AP1M1_HUMAN
Evidence for PS localization
Functions
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AP1M1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 27.4510 | 4 | no |
| GO:0046872 | metal ion binding | 27.4510 | 5 | no |
| GO:0043168 | anion binding | 23.5294 | 4 | no |
| GO:0003723 | RNA binding | 23.5294 | 4 | no |
| GO:0000166 | nucleotide binding | 21.5686 | 4 | no |
| GO:0035615 | clathrin adaptor activity | 7.8431 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AP1M1_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 47.0588 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 47.0588 | 4 | no |
| GO:0022607 | cellular component assembly | 45.0980 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 43.1373 | 4 | no |
| GO:0006996 | organelle organization | 39.2157 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 39.2157 | 4 | no |
| GO:0071702 | organic substance transport | 37.2549 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 37.2549 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 37.2549 | 4 | no |
| GO:0010646 | regulation of cell communication | 35.2941 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 33.3333 | 4 | no |
| GO:0015031 | protein transport | 31.3725 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 31.3725 | 4 | no |
| GO:0006886 | intracellular protein transport | 29.4118 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 29.4118 | 5 | no |
| GO:0051049 | regulation of transport | 27.4510 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.4902 | 4 | no |
| GO:0009966 | regulation of signal transduction | 25.4902 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 25.4902 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 25.4902 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.4902 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.4902 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.4902 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.4902 | 5 | no |
| GO:0043933 | protein-containing complex organization | 25.4902 | 4 | no |
| GO:0009894 | regulation of catabolic process | 23.5294 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.5294 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 23.5294 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.5294 | 6 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.5294 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.5294 | 4 | no |
| GO:0036211 | protein modification process | 21.5686 | 4 | no |
| GO:0043412 | macromolecule modification | 21.5686 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.5686 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.5686 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.5686 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.5686 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 21.5686 | 5 | no |
| GO:0070925 | organelle assembly | 19.6078 | 5 | yes |
| GO:0016050 | vesicle organization | 13.7255 | 5 | yes |
| GO:0032438 | melanosome organization | 9.8039 | 7 | yes |
| GO:0033363 | secretory granule organization | 9.8039 | 6 | yes |
| GO:0048753 | pigment granule organization | 9.8039 | 6 | yes |
| GO:0060155 | platelet dense granule organization | 9.8039 | 7 | yes |
| GO:1903232 | melanosome assembly | 9.8039 | 6 | yes |
| GO:0035646 | endosome to melanosome transport | 5.8824 | 5 | yes |
| GO:0043485 | endosome to pigment granule transport | 5.8824 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| HLAA_HUMAN | [view interactions] | Low throughput | no | no |
| ARF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STING_HUMAN | [view interactions] | Low throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BST2_HUMAN | [view interactions] | Low throughput | no | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VAMP4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TGON2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MARHB_HUMAN | [view interactions] | Low throughput | no | no |
| VANG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NMDE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ATG9A_HUMAN | [view interactions] | Low throughput | no | yes |
| AP1S3_HUMAN | [view interactions] | Low throughput | no | yes |
| KI13A_HUMAN | [view interactions] | Low throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | Low throughput | no | no |
| ARFRP_HUMAN | [view interactions] | Low throughput | no | yes |
| LYAM3_HUMAN | [view interactions] | Low throughput | no | no |
| CORO7_HUMAN | [view interactions] | Low throughput | no | no |
| AFTIN_HUMAN | [view interactions] | Low throughput | no | yes |
| AP1S1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| ENTR1_HUMAN | [view interactions] | High throughput | no | no |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| AP1S2_HUMAN | [view interactions] | High throughput | no | no |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| RN19B_HUMAN | [view interactions] | High throughput | no | yes |
| FBX4_HUMAN | [view interactions] | High throughput | no | no |
| TLR2_HUMAN | [view interactions] | High throughput | no | no |
| CBPD_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMM59_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| ALBU_HUMAN | [view interactions] | High throughput | no | no |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| MTF1_HUMAN | [view interactions] | High throughput | no | no |
| LDOC1_HUMAN | [view interactions] | High throughput | no | no |
| ZBT43_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT14_HUMAN | [view interactions] | High throughput | no | yes |
| ETV6_HUMAN | [view interactions] | High throughput | no | no |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KR107_HUMAN | [view interactions] | High throughput | no | no |
| IKZF1_HUMAN | [view interactions] | High throughput | no | no |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| RUN3A_HUMAN | [view interactions] | High throughput | no | yes |
| K1C40_HUMAN | [view interactions] | High throughput | no | no |
| DZIP3_HUMAN | [view interactions] | High throughput | no | yes |
| PHC2_HUMAN | [view interactions] | High throughput | no | yes |
| FAM9B_HUMAN | [view interactions] | High throughput | no | no |
| ZBT44_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT8A_HUMAN | [view interactions] | High throughput | no | yes |
| TIFA_HUMAN | [view interactions] | High throughput | no | yes |
| PNMA5_HUMAN | [view interactions] | High throughput | no | yes |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| ADIP_HUMAN | [view interactions] | High throughput | no | yes |
| ZCC17_HUMAN | [view interactions] | High throughput | no | yes |
| PURB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYOD1_HUMAN | [view interactions] | High throughput | no | no |
