Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

HCN1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (PubMed). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
100 Ser Phe Developmentalandepilepticencephalopathy24(DEE24) -
272 Ser Pro Developmentalandepilepticencephalopathy24(DEE24) -
279 His Tyr Developmentalandepilepticencephalopathy24(DEE24) -
297 Arg Thr Developmentalandepilepticencephalopathy24(DEE24) -
401 Asp His Developmentalandepilepticencephalopathy24(DEE24) -
153 Met Ile Developmentalandepilepticencephalopathy24(DEE24) -
391 Gly Asp Developmentalandepilepticencephalopathy24(DEE24) -
243 Met Arg Generalizedepilepsywithfebrileseizuresplus10(GEFSP10) -
305 Met Leu Developmentalandepilepticencephalopathy24(DEE24) -
329 Cys Ser Generalizedepilepsywithfebrileseizuresplus10(GEFSP10) -
391 Gly Cys Generalizedepilepsywithfebrileseizuresplus10(GEFSP10) -
391 Gly Ser Generalizedepilepsywithfebrileseizuresplus10(GEFSP10) -
397 Ile Leu Developmentalandepilepticencephalopathy24(DEE24) -
399 Ser Pro Developmentalandepilepticencephalopathy24(DEE24) -
414 Val Met Generalizedepilepsywithfebrileseizuresplus10(GEFSP10) -
590 Arg Gln Generalizedepilepsywithfebrileseizuresplus10(GEFSP10) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in HCN1_HUMAN
GO:0017076 purine nucleotide binding 34.8837 4 yes
GO:0030554 adenyl nucleotide binding 34.8837 5 yes
GO:0032555 purine ribonucleotide binding 34.8837 4 yes
GO:0032559 adenyl ribonucleotide binding 34.8837 5 yes
GO:0019900 kinase binding 25.5814 4 no
GO:0019901 protein kinase binding 25.5814 5 no
GO:0005524 ATP binding 23.2558 5 no
GO:0016301 kinase activity 23.2558 4 no
GO:0035639 purine ribonucleoside triphosphate binding 23.2558 4 no
GO:0046872 metal ion binding 23.2558 4 no
GO:0004674 protein serine/threonine kinase activity 20.9302 4 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 20.9302 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 20.9302 4 no
GO:0106310 protein serine kinase activity 20.9302 4 no
GO:0030551 cyclic nucleotide binding 13.9535 4 yes
GO:0030552 cAMP binding 11.6279 4 yes
GO:0005216 ion channel activity 9.3023 4 yes
GO:0005217 intracellular ligand-gated ion channel activity 9.3023 6 yes
GO:0005221 intracellular cyclic nucleotide activated cation channel activity 9.3023 7 yes
GO:0005261 cation channel activity 9.3023 5 yes
GO:0008324 cation transmembrane transporter activity 9.3023 4 yes
GO:0015267 channel activity 9.3023 4 yes
GO:0015276 ligand-gated ion channel activity 9.3023 5 yes
GO:0022834 ligand-gated channel activity 9.3023 6 yes
GO:0022836 gated channel activity 9.3023 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 9.3023 4 yes
GO:0043855 cyclic nucleotide-gated ion channel activity 9.3023 6 yes
GO:0099094 ligand-gated cation channel activity 9.3023 6 yes
GO:0005222 intracellular cAMP-activated cation channel activity 6.9767 8 yes
GO:0005244 voltage-gated ion channel activity 6.9767 4 yes
GO:0005248 voltage-gated sodium channel activity 6.9767 7 yes
GO:0005249 voltage-gated potassium channel activity 6.9767 6 yes
GO:0005267 potassium channel activity 6.9767 6 yes
GO:0005272 sodium channel activity 6.9767 6 yes
GO:0015079 potassium ion transmembrane transporter activity 6.9767 6 yes
GO:0015081 sodium ion transmembrane transporter activity 6.9767 6 yes
GO:0022832 voltage-gated channel activity 6.9767 6 yes
GO:0022843 voltage-gated cation channel activity 6.9767 5 yes
GO:0046873 metal ion transmembrane transporter activity 6.9767 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in HCN1_HUMAN
GO:0010646 regulation of cell communication 60.4651 4 yes
GO:0048523 negative regulation of cellular process 55.8140 4 yes
GO:0009966 regulation of signal transduction 51.1628 4 no
GO:0048522 positive regulation of cellular process 48.8372 4 no
GO:0060255 regulation of macromolecule metabolic process 41.8605 4 no
