TRIM9_HUMAN
Evidence for PS localization
Functions
E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TRIM9_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 16.0494 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 8.6420 | 4 | yes |
| GO:0046914 | transition metal ion binding | 7.4074 | 5 | yes |
| GO:0008270 | zinc ion binding | 4.9383 | 6 | yes |
| GO:0004842 | ubiquitin-protein transferase activity | 2.4691 | 4 | yes |
| GO:0061630 | ubiquitin protein ligase activity | 2.4691 | 5 | yes |
| GO:0061659 | ubiquitin-like protein ligase activity | 2.4691 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TRIM9_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 44.4444 | 4 | no |
| GO:0010646 | regulation of cell communication | 40.7407 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 40.7407 | 4 | no |
| GO:0006996 | organelle organization | 35.8025 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 34.5679 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 32.0988 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 32.0988 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 30.8642 | 4 | no |
| GO:0022607 | cellular component assembly | 29.6296 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 29.6296 | 6 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 29.6296 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 29.6296 | 4 | no |
| GO:0008104 | protein localization | 28.3951 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 27.1605 | 4 | no |
| GO:0030030 | cell projection organization | 25.9259 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 25.9259 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.6914 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 24.6914 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 23.4568 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.4568 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.4568 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 23.4568 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.4568 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 23.4568 | 5 | no |
| GO:0007010 | cytoskeleton organization | 23.4568 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 22.2222 | 7 | no |
| GO:0051049 | regulation of transport | 22.2222 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.2222 | 4 | no |
| GO:0071702 | organic substance transport | 22.2222 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 20.9877 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 20.9877 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.9877 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 20.9877 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.9877 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 20.9877 | 5 | no |
| GO:0006508 | proteolysis | 7.4074 | 4 | yes |
| GO:0009057 | macromolecule catabolic process | 7.4074 | 4 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 7.4074 | 4 | yes |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 6.1728 | 7 | yes |
| GO:0019941 | modification-dependent protein catabolic process | 6.1728 | 6 | yes |
| GO:0030163 | protein catabolic process | 6.1728 | 4 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 6.1728 | 5 | yes |
| GO:0044265 | cellular macromolecule catabolic process | 6.1728 | 4 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 6.1728 | 5 | yes |
| GO:0010498 | proteasomal protein catabolic process | 4.9383 | 5 | yes |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 4.9383 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in TRIM9_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 3.7037 | 3 | no |
| DOID:0060038 | specific developmental disorder | 3.7037 | 3 | no |
| DOID:1059 | intellectual disability | 3.7037 | 4 | no |
| DOID:0060307 | autosomal dominant intellectual developmental disorder | 2.4691 | 5 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EVL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FBW1A_HUMAN | [view interactions] | Low throughput | no | yes |
| VASP_HUMAN | [view interactions] | Low throughput | no | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SNP25_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GLU2B_HUMAN | [view interactions] | Low throughput | no | yes |
| ACTA_HUMAN | [view interactions] | Low throughput | no | no |
| FBW1B_HUMAN | [view interactions] | Low throughput | no | yes |
| TBK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DCC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | Low throughput | no | no |
| SCAP_HUMAN | [view interactions] | Low throughput | no | yes |
| ENAH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| PEX5_HUMAN | [view interactions] | High throughput | no | yes |
| AFAP1_HUMAN | [view interactions] | High throughput | no | yes |
| SI1L2_HUMAN | [view interactions] | High throughput | no | yes |
| CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| LIMD1_HUMAN | [view interactions] | High throughput | no | yes |
| ERC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIBRA_HUMAN | [view interactions] | High throughput | no | yes |
| SH3R1_HUMAN | [view interactions] | High throughput | no | yes |
| R3HD2_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBLB_HUMAN | [view interactions] | High throughput | no | yes |
| RTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PACS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NYAP2_HUMAN | [view interactions] | High throughput | no | no |
| M4K4_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRGP1_HUMAN | [view interactions] | High throughput | no | no |
| CPEB4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DIP2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPP_HUMAN | [view interactions] | High throughput | no | yes |
| PM34_HUMAN | [view interactions] | High throughput | no | yes |
| BSN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMU1_HUMAN | [view interactions] | High throughput | no | yes |
| LRC47_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRAG1_HUMAN | [view interactions] | High throughput | no | yes |
| TAB3_HUMAN | [view interactions] | High throughput | no | yes |
| ZC12C_HUMAN | [view interactions] | High throughput | no | yes |
| P3C2A_HUMAN | [view interactions] | High throughput | no | yes |
| SURF4_HUMAN | [view interactions] | High throughput | no | yes |
| PKP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEAK1_HUMAN | [view interactions] | High throughput | no | yes |
| NCK5L_HUMAN | [view interactions] | High throughput | no | yes |
| FBX41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GGA2_HUMAN | [view interactions] | High throughput | no | yes |
| CTIF_HUMAN | [view interactions] | High throughput | no | yes |
| NYAP1_HUMAN | [view interactions] | High throughput | no | no |
| IBTK_HUMAN | [view interactions] | High throughput | no | yes |
| PRC2B_HUMAN | [view interactions] | High throughput | no | no |
| ZFYV1_HUMAN | [view interactions] | High throughput | no | yes |
| F168A_HUMAN | [view interactions] | High throughput | no | yes |
| CEP85_HUMAN | [view interactions] | High throughput | no | no |
| CEP55_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHPR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KATIP_HUMAN | [view interactions] | High throughput | no | yes |
