CACB3_HUMAN
Evidence for PS localization
Functions
Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation . Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CACB3_HUMAN |
|---|---|---|---|---|
| GO:0005216 | monoatomic ion channel activity | 56.2500 | 4 | yes |
| GO:0005244 | voltage-gated monoatomic ion channel activity | 56.2500 | 5 | yes |
| GO:0005261 | monoatomic cation channel activity | 56.2500 | 5 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 56.2500 | 4 | yes |
| GO:0015267 | channel activity | 56.2500 | 4 | yes |
| GO:0022832 | voltage-gated channel activity | 56.2500 | 6 | yes |
| GO:0022836 | gated channel activity | 56.2500 | 5 | yes |
| GO:0022843 | voltage-gated monoatomic cation channel activity | 56.2500 | 6 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 56.2500 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 56.2500 | 5 | yes |
| GO:0005245 | voltage-gated calcium channel activity | 50.0000 | 7 | yes |
| GO:0005262 | calcium channel activity | 50.0000 | 6 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 50.0000 | 6 | yes |
| GO:0043169 | cation binding | 50.0000 | 4 | no |
| GO:0046872 | metal ion binding | 50.0000 | 5 | no |
| GO:0008331 | high voltage-gated calcium channel activity | 31.2500 | 8 | yes |
| GO:0019900 | kinase binding | 31.2500 | 4 | no |
| GO:0019901 | protein kinase binding | 25.0000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CACB3_HUMAN |
|---|---|---|---|---|
| GO:0006811 | monoatomic ion transport | 56.2500 | 4 | yes |
| GO:0006812 | monoatomic cation transport | 56.2500 | 5 | yes |
| GO:0030001 | metal ion transport | 56.2500 | 6 | yes |
| GO:0098655 | monoatomic cation transmembrane transport | 56.2500 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 56.2500 | 4 | yes |
| GO:0006816 | calcium ion transport | 50.0000 | 7 | yes |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | yes |
| GO:0051049 | regulation of transport | 50.0000 | 4 | yes |
| GO:0070588 | calcium ion transmembrane transport | 50.0000 | 5 | yes |
| GO:0010959 | regulation of metal ion transport | 43.7500 | 6 | yes |
| GO:0034762 | regulation of transmembrane transport | 43.7500 | 4 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 43.7500 | 5 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 43.7500 | 5 | yes |
| GO:0051924 | regulation of calcium ion transport | 43.7500 | 7 | yes |
| GO:0097553 | calcium ion transmembrane import into cytosol | 43.7500 | 6 | yes |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 43.7500 | 6 | yes |
| GO:0007268 | chemical synaptic transmission | 37.5000 | 7 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 37.5000 | 6 | yes |
| GO:0099536 | synaptic signaling | 37.5000 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 37.5000 | 5 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 37.5000 | 7 | yes |
| GO:0098657 | import into cell | 37.5000 | 4 | no |
| GO:0071310 | cellular response to organic substance | 37.5000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 37.5000 | 4 | no |
| GO:0051050 | positive regulation of transport | 31.2500 | 4 | yes |
| GO:0001508 | action potential | 31.2500 | 4 | no |
| GO:0070509 | calcium ion import | 31.2500 | 8 | no |
| GO:0098659 | inorganic cation import across plasma membrane | 31.2500 | 5 | no |
| GO:0098703 | calcium ion import across plasma membrane | 31.2500 | 6 | no |
| GO:0099587 | inorganic ion import across plasma membrane | 31.2500 | 4 | no |
| GO:1902656 | calcium ion import into cytosol | 31.2500 | 8 | no |
| GO:0010243 | response to organonitrogen compound | 31.2500 | 4 | no |
| GO:0010646 | regulation of cell communication | 31.2500 | 4 | no |
| GO:0071417 | cellular response to organonitrogen compound | 31.2500 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 31.2500 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 31.2500 | 4 | no |
| GO:0008104 | protein localization | 25.0000 | 4 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 25.0000 | 4 | yes |
| GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 25.0000 | 5 | yes |
| GO:0043270 | positive regulation of monoatomic ion transport | 25.0000 | 5 | yes |
| GO:0051928 | positive regulation of calcium ion transport | 25.0000 | 6 | yes |
| GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | no |
| GO:0044057 | regulation of system process | 25.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 25.0000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 25.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 25.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 25.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 25.0000 | 4 | no |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 18.7500 | 4 | yes |
