AGAP1_HUMAN
Evidence for PS localization
Functions
GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AGAP1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 36.8421 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 36.8421 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 36.8421 | 4 | yes |
| GO:0003924 | GTPase activity | 28.9474 | 7 | yes |
| GO:0005525 | GTP binding | 28.9474 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 28.9474 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 28.9474 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 28.9474 | 6 | yes |
| GO:0019001 | guanyl nucleotide binding | 28.9474 | 5 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 28.9474 | 5 | yes |
| GO:0030695 | GTPase regulator activity | 23.6842 | 4 | yes |
| GO:0005096 | GTPase activator activity | 21.0526 | 4 | yes |
| GO:0046872 | metal ion binding | 21.0526 | 4 | yes |
| GO:0019900 | kinase binding | 21.0526 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AGAP1_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 57.8947 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 47.3684 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 44.7368 | 4 | no |
| GO:0009966 | regulation of signal transduction | 42.1053 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 42.1053 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 42.1053 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 42.1053 | 4 | no |
| GO:0008104 | protein localization | 39.4737 | 4 | yes |
| GO:0071702 | organic substance transport | 39.4737 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 39.4737 | 4 | no |
| GO:0071705 | nitrogen compound transport | 36.8421 | 4 | yes |
| GO:0030030 | cell projection organization | 36.8421 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 36.8421 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 34.2105 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 34.2105 | 5 | no |
| GO:0051049 | regulation of transport | 34.2105 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 34.2105 | 6 | no |
| GO:0015031 | protein transport | 31.5789 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 31.5789 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 31.5789 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 31.5789 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 31.5789 | 5 | no |
| GO:0006996 | organelle organization | 31.5789 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 28.9474 | 4 | no |
| GO:0031399 | regulation of protein modification process | 28.9474 | 6 | no |
| GO:0022607 | cellular component assembly | 28.9474 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 28.9474 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 28.9474 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.3158 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.3158 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 26.3158 | 7 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 26.3158 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 26.3158 | 4 | no |
| GO:0007010 | cytoskeleton organization | 26.3158 | 5 | no |
| GO:0007264 | small GTPase mediated signal transduction | 26.3158 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 26.3158 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.3158 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.3158 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 26.3158 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 26.3158 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.6842 | 7 | no |
| GO:0006886 | intracellular protein transport | 23.6842 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 23.6842 | 5 | no |
| GO:0007265 | Ras protein signal transduction | 23.6842 | 5 | no |
| GO:0010941 | regulation of cell death | 23.6842 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 23.6842 | 7 | no |
| GO:0030334 | regulation of cell migration | 23.6842 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.6842 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 23.6842 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 23.6842 | 5 | no |
| GO:0050807 | regulation of synapse organization | 23.6842 | 5 | no |
| GO:0051093 | negative regulation of developmental process | 23.6842 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 23.6842 | 5 | no |
| GO:2000145 | regulation of cell motility | 23.6842 | 4 | no |
| GO:0032880 | regulation of protein localization | 23.6842 | 5 | no |
| GO:0060341 | regulation of cellular localization | 23.6842 | 4 | no |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 23.6842 | 6 | no |
| GO:0043549 | regulation of kinase activity | 21.0526 | 5 | no |
| GO:0051338 | regulation of transferase activity | 21.0526 | 4 | no |
| GO:0071310 | cellular response to organic substance | 21.0526 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 21.0526 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 21.0526 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.0526 | 4 | no |
| GO:0033043 | regulation of organelle organization | 21.0526 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 21.0526 | 4 | no |