| VPS52_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP3M2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DOLK_HUMAN | [view interactions] | High throughput | no | no |
| NUP35_HUMAN | [view interactions] | High throughput | no | yes |
| WASF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RINI_HUMAN | [view interactions] | High throughput | no | yes |
| ZN622_HUMAN | [view interactions] | High throughput | no | yes |
| S35B2_HUMAN | [view interactions] | High throughput | no | no |
| FACR1_HUMAN | [view interactions] | High throughput | no | yes |
| TAB2_HUMAN | [view interactions] | High throughput | no | yes |
| CDS2_HUMAN | [view interactions] | High throughput | no | yes |
| TTC5_HUMAN | [view interactions] | High throughput | no | yes |
| SNCAP_HUMAN | [view interactions] | High throughput | no | no |
| TXD17_HUMAN | [view interactions] | High throughput | no | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDZ11_HUMAN | [view interactions] | High throughput | no | yes |
| PLCC_HUMAN | [view interactions] | High throughput | no | no |
| EXOS8_HUMAN | [view interactions] | High throughput | no | yes |
| PSMG2_HUMAN | [view interactions] | High throughput | no | yes |
| WDR12_HUMAN | [view interactions] | High throughput | no | yes |
| DPF1_HUMAN | [view interactions] | High throughput | no | yes |
| PCLO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIPA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 4ET_HUMAN | [view interactions] | High throughput | no | yes |
| PPIH_HUMAN | [view interactions] | High throughput | no | yes |
| SHOC2_HUMAN | [view interactions] | High throughput | no | yes |
| RHG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HACD3_HUMAN | [view interactions] | High throughput | no | yes |
| STML2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP6R1_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRBS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GKAP1_HUMAN | [view interactions] | High throughput | no | no |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGO2_HUMAN | [view interactions] | High throughput | no | yes |
| DYN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP1M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WWC2_HUMAN | [view interactions] | High throughput | no | yes |
| CTND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAB1_HUMAN | [view interactions] | High throughput | no | yes |
| CLIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN5_HUMAN | [view interactions] | High throughput | no | yes |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| DVL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YTHD1_HUMAN | [view interactions] | High throughput | no | no |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| GPSM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTH2_HUMAN | [view interactions] | High throughput | no | yes |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEX3D_HUMAN | [view interactions] | High throughput | no | yes |
| SEM4C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K1C40_HUMAN | [view interactions] | High throughput | no | no |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| BFSP1_HUMAN | [view interactions] | High throughput | no | no |
| GFAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARI1_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW2_HUMAN | [view interactions] | High throughput | no | yes |
| ZEP2_HUMAN | [view interactions] | High throughput | no | no |
| CF210_HUMAN | [view interactions] | High throughput | no | no |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| Z3H7A_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAT1_HUMAN | [view interactions] | High throughput | no | yes |
| PCGF3_HUMAN | [view interactions] | High throughput | no | yes |
| MDM2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI46_HUMAN | [view interactions] | High throughput | no | no |
| RN166_HUMAN | [view interactions] | High throughput | no | no |
| CHFR_HUMAN | [view interactions] | High throughput | no | no |
| TRIM8_HUMAN | [view interactions] | High throughput | no | yes |
| TRI27_HUMAN | [view interactions] | High throughput | no | yes |
| LONF1_HUMAN | [view interactions] | High throughput | no | yes |
| DTX3L_HUMAN | [view interactions] | High throughput | no | yes |
| C19L2_HUMAN | [view interactions] | High throughput | no | yes |
| KC1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IKBD_HUMAN | [view interactions] | High throughput | no | no |
| RRF2M_HUMAN | [view interactions] | High throughput | no | yes |
| MUL1_HUMAN | [view interactions] | High throughput | no | no |
| TSSK3_HUMAN | [view interactions] | High throughput | no | no |
| SPG21_HUMAN | [view interactions] | High throughput | no | yes |
| AP3M1_HUMAN | [view interactions] | High throughput | no | yes |
| UTP25_HUMAN | [view interactions] | High throughput | no | yes |
| F90A1_HUMAN | [view interactions] | High throughput | no | no |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCF1_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL2_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODFP2_HUMAN | [view interactions] | High throughput | no | no |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| ADIP_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| ROR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP2_HUMAN | [view interactions] | High throughput | no | yes |
| UBP21_HUMAN | [view interactions] | High throughput | no | no |
| F124B_HUMAN | [view interactions] | High throughput | no | yes |
| UB2G2_HUMAN | [view interactions] | High throughput | no | yes |
| STX19_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| RELL2_HUMAN | [view interactions] | High throughput | no | no |
| KLHL2_HUMAN | [view interactions] | High throughput | no | no |
| SGPL1_HUMAN | [view interactions] | High throughput | no | yes |
| SPA24_HUMAN | [view interactions] | High throughput | no | no |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO16_HUMAN | [view interactions] | High throughput | no | no |
| SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLPR4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TANC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPD2B_HUMAN | [view interactions] | High throughput | no | no |
| CTND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHG39_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EST1A_HUMAN | [view interactions] | High throughput | no | yes |
| MILK2_HUMAN | [view interactions] | High throughput | no | no |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| CP131_HUMAN | [view interactions] | High throughput | no | no |
| PHLB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLPR3_HUMAN | [view interactions] | High throughput | no | no |
| CE120_HUMAN | [view interactions] | High throughput | no | no |
| C170B_HUMAN | [view interactions] | High throughput | no | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| LUZP1_HUMAN | [view interactions] | High throughput | no | yes |
| TDRD3_HUMAN | [view interactions] | High throughput | no | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AZI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMG7_HUMAN | [view interactions] | High throughput | no | no |