GO:0051128 regulation of cellular component organization 39.5349 4 no
GO:0006996 organelle organization 37.2093 4 no
GO:0051171 regulation of nitrogen compound metabolic process 37.2093 4 no
GO:0080090 regulation of primary metabolic process 37.2093 4 no
GO:0022607 cellular component assembly 37.2093 4 yes
GO:0051049 regulation of transport 37.2093 4 yes
GO:0031323 regulation of cellular metabolic process 34.8837 4 no
GO:0006796 phosphate-containing compound metabolic process 32.5581 4 no
GO:0036211 protein modification process 32.5581 4 no
GO:0043412 macromolecule modification 32.5581 4 no
GO:1902531 regulation of intracellular signal transduction 32.5581 5 no
GO:0008104 protein localization 32.5581 4 yes
GO:0033043 regulation of organelle organization 30.2326 5 no
GO:0048585 negative regulation of response to stimulus 30.2326 4 no
GO:0051246 regulation of protein metabolic process 30.2326 5 no
GO:0080134 regulation of response to stress 30.2326 4 no
GO:0010648 negative regulation of cell communication 30.2326 5 yes
GO:0023057 negative regulation of signaling 30.2326 4 yes
GO:0006468 protein phosphorylation 27.9070 5 no
GO:0009892 negative regulation of metabolic process 27.9070 4 no
GO:0010605 negative regulation of macromolecule metabolic process 27.9070 5 no
GO:0016310 phosphorylation 27.9070 5 no
GO:0019220 regulation of phosphate metabolic process 27.9070 6 no
GO:0051174 regulation of phosphorus metabolic process 27.9070 5 no
GO:0022603 regulation of anatomical structure morphogenesis 27.9070 4 no
GO:0051493 regulation of cytoskeleton organization 27.9070 6 no
GO:0009968 negative regulation of signal transduction 25.5814 5 no
GO:0010468 regulation of gene expression 25.5814 5 no
GO:0010941 regulation of cell death 25.5814 4 no
GO:0031399 regulation of protein modification process 25.5814 6 no
GO:0042325 regulation of phosphorylation 25.5814 7 no
GO:0042981 regulation of apoptotic process 25.5814 6 no
GO:0043067 regulation of programmed cell death 25.5814 5 no
GO:0043086 negative regulation of catalytic activity 25.5814 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 25.5814 5 no
GO:0007010 cytoskeleton organization 25.5814 5 no
GO:0048584 positive regulation of response to stimulus 25.5814 4 no
GO:0099177 regulation of trans-synaptic signaling 23.2558 4 yes
GO:0001932 regulation of protein phosphorylation 23.2558 7 no
GO:0031324 negative regulation of cellular metabolic process 23.2558 5 no
GO:0043408 regulation of MAPK cascade 23.2558 6 no
GO:0009967 positive regulation of signal transduction 23.2558 5 no
GO:0010647 positive regulation of cell communication 23.2558 5 no
GO:0023056 positive regulation of signaling 23.2558 4 no
GO:0030030 cell projection organization 23.2558 4 no
GO:0044087 regulation of cellular component biogenesis 23.2558 4 no
GO:1902903 regulation of supramolecular fiber organization 23.2558 5 no
GO:0050804 modulation of chemical synaptic transmission 23.2558 5 yes
GO:0009893 positive regulation of metabolic process 20.9302 4 no
GO:0010604 positive regulation of macromolecule metabolic process 20.9302 5 no
GO:0042127 regulation of cell population proliferation 20.9302 4 no
GO:0051248 negative regulation of protein metabolic process 20.9302 6 no
GO:0051338 regulation of transferase activity 20.9302 4 no
GO:0051130 positive regulation of cellular component organization 20.9302 5 no
GO:0043254 regulation of protein-containing complex assembly 20.9302 5 no
GO:0043269 regulation of ion transport 20.9302 5 yes
GO:0071310 cellular response to organic substance 18.6047 4 yes
GO:0034762 regulation of transmembrane transport 18.6047 4 yes
GO:0043933 protein-containing complex organization 18.6047 4 yes
GO:0065003 protein-containing complex assembly 16.2791 5 yes
GO:1901701 cellular response to oxygen-containing compound 13.9535 4 yes
GO:0034765 regulation of ion transmembrane transport 13.9535 5 yes
GO:0071417 cellular response to organonitrogen compound 11.6279 4 yes
GO:1901699 cellular response to nitrogen compound 11.6279 4 yes
GO:0006811 ion transport 11.6279 4 yes
GO:0010243 response to organonitrogen compound 11.6279 4 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 9.3023 6 yes
GO:0071407 cellular response to organic cyclic compound 9.3023 5 yes
GO:0006812 cation transport 9.3023 5 yes
GO:0014070 response to organic cyclic compound 9.3023 4 yes
GO:0030001 metal ion transport 9.3023 6 yes
GO:0051259 protein complex oligomerization 9.3023 6 yes
GO:0051260 protein homooligomerization 9.3023 7 yes
GO:0071320 cellular response to cAMP 6.9767 5 yes
GO:0071805 potassium ion transmembrane transport 6.9767 6 yes
GO:0098655 cation transmembrane transport 6.9767 4 yes
GO:0098660 inorganic ion transmembrane transport 6.9767 4 yes
GO:0098662 inorganic cation transmembrane transport 6.9767 5 yes
GO:0003254 regulation of membrane depolarization 6.9767 4 yes
GO:0006813 potassium ion transport 6.9767 7 yes
GO:0006814 sodium ion transport 6.9767 7 yes
GO:0014074 response to purine-containing compound 6.9767 5 yes
GO:0035725 sodium ion transmembrane transport 6.9767 6 yes
GO:0046683 response to organophosphorus 6.9767 4 yes
GO:0048666 neuron development 6.9767 4 yes
GO:0050805 negative regulation of synaptic transmission 6.9767 5 yes
GO:0051591 response to cAMP 6.9767 4 yes
GO:0051967 negative regulation of synaptic transmission, glutamatergic 4.6512 6 yes
GO:0042461 photoreceptor cell development 4.6512 5 yes
GO:0042462 eye photoreceptor cell development 4.6512 6 yes
GO:0045176 apical protein localization 4.6512 5 yes
GO:0046549 retinal cone cell development 4.6512 7 yes
GO:0051262 protein tetramerization 4.6512 7 yes
GO:0051289 protein homotetramerization 4.6512 8 yes

Disease

Term Name % Distance from top the of the tree Annotated in HCN1_HUMAN
DOID:331 central nervous system disease 9.3023 3 yes
DOID:936 brain disease 9.3023 4 yes
DOID:0050701 electroclinical syndrome 4.6512 6 yes
DOID:0060170 generalized epilepsy with febrile seizures plus 4.6512 7 yes
DOID:0080429 developmental and epileptic encephalopathy 24 4.6512 8 yes
DOID:0111296 generalized epilepsy with febrile seizures plus 10 4.6512 8 yes
DOID:0112202 developmental and epileptic encephalopathy 4.6512 7 yes
DOID:1826 epilepsy 4.6512 5 yes
DOID:1827 idiopathic generalized epilepsy 4.6512 6 yes

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
PEX5R_HUMAN [view entry] [view interactions] Low throughput yes yes
HCN4_HUMAN [view interactions] Low throughput no yes
HCN2_HUMAN [view entry] [view interactions] Low throughput yes no
HCN1_HUMAN [view entry] [view interactions] Low throughput yes yes
HCN3_HUMAN [view interactions] Low throughput no yes
NED4L_HUMAN [view interactions] Low throughput no yes
TMM74_HUMAN [view interactions] Low throughput no no
SH319_HUMAN [view interactions] High throughput no no
MPDZ_HUMAN [view entry] [view interactions] High throughput yes yes
TENS1_HUMAN [view interactions] High throughput no no
SPTN2_HUMAN [view entry] [view interactions] High throughput yes yes
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
SPKAP_HUMAN [view interactions] High throughput no yes
SHRM3_HUMAN [view interactions] High throughput no yes
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
RP3A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB3I_HUMAN [view interactions] High throughput no no
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes
KAP0_HUMAN [view entry] [view interactions] High throughput yes yes
PAK3_HUMAN [view entry] [view interactions] High throughput yes no
PAK1_HUMAN [view entry] [view interactions] High throughput yes yes
NF1_HUMAN [view entry] [view interactions] High throughput yes no
