Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CAC1E_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells (PubMed). They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the high-voltage activated (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CAC1E_HUMAN
GO:0005216 monoatomic ion channel activity 46.1538 4 yes
GO:0005244 voltage-gated monoatomic ion channel activity 46.1538 5 yes
GO:0005261 monoatomic cation channel activity 46.1538 5 yes
GO:0008324 monoatomic cation transmembrane transporter activity 46.1538 4 yes
GO:0015267 channel activity 46.1538 4 yes
GO:0022832 voltage-gated channel activity 46.1538 6 yes
GO:0022836 gated channel activity 46.1538 5 yes
GO:0022843 voltage-gated monoatomic cation channel activity 46.1538 6 yes
GO:0022890 inorganic cation transmembrane transporter activity 46.1538 4 yes
GO:0043169 cation binding 46.1538 4 yes
GO:0046872 metal ion binding 46.1538 5 yes
GO:0046873 metal ion transmembrane transporter activity 46.1538 5 yes
GO:0005245 voltage-gated calcium channel activity 38.4615 7 yes
GO:0005262 calcium channel activity 38.4615 6 yes
GO:0015085 calcium ion transmembrane transporter activity 38.4615 6 yes
GO:0019900 kinase binding 38.4615 4 no
GO:0019901 protein kinase binding 38.4615 5 no
GO:0005509 calcium ion binding 23.0769 6 yes
GO:0008331 high voltage-gated calcium channel activity 23.0769 8 yes
GO:0019209 kinase activator activity 23.0769 4 no
GO:0019887 protein kinase regulator activity 23.0769 4 no
GO:0030295 protein kinase activator activity 23.0769 5 no
GO:0000166 nucleotide binding 23.0769 4 no
GO:0017076 purine nucleotide binding 23.0769 5 no
GO:0030554 adenyl nucleotide binding 23.0769 6 no
GO:0032555 purine ribonucleotide binding 23.0769 4 no
GO:0032559 adenyl ribonucleotide binding 23.0769 5 no
GO:0043168 anion binding 23.0769 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in CAC1E_HUMAN
GO:0048522 positive regulation of cellular process 69.2308 4 no
GO:0034762 regulation of transmembrane transport 61.5385 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 61.5385 5 no
GO:0043269 regulation of monoatomic ion transport 61.5385 5 no
GO:0051049 regulation of transport 61.5385 4 no
GO:0010959 regulation of metal ion transport 53.8462 6 no
GO:1904062 regulation of monoatomic cation transmembrane transport 53.8462 6 no
GO:0022898 regulation of transmembrane transporter activity 46.1538 4 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 46.1538 5 no
GO:0048523 negative regulation of cellular process 46.1538 4 no
GO:0051924 regulation of calcium ion transport 46.1538 7 no
GO:1903169 regulation of calcium ion transmembrane transport 46.1538 7 no
GO:0006811 monoatomic ion transport 38.4615 4 yes
GO:0006812 monoatomic cation transport 38.4615 5 yes
GO:0030001 metal ion transport 38.4615 6 yes
GO:0098655 monoatomic cation transmembrane transport 38.4615 4 yes
GO:0098662 inorganic cation transmembrane transport 38.4615 4 yes
GO:0001932 regulation of protein phosphorylation 38.4615 7 no
GO:0001934 positive regulation of protein phosphorylation 38.4615 8 no
GO:0009893 positive regulation of metabolic process 38.4615 4 no
GO:0010562 positive regulation of phosphorus metabolic process 38.4615 6 no
GO:0010604 positive regulation of macromolecule metabolic process 38.4615 5 no
GO:0010646 regulation of cell communication 38.4615 4 no
GO:0019220 regulation of phosphate metabolic process 38.4615 6 no
GO:0031323 regulation of cellular metabolic process 38.4615 4 no
GO:0031325 positive regulation of cellular metabolic process 38.4615 5 no
GO:0031399 regulation of protein modification process 38.4615 6 no
GO:0031401 positive regulation of protein modification process 38.4615 7 no
GO:0032411 positive regulation of transporter activity 38.4615 4 no
GO:0032414 positive regulation of ion transmembrane transporter activity 38.4615 5 no
GO:0034764 positive regulation of transmembrane transport 38.4615 5 no
GO:0034767 positive regulation of monoatomic ion transmembrane transport 38.4615 6 no
GO:0042325 regulation of phosphorylation 38.4615 7 no
GO:0042327 positive regulation of phosphorylation 38.4615 8 no
GO:0043270 positive regulation of monoatomic ion transport 38.4615 5 no
GO:0044057 regulation of system process 38.4615 4 no
GO:0045937 positive regulation of phosphate metabolic process 38.4615 7 no
GO:0048584 positive regulation of response to stimulus 38.4615 4 no
GO:0051050 positive regulation of transport 38.4615 4 no
GO:0051174 regulation of phosphorus metabolic process 38.4615 5 no
GO:0051246 regulation of protein metabolic process 38.4615 5 no
GO:0051247 positive regulation of protein metabolic process 38.4615 6 no
GO:0060255 regulation of macromolecule metabolic process 38.4615 4 no
GO:0071310 cellular response to organic substance 38.4615 4 no
GO:0080090 regulation of primary metabolic process 38.4615 4 no
GO:1901019 regulation of calcium ion transmembrane transporter activity 38.4615 6 no
GO:1901385 regulation of voltage-gated calcium channel activity 38.4615 7 no
GO:2001257 regulation of cation channel activity 38.4615 6 no
GO:0008104 protein localization 38.4615 4 no
GO:0006816 calcium ion transport 30.7692 7 yes
GO:0007268 chemical synaptic transmission 30.7692 7 yes
GO:0070588 calcium ion transmembrane transport 30.7692 5 yes
GO:0098916 anterograde trans-synaptic signaling 30.7692 6 yes
GO:0099536 synaptic signaling 30.7692 4 yes
GO:0099537 trans-synaptic signaling 30.7692 5 yes
GO:0009892 negative regulation of metabolic process 30.7692 4 no
GO:0009966 regulation of signal transduction 30.7692 4 no
GO:0010605 negative regulation of macromolecule metabolic process 30.7692 5 no
GO:0033674 positive regulation of kinase activity 30.7692 6 no
GO:0043085 positive regulation of catalytic activity 30.7692 4 no
GO:0043549 regulation of kinase activity 30.7692 5 no
GO:0045859 regulation of protein kinase activity 30.7692 6 no
GO:0045860 positive regulation of protein kinase activity 30.7692 7 no
GO:0051248 negative regulation of protein metabolic process 30.7692 6 no
GO:0051338 regulation of transferase activity 30.7692 4 no
GO:0051347 positive regulation of transferase activity 30.7692 5 no
GO:0051928 positive regulation of calcium ion transport 30.7692 6 no
GO:0141124 intracellular signaling cassette 30.7692 4 no
GO:1901021 positive regulation of calcium ion transmembrane transporter activity 30.7692 6 no
GO:1901841 regulation of high voltage-gated calcium channel activity 30.7692 8 no
GO:1904064 positive regulation of cation transmembrane transport 30.7692 7 no
GO:1904427 positive regulation of calcium ion transmembrane transport 30.7692 7 no
GO:2001259 positive regulation of cation channel activity 30.7692 6 no
GO:0006996 organelle organization 30.7692 4 no
GO:0010243 response to organonitrogen compound 30.7692 4 no
GO:0034330 cell junction organization 30.7692 4 no
GO:0050808 synapse organization 30.7692 5 no
GO:0097553 calcium ion transmembrane import into cytosol 23.0769 6 yes
GO:0001933 negative regulation of protein phosphorylation 23.0769 8 no
GO:0006937 regulation of muscle contraction 23.0769 6 no
GO:0008016 regulation of heart contraction 23.0769 6 no
GO:0009967 positive regulation of signal transduction 23.0769 5 no
GO:0010563 negative regulation of phosphorus metabolic process 23.0769 6 no
GO:0010564 regulation of cell cycle process 23.0769 5 no
GO:0010647 positive regulation of cell communication 23.0769 5 no
GO:0023056 positive regulation of signaling 23.0769 4 no
GO:0031324 negative regulation of cellular metabolic process 23.0769 5 no
GO:0031400 negative regulation of protein modification process 23.0769 7 no
GO:0042326 negative regulation of phosphorylation 23.0769 8 no
GO:0045936 negative regulation of phosphate metabolic process 23.0769 7 no
GO:0051726 regulation of cell cycle 23.0769 4 no
GO:0090257 regulation of muscle system process 23.0769 5 no
GO:1902531 regulation of intracellular signal transduction 23.0769 5 no
GO:1903522 regulation of blood circulation 23.0769 5 no
GO:0007010 cytoskeleton organization 23.0769 5 no
GO:0010975 regulation of neuron projection development 23.0769 7 no
GO:0022603 regulation of anatomical structure morphogenesis 23.0769 4 no
GO:0022607 cellular component assembly 23.0769 4 no
GO:0031344 regulation of cell projection organization 23.0769 5 no
GO:0051128 regulation of cellular component organization 23.0769 4 no
GO:0072657 protein localization to membrane 23.0769 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.0769 6 no
GO:0007528 neuromuscular junction development 23.0769 6 no
GO:0071417 cellular response to organonitrogen compound 23.0769 4 no
GO:1901699 cellular response to nitrogen compound 23.0769 4 no
GO:1901701 cellular response to oxygen-containing compound 23.0769 4 no
GO:0001508 action potential 23.0769 4 no
GO:0070509 calcium ion import 15.3846 8 yes
GO:0098657 import into cell 15.3846 4 yes
GO:0098659 inorganic cation import across plasma membrane 15.3846 5 yes
GO:0098703 calcium ion import across plasma membrane 15.3846 6 yes
GO:0099587 inorganic ion import across plasma membrane 15.3846 4 yes
GO:1902656 calcium ion import into cytosol 15.3846 8 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
EFHC1_HUMAN [view interactions] Low throughput no yes
GBB2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
CACB3_HUMAN [view entry] [view interactions] Low throughput yes no
CA2D1_HUMAN [view entry] [view interactions] Low throughput yes yes
CACB1_HUMAN [view entry] [view interactions] Low throughput yes yes
CABP4_HUMAN [view interactions] Low throughput no no
H2B2E_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CACB4_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC4_HUMAN [view interactions] High throughput no yes
MET_HUMAN [view interactions] High throughput no yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no