Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CAC1E_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells (PubMed). They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the high-voltage activated (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CAC1E_HUMAN
GO:0005216 ion channel activity 57.8947 4 yes
GO:0005244 voltage-gated ion channel activity 57.8947 4 yes
GO:0005245 voltage-gated calcium channel activity 57.8947 6 yes
GO:0005261 cation channel activity 57.8947 5 yes
GO:0005262 calcium channel activity 57.8947 6 yes
GO:0008324 cation transmembrane transporter activity 57.8947 4 yes
GO:0015085 calcium ion transmembrane transporter activity 57.8947 6 yes
GO:0015267 channel activity 57.8947 4 yes
GO:0022832 voltage-gated channel activity 57.8947 6 yes
GO:0022836 gated channel activity 57.8947 5 yes
GO:0022843 voltage-gated cation channel activity 57.8947 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 57.8947 4 yes
GO:0046873 metal ion transmembrane transporter activity 57.8947 5 yes
GO:0046872 metal ion binding 52.6316 4 yes
GO:0019900 kinase binding 26.3158 4 no
GO:0019901 protein kinase binding 26.3158 5 no
GO:0005246 calcium channel regulator activity 26.3158 4 no
GO:0005509 calcium ion binding 21.0526 5 yes
GO:0019209 kinase activator activity 21.0526 4 no
GO:0019887 protein kinase regulator activity 21.0526 4 no
GO:0030295 protein kinase activator activity 21.0526 5 no
GO:0035254 glutamate receptor binding 21.0526 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in CAC1E_HUMAN
GO:0051049 regulation of transport 84.2105 4 yes
GO:0034762 regulation of transmembrane transport 78.9474 4 yes
GO:0034765 regulation of ion transmembrane transport 78.9474 5 yes
GO:0043269 regulation of ion transport 78.9474 5 yes
GO:0048522 positive regulation of cellular process 68.4211 4 no
GO:0022898 regulation of transmembrane transporter activity 57.8947 4 no
GO:0032412 regulation of ion transmembrane transporter activity 57.8947 5 no
GO:1904062 regulation of cation transmembrane transport 57.8947 6 no
GO:2001257 regulation of cation channel activity 57.8947 6 no
GO:0051050 positive regulation of transport 47.3684 4 no
GO:0008104 protein localization 42.1053 4 no
GO:0009966 regulation of signal transduction 42.1053 4 no
GO:0010646 regulation of cell communication 42.1053 4 no
GO:0032411 positive regulation of transporter activity 42.1053 4 no
GO:0032414 positive regulation of ion transmembrane transporter activity 42.1053 5 no
GO:0034764 positive regulation of transmembrane transport 42.1053 5 no
GO:0034767 positive regulation of ion transmembrane transport 42.1053 6 no
GO:0043270 positive regulation of ion transport 42.1053 5 no
GO:1904064 positive regulation of cation transmembrane transport 42.1053 7 no
GO:2001259 positive regulation of cation channel activity 42.1053 6 no
GO:0006811 ion transport 36.8421 4 yes
GO:0006812 cation transport 36.8421 5 yes
GO:0030001 metal ion transport 36.8421 6 yes
GO:0010959 regulation of metal ion transport 36.8421 6 no
GO:0031323 regulation of cellular metabolic process 36.8421 4 no
GO:0044057 regulation of system process 36.8421 4 no
GO:0051171 regulation of nitrogen compound metabolic process 36.8421 4 no
GO:0051924 regulation of calcium ion transport 36.8421 7 no
GO:0060255 regulation of macromolecule metabolic process 36.8421 4 no
GO:0080090 regulation of primary metabolic process 36.8421 4 no
GO:1901019 regulation of calcium ion transmembrane transporter activity 36.8421 6 no
GO:1903169 regulation of calcium ion transmembrane transport 36.8421 7 no
GO:0006816 calcium ion transport 31.5789 7 yes
GO:0001932 regulation of protein phosphorylation 31.5789 7 no
GO:0001934 positive regulation of protein phosphorylation 31.5789 8 no
GO:0009893 positive regulation of metabolic process 31.5789 4 no
GO:0010562 positive regulation of phosphorus metabolic process 31.5789 6 no
GO:0010604 positive regulation of macromolecule metabolic process 31.5789 5 no
GO:0019220 regulation of phosphate metabolic process 31.5789 6 no
GO:0031325 positive regulation of cellular metabolic process 31.5789 5 no
GO:0031399 regulation of protein modification process 31.5789 6 no
GO:0031401 positive regulation of protein modification process 31.5789 7 no
GO:0042325 regulation of phosphorylation 31.5789 7 no
GO:0042327 positive regulation of phosphorylation 31.5789 8 no
GO:0045937 positive regulation of phosphate metabolic process 31.5789 7 no
GO:0048523 negative regulation of cellular process 31.5789 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 31.5789 5 no
GO:0051174 regulation of phosphorus metabolic process 31.5789 5 no
GO:0051246 regulation of protein metabolic process 31.5789 5 no
GO:0051247 positive regulation of protein metabolic process 31.5789 6 no
GO:0072657 protein localization to membrane 31.5789 4 no
GO:1901385 regulation of voltage-gated calcium channel activity 31.5789 7 no
GO:0008016 regulation of heart contraction 26.3158 6 no
GO:0009892 negative regulation of metabolic process 26.3158 4 no
GO:0010605 negative regulation of macromolecule metabolic process 26.3158 5 no