| GO:0002684 | positive regulation of immune system process | 18.7500 | 4 | yes |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 18.7500 | 4 | yes |
| GO:0007528 | neuromuscular junction development | 18.7500 | 6 | yes |
| GO:0034330 | cell junction organization | 18.7500 | 4 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 18.7500 | 5 | yes |
| GO:0034767 | positive regulation of monoatomic ion transmembrane transport | 18.7500 | 6 | yes |
| GO:0048584 | positive regulation of response to stimulus | 18.7500 | 4 | yes |
| GO:0050776 | regulation of immune response | 18.7500 | 4 | yes |
| GO:0050778 | positive regulation of immune response | 18.7500 | 5 | yes |
| GO:0050808 | synapse organization | 18.7500 | 5 | yes |
| GO:0050851 | antigen receptor-mediated signaling pathway | 18.7500 | 5 | yes |
| GO:0050852 | T cell receptor signaling pathway | 18.7500 | 6 | yes |
| GO:0060402 | calcium ion transport into cytosol | 18.7500 | 4 | yes |
| GO:0061577 | calcium ion transmembrane transport via high voltage-gated calcium channel | 18.7500 | 6 | yes |
| GO:1901019 | regulation of calcium ion transmembrane transporter activity | 18.7500 | 6 | yes |
| GO:1901385 | regulation of voltage-gated calcium channel activity | 18.7500 | 7 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 18.7500 | 7 | yes |
| GO:1904427 | positive regulation of calcium ion transmembrane transport | 18.7500 | 7 | yes |
| GO:2001257 | regulation of cation channel activity | 18.7500 | 6 | yes |
| GO:0032411 | positive regulation of transporter activity | 12.5000 | 4 | yes |
| GO:0032414 | positive regulation of ion transmembrane transporter activity | 12.5000 | 5 | yes |
| GO:0098903 | regulation of membrane repolarization during action potential | 12.5000 | 4 | yes |
| GO:1901021 | positive regulation of calcium ion transmembrane transporter activity | 12.5000 | 6 | yes |
| GO:1901387 | positive regulation of voltage-gated calcium channel activity | 12.5000 | 7 | yes |
| GO:1901841 | regulation of high voltage-gated calcium channel activity | 12.5000 | 8 | yes |
| GO:1901843 | positive regulation of high voltage-gated calcium channel activity | 12.5000 | 8 | yes |
| GO:1990778 | protein localization to cell periphery | 12.5000 | 5 | yes |
| GO:2001259 | positive regulation of cation channel activity | 12.5000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CAC1D_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAC1E_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CAC1C_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GEM_HUMAN | [view interactions] | Low throughput | no | yes |
| PAX6_HUMAN | [view interactions] | Low throughput | no | no |
| CAC1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CAC1B_HUMAN | [view interactions] | Low throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | Low throughput | no | yes |
| LITAF_HUMAN | [view interactions] | Low throughput | no | yes |
| CA2D1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TNFL6_HUMAN | [view interactions] | High throughput | no | yes |
| ZFY_HUMAN | [view interactions] | High throughput | no | yes |
| WIPI3_HUMAN | [view interactions] | High throughput | no | no |
| CBARP_HUMAN | [view interactions] | High throughput | no | no |
| CACB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CACB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP76_HUMAN | [view interactions] | High throughput | no | yes |
| MEOX1_HUMAN | [view interactions] | High throughput | no | no |
| SKI2_HUMAN | [view interactions] | High throughput | no | yes |
| CPIN1_HUMAN | [view interactions] | High throughput | no | no |
| CMIP1_HUMAN | [view interactions] | High throughput | no | no |
| MTUS2_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP2_HUMAN | [view interactions] | High throughput | no | no |
| CACB2_HUMAN | [view interactions] | High throughput | no | yes |
| PLCG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EYA1_HUMAN | [view interactions] | High throughput | no | no |
| CYTSA_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZY11B_HUMAN | [view interactions] | High throughput | no | yes |
| LRC15_HUMAN | [view interactions] | High throughput | no | no |
| TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX5_HUMAN | [view interactions] | High throughput | no | yes |