AP1M1_HUMAN
Evidence for PS localization
Functions
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 64%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
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AP1M1_HUMAN has binary interactions with 50 proteins
Isoforms
Interacting regions
Canonical [AP1M1_HUMAN]
Isoform [Q9BXS5-2] alignment
Isoform [K7EJL1] alignment
Isoform [E7ENJ6] alignment
Isoform [K7ENA7] alignment
Isoform [K7EPJ8] alignment
Isoform [K7ER75] alignment
Isoform [K7EQX3] alignment
Isoform [K7EQ90] alignment
Isoform [A0A087WZX7] alignment
LOADING 29%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AP1M1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 27.4510 | 4 | no |
| GO:0046872 | metal ion binding | 27.4510 | 5 | no |
| GO:0043168 | anion binding | 23.5294 | 4 | no |
| GO:0003723 | RNA binding | 23.5294 | 4 | no |
| GO:0000166 | nucleotide binding | 21.5686 | 4 | no |
| GO:0035615 | clathrin adaptor activity | 7.8431 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AP1M1_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 47.0588 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 47.0588 | 4 | no |
| GO:0022607 | cellular component assembly | 45.0980 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 43.1373 | 4 | no |
| GO:0006996 | organelle organization | 39.2157 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 39.2157 | 4 | no |
| GO:0071702 | organic substance transport | 37.2549 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 37.2549 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 37.2549 | 4 | no |
| GO:0010646 | regulation of cell communication | 35.2941 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 33.3333 | 4 | no |
| GO:0015031 | protein transport | 31.3725 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 31.3725 | 4 | no |
| GO:0006886 | intracellular protein transport | 29.4118 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 29.4118 | 5 | no |
| GO:0051049 | regulation of transport | 27.4510 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.4902 | 4 | no |
| GO:0009966 | regulation of signal transduction | 25.4902 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 25.4902 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 25.4902 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.4902 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.4902 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.4902 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.4902 | 5 | no |
| GO:0043933 | protein-containing complex organization | 25.4902 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| ACADM_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| ADIP_HUMAN | [view interactions] | High throughput | no | yes |
| AFTIN_HUMAN | [view interactions] | Low throughput | no | yes |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| ALBU_HUMAN | [view interactions] | High throughput | no | no |
| AMOT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1G2_HUMAN | [view interactions] | High throughput | no | yes |
| AP1M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1M2_HUMAN | [view interactions] | High throughput | no | no |
| AP1S1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1S2_HUMAN | [view interactions] | High throughput | no | no |
| AP1S3_HUMAN | [view interactions] | Low throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP4AT_HUMAN | [view interactions] | High throughput | no | no |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| AR6P4_HUMAN | [view interactions] | High throughput | no | yes |
| ARF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARFRP_HUMAN | [view interactions] | Low throughput | no | yes |
| ARNT2_HUMAN | [view interactions] | High throughput | no | yes |