PLCG1_HUMAN
Evidence for PS localization
Functions
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 . Plays a role in actin reorganization and cell migration (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PLCG1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 40.5660 | 4 | no |
| GO:0000166 | nucleotide binding | 33.0189 | 4 | no |
| GO:0017076 | purine nucleotide binding | 33.0189 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 33.0189 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.0755 | 4 | no |
| GO:0043169 | cation binding | 29.2453 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 28.3019 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 28.3019 | 5 | no |
| GO:0046872 | metal ion binding | 27.3585 | 5 | yes |
| GO:0005524 | ATP binding | 27.3585 | 5 | no |
| GO:0019900 | kinase binding | 24.5283 | 4 | yes |
| GO:0019901 | protein kinase binding | 23.5849 | 5 | yes |
| GO:0016301 | kinase activity | 20.7547 | 4 | no |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 20.7547 | 4 | no |
| GO:0030695 | GTPase regulator activity | 13.2075 | 4 | yes |
| GO:0005509 | calcium ion binding | 8.4906 | 6 | yes |
| GO:1990782 | protein tyrosine kinase binding | 8.4906 | 6 | yes |
| GO:0030971 | receptor tyrosine kinase binding | 7.5472 | 4 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 5.6604 | 5 | yes |
| GO:0035254 | glutamate receptor binding | 5.6604 | 4 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 5.6604 | 4 | yes |
| GO:0005126 | cytokine receptor binding | 4.7170 | 4 | yes |
| GO:0005165 | neurotrophin receptor binding | 3.7736 | 5 | yes |
| GO:0005167 | neurotrophin TRK receptor binding | 3.7736 | 6 | yes |
| GO:0005168 | neurotrophin TRKA receptor binding | 3.7736 | 7 | yes |
| GO:0004435 | phosphatidylinositol phospholipase C activity | 2.8302 | 7 | yes |
| GO:0004620 | phospholipase activity | 2.8302 | 5 | yes |
| GO:0004629 | phospholipase C activity | 2.8302 | 6 | yes |
| GO:0008081 | phosphoric diester hydrolase activity | 2.8302 | 5 | yes |
| GO:0016298 | lipase activity | 2.8302 | 4 | yes |
| GO:0050429 | calcium-dependent phospholipase C activity | 1.8868 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PLCG1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 66.9811 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 58.4906 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 55.6604 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 54.7170 | 4 | no |
| GO:0010646 | regulation of cell communication | 52.8302 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 51.8868 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.9434 | 4 | no |
| GO:0009966 | regulation of signal transduction | 48.1132 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 43.3962 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 42.4528 | 4 | no |
| GO:0006996 | organelle organization | 41.5094 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 41.5094 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 41.5094 | 5 | no |
| GO:0010468 | regulation of gene expression | 40.5660 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.5660 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 40.5660 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 40.5660 | 5 | no |
| GO:0022607 | cellular component assembly | 36.7925 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 35.8491 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 34.9057 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 34.9057 | 5 | no |
| GO:0023056 | positive regulation of signaling | 34.9057 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 34.9057 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 33.0189 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 33.0189 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 33.0189 | 6 | no |
| GO:0031399 | regulation of protein modification process | 32.0755 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 32.0755 | 7 | no |
| GO:0051130 | positive regulation of cellular component organization | 32.0755 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 32.0755 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 32.0755 | 4 | yes |
| GO:0051049 | regulation of transport | 32.0755 | 4 | yes |
| GO:0030030 | cell projection organization | 31.1321 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.1887 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 29.2453 | 7 | no |
| GO:0009967 | positive regulation of signal transduction | 29.2453 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 29.2453 | 5 | no |
| GO:0033043 | regulation of organelle organization | 29.2453 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 28.3019 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 28.3019 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.3585 | 5 | no |
| GO:0007010 | cytoskeleton organization | 26.4151 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.4151 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 26.4151 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 26.4151 | 7 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 26.4151 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 26.4151 | 4 | yes |
| GO:0080134 | regulation of response to stress | 25.4717 | 4 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.4717 | 6 | no |
| GO:0043412 | macromolecule modification | 25.4717 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 25.4717 | 5 | no |
| GO:0060341 | regulation of cellular localization | 25.4717 | 4 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 25.4717 | 4 | yes |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 25.4717 | 5 | yes |
| GO:2000145 | regulation of cell motility | 24.5283 | 4 | yes |
| GO:0008104 | protein localization | 24.5283 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 24.5283 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 24.5283 | 5 | no |
| GO:0042327 | positive regulation of phosphorylation | 24.5283 | 8 | no |
| GO:0043066 | negative regulation of apoptotic process | 24.5283 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 24.5283 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 24.5283 | 4 | no |
| GO:0043933 | protein-containing complex organization | 24.5283 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 24.5283 | 7 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.5283 | 6 | no |
| GO:0009890 | negative regulation of biosynthetic process | 24.5283 | 5 | no |
| GO:0032880 | regulation of protein localization | 24.5283 | 5 | no |
| GO:0030334 | regulation of cell migration | 24.5283 | 5 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 23.5849 | 8 | no |
| GO:0036211 | protein modification process | 23.5849 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.5849 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 23.5849 | 6 | no |
| GO:0051094 | positive regulation of developmental process | 23.5849 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 22.6415 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 22.6415 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 22.6415 | 6 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 22.6415 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 22.6415 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.6415 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 21.6981 | 4 | yes |
| GO:2000026 | regulation of multicellular organismal development | 21.6981 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 21.6981 | 7 | no |
| GO:0045595 | regulation of cell differentiation | 21.6981 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 21.6981 | 5 | no |
| GO:0071310 | cellular response to organic substance | 21.6981 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.6981 | 6 | no |
| GO:0051129 | negative regulation of cellular component organization | 21.6981 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 21.6981 | 5 | yes |
| GO:0051050 | positive regulation of transport | 21.6981 | 4 | yes |
| GO:2000147 | positive regulation of cell motility | 20.7547 | 5 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 20.7547 | 5 | yes |
| GO:0030335 | positive regulation of cell migration | 20.7547 | 6 | yes |
| GO:0040017 | positive regulation of locomotion | 20.7547 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 20.7547 | 4 | yes |
| GO:0002684 | positive regulation of immune system process | 19.8113 | 4 | yes |
| GO:0050776 | regulation of immune response | 18.8679 | 4 | yes |
| GO:0032101 | regulation of response to external stimulus | 17.9245 | 4 | yes |
| GO:0141124 | intracellular signaling cassette | 16.0377 | 4 | yes |
| GO:0034762 | regulation of transmembrane transport | 15.0943 | 4 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 15.0943 | 5 | yes |
| GO:0071363 | cellular response to growth factor stimulus | 14.1509 | 4 | yes |
| GO:0050778 | positive regulation of immune response | 14.1509 | 5 | yes |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 13.2075 | 4 | yes |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 13.2075 | 4 | yes |
| GO:0031347 | regulation of defense response | 13.2075 | 5 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 13.2075 | 5 | yes |
| GO:0010959 | regulation of metal ion transport | 12.2642 | 6 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 12.2642 | 5 | yes |
| GO:0038127 | ERBB signaling pathway | 12.2642 | 6 | yes |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 11.3208 | 6 | yes |
| GO:0007173 | epidermal growth factor receptor signaling pathway | 11.3208 | 7 | yes |
| GO:0010632 | regulation of epithelial cell migration | 11.3208 | 4 | yes |
| GO:0043270 | positive regulation of monoatomic ion transport | 11.3208 | 5 | yes |
| GO:0010634 | positive regulation of epithelial cell migration | 10.3774 | 5 | yes |
| GO:0006811 | monoatomic ion transport | 9.4340 | 4 | yes |
| GO:0006812 | monoatomic cation transport | 9.4340 | 5 | yes |
| GO:0030001 | metal ion transport | 9.4340 | 6 | yes |
| GO:0034767 | positive regulation of monoatomic ion transmembrane transport | 9.4340 | 6 | yes |
| GO:0038093 | Fc receptor signaling pathway | 9.4340 | 5 | yes |
| GO:0043065 | positive regulation of apoptotic process | 9.4340 | 6 | yes |
| GO:0043068 | positive regulation of programmed cell death | 9.4340 | 5 | yes |
| GO:0051924 | regulation of calcium ion transport | 8.4906 | 7 | yes |
| GO:0002683 | negative regulation of immune system process | 8.4906 | 4 | yes |
| GO:0006816 | calcium ion transport | 8.4906 | 7 | yes |
| GO:0010594 | regulation of endothelial cell migration | 8.4906 | 5 | yes |
| GO:0050851 | antigen receptor-mediated signaling pathway | 8.4906 | 5 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 7.5472 | 7 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 7.5472 | 7 | yes |
| GO:0050727 | regulation of inflammatory response | 7.5472 | 5 | yes |
| GO:0051928 | positive regulation of calcium ion transport | 6.6038 | 6 | yes |
| GO:0070588 | calcium ion transmembrane transport | 6.6038 | 5 | yes |
| GO:0070849 | response to epidermal growth factor | 6.6038 | 4 | yes |
| GO:0071364 | cellular response to epidermal growth factor stimulus | 6.6038 | 5 | yes |
| GO:0097553 | calcium ion transmembrane import into cytosol | 6.6038 | 6 | yes |
| GO:0098655 | monoatomic cation transmembrane transport | 6.6038 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 6.6038 | 4 | yes |
| GO:1901342 | regulation of vasculature development | 6.6038 | 5 | yes |
| GO:0001701 | in utero embryonic development | 6.6038 | 6 | yes |
| GO:0009792 | embryo development ending in birth or egg hatching | 6.6038 | 4 | yes |
| GO:0010595 | positive regulation of endothelial cell migration | 6.6038 | 6 | yes |
| GO:0043009 | chordate embryonic development | 6.6038 | 5 | yes |
| GO:0045765 | regulation of angiogenesis | 6.6038 | 5 | yes |
| GO:0051282 | regulation of sequestering of calcium ion | 6.6038 | 4 | yes |
| GO:1904427 | positive regulation of calcium ion transmembrane transport | 5.6604 | 7 | yes |
| GO:0006644 | phospholipid metabolic process | 5.6604 | 4 | yes |
| GO:0031348 | negative regulation of defense response | 5.6604 | 5 | yes |
| GO:0032102 | negative regulation of response to external stimulus | 5.6604 | 5 | yes |
| GO:0043535 | regulation of blood vessel endothelial cell migration | 5.6604 | 6 | yes |
| GO:0046486 | glycerolipid metabolic process | 5.6604 | 4 | yes |
| GO:0050728 | negative regulation of inflammatory response | 5.6604 | 6 | yes |
| GO:0050852 | T cell receptor signaling pathway | 5.6604 | 6 | yes |
| GO:1904035 | regulation of epithelial cell apoptotic process | 4.7170 | 6 | yes |
| GO:0002861 | regulation of inflammatory response to antigenic stimulus | 4.7170 | 5 | yes |
| GO:0002862 | negative regulation of inflammatory response to antigenic stimulus | 4.7170 | 6 | yes |
| GO:0006650 | glycerophospholipid metabolic process | 4.7170 | 5 | yes |
| GO:0043536 | positive regulation of blood vessel endothelial cell migration | 4.7170 | 7 | yes |
| GO:0048015 | phosphatidylinositol-mediated signaling | 4.7170 | 4 | yes |
| GO:0050678 | regulation of epithelial cell proliferation | 4.7170 | 5 | yes |
| GO:0050679 | positive regulation of epithelial cell proliferation | 4.7170 | 6 | yes |
| GO:0050777 | negative regulation of immune response | 4.7170 | 5 | yes |
| GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 4.7170 | 5 | yes |
| GO:1904018 | positive regulation of vasculature development | 3.7736 | 5 | yes |
| GO:1904037 | positive regulation of epithelial cell apoptotic process | 3.7736 | 7 | yes |
| GO:0001936 | regulation of endothelial cell proliferation | 3.7736 | 6 | yes |
| GO:0001938 | positive regulation of endothelial cell proliferation | 3.7736 | 7 | yes |
| GO:0045766 | positive regulation of angiogenesis | 3.7736 | 6 | yes |
| GO:0046488 | phosphatidylinositol metabolic process | 3.7736 | 6 | yes |
| GO:0051209 | release of sequestered calcium ion into cytosol | 3.7736 | 6 | yes |
| GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | 3.7736 | 6 | yes |
| GO:0051283 | negative regulation of sequestering of calcium ion | 3.7736 | 5 | yes |
| GO:1905562 | regulation of vascular endothelial cell proliferation | 2.8302 | 7 | yes |
| GO:1905564 | positive regulation of vascular endothelial cell proliferation | 2.8302 | 8 | yes |
| GO:2000351 | regulation of endothelial cell apoptotic process | 2.8302 | 7 | yes |
| GO:0016042 | lipid catabolic process | 2.8302 | 4 | yes |
| GO:0038095 | Fc-epsilon receptor signaling pathway | 2.8302 | 6 | yes |
| GO:0046434 | organophosphate catabolic process | 2.8302 | 4 | yes |
| GO:2000353 | positive regulation of endothelial cell apoptotic process | 1.8868 | 8 | yes |
| GO:0009395 | phospholipid catabolic process | 1.8868 | 5 | yes |
| GO:0019722 | calcium-mediated signaling | 1.8868 | 5 | yes |
| GO:0044242 | cellular lipid catabolic process | 1.8868 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CBL_HUMAN | [view interactions] | Low throughput | no | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GASR_HUMAN | [view interactions] | Low throughput | no | no |
| TNR6_HUMAN | [view interactions] | Low throughput | no | no |
| PK3CA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PGFRA_HUMAN | [view interactions] | Low throughput | no | no |
| ERBB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PLD1_HUMAN | [view interactions] | Low throughput | no | no |
| FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LTK_HUMAN | [view interactions] | Low throughput | no | no |
| EF1A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPHB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GIT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LYAM2_HUMAN | [view interactions] | Low throughput | no | no |
| DGKZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLD2_HUMAN | [view interactions] | Low throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHB_HUMAN | [view interactions] | Low throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ALK_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PDGFA_HUMAN | [view interactions] | Low throughput | no | yes |
| KPCD1_HUMAN | [view interactions] | Low throughput | no | yes |
| ZAP70_HUMAN | [view interactions] | Low throughput | no | no |
| RHG32_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NTAL_HUMAN | [view interactions] | Low throughput | no | no |
| SH2B3_HUMAN | [view interactions] | Low throughput | no | yes |
| IRS2_HUMAN | [view interactions] | Low throughput | no | yes |
| AP180_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TUB_HUMAN | [view interactions] | Low throughput | no | yes |
| RON_HUMAN | [view interactions] | Low throughput | no | yes |
| BAG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BLNK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| IBTK_HUMAN | [view interactions] | Low throughput | no | yes |
| PML_HUMAN | [view interactions] | Low throughput | no | yes |
| NPM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SPY1_HUMAN | [view interactions] | Low throughput | no | yes |
| DAB1_HUMAN | [view interactions] | Low throughput | no | yes |
| JAK1_HUMAN | [view interactions] | Low throughput | no | yes |
| TEC_HUMAN | [view interactions] | Low throughput | no | yes |
| PTN6_HUMAN | [view interactions] | Low throughput | no | no |
| GRB14_HUMAN | [view interactions] | Low throughput | no | yes |
| CISH_HUMAN | [view interactions] | Low throughput | no | yes |
| IRS4_HUMAN | [view interactions] | Low throughput | no | no |
| RPGF5_HUMAN | [view interactions] | Low throughput | no | yes |
| KPCE_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NCAM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RGPS2_HUMAN | [view interactions] | Low throughput | no | yes |
| PKN2_HUMAN | [view interactions] | Low throughput | no | yes |
| PAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRPM7_HUMAN | [view interactions] | Low throughput | no | no |
| TNK1_HUMAN | [view interactions] | Low throughput | no | yes |
| PICAL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PECA1_HUMAN | [view interactions] | Low throughput | no | no |
| EPOR_HUMAN | [view interactions] | Low throughput | no | no |
| GAB2_HUMAN | [view interactions] | Low throughput | no | yes |
| GELS_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ANM8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAP6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTPRJ_HUMAN | [view interactions] | Low throughput | no | yes |
| RACK1_HUMAN | [view interactions] | Low throughput | no | yes |
| ASAP2_HUMAN | [view interactions] | Low throughput | no | yes |
| ASAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| M4K1_HUMAN | [view interactions] | Low throughput | no | no |
| ABL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GHR_HUMAN | [view interactions] | Low throughput | no | yes |
| SHAN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| JAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SOS2_HUMAN | [view interactions] | Low throughput | no | yes |
| SOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RIN3_HUMAN | [view interactions] | Low throughput | no | yes |
| TRPC3_HUMAN | [view interactions] | Low throughput | no | no |
| GAB1_HUMAN | [view interactions] | Low throughput | no | yes |
| LEPR_HUMAN | [view interactions] | Low throughput | no | no |
| RET_HUMAN | [view interactions] | Low throughput | no | yes |
| NTRK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHIP1_HUMAN | [view interactions] | Low throughput | no | no |
| VGFR1_HUMAN | [view interactions] | Low throughput | no | no |
| PTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DDIT4_HUMAN | [view interactions] | Low throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LCP2_HUMAN | [view interactions] | Low throughput | no | yes |
| TESP1_HUMAN | [view interactions] | Low throughput | no | yes |
| NFAT5_HUMAN | [view interactions] | Low throughput | no | yes |
| FGFR2_HUMAN | [view interactions] | Low throughput | no | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| UFO_HUMAN | [view interactions] | Low throughput | no | no |
| VILI_HUMAN | [view interactions] | Low throughput | no | no |
| AGAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CD22_HUMAN | [view interactions] | Low throughput | no | no |
| KHDR1_HUMAN | [view interactions] | Low throughput | no | yes |
| INSR_HUMAN | [view interactions] | Low throughput | no | yes |
| PGFRB_HUMAN | [view interactions] | Low throughput | no | yes |
| LAT_HUMAN | [view interactions] | Low throughput | no | no |
| PLCG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VGFR2_HUMAN | [view interactions] | Low throughput | no | no |
| KIT_HUMAN | [view interactions] | Low throughput | no | no |
| NTRK1_HUMAN | [view interactions] | Low throughput | no | yes |
| KSYK_HUMAN | [view interactions] | Low throughput | no | no |
| STK11_HUMAN | [view interactions] | Low throughput | no | yes |
| RHOU_HUMAN | [view interactions] | Low throughput | no | no |
| SYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RASA1_HUMAN | [view interactions] | Low throughput | no | yes |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| PTN11_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AKT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 3BP2_HUMAN | [view interactions] | Low throughput | no | yes |
| VAV_HUMAN | [view interactions] | Low throughput | no | no |
| FGFR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AGTR1_HUMAN | [view interactions] | Low throughput | no | no |
| FYB1_HUMAN | [view interactions] | Low throughput | no | no |
| DYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WASP_HUMAN | [view interactions] | Low throughput | no | yes |
| HAVR2_HUMAN | [view interactions] | Low throughput | no | no |
| THMS1_HUMAN | [view interactions] | Low throughput | no | no |
| CAV1_HUMAN | [view interactions] | Low throughput | no | no |
| FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ITK_HUMAN | [view interactions] | Low throughput | no | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| RBM11_HUMAN | [view interactions] | High throughput | no | no |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLCG2_HUMAN | [view interactions] | High throughput | no | yes |
| HCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| PLXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLXB2_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| MB12B_HUMAN | [view interactions] | High throughput | no | no |
| GA2L1_HUMAN | [view interactions] | High throughput | no | yes |
| SNX11_HUMAN | [view interactions] | High throughput | no | yes |
| TEKT2_HUMAN | [view interactions] | High throughput | no | no |
| LRAD4_HUMAN | [view interactions] | High throughput | no | yes |
| DOK2_HUMAN | [view interactions] | High throughput | no | no |
| SPN90_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CACB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC120_HUMAN | [view interactions] | High throughput | no | no |
| TTC9B_HUMAN | [view interactions] | High throughput | no | yes |
| KCNJ5_HUMAN | [view interactions] | High throughput | no | yes |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| ZN785_HUMAN | [view interactions] | High throughput | no | no |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| DUS9_HUMAN | [view interactions] | High throughput | no | no |
| MGDP1_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A1_HUMAN | [view interactions] | High throughput | no | no |
| TP4A2_HUMAN | [view interactions] | High throughput | no | yes |
| PTN12_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| FEM1A_HUMAN | [view interactions] | High throughput | no | no |
| DLGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTPN_HUMAN | [view interactions] | High throughput | no | yes |
| MILK1_HUMAN | [view interactions] | High throughput | no | yes |
| TGM1_HUMAN | [view interactions] | High throughput | no | no |
| MT1F_HUMAN | [view interactions] | High throughput | no | no |
| DPYL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GARE1_HUMAN | [view interactions] | High throughput | no | yes |
| CYS1_HUMAN | [view interactions] | High throughput | no | no |
| AT7L1_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF2_HUMAN | [view interactions] | High throughput | no | yes |
| SPXN4_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NHSL3_HUMAN | [view interactions] | High throughput | no | yes |
| RBX2_HUMAN | [view interactions] | High throughput | no | yes |
| CS025_HUMAN | [view interactions] | High throughput | no | no |
| MTG16_HUMAN | [view interactions] | High throughput | no | yes |
| ERRFI_HUMAN | [view interactions] | High throughput | no | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| HERC5_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DOK1_HUMAN | [view interactions] | High throughput | no | yes |
| NELL1_HUMAN | [view interactions] | High throughput | no | yes |
| ICAL_HUMAN | [view interactions] | High throughput | no | yes |
| ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLX4_HUMAN | [view interactions] | High throughput | no | no |
| DUS15_HUMAN | [view interactions] | High throughput | no | no |
| SNX17_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAIP_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA2_HUMAN | [view interactions] | High throughput | no | no |
| NTM1A_HUMAN | [view interactions] | High throughput | no | yes |
| S23A1_HUMAN | [view interactions] | High throughput | no | no |
| EHD4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EXTL3_HUMAN | [view interactions] | High throughput | no | yes |
| TF3C4_HUMAN | [view interactions] | High throughput | no | no |
| ARHGB_HUMAN | [view interactions] | High throughput | no | yes |
| LIMD1_HUMAN | [view interactions] | High throughput | no | yes |
| RL13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADPPT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RRAS_HUMAN | [view interactions] | High throughput | no | yes |
| DPP2_HUMAN | [view interactions] | High throughput | no | yes |
| RIC8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFS_HUMAN | [view interactions] | High throughput | no | no |
| SARNP_HUMAN | [view interactions] | High throughput | no | yes |
| UBR7_HUMAN | [view interactions] | High throughput | no | yes |
| SKI8_HUMAN | [view interactions] | High throughput | no | yes |
| RGS7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYGB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RYR1_HUMAN | [view interactions] | High throughput | no | no |
| PYRG1_HUMAN | [view interactions] | High throughput | no | no |
| CKAP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCMBP_HUMAN | [view interactions] | High throughput | no | yes |
| PEPL1_HUMAN | [view interactions] | High throughput | no | yes |
| PFKAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRE1B_HUMAN | [view interactions] | High throughput | no | yes |
| STRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ID4_HUMAN | [view interactions] | High throughput | no | no |
| UCHL5_HUMAN | [view interactions] | High throughput | no | yes |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| SKI2_HUMAN | [view interactions] | High throughput | no | yes |
| IL3RA_HUMAN | [view interactions] | High throughput | no | yes |
| TIPRL_HUMAN | [view interactions] | High throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UN45A_HUMAN | [view interactions] | High throughput | no | yes |
| SUV92_HUMAN | [view interactions] | High throughput | no | no |
| CSN7A_HUMAN | [view interactions] | High throughput | no | yes |
| CSN8_HUMAN | [view interactions] | High throughput | no | yes |
| ZP2_HUMAN | [view interactions] | High throughput | no | no |
| CSN2_HUMAN | [view interactions] | High throughput | no | yes |
| SC24B_HUMAN | [view interactions] | High throughput | no | yes |
| CSN4_HUMAN | [view interactions] | High throughput | no | yes |
| FCG2B_HUMAN | [view interactions] | High throughput | no | no |
| NCK1_HUMAN | [view interactions] | High throughput | no | yes |
| PHAR2_HUMAN | [view interactions] | High throughput | no | yes |
| CSN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FCG2C_HUMAN | [view interactions] | High throughput | no | no |
| CSN6_HUMAN | [view interactions] | High throughput | no | yes |
| ANT3_HUMAN | [view interactions] | High throughput | no | no |
| CATS_HUMAN | [view interactions] | High throughput | no | no |
| CSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FANCA_HUMAN | [view interactions] | High throughput | no | no |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAF1A_HUMAN | [view interactions] | High throughput | no | yes |
| PIPNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| E41L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| I20L2_HUMAN | [view interactions] | High throughput | no | yes |
| ROCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFF2_HUMAN | [view interactions] | High throughput | no | yes |
| HEXA_HUMAN | [view interactions] | High throughput | no | yes |
| TDRD1_HUMAN | [view interactions] | High throughput | no | no |
| HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIRE_HUMAN | [view interactions] | High throughput | no | no |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| DNLI3_HUMAN | [view interactions] | High throughput | no | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NELFB_HUMAN | [view interactions] | High throughput | no | yes |
| ADDA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX7_HUMAN | [view interactions] | High throughput | no | yes |
| PLCB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAG1_HUMAN | [view interactions] | High throughput | no | no |
| NSUN2_HUMAN | [view interactions] | High throughput | no | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN1_HUMAN | [view interactions] | High throughput | no | no |
| PLAK2_HUMAN | [view interactions] | High throughput | no | no |
| DNJC3_HUMAN | [view interactions] | High throughput | no | yes |
| PERE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EFL1_HUMAN | [view interactions] | High throughput | no | yes |
| MEPE_HUMAN | [view interactions] | High throughput | no | no |
| TXND5_HUMAN | [view interactions] | High throughput | no | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| MINT_HUMAN | [view interactions] | High throughput | no | yes |
| ZFR_HUMAN | [view interactions] | High throughput | no | yes |
| BICRA_HUMAN | [view interactions] | High throughput | no | yes |
| DOCK7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIPA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THUM3_HUMAN | [view interactions] | High throughput | no | yes |
| ADNP_HUMAN | [view interactions] | High throughput | no | yes |
| CSN7B_HUMAN | [view interactions] | High throughput | no | yes |
| PAR3_HUMAN | [view interactions] | High throughput | no | no |
| XPO5_HUMAN | [view interactions] | High throughput | no | yes |
| DLGP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDT5_HUMAN | [view interactions] | High throughput | no | no |
| RBP2_HUMAN | [view interactions] | High throughput | no | yes |
| TLN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DCAF1_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD244_HUMAN | [view interactions] | High throughput | no | no |
| SH21B_HUMAN | [view interactions] | High throughput | no | no |
| KHDR2_HUMAN | [view interactions] | High throughput | no | yes |
| DDR1_HUMAN | [view interactions] | High throughput | no | yes |
| PRP4B_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRC_HUMAN | [view interactions] | High throughput | no | no |
| RSSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEAK1_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
| P55G_HUMAN | [view interactions] | High throughput | no | yes |
| STA5A_HUMAN | [view interactions] | High throughput | no | no |
| STA5B_HUMAN | [view interactions] | High throughput | no | yes |
| KAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHAG1_HUMAN | [view interactions] | High throughput | no | yes |