| GO:0042327 | positive regulation of phosphorylation | 21.0526 | 8 | no |
| GO:0045596 | negative regulation of cell differentiation | 21.0526 | 5 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 21.0526 | 7 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 21.0526 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 21.0526 | 4 | no |
| GO:0051223 | regulation of protein transport | 21.0526 | 5 | no |
| GO:0070201 | regulation of establishment of protein localization | 21.0526 | 6 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GCYA1_HUMAN | [view interactions] | Low throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | Low throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AGAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRB7_HUMAN | [view interactions] | High throughput | no | no |
| SMN_HUMAN | [view interactions] | High throughput | no | yes |
| KITH_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| ZN534_HUMAN | [view interactions] | High throughput | no | no |
| RSP14_HUMAN | [view interactions] | High throughput | no | no |
| PRAF1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| DCLK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| NADK_HUMAN | [view interactions] | High throughput | no | yes |
| AFAD_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| MELK_HUMAN | [view interactions] | High throughput | no | yes |
| TBC25_HUMAN | [view interactions] | High throughput | no | yes |
| SYDE1_HUMAN | [view interactions] | High throughput | no | yes |
| NAV1_HUMAN | [view interactions] | High throughput | no | yes |
| F110B_HUMAN | [view interactions] | High throughput | no | yes |
| SRS12_HUMAN | [view interactions] | High throughput | no | no |
| MAGI1_HUMAN | [view interactions] | High throughput | no | no |
| TESK2_HUMAN | [view interactions] | High throughput | no | yes |
| F110A_HUMAN | [view interactions] | High throughput | no | yes |
| KI13B_HUMAN | [view interactions] | High throughput | no | yes |
| SH3B4_HUMAN | [view interactions] | High throughput | no | yes |
| LRFN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CING_HUMAN | [view interactions] | High throughput | no | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NGAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT21_HUMAN | [view interactions] | High throughput | no | yes |
| PHLB2_HUMAN | [view interactions] | High throughput | no | yes |
| AN34A_HUMAN | [view interactions] | High throughput | no | no |
| DEN4C_HUMAN | [view interactions] | High throughput | no | yes |
| SPD2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K21_HUMAN | [view interactions] | High throughput | no | yes |
| ZN638_HUMAN | [view interactions] | High throughput | no | yes |
| TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| CDK16_HUMAN | [view interactions] | High throughput | no | yes |
| MPIP2_HUMAN | [view interactions] | High throughput | no | no |
| NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IF4E2_HUMAN | [view interactions] | High throughput | no | no |
| MAST3_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD3_HUMAN | [view interactions] | High throughput | no | yes |
| GAB2_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1H_HUMAN | [view interactions] | High throughput | no | yes |
| UBP21_HUMAN | [view interactions] | High throughput | no | no |
| FA53C_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| SIN1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB3I_HUMAN | [view interactions] | High throughput | no | no |
| EDC3_HUMAN | [view interactions] | High throughput | no | yes |
| DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
| DEN1A_HUMAN | [view interactions] | High throughput | no | no |
| RTKN_HUMAN | [view interactions] | High throughput | no | yes |
| CBY1_HUMAN | [view interactions] | High throughput | no | no |
| CBWD1_HUMAN | [view interactions] | High throughput | no | yes |
| MIER2_HUMAN | [view interactions] | High throughput | no | yes |
| PRP4_HUMAN | [view interactions] | High throughput | no | yes |
| P4HA3_HUMAN | [view interactions] | High throughput | no | no |
| PCDAC_HUMAN | [view interactions] | High throughput | no | yes |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| FLCN_HUMAN | [view interactions] | High throughput | no | yes |
| PCD20_HUMAN | [view interactions] | High throughput | no | no |
| PCDAA_HUMAN | [view interactions] | High throughput | no | no |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAD23_HUMAN | [view interactions] | High throughput | no | yes |
| TRI52_HUMAN | [view interactions] | High throughput | no | yes |
| CBWD2_HUMAN | [view interactions] | High throughput | no | no |
| CD6_HUMAN | [view interactions] | High throughput | no | no |
| NUBP1_HUMAN | [view interactions] | High throughput | no | yes |
| TANC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZCH10_HUMAN | [view interactions] | High throughput | no | yes |
| NCKP5_HUMAN | [view interactions] | High throughput | no | no |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TANC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ICLN_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |