AGRL3_HUMAN
Evidence for PS localization
Functions
Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (PubMed). Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AGRL3_HUMAN |
|---|---|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | 33.3333 | 4 | yes |
| GO:0046872 | metal ion binding | 33.3333 | 4 | yes |
| GO:0005509 | calcium ion binding | 25.0000 | 5 | yes |
| GO:0019900 | kinase binding | 25.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 25.0000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AGRL3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 58.3333 | 4 | no |
| GO:0030030 | cell projection organization | 50.0000 | 4 | no |
| GO:0031175 | neuron projection development | 50.0000 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 50.0000 | 5 | no |
| GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 41.6667 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 41.6667 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 41.6667 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 41.6667 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 41.6667 | 5 | no |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 33.3333 | 4 | yes |
| GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | 33.3333 | 5 | yes |
| GO:0007416 | synapse assembly | 33.3333 | 6 | yes |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | yes |
| GO:0034329 | cell junction assembly | 33.3333 | 5 | yes |
| GO:0034330 | cell junction organization | 33.3333 | 4 | yes |
| GO:0050808 | synapse organization | 33.3333 | 5 | yes |
| GO:0010975 | regulation of neuron projection development | 33.3333 | 7 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 33.3333 | 4 | no |
| GO:0050807 | regulation of synapse organization | 33.3333 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 33.3333 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 33.3333 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 33.3333 | 4 | no |
| GO:0001764 | neuron migration | 25.0000 | 4 | yes |
| GO:0007411 | axon guidance | 25.0000 | 8 | no |
| GO:0008104 | protein localization | 25.0000 | 4 | no |
| GO:0097485 | neuron projection guidance | 25.0000 | 7 | no |
| GO:0031323 | regulation of cellular metabolic process | 25.0000 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | no |
| GO:0051049 | regulation of transport | 25.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 25.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:0019722 | calcium-mediated signaling | 25.0000 | 5 | no |
| GO:0019932 | second-messenger-mediated signaling | 25.0000 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 25.0000 | 5 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 5 | no |
| GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 25.0000 | 4 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 25.0000 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 25.0000 | 4 | no |
| GO:0033043 | regulation of organelle organization | 25.0000 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 25.0000 | 6 | no |
| GO:0007420 | brain development | 16.6667 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| FLRT2_HUMAN | [view interactions] | Low throughput | no | no |
| FLRT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TEN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UNC5D_HUMAN | [view interactions] | Low throughput | no | no |
| AGRL3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNF24_HUMAN | [view interactions] | High throughput | no | yes |
| ASGR2_HUMAN | [view interactions] | High throughput | no | no |
| FLRT1_HUMAN | [view interactions] | High throughput | no | no |
| LPAR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| C3AR_HUMAN | [view interactions] | High throughput | no | no |
| MMP26_HUMAN | [view interactions] | High throughput | no | no |
| CLC2D_HUMAN | [view interactions] | High throughput | no | yes |
| IPPK_HUMAN | [view interactions] | High throughput | no | yes |
| YIPF3_HUMAN | [view interactions] | High throughput | no | yes |
| TM169_HUMAN | [view interactions] | High throughput | no | yes |
| HYPM_HUMAN | [view interactions] | High throughput | no | no |
| TMEM9_HUMAN | [view interactions] | High throughput | no | no |
| SUN3_HUMAN | [view interactions] | High throughput | no | no |
| KCP3_HUMAN | [view interactions] | High throughput | no | yes |
| TPOR_HUMAN | [view interactions] | High throughput | no | no |
| GPV_HUMAN | [view interactions] | High throughput | no | no |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S22A4_HUMAN | [view interactions] | High throughput | no | yes |
| MARH1_HUMAN | [view interactions] | High throughput | no | yes |
| LEG1_HUMAN | [view interactions] | High throughput | no | yes |
| YTDC1_HUMAN | [view interactions] | High throughput | no | yes |
| AGRL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIF5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCAM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPMIP_HUMAN | [view interactions] | High throughput | no | no |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| FINC_HUMAN | [view interactions] | Computational | no | yes |