CNTP2_HUMAN
Evidence for PS localization
Functions
Required for gap junction formation (Probable). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction. [View more on UniProt]
Protein features
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 82%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Interacting regions
Canonical [CNTP2_HUMAN]
Isoform [Q9UHC6-2] alignment
Isoform [B7Z1Y6] alignment
Isoform [A0A0D9SES4] alignment
Isoform [A0A0J9YWG3] alignment
Isoform [A0A0J9YYA0] alignment
LOADING 62%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CNTP2_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 25.0000 | 4 | no |
| GO:0000166 | nucleotide binding | 23.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 23.0000 | 5 | no |
| GO:0043169 | cation binding | 23.0000 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 22.0000 | 4 | no |
| GO:0046872 | metal ion binding | 22.0000 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.0000 | 4 | no |
| GO:0002020 | protease binding | 3.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CNTP2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 47.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 38.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 37.0000 | 4 | yes |
| GO:0008104 | protein localization | 34.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 33.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 32.0000 | 4 | no |
| GO:0006996 | organelle organization | 32.0000 | 4 | no |
| GO:0051049 | regulation of transport | 28.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 27.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 26.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 24.0000 | 4 | no |
| GO:0043933 | protein-containing complex organization | 23.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.0000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 23.0000 | 4 | no |
| GO:0030030 | cell projection organization | 22.0000 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 21.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.0000 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 20.0000 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 18.0000 | 5 | yes |
| GO:0048812 | neuron projection morphogenesis | 15.0000 | 5 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 15.0000 | 5 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 15.0000 | 4 | yes |
| GO:0031175 | neuron projection development | 14.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ADA22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADDG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGRL1_HUMAN | [view interactions] | High throughput | no | no |
| AGRL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMER2_HUMAN | [view interactions] | High throughput | no | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| APBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AQP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARF5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARFG1_HUMAN | [view interactions] | High throughput | no | no |
| AT2C1_HUMAN | [view interactions] | High throughput | no | yes |
| BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CACB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CBPE_HUMAN | [view interactions] | Low throughput | no | yes |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNDP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CNTN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CNTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |