AGRL3_HUMAN
Evidence for PS localization
Functions
Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (PubMed). Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AGRL3_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 32.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 32.0000 | 5 | yes |
| GO:0043168 | anion binding | 32.0000 | 4 | no |
| GO:0000166 | nucleotide binding | 24.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 24.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 24.0000 | 4 | no |
| GO:0004930 | G protein-coupled receptor activity | 12.0000 | 4 | yes |
| GO:0005509 | calcium ion binding | 12.0000 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AGRL3_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 60.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 56.0000 | 4 | no |
| GO:0030030 | cell projection organization | 48.0000 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 44.0000 | 5 | no |
| GO:0010646 | regulation of cell communication | 44.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 40.0000 | 4 | yes |
| GO:0031175 | neuron projection development | 40.0000 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 40.0000 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 40.0000 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | no |
| GO:0008104 | protein localization | 36.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 36.0000 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 36.0000 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 32.0000 | 5 | no |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 28.0000 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 28.0000 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 28.0000 | 7 | no |
| GO:0141124 | intracellular signaling cassette | 28.0000 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 28.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 28.0000 | 4 | no |
| GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | 24.0000 | 5 | yes |
| GO:0034330 | cell junction organization | 24.0000 | 4 | yes |
| GO:0050807 | regulation of synapse organization | 24.0000 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 24.0000 | 4 | no |
| GO:0006996 | organelle organization | 24.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 24.0000 | 5 | no |
| GO:0072657 | protein localization to membrane | 24.0000 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 24.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.0000 | 5 | no |
| GO:0022604 | regulation of cell morphogenesis | 24.0000 | 5 | no |
| GO:0051049 | regulation of transport | 24.0000 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 24.0000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 24.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 24.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 24.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 24.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 24.0000 | 4 | no |
| GO:0033043 | regulation of organelle organization | 24.0000 | 5 | no |
| GO:0071310 | cellular response to organic substance | 24.0000 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 24.0000 | 4 | no |
| GO:0034329 | cell junction assembly | 20.0000 | 5 | yes |
| GO:0050808 | synapse organization | 20.0000 | 5 | yes |
| GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 20.0000 | 4 | yes |
| GO:0001764 | neuron migration | 16.0000 | 4 | yes |
| GO:0007416 | synapse assembly | 16.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| FLRT2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FLRT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UNC5D_HUMAN | [view interactions] | Low throughput | no | no |
| AGRL3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TEN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GNA13_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAI1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNF24_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| ASGR2_HUMAN | [view interactions] | High throughput | no | no |
| FLRT1_HUMAN | [view interactions] | High throughput | no | no |
| LPAR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| C3AR_HUMAN | [view interactions] | High throughput | no | no |
| MMP26_HUMAN | [view interactions] | High throughput | no | no |
| CLC2D_HUMAN | [view interactions] | High throughput | no | yes |
| IPPK_HUMAN | [view interactions] | High throughput | no | yes |
| YIPF3_HUMAN | [view interactions] | High throughput | no | yes |
| TM169_HUMAN | [view interactions] | High throughput | no | yes |
| HYPM_HUMAN | [view interactions] | High throughput | no | no |
| TMEM9_HUMAN | [view interactions] | High throughput | no | no |
| SUN3_HUMAN | [view interactions] | High throughput | no | no |
| KCP3_HUMAN | [view interactions] | High throughput | no | yes |
| TPOR_HUMAN | [view interactions] | High throughput | no | no |
| GPV_HUMAN | [view interactions] | High throughput | no | no |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S22A4_HUMAN | [view interactions] | High throughput | no | yes |
| MARH1_HUMAN | [view interactions] | High throughput | no | yes |
| LEG1_HUMAN | [view interactions] | High throughput | no | yes |
| YTDC1_HUMAN | [view interactions] | High throughput | no | yes |
| OTU7A_HUMAN | [view interactions] | High throughput | no | no |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |
| AGRL1_HUMAN | [view interactions] | High throughput | no | no |
| KIF5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCAM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPMIP_HUMAN | [view interactions] | High throughput | no | no |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| CDKL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRC4C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTK7_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAOK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |