SEP11_HUMAN
Evidence for PS localization
Functions
Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity . During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SEP11_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 27.7778 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 27.7778 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.7778 | 4 | yes |
| GO:0019900 | kinase binding | 27.7778 | 4 | no |
| GO:0003924 | GTPase activity | 22.2222 | 7 | yes |
| GO:0005525 | GTP binding | 22.2222 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 22.2222 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 22.2222 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 22.2222 | 6 | yes |
| GO:0019001 | guanyl nucleotide binding | 22.2222 | 5 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 22.2222 | 5 | yes |
| GO:0003723 | RNA binding | 22.2222 | 4 | no |
| GO:0019901 | protein kinase binding | 22.2222 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SEP11_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 52.7778 | 4 | no |
| GO:0010646 | regulation of cell communication | 47.2222 | 4 | no |
| GO:0008104 | protein localization | 44.4444 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 44.4444 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 44.4444 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 41.6667 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 41.6667 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 41.6667 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 41.6667 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 41.6667 | 4 | no |
| GO:0006996 | organelle organization | 41.6667 | 4 | no |
| GO:0009966 | regulation of signal transduction | 38.8889 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 38.8889 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 38.8889 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 36.1111 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 33.3333 | 6 | no |
| GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
| GO:0051049 | regulation of transport | 33.3333 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 33.3333 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | no |
| GO:0033043 | regulation of organelle organization | 33.3333 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 30.5556 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 30.5556 | 7 | no |
| GO:0051050 | positive regulation of transport | 30.5556 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 27.7778 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.7778 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.7778 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 27.7778 | 7 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 27.7778 | 7 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.7778 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 27.7778 | 4 | no |
| GO:0022607 | cellular component assembly | 27.7778 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.7778 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 25.0000 | 4 | no |
| GO:0071702 | organic substance transport | 25.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 25.0000 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 25.0000 | 8 | no |
| GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0051726 | regulation of cell cycle | 25.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 25.0000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 25.0000 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 25.0000 | 5 | no |
| GO:0010941 | regulation of cell death | 25.0000 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 25.0000 | 5 | no |
| GO:0015031 | protein transport | 22.2222 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 22.2222 | 8 | no |
| GO:0031400 | negative regulation of protein modification process | 22.2222 | 7 | no |
| GO:0033674 | positive regulation of kinase activity | 22.2222 | 6 | no |
| GO:0043269 | regulation of ion transport | 22.2222 | 5 | no |
| GO:0043549 | regulation of kinase activity | 22.2222 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 22.2222 | 6 | no |
| GO:0051338 | regulation of transferase activity | 22.2222 | 4 | no |
| GO:0051347 | positive regulation of transferase activity | 22.2222 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.2222 | 4 | no |
| GO:0030030 | cell projection organization | 22.2222 | 4 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 22.2222 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 22.2222 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 22.2222 | 6 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 22.2222 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.2222 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 22.2222 | 6 | no |
| GO:0010638 | positive regulation of organelle organization | 22.2222 | 6 | no |
| GO:0032880 | regulation of protein localization | 22.2222 | 5 | no |
| GO:0060341 | regulation of cellular localization | 22.2222 | 4 | no |
| GO:1903829 | positive regulation of protein localization | 22.2222 | 5 | no |
| GO:0061640 | cytoskeleton-dependent cytokinesis | 8.3333 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SEP11_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 5.5556 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 5.5556 | 5 | no |
| DOID:114 | heart disease | 5.5556 | 3 | no |
| DOID:2843 | long QT syndrome | 5.5556 | 6 | no |
| DOID:1289 | neurodegenerative disease | 5.5556 | 4 | no |
| DOID:331 | central nervous system disease | 5.5556 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SEPT5_HUMAN | [view interactions] | Low throughput | no | no |
| SEPT9_HUMAN | [view interactions] | Low throughput | no | no |
| SEPT7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SEPT2_HUMAN | [view interactions] | Low throughput | no | no |
| SEP14_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BEND3_HUMAN | [view interactions] | High throughput | no | yes |
| SEPT6_HUMAN | [view interactions] | High throughput | no | yes |
| 2A5D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENKD1_HUMAN | [view interactions] | High throughput | no | yes |
| CE192_HUMAN | [view interactions] | High throughput | no | yes |
| RRP1B_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| RL27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| SEPT1_HUMAN | [view interactions] | High throughput | no | no |
| MORN4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| PRCC_HUMAN | [view interactions] | High throughput | no | yes |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| RRP44_HUMAN | [view interactions] | High throughput | no | yes |
| CHRD1_HUMAN | [view interactions] | High throughput | no | yes |
| SCYL2_HUMAN | [view interactions] | High throughput | no | yes |
| CDK5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEP12_HUMAN | [view interactions] | High throughput | no | no |
| BORG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEPT3_HUMAN | [view interactions] | High throughput | no | no |
| BECN1_HUMAN | [view interactions] | High throughput | no | yes |
| SEPT8_HUMAN | [view interactions] | High throughput | no | no |
| ZMAT3_HUMAN | [view interactions] | High throughput | no | yes |
| SEP10_HUMAN | [view interactions] | High throughput | no | yes |
| E2AK4_HUMAN | [view interactions] | High throughput | no | yes |
| PODO_HUMAN | [view interactions] | High throughput | no | no |
| RM12_HUMAN | [view interactions] | High throughput | no | yes |
| FOXA1_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SEPT4_HUMAN | [view interactions] | High throughput | no | no |
| RGS3_HUMAN | [view interactions] | High throughput | no | no |
| ACAP3_HUMAN | [view interactions] | High throughput | no | no |
| CEP72_HUMAN | [view interactions] | High throughput | no | yes |
| SYHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPVL_HUMAN | [view interactions] | High throughput | no | no |
| WDFY1_HUMAN | [view interactions] | High throughput | no | yes |
| ITA2B_HUMAN | [view interactions] | High throughput | no | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDES1_HUMAN | [view interactions] | High throughput | no | no |
| MD2BP_HUMAN | [view interactions] | High throughput | no | no |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| SC22B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SUCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XRCC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIN3A_HUMAN | [view interactions] | High throughput | no | yes |
| SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THTR_HUMAN | [view interactions] | High throughput | no | yes |
| NHRF2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TCOF_HUMAN | [view interactions] | High throughput | no | yes |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOSB1_HUMAN | [view interactions] | High throughput | no | yes |
| TM177_HUMAN | [view interactions] | High throughput | no | no |
| TMEM9_HUMAN | [view interactions] | High throughput | no | no |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FERM2_HUMAN | [view interactions] | High throughput | no | yes |
| SMCA2_HUMAN | [view interactions] | High throughput | no | yes |
| THTM_HUMAN | [view interactions] | High throughput | no | yes |
| SF01_HUMAN | [view interactions] | High throughput | no | yes |
| S23IP_HUMAN | [view interactions] | High throughput | no | yes |
| LRCH3_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | Computational | no | yes |