GO:0033674 positive regulation of kinase activity 26.3158 6 no
GO:0043085 positive regulation of catalytic activity 26.3158 4 no
GO:0043549 regulation of kinase activity 26.3158 5 no
GO:0045859 regulation of protein kinase activity 26.3158 6 no
GO:0045860 positive regulation of protein kinase activity 26.3158 7 no
GO:0050804 modulation of chemical synaptic transmission 26.3158 5 no
GO:0051128 regulation of cellular component organization 26.3158 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 26.3158 5 no
GO:0051248 negative regulation of protein metabolic process 26.3158 6 no
GO:0051338 regulation of transferase activity 26.3158 4 no
GO:0051347 positive regulation of transferase activity 26.3158 5 no
GO:0051928 positive regulation of calcium ion transport 26.3158 6 no
GO:0099177 regulation of trans-synaptic signaling 26.3158 4 no
GO:1901021 positive regulation of calcium ion transmembrane transporter activity 26.3158 6 no
GO:1903522 regulation of blood circulation 26.3158 5 no
GO:1904427 positive regulation of calcium ion transmembrane transport 26.3158 7 no
GO:0016192 vesicle-mediated transport 26.3158 4 no
GO:0010647 positive regulation of cell communication 26.3158 5 no
GO:0023056 positive regulation of signaling 26.3158 4 no
GO:0007268 chemical synaptic transmission 21.0526 6 yes
GO:0098916 anterograde trans-synaptic signaling 21.0526 5 yes
GO:0099537 trans-synaptic signaling 21.0526 4 yes
GO:0001933 negative regulation of protein phosphorylation 21.0526 8 no
GO:0006996 organelle organization 21.0526 4 no
GO:0010038 response to metal ion 21.0526 4 no
GO:0010243 response to organonitrogen compound 21.0526 4 no
GO:0010563 negative regulation of phosphorus metabolic process 21.0526 6 no
GO:0031324 negative regulation of cellular metabolic process 21.0526 5 no
GO:0031400 negative regulation of protein modification process 21.0526 7 no
GO:0033365 protein localization to organelle 21.0526 5 no
GO:0042326 negative regulation of phosphorylation 21.0526 8 no
GO:0045936 negative regulation of phosphate metabolic process 21.0526 7 no
GO:0051051 negative regulation of transport 21.0526 4 no
GO:0072594 establishment of protein localization to organelle 21.0526 4 no
GO:0098655 cation transmembrane transport 21.0526 4 no
GO:0098660 inorganic ion transmembrane transport 21.0526 4 no
GO:0098662 inorganic cation transmembrane transport 21.0526 5 no
GO:1901841 regulation of high voltage-gated calcium channel activity 21.0526 8 no
GO:1902531 regulation of intracellular signal transduction 21.0526 5 no
GO:0022603 regulation of anatomical structure morphogenesis 21.0526 4 no
GO:1990778 protein localization to cell periphery 21.0526 5 no
GO:0034330 cell junction organization 21.0526 4 no
GO:0050808 synapse organization 21.0526 5 no
GO:0015031 protein transport 21.0526 4 no
GO:0050806 positive regulation of synaptic transmission 21.0526 5 no
GO:0051966 regulation of synaptic transmission, glutamatergic 21.0526 6 no
GO:0051968 positive regulation of synaptic transmission, glutamatergic 21.0526 6 no
GO:0071702 organic substance transport 21.0526 4 no
GO:0071705 nitrogen compound transport 21.0526 4 no
GO:0099601 regulation of neurotransmitter receptor activity 21.0526 4 no
GO:2000311 regulation of AMPA receptor activity 21.0526 5 no
GO:0070509 calcium ion import 10.5263 8 yes

Disease

Term Name % Distance from top the of the tree Annotated in CAC1E_HUMAN
DOID:0050700 cardiomyopathy 10.5263 4 no
DOID:0060036 intrinsic cardiomyopathy 10.5263 5 no
DOID:114 heart disease 10.5263 3 no
DOID:2843 long QT syndrome 10.5263 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CABP4_HUMAN [view interactions] Low throughput no no
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
EFHC1_HUMAN [view interactions] Low throughput no yes
GBB2_HUMAN [view entry] [view interactions] Low throughput yes yes
MDM2_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
H2B2E_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CACB4_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC4_HUMAN [view interactions] High throughput no yes
MET_HUMAN [view interactions] High throughput no yes
CCG7_HUMAN [view entry] [view interactions] Computational yes no
CACB2_HUMAN [view interactions] Computational no yes
CAC1A_HUMAN [view interactions] Computational no no
CA2D2_HUMAN [view entry] [view interactions] Computational yes yes
SMAD9_HUMAN [view interactions] Computational no yes
CCG3_HUMAN [view entry] [view interactions] Computational yes no
CA2D4_HUMAN [view interactions] Computational no no
INS_HUMAN [view interactions] Computational no no
CACB1_HUMAN [view entry] [view interactions] Computational yes yes
RYR1_HUMAN [view interactions] Computational no no
CACB3_HUMAN [view entry] [view interactions] Computational yes no
CAC1B_HUMAN [view interactions] Computational no yes
CA2D1_HUMAN [view entry] [view interactions] Computational yes yes
CA2D3_HUMAN [view entry] [view interactions] Computational yes no
CAC1H_HUMAN [view entry] [view interactions] Computational yes yes
CCG4_HUMAN [view entry] [view interactions] Computational yes no