| BACH2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI27_HUMAN | [view interactions] | High throughput | no | yes |
| FBLN4_HUMAN | [view interactions] | High throughput | no | no |
| SP4_HUMAN | [view interactions] | High throughput | no | yes |
| RSP14_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PICK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFP11_HUMAN | [view interactions] | High throughput | no | no |
| LZTS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NECA1_HUMAN | [view interactions] | High throughput | no | yes |
| PAX6_HUMAN | [view interactions] | High throughput | no | no |
| SDCB2_HUMAN | [view interactions] | High throughput | no | yes |
| KR108_HUMAN | [view interactions] | High throughput | no | no |
| ATF4_HUMAN | [view interactions] | High throughput | no | no |
| TRI41_HUMAN | [view interactions] | High throughput | no | yes |
| AXIN2_HUMAN | [view interactions] | High throughput | no | yes |
| ZBTB3_HUMAN | [view interactions] | High throughput | no | yes |
| EVI5L_HUMAN | [view interactions] | High throughput | no | yes |
| ROP1A_HUMAN | [view interactions] | High throughput | no | no |
| MEA1_HUMAN | [view interactions] | High throughput | no | no |
| ARNT2_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRAT2_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR3_HUMAN | [view interactions] | High throughput | no | yes |
| GCSAM_HUMAN | [view interactions] | High throughput | no | yes |
| OLIG3_HUMAN | [view interactions] | High throughput | no | no |
| RP9_HUMAN | [view interactions] | High throughput | no | yes |
| F219B_HUMAN | [view interactions] | High throughput | no | no |
| ZN655_HUMAN | [view interactions] | High throughput | no | yes |
| ZNF19_HUMAN | [view interactions] | High throughput | no | no |
| ZN219_HUMAN | [view interactions] | High throughput | no | yes |
| NKAP_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP7_HUMAN | [view interactions] | High throughput | no | yes |
| THAP6_HUMAN | [view interactions] | High throughput | no | no |
| ZN552_HUMAN | [view interactions] | High throughput | no | no |
| ZNF8_HUMAN | [view interactions] | High throughput | no | yes |
| NKAP1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN276_HUMAN | [view interactions] | High throughput | no | yes |
| AP4AT_HUMAN | [view interactions] | High throughput | no | no |
| MK_HUMAN | [view interactions] | High throughput | no | no |
| ZSC16_HUMAN | [view interactions] | High throughput | no | yes |
| PAK5_HUMAN | [view interactions] | High throughput | no | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPC_HUMAN | [view interactions] | High throughput | no | yes |
| CIAO1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CE57L_HUMAN | [view interactions] | High throughput | no | yes |
| KR103_HUMAN | [view interactions] | High throughput | no | no |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| CASP8_HUMAN | [view interactions] | High throughput | no | yes |
| RPGF3_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM1_HUMAN | [view interactions] | High throughput | no | no |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMOT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPAT6_HUMAN | [view interactions] | High throughput | no | no |
| CCD33_HUMAN | [view interactions] | High throughput | no | no |
| LRMDA_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CG057_HUMAN | [view interactions] | High throughput | no | no |
| AR6P4_HUMAN | [view interactions] | High throughput | no | yes |
| KIF24_HUMAN | [view interactions] | High throughput | no | no |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| DCP2_HUMAN | [view interactions] | High throughput | no | yes |
| GASP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| MPZL2_HUMAN | [view interactions] | High throughput | no | yes |
| NECP2_HUMAN | [view interactions] | High throughput | no | yes |
| SACA1_HUMAN | [view interactions] | High throughput | no | no |
| CAH14_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| NCBP1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2A_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| RIOK1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| WIPI2_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT7B_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPT33_HUMAN | [view interactions] | High throughput | no | no |
| COMT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1M2_HUMAN | [view interactions] | High throughput | no | no |
| PCDB3_HUMAN | [view interactions] | High throughput | no | no |
| PCDB7_HUMAN | [view interactions] | High throughput | no | yes |
| LRC25_HUMAN | [view interactions] | High throughput | no | yes |
| MICA_HUMAN | [view interactions] | High throughput | no | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| RHG18_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NECP1_HUMAN | [view interactions] | High throughput | no | no |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| SC23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| RUFY1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCPS_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| RNH2A_HUMAN | [view interactions] | High throughput | no | no |
| RNH2B_HUMAN | [view interactions] | High throughput | no | yes |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACADM_HUMAN | [view interactions] | High throughput | no | yes |
| HSP74_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FRIH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCP60_HUMAN | [view interactions] | High throughput | no | yes |
| MESD_HUMAN | [view interactions] | High throughput | no | yes |
| INP4B_HUMAN | [view interactions] | High throughput | no | no |
| MCA3_HUMAN | [view interactions] | High throughput | no | yes |
| AP1G2_HUMAN | [view interactions] | High throughput | no | yes |
| SYEP_HUMAN | [view interactions] | High throughput | no | yes |
| SP1_HUMAN | [view interactions] | High throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MSH2_HUMAN | [view interactions] | High throughput | no | yes |
| SYMC_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLGB_HUMAN | [view interactions] | High throughput | no | yes |
| RHG01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| NMI_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IAH1_HUMAN | [view interactions] | High throughput | no | yes |
| RBIS_HUMAN | [view interactions] | High throughput | no | no |
| GOLP3_HUMAN | [view interactions] | High throughput | no | no |
| RISC_HUMAN | [view interactions] | High throughput | no | yes |
| SEP11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYLC_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC_HUMAN | [view interactions] | High throughput | no | yes |