JIP3_HUMAN [view entry] [view interactions] High throughput yes yes
JIP2_HUMAN [view entry] [view interactions] High throughput yes no
JIP1_HUMAN [view entry] [view interactions] High throughput yes yes
KCD16_HUMAN [view entry] [view interactions] High throughput yes yes
KCD12_HUMAN [view entry] [view interactions] High throughput yes no
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
GEPH_HUMAN [view entry] [view interactions] High throughput yes yes
GIT1_HUMAN [view entry] [view interactions] High throughput yes yes
GABR2_HUMAN [view entry] [view interactions] High throughput yes yes
DSCAM_HUMAN [view interactions] High throughput no yes
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
CN37_HUMAN [view entry] [view interactions] High throughput yes no
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2B_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
BSN_HUMAN [view entry] [view interactions] High throughput yes yes
ASIC1_HUMAN [view interactions] High throughput no no
ARHG7_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
RN123_HUMAN [view interactions] High throughput no yes
AKT3_HUMAN [view interactions] High throughput no yes
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
NDRG2_HUMAN [view entry] [view interactions] High throughput yes yes
AACT_HUMAN [view entry] [view interactions] High throughput yes no
TYPH_HUMAN [view interactions] High throughput no no
PEX5_HUMAN [view interactions] High throughput no yes
H2A2C_HUMAN [view interactions] High throughput no yes
GSDMA_HUMAN [view interactions] High throughput no no
EVPL_HUMAN [view interactions] High throughput no yes
FIBA_HUMAN [view interactions] High throughput no no
SPB4_HUMAN [view interactions] High throughput no no
MVP_HUMAN [view entry] [view interactions] High throughput yes yes
RABP2_HUMAN [view interactions] High throughput no no
CO3_HUMAN [view entry] [view interactions] High throughput yes no
SPB3_HUMAN [view interactions] High throughput no no
CO4A_HUMAN [view interactions] High throughput no no
HUTH_HUMAN [view interactions] High throughput no yes
CALL5_HUMAN [view entry] [view interactions] High throughput yes no
ANXA8_HUMAN [view interactions] High throughput no no
NGAL_HUMAN [view interactions] High throughput no no
GLTP_HUMAN [view interactions] High throughput no no
TREX2_HUMAN [view interactions] High throughput no no
LEG3_HUMAN [view interactions] High throughput no yes
H2AY_HUMAN [view interactions] High throughput no yes
HBB_HUMAN [view interactions] High throughput no no
HPT_HUMAN [view interactions] High throughput no no
ST2B1_HUMAN [view interactions] High throughput no yes
SPB5_HUMAN [view interactions] High throughput no no
CAPG_HUMAN [view entry] [view interactions] High throughput yes no
TRFE_HUMAN [view interactions] High throughput no no
TRI29_HUMAN [view interactions] High throughput no no
PEPL_HUMAN [view interactions] High throughput no yes
EPIPL_HUMAN [view entry] [view interactions] High throughput yes no
RDHE2_HUMAN [view interactions] High throughput no yes
FIBG_HUMAN [view entry] [view interactions] High throughput yes no
LEG7_HUMAN [view interactions] High throughput no no
A1AT_HUMAN [view interactions] High throughput no no
HMOX1_HUMAN [view interactions] High throughput no no
FBX50_HUMAN [view interactions] High throughput no no
I36RA_HUMAN [view interactions] High throughput no no
INVO_HUMAN [view interactions] High throughput no no
AL1A3_HUMAN [view interactions] High throughput no yes
TGM1_HUMAN [view interactions] High throughput no no
PKP1_HUMAN [view interactions] High throughput no no
PA24D_HUMAN [view interactions] High throughput no no
POF1B_HUMAN [view interactions] High throughput no no
KLK10_HUMAN [view interactions] High throughput no no
ILEU_HUMAN [view interactions] High throughput no no
CSK_HUMAN [view interactions] High throughput no yes