CACB3_HUMAN
Evidence for PS localization
Functions
Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation . Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CACB3_HUMAN |
|---|---|---|---|---|
| GO:0005216 | ion channel activity | 41.6667 | 4 | yes |
| GO:0005244 | voltage-gated ion channel activity | 41.6667 | 4 | yes |
| GO:0005261 | cation channel activity | 41.6667 | 5 | yes |
| GO:0008324 | cation transmembrane transporter activity | 41.6667 | 4 | yes |
| GO:0015267 | channel activity | 41.6667 | 4 | yes |
| GO:0022832 | voltage-gated channel activity | 41.6667 | 6 | yes |
| GO:0022836 | gated channel activity | 41.6667 | 5 | yes |
| GO:0022843 | voltage-gated cation channel activity | 41.6667 | 5 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 41.6667 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 41.6667 | 5 | yes |
| GO:0005245 | voltage-gated calcium channel activity | 38.8889 | 6 | yes |
| GO:0005262 | calcium channel activity | 38.8889 | 6 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 38.8889 | 6 | yes |
| GO:0046872 | metal ion binding | 27.7778 | 4 | no |
| GO:0005246 | calcium channel regulator activity | 13.8889 | 4 | yes |
| GO:0008331 | high voltage-gated calcium channel activity | 8.3333 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CACB3_HUMAN |
|---|---|---|---|---|
| GO:0051049 | regulation of transport | 63.8889 | 4 | yes |
| GO:0043269 | regulation of ion transport | 58.3333 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 47.2222 | 4 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 47.2222 | 5 | yes |
| GO:0048522 | positive regulation of cellular process | 47.2222 | 4 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 36.1111 | 6 | yes |
| GO:0016192 | vesicle-mediated transport | 36.1111 | 4 | no |
| GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
| GO:0051050 | positive regulation of transport | 30.5556 | 4 | yes |
| GO:2001257 | regulation of cation channel activity | 30.5556 | 6 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 30.5556 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 30.5556 | 4 | no |
| GO:0008104 | protein localization | 30.5556 | 4 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 30.5556 | 4 | yes |
| GO:0032412 | regulation of ion transmembrane transporter activity | 30.5556 | 5 | yes |
| GO:0006897 | endocytosis | 27.7778 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 27.7778 | 5 | no |
| GO:0023056 | positive regulation of signaling | 27.7778 | 4 | no |
| GO:0050806 | positive regulation of synaptic transmission | 27.7778 | 5 | no |
| GO:0043270 | positive regulation of ion transport | 25.0000 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 25.0000 | 4 | no |
| GO:0015031 | protein transport | 25.0000 | 4 | no |
| GO:0071702 | organic substance transport | 25.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 22.2222 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 22.2222 | 4 | yes |
| GO:0051046 | regulation of secretion | 22.2222 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 22.2222 | 4 | no |
| GO:1903530 | regulation of secretion by cell | 22.2222 | 4 | no |
| GO:0009966 | regulation of signal transduction | 22.2222 | 4 | no |
| GO:0006811 | ion transport | 22.2222 | 4 | yes |
| GO:0006812 | cation transport | 22.2222 | 5 | yes |
| GO:0006816 | calcium ion transport | 22.2222 | 7 | yes |
| GO:0007268 | chemical synaptic transmission | 22.2222 | 6 | yes |
| GO:0010959 | regulation of metal ion transport | 22.2222 | 6 | yes |
| GO:0030001 | metal ion transport | 22.2222 | 6 | yes |
| GO:0051924 | regulation of calcium ion transport | 19.4444 | 7 | yes |
| GO:0072657 | protein localization to membrane | 19.4444 | 4 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 19.4444 | 7 | yes |
| GO:1990778 | protein localization to cell periphery | 19.4444 | 5 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 16.6667 | 5 | yes |
| GO:0034767 | positive regulation of ion transmembrane transport | 16.6667 | 6 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 16.6667 | 7 | yes |
| GO:0032414 | positive regulation of ion transmembrane transporter activity | 13.8889 | 5 | yes |
| GO:1901019 | regulation of calcium ion transmembrane transporter activity | 13.8889 | 6 | yes |
| GO:1901385 | regulation of voltage-gated calcium channel activity | 13.8889 | 7 | yes |
| GO:2001259 | positive regulation of cation channel activity | 13.8889 | 6 | yes |
| GO:0032411 | positive regulation of transporter activity | 13.8889 | 4 | yes |
| GO:0034330 | cell junction organization | 11.1111 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 11.1111 | 4 | yes |
| GO:0050808 | synapse organization | 11.1111 | 5 | yes |
| GO:0098655 | cation transmembrane transport | 11.1111 | 4 | yes |
| GO:0098660 | inorganic ion transmembrane transport | 11.1111 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 11.1111 | 5 | yes |
| GO:0007528 | neuromuscular junction development | 11.1111 | 6 | yes |
| GO:0050776 | regulation of immune response | 8.3333 | 4 | yes |
| GO:0050778 | positive regulation of immune response | 8.3333 | 5 | yes |
| GO:0051928 | positive regulation of calcium ion transport | 8.3333 | 6 | yes |
| GO:0060402 | calcium ion transport into cytosol | 8.3333 | 4 | yes |
| GO:0061577 | calcium ion transmembrane transport via high voltage-gated calcium channel | 8.3333 | 7 | yes |
| GO:0070588 | calcium ion transmembrane transport | 8.3333 | 6 | yes |
| GO:0072659 | protein localization to plasma membrane | 8.3333 | 5 | yes |
| GO:0097553 | calcium ion transmembrane import into cytosol | 8.3333 | 7 | yes |
| GO:1904427 | positive regulation of calcium ion transmembrane transport | 8.3333 | 7 | yes |
| GO:0002684 | positive regulation of immune system process | 8.3333 | 4 | yes |
| GO:0050851 | antigen receptor-mediated signaling pathway | 5.5556 | 5 | yes |
| GO:0050852 | T cell receptor signaling pathway | 5.5556 | 6 | yes |
| GO:0098903 | regulation of membrane repolarization during action potential | 5.5556 | 4 | yes |
| GO:1901021 | positive regulation of calcium ion transmembrane transporter activity | 5.5556 | 6 | yes |
| GO:1901387 | positive regulation of voltage-gated calcium channel activity | 5.5556 | 7 | yes |
| GO:1901841 | regulation of high voltage-gated calcium channel activity | 5.5556 | 8 | yes |
| GO:1901843 | positive regulation of high voltage-gated calcium channel activity | 5.5556 | 8 | yes |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 5.5556 | 4 | yes |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 5.5556 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SYT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CAC1C_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GEM_HUMAN | [view interactions] | Low throughput | no | yes |
| PAX6_HUMAN | [view interactions] | Low throughput | no | no |
| CAC1A_HUMAN | [view interactions] | Low throughput | no | no |
| CAC1B_HUMAN | [view interactions] | Low throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | Low throughput | no | yes |
| LITAF_HUMAN | [view interactions] | Low throughput | no | yes |
| CAC1D_HUMAN | [view interactions] | Low throughput | no | yes |
| CA2D1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TNFL6_HUMAN | [view interactions] | High throughput | no | yes |
| ZFY_HUMAN | [view interactions] | High throughput | no | yes |
| CBARP_HUMAN | [view interactions] | High throughput | no | no |
| WIPI3_HUMAN | [view interactions] | High throughput | no | no |
| CACB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CACB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| CEP76_HUMAN | [view interactions] | High throughput | no | yes |
| MEOX1_HUMAN | [view interactions] | High throughput | no | no |
| SKIV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPIN1_HUMAN | [view interactions] | High throughput | no | no |
| CT085_HUMAN | [view interactions] | High throughput | no | no |
| MTUS2_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP2_HUMAN | [view interactions] | High throughput | no | no |
| CACB2_HUMAN | [view interactions] | High throughput | no | yes |
| PLCG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EYA1_HUMAN | [view interactions] | High throughput | no | no |
| CYTSA_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZY11B_HUMAN | [view interactions] | High throughput | no | yes |
| LRC15_HUMAN | [view interactions] | High throughput | no | no |
| TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX5_HUMAN | [view interactions] | High throughput | no | yes |
| CCG1_HUMAN | [view interactions] | Computational | no | no |
| CA2D4_HUMAN | [view interactions] | Computational | no | no |
| CTSR1_HUMAN | [view interactions] | Computational | no | no |
| CCG3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CA2D2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAC1F_HUMAN | [view interactions] | Computational | no | no |
| GBG1_HUMAN | [view interactions] | Computational | no | no |
| KGUA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBG11_HUMAN | [view interactions] | Computational | no | no |
| CAC1S_HUMAN | [view interactions] | Computational | no | no |
| GBG12_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBG4_HUMAN | [view interactions] | Computational | no | no |
| CCG6_HUMAN | [view interactions] | Computational | no | no |
| GNB5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CCG7_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| INS_HUMAN | [view interactions] | Computational | no | no |
| GBG2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBG7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| STX1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG8_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CCG2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GBG13_HUMAN | [view interactions] | Computational | no | no |
| SNP25_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBG8_HUMAN | [view interactions] | Computational | no | no |
| CAC1E_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CCG4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SYT5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CTSR3_HUMAN | [view interactions] | Computational | no | no |
| GBB4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CA2D3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GBG10_HUMAN | [view interactions] | Computational | no | no |
| CAC1H_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBG3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GBB3_HUMAN | [view interactions] | Computational | no | yes |
| GBG5_HUMAN | [view interactions] | Computational | no | no |
| GBGT2_HUMAN | [view interactions] | Computational | no | no |
| STXB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |