AFAD_HUMAN
Evidence for PS localization
Functions
Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) . Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed). May play a key role in the organization of epithelial structures of the embryonic ectoderm . Essential for the organization of adherens junctions (PubMed). [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
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AFAD_HUMAN has binary interactions with 50 proteins
Isoforms
Interacting regions
Canonical [AFAD_HUMAN]
Isoform [J3KN01] alignment
Isoform [A8MQ02] alignment
Isoform [Q5TIG5] alignment
Isoform [P55196-1] alignment
Isoform [P55196-2] alignment
Isoform [P55196-3] alignment
Isoform [P55196-5] alignment
Isoform [P55196-6] alignment
Isoform [F8W9I4] alignment
Isoform [H0YA98] alignment
Isoform [H0Y9I0] alignment
Isoform [H0Y8L4] alignment
Isoform [H0Y8U8] alignment
Isoform [H0Y948] alignment
Isoform [H0Y7R8] alignment
Isoform [A0A804HJ20] alignment
Isoform [E9PFY5] alignment
LOADING 28%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AFAD_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 28.2443 | 4 | no |
| GO:0000166 | nucleotide binding | 24.4275 | 4 | no |
| GO:0017076 | purine nucleotide binding | 24.4275 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 24.4275 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 24.4275 | 4 | no |
| GO:0045296 | cadherin binding | 21.3740 | 4 | yes |
| GO:0019900 | kinase binding | 20.6107 | 4 | no |
| GO:0003779 | actin binding | 14.5038 | 4 | yes |
| GO:0031267 | small GTPase binding | 7.6336 | 5 | yes |
| GO:0051020 | GTPase binding | 7.6336 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AFAD_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 51.9084 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 51.1450 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 50.3817 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 44.2748 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 43.5115 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 42.7481 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 41.9847 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 38.9313 | 4 | no |
| GO:0008104 | protein localization | 35.8779 | 4 | yes |
| GO:0022607 | cellular component assembly | 34.3511 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 34.3511 | 5 | no |
| GO:0006996 | organelle organization | 32.8244 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 32.0611 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 32.0611 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 32.0611 | 5 | yes |
| GO:0010468 | regulation of gene expression | 31.2977 | 6 | yes |
| GO:0009893 | positive regulation of metabolic process | 30.5344 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.7710 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 27.4809 | 5 | yes |
| GO:0051049 | regulation of transport | 26.7176 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 26.7176 | 5 | no |
| GO:0030030 | cell projection organization | 26.7176 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.9542 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.1908 | 5 | no |
| GO:0007010 | cytoskeleton organization | 25.1908 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 4F2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AAAT_HUMAN | [view interactions] | High throughput | no | no |
| ABLM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABLM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADCY9_HUMAN | [view interactions] | High throughput | no | yes |
| ADIP_HUMAN | [view interactions] | Low throughput | no | yes |
| AF17_HUMAN | [view interactions] | High throughput | no | yes |
| AFAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AGAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AMOL1_HUMAN | [view interactions] | High throughput | no | no |
| AN34A_HUMAN | [view interactions] | High throughput | no | no |
| ANR26_HUMAN | [view interactions] | High throughput | no | yes |
| APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AR13B_HUMAN | [view interactions] | High throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARI1_HUMAN | [view interactions] | High throughput | no | yes |