CNTP2_HUMAN
Evidence for PS localization
Functions
Required for gap junction formation (Probable). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CNTP2_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 22.8571 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 22.8571 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.8571 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CNTP2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 51.4286 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 45.7143 | 4 | yes |
| GO:0010646 | regulation of cell communication | 42.8571 | 4 | no |
| GO:0006996 | organelle organization | 40.0000 | 4 | no |
| GO:0051049 | regulation of transport | 37.1429 | 4 | no |
| GO:0007010 | cytoskeleton organization | 37.1429 | 5 | no |
| GO:0008104 | protein localization | 34.2857 | 4 | yes |
| GO:0030030 | cell projection organization | 34.2857 | 4 | yes |
| GO:0031175 | neuron projection development | 31.4286 | 6 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 31.4286 | 5 | yes |
| GO:0022607 | cellular component assembly | 31.4286 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 31.4286 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 31.4286 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 31.4286 | 4 | no |
| GO:0043269 | regulation of ion transport | 25.7143 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 25.7143 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.8571 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 22.8571 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.8571 | 4 | no |
| GO:0032990 | cell part morphogenesis | 20.0000 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 20.0000 | 4 | yes |
| GO:0048812 | neuron projection morphogenesis | 20.0000 | 7 | yes |
| GO:0048858 | cell projection morphogenesis | 20.0000 | 5 | yes |
| GO:0050890 | cognition | 20.0000 | 4 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 20.0000 | 6 | yes |
| GO:0007612 | learning | 17.1429 | 4 | yes |
| GO:0061024 | membrane organization | 14.2857 | 4 | yes |
| GO:0007420 | brain development | 11.4286 | 4 | yes |
| GO:0071205 | protein localization to juxtaparanode region of axon | 11.4286 | 6 | yes |
| GO:0099612 | protein localization to axon | 11.4286 | 5 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 8.5714 | 5 | yes |
| GO:0045161 | neuronal ion channel clustering | 8.5714 | 5 | yes |
| GO:0045163 | clustering of voltage-gated potassium channels | 8.5714 | 6 | yes |
| GO:1901888 | regulation of cell junction assembly | 8.5714 | 5 | yes |
| GO:0021761 | limbic system development | 5.7143 | 4 | yes |
| GO:0031223 | auditory behavior | 5.7143 | 4 | yes |
| GO:0042297 | vocal learning | 5.7143 | 5 | yes |
| GO:0098596 | imitative learning | 5.7143 | 6 | yes |
| GO:0098597 | observational learning | 5.7143 | 5 | yes |
| GO:0098598 | learned vocalization behavior or vocal learning | 5.7143 | 4 | yes |
| GO:1901890 | positive regulation of cell junction assembly | 5.7143 | 6 | yes |
| GO:1903596 | regulation of gap junction assembly | 5.7143 | 6 | yes |
| GO:1903598 | positive regulation of gap junction assembly | 5.7143 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in CNTP2_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 20.0000 | 3 | no |
| DOID:936 | brain disease | 11.4286 | 4 | no |
| DOID:0050951 | hereditary ataxia | 8.5714 | 5 | no |
| DOID:1289 | neurodegenerative disease | 8.5714 | 4 | no |
| DOID:1826 | epilepsy | 8.5714 | 5 | no |
| DOID:0050753 | cerebellar ataxia | 5.7143 | 6 | no |
| DOID:1441 | autosomal dominant cerebellar ataxia | 5.7143 | 7 | no |
| DOID:0050701 | electroclinical syndrome | 5.7143 | 6 | no |
| DOID:0112202 | developmental and epileptic encephalopathy | 5.7143 | 7 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CSKP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PDIA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CNTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CBPE_HUMAN | [view interactions] | Low throughput | no | yes |
| CNTN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCNA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MPDZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MPP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| E41L3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GPR37_HUMAN | [view interactions] | Low throughput | no | no |
| GABR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CTR9_HUMAN | [view interactions] | High throughput | no | yes |
| ZMIZ1_HUMAN | [view interactions] | High throughput | no | no |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| RPB7_HUMAN | [view interactions] | High throughput | no | yes |
| GORS2_HUMAN | [view interactions] | High throughput | no | yes |
| MACF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCAB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCND3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCIP2_HUMAN | [view interactions] | High throughput | no | no |
| KCNQ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NFASC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EPB41_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| LGI1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| FOXP2_HUMAN | [view interactions] | Computational | no | yes |
| NLGNX_HUMAN | [view entry] [view interactions] | Computational | yes | yes |