throughput | no | no |
| BIN2_HUMAN | [view interactions] | High throughput | no | no |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| SC24C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| RM55_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |