PLCG1_HUMAN
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 . Plays a role in actin reorganization and cell migration (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
ELM instance | Name | Type | Start | End | Partner |
---|---|---|---|---|---|
ELMI003742 | LIG_SH2_CRK | LIG | 1253 | 1257 | - |
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PLCG1_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 49.1667 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 48.3333 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 46.6667 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 37.5000 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 36.6667 | 5 | no |
GO:0005524 | ATP binding | 35.0000 | 5 | no |
GO:0046872 | metal ion binding | 30.0000 | 4 | yes |
GO:0016301 | kinase activity | 29.1667 | 4 | no |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 29.1667 | 4 | no |
GO:0019900 | kinase binding | 25.8333 | 4 | yes |
GO:0019901 | protein kinase binding | 25.0000 | 5 | yes |
GO:0004712 | protein serine/threonine/tyrosine kinase activity | 25.0000 | 4 | no |
GO:0005509 | calcium ion binding | 5.0000 | 5 | yes |
GO:0005126 | cytokine receptor binding | 4.1667 | 4 | yes |
GO:0042578 | phosphoric ester hydrolase activity | 4.1667 | 4 | yes |
GO:0005165 | neurotrophin receptor binding | 3.3333 | 5 | yes |
GO:0005167 | neurotrophin TRK receptor binding | 3.3333 | 6 | yes |
GO:0005168 | neurotrophin TRKA receptor binding | 3.3333 | 7 | yes |
GO:0004435 | phosphatidylinositol phospholipase C activity | 2.5000 | 7 | yes |
GO:0004620 | phospholipase activity | 2.5000 | 5 | yes |
GO:0004629 | phospholipase C activity | 2.5000 | 6 | yes |
GO:0008081 | phosphoric diester hydrolase activity | 2.5000 | 5 | yes |
GO:0016298 | lipase activity | 2.5000 | 4 | yes |
GO:0050429 | calcium-dependent phospholipase C activity | 1.6667 | 7 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PLCG1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | yes |
GO:0010646 | regulation of cell communication | 59.1667 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 55.8333 | 4 | no |
GO:0009966 | regulation of signal transduction | 54.1667 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 54.1667 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 53.3333 | 4 | no |
GO:0048523 | negative regulation of cellular process | 53.3333 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 51.6667 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 47.5000 | 4 | no |
GO:0051128 | regulation of cellular component organization | 46.6667 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 43.3333 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 41.6667 | 5 | no |
GO:0010468 | regulation of gene expression | 40.8333 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 39.1667 | 5 | no |
GO:0010941 | regulation of cell death | 38.3333 | 4 | yes |
GO:1902531 | regulation of intracellular signal transduction | 38.3333 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 37.5000 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 37.5000 | 5 | no |
GO:0051049 | regulation of transport | 36.6667 | 4 | yes |
GO:0042325 | regulation of phosphorylation | 36.6667 | 7 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 36.6667 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 35.8333 | 4 | yes |
GO:0071310 | cellular response to organic substance | 35.0000 | 4 | yes |
GO:0006996 | organelle organization | 35.0000 | 4 | no |
GO:0010647 | positive regulation of cell communication | 34.1667 | 5 | no |
GO:0023056 | positive regulation of signaling | 34.1667 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 33.3333 | 4 | yes |
GO:0043085 | positive regulation of catalytic activity | 33.3333 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 33.3333 | 5 | no |
GO:0042981 | regulation of apoptotic process | 32.5000 | 6 | yes |
GO:0043067 | regulation of programmed cell death | 32.5000 | 5 | yes |
GO:0022607 | cellular component assembly | 32.5000 | 4 | no |
GO:0031399 | regulation of protein modification process | 32.5000 | 6 | no |
GO:0009892 | negative regulation of metabolic process | 32.5000 | 4 | no |
GO:0030030 | cell projection organization | 31.6667 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 31.6667 | 6 | no |
GO:0043412 | macromolecule modification | 31.6667 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.8333 | 5 | no |
GO:0036211 | protein modification process | 30.8333 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 29.1667 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 29.1667 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 29.1667 | 5 | no |
GO:0001932 | regulation of protein phosphorylation | 28.3333 | 7 | no |
GO:0051338 | regulation of transferase activity | 28.3333 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 27.5000 | 4 | yes |
GO:0080134 | regulation of response to stress | 27.5000 | 4 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 27.5000 | 5 | no |
GO:0043549 | regulation of kinase activity | 27.5000 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 27.5000 | 4 | no |
GO:0051336 | regulation of hydrolase activity | 27.5000 | 4 | no |
GO:0033043 | regulation of organelle organization | 27.5000 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 27.5000 | 5 | no |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 26.6667 | 4 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 26.6667 | 4 | yes |
GO:0010562 | positive regulation of phosphorus metabolic process | 26.6667 | 6 | no |
GO:0042327 | positive regulation of phosphorylation | 26.6667 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 26.6667 | 7 | no |
GO:0031344 | regulation of cell projection organization | 26.6667 | 5 | no |
GO:0045595 | regulation of cell differentiation | 26.6667 | 4 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 26.6667 | 6 | no |
GO:0016310 | phosphorylation | 26.6667 | 5 | no |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 25.8333 | 5 | yes |
GO:0051252 | regulation of RNA metabolic process | 25.8333 | 5 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 25.8333 | 5 | no |
GO:0048585 | negative regulation of response to stimulus | 25.0000 | 4 | yes |
GO:0051094 | positive regulation of developmental process | 25.0000 | 4 | yes |
GO:2000145 | regulation of cell motility | 25.0000 | 4 | yes |
GO:1902533 | positive regulation of intracellular signal transduction | 25.0000 | 6 | no |
GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
GO:0030334 | regulation of cell migration | 24.1667 | 5 | yes |
GO:0051050 | positive regulation of transport | 24.1667 | 4 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 24.1667 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 24.1667 | 4 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 24.1667 | 5 | no |
GO:0060548 | negative regulation of cell death | 24.1667 | 5 | no |
GO:0006468 | protein phosphorylation | 24.1667 | 5 | no |
GO:0051240 | positive regulation of multicellular organismal process | 23.3333 | 4 | yes |
GO:0009894 | regulation of catabolic process | 23.3333 | 4 | no |
GO:0031401 | positive regulation of protein modification process | 23.3333 | 7 | no |
GO:0006355 | regulation of DNA-templated transcription | 23.3333 | 6 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 23.3333 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 23.3333 | 6 | no |
GO:0008284 | positive regulation of cell population proliferation | 22.5000 | 5 | yes |
GO:1901701 | cellular response to oxygen-containing compound | 22.5000 | 4 | no |
GO:0002684 | positive regulation of immune system process | 21.6667 | 4 | yes |
GO:2000026 | regulation of multicellular organismal development | 21.6667 | 4 | yes |
GO:0001934 | positive regulation of protein phosphorylation | 21.6667 | 8 | no |
GO:0060341 | regulation of cellular localization | 21.6667 | 4 | no |
GO:0010243 | response to organonitrogen compound | 21.6667 | 4 | no |
GO:0051493 | regulation of cytoskeleton organization | 21.6667 | 6 | no |
GO:0043066 | negative regulation of apoptotic process | 21.6667 | 7 | no |
GO:0043069 | negative regulation of programmed cell death | 21.6667 | 6 | no |
GO:0010648 | negative regulation of cell communication | 20.8333 | 5 | no |
GO:0023057 | negative regulation of signaling | 20.8333 | 4 | no |
GO:0051129 | negative regulation of cellular component organization | 20.8333 | 5 | no |
GO:0030155 | regulation of cell adhesion | 20.8333 | 4 | no |
GO:0032101 | regulation of response to external stimulus | 20.0000 | 4 | yes |
GO:0050776 | regulation of immune response | 20.0000 | 4 | yes |
GO:0030335 | positive regulation of cell migration | 19.1667 | 6 | yes |
GO:0040017 | positive regulation of locomotion | 19.1667 | 4 | yes |
GO:0043269 | regulation of ion transport | 19.1667 | 5 | yes |
GO:2000147 | positive regulation of cell motility | 19.1667 | 5 | yes |
GO:0010942 | positive regulation of cell death | 17.5000 | 5 | yes |
GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 15.0000 | 4 | yes |
GO:0010959 | regulation of metal ion transport | 15.0000 | 6 | yes |
GO:0034762 | regulation of transmembrane transport | 15.0000 | 4 | yes |
GO:0050778 | positive regulation of immune response | 15.0000 | 5 | yes |
GO:0070848 | response to growth factor | 15.0000 | 4 | yes |
GO:0002429 | immune response-activating cell surface receptor signaling pathway | 14.1667 | 4 | yes |
GO:0031347 | regulation of defense response | 14.1667 | 5 | yes |
GO:0043065 | positive regulation of apoptotic process | 14.1667 | 7 | yes |
GO:0043068 | positive regulation of programmed cell death | 14.1667 | 6 | yes |
GO:0071363 | cellular response to growth factor stimulus | 14.1667 | 5 | yes |
GO:0034765 | regulation of ion transmembrane transport | 12.5000 | 5 | yes |
GO:0043270 | positive regulation of ion transport | 12.5000 | 5 | yes |
GO:1904062 | regulation of cation transmembrane transport | 12.5000 | 6 | yes |
GO:0038093 | Fc receptor signaling pathway | 11.6667 | 5 | yes |
GO:0034764 | positive regulation of transmembrane transport | 10.8333 | 5 | yes |
GO:0051924 | regulation of calcium ion transport | 10.8333 | 7 | yes |
GO:0002683 | negative regulation of immune system process | 9.1667 | 4 | yes |
GO:0007173 | epidermal growth factor receptor signaling pathway | 9.1667 | 7 | yes |
GO:0010632 | regulation of epithelial cell migration | 9.1667 | 4 | yes |
GO:0032102 | negative regulation of response to external stimulus | 9.1667 | 5 | yes |
GO:0034767 | positive regulation of ion transmembrane transport | 9.1667 | 6 | yes |
GO:0038127 | ERBB signaling pathway | 9.1667 | 6 | yes |
GO:0050727 | regulation of inflammatory response | 9.1667 | 5 | yes |
GO:0031348 | negative regulation of defense response | 8.3333 | 5 | yes |
GO:0050728 | negative regulation of inflammatory response | 8.3333 | 6 | yes |
GO:1904064 | positive regulation of cation transmembrane transport | 8.3333 | 7 | yes |
GO:0010634 | positive regulation of epithelial cell migration | 7.5000 | 5 | yes |
GO:0050851 | antigen receptor-mediated signaling pathway | 7.5000 | 5 | yes |
GO:1903169 | regulation of calcium ion transmembrane transport | 7.5000 | 7 | yes |
GO:0010594 | regulation of endothelial cell migration | 6.6667 | 5 | yes |
GO:0046486 | glycerolipid metabolic process | 6.6667 | 4 | yes |
GO:0050777 | negative regulation of immune response | 6.6667 | 5 | yes |
GO:0002861 | regulation of inflammatory response to antigenic stimulus | 5.8333 | 5 | yes |
GO:0002862 | negative regulation of inflammatory response to antigenic stimulus | 5.8333 | 6 | yes |
GO:0006644 | phospholipid metabolic process | 5.8333 | 4 | yes |
GO:0006650 | glycerophospholipid metabolic process | 5.8333 | 5 | yes |
GO:0045765 | regulation of angiogenesis | 5.8333 | 5 | yes |
GO:0050678 | regulation of epithelial cell proliferation | 5.8333 | 5 | yes |
GO:0050852 | T cell receptor signaling pathway | 5.8333 | 6 | yes |
GO:0051282 | regulation of sequestering of calcium ion | 5.8333 | 4 | yes |
GO:0071364 | cellular response to epidermal growth factor stimulus | 5.8333 | 4 | yes |
GO:1901342 | regulation of vasculature development | 5.8333 | 5 | yes |
GO:0010595 | positive regulation of endothelial cell migration | 5.0000 | 6 | yes |
GO:0043535 | regulation of blood vessel endothelial cell migration | 5.0000 | 6 | yes |
GO:0046488 | phosphatidylinositol metabolic process | 5.0000 | 6 | yes |
GO:0050679 | positive regulation of epithelial cell proliferation | 5.0000 | 6 | yes |
GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 5.0000 | 5 | yes |
GO:0051928 | positive regulation of calcium ion transport | 5.0000 | 6 | yes |
GO:0001936 | regulation of endothelial cell proliferation | 4.1667 | 6 | yes |
GO:0038095 | Fc-epsilon receptor signaling pathway | 4.1667 | 6 | yes |
GO:0043536 | positive regulation of blood vessel endothelial cell migration | 4.1667 | 7 | yes |
GO:0045766 | positive regulation of angiogenesis | 4.1667 | 6 | yes |
GO:1904018 | positive regulation of vasculature development | 4.1667 | 5 | yes |
GO:1904035 | regulation of epithelial cell apoptotic process | 4.1667 | 7 | yes |
GO:1904427 | positive regulation of calcium ion transmembrane transport | 4.1667 | 7 | yes |
GO:0001938 | positive regulation of endothelial cell proliferation | 3.3333 | 7 | yes |
GO:1904037 | positive regulation of epithelial cell apoptotic process | 3.3333 | 8 | yes |
GO:0019722 | calcium-mediated signaling | 2.5000 | 5 | yes |
GO:0019932 | second-messenger-mediated signaling | 2.5000 | 4 | yes |
GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | 2.5000 | 6 | yes |
GO:2000351 | regulation of endothelial cell apoptotic process | 2.5000 | 8 | yes |
GO:0009395 | phospholipid catabolic process | 1.6667 | 5 | yes |
GO:0016042 | lipid catabolic process | 1.6667 | 4 | yes |
GO:0044242 | cellular lipid catabolic process | 1.6667 | 4 | yes |
GO:0046434 | organophosphate catabolic process | 1.6667 | 4 | yes |
GO:1905562 | regulation of vascular endothelial cell proliferation | 1.6667 | 7 | yes |
GO:1905564 | positive regulation of vascular endothelial cell proliferation | 1.6667 | 8 | yes |
GO:2000353 | positive regulation of endothelial cell apoptotic process | 1.6667 | 9 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in PLCG1_HUMAN |
---|---|---|---|---|
DOID:0050686 | organ system cancer | 3.3333 | 3 | no |
DOID:114 | heart disease | 2.5000 | 3 | no |
DOID:331 | central nervous system disease | 2.5000 | 3 | no |
DOID:193 | reproductive organ cancer | 1.6667 | 4 | no |
DOID:0050700 | cardiomyopathy | 1.6667 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 1.6667 | 5 | no |
DOID:0080000 | muscular disease | 1.6667 | 3 | no |
DOID:423 | myopathy | 1.6667 | 5 | no |
DOID:66 | muscle tissue disease | 1.6667 | 4 | no |
DOID:1289 | neurodegenerative disease | 1.6667 | 4 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
PGFRA_HUMAN | [view interactions] | Low throughput | no | no |
ERBB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
PLD1_HUMAN | [view interactions] | Low throughput | no | no |
FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EF1A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EPHB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GIT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
LYAM2_HUMAN | [view interactions] | Low throughput | no | no |
DGKZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PLD2_HUMAN | [view interactions] | Low throughput | no | yes |
SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SHB_HUMAN | [view interactions] | Low throughput | no | yes |
RHOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ALK_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PDGFA_HUMAN | [view interactions] | Low throughput | no | yes |
KPCD1_HUMAN | [view interactions] | Low throughput | no | yes |
ZAP70_HUMAN | [view interactions] | Low throughput | no | no |
RHG32_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NTAL_HUMAN | [view interactions] | Low throughput | no | no |
SH2B3_HUMAN | [view interactions] | Low throughput | no | yes |
IRS2_HUMAN | [view interactions] | Low throughput | no | yes |
AP180_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TUB_HUMAN | [view interactions] | Low throughput | no | yes |
RON_HUMAN | [view interactions] | Low throughput | no | yes |
BAG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
LTK_HUMAN | [view interactions] | Low throughput | no | no |
PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
BLNK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
IBTK_HUMAN | [view interactions] | Low throughput | no | yes |
PML_HUMAN | [view interactions] | Low throughput | no | yes |
NPM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SPY1_HUMAN | [view interactions] | Low throughput | no | yes |
DAB1_HUMAN | [view interactions] | Low throughput | no | yes |
JAK1_HUMAN | [view interactions] | Low throughput | no | yes |
TEC_HUMAN | [view interactions] | Low throughput | no | yes |
PTN6_HUMAN | [view interactions] | Low throughput | no | no |
GRB14_HUMAN | [view interactions] | Low throughput | no | yes |
CISH_HUMAN | [view interactions] | Low throughput | no | yes |
IRS4_HUMAN | [view interactions] | Low throughput | no | no |
RPGF5_HUMAN | [view interactions] | Low throughput | no | yes |
KPCE_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NCAM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
RGPS2_HUMAN | [view interactions] | Low throughput | no | yes |
PKN2_HUMAN | [view interactions] | Low throughput | no | yes |
PAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HNRPQ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TRPM7_HUMAN | [view interactions] | Low throughput | no | no |
TNK1_HUMAN | [view interactions] | Low throughput | no | yes |
PICAL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PECA1_HUMAN | [view interactions] | Low throughput | no | no |
GAB2_HUMAN | [view interactions] | Low throughput | no | yes |
GELS_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ANM8_HUMAN | [view interactions] | Low throughput | no | yes |
MAP6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PTPRJ_HUMAN | [view interactions] | Low throughput | no | yes |
EPOR_HUMAN | [view interactions] | Low throughput | no | no |
RACK1_HUMAN | [view interactions] | Low throughput | no | yes |
ASAP2_HUMAN | [view interactions] | Low throughput | no | yes |
ASAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
M4K1_HUMAN | [view interactions] | Low throughput | no | no |
ABL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GHR_HUMAN | [view interactions] | Low throughput | no | yes |
SHAN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SOS2_HUMAN | [view interactions] | Low throughput | no | yes |
JAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ABL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RIN3_HUMAN | [view interactions] | Low throughput | no | yes |
TRPC3_HUMAN | [view interactions] | Low throughput | no | no |
GAB1_HUMAN | [view interactions] | Low throughput | no | yes |
LEPR_HUMAN | [view interactions] | Low throughput | no | no |
RET_HUMAN | [view interactions] | Low throughput | no | yes |
SHIP1_HUMAN | [view interactions] | Low throughput | no | no |
VGFR1_HUMAN | [view interactions] | Low throughput | no | no |
PTN1_HUMAN | [view interactions] | Low throughput | no | yes |
RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
DDIT4_HUMAN | [view interactions] | Low throughput | no | yes |
GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
LCP2_HUMAN | [view interactions] | Low throughput | no | yes |
TESP1_HUMAN | [view interactions] | Low throughput | no | yes |
NFAT5_HUMAN | [view interactions] | Low throughput | no | yes |
FGFR2_HUMAN | [view interactions] | Low throughput | no | yes |
EGFR_HUMAN | [view interactions] | Low throughput | no | no |
UFO_HUMAN | [view interactions] | Low throughput | no | no |
VILI_HUMAN | [view interactions] | Low throughput | no | no |
AGAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CD22_HUMAN | [view interactions] | Low throughput | no | no |
KHDR1_HUMAN | [view interactions] | Low throughput | no | yes |
INSR_HUMAN | [view interactions] | Low throughput | no | yes |
PGFRB_HUMAN | [view interactions] | Low throughput | no | yes |
LAT_HUMAN | [view interactions] | Low throughput | no | no |
PLCG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VGFR2_HUMAN | [view interactions] | Low throughput | no | no |
KIT_HUMAN | [view interactions] | Low throughput | no | no |
NTRK1_HUMAN | [view interactions] | Low throughput | no | yes |
KSYK_HUMAN | [view interactions] | Low throughput | no | no |
STK11_HUMAN | [view interactions] | Low throughput | no | yes |
RHOU_HUMAN | [view interactions] | Low throughput | no | no |
SYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
RASA1_HUMAN | [view interactions] | Low throughput | no | yes |
PTN11_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
P85A_HUMAN | [view interactions] | Low throughput | no | yes |
AKT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
3BP2_HUMAN | [view interactions] | Low throughput | no | yes |
VAV_HUMAN | [view interactions] | Low throughput | no | no |
FGFR1_HUMAN | [view interactions] | Low throughput | no | yes |
AGTR1_HUMAN | [view interactions] | Low throughput | no | no |
FYB1_HUMAN | [view interactions] | Low throughput | no | no |
DYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
WASP_HUMAN | [view interactions] | Low throughput | no | yes |
HAVR2_HUMAN | [view interactions] | Low throughput | no | no |
THMS1_HUMAN | [view interactions] | Low throughput | no | no |
CAV1_HUMAN | [view interactions] | Low throughput | no | no |
FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ITK_HUMAN | [view interactions] | Low throughput | no | no |
CBL_HUMAN | [view interactions] | Low throughput | no | yes |
NTRK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NTRK3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GASR_HUMAN | [view interactions] | Low throughput | no | no |
TNR6_HUMAN | [view interactions] | Low throughput | no | no |
PK3CA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ANDR_HUMAN | [view interactions] | High throughput | no | no |
MET_HUMAN | [view interactions] | High throughput | no | yes |
ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLCG2_HUMAN | [view interactions] | High throughput | no | yes |
HCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TRI14_HUMAN | [view interactions] | High throughput | no | yes |
PLXB1_HUMAN | [view interactions] | High throughput | no | yes |
PLXB2_HUMAN | [view interactions] | High throughput | no | yes |
ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NXF1_HUMAN | [view interactions] | High throughput | no | yes |
MB12B_HUMAN | [view interactions] | High throughput | no | no |
GA2L1_HUMAN | [view interactions] | High throughput | no | yes |
SNX11_HUMAN | [view interactions] | High throughput | no | yes |
TEKT2_HUMAN | [view interactions] | High throughput | no | no |
LRAD4_HUMAN | [view interactions] | High throughput | no | yes |
DOK2_HUMAN | [view interactions] | High throughput | no | no |
SPN90_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CACB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CC120_HUMAN | [view interactions] | High throughput | no | no |
TTC9B_HUMAN | [view interactions] | High throughput | no | yes |
KCNJ5_HUMAN | [view interactions] | High throughput | no | yes |
LZTS2_HUMAN | [view interactions] | High throughput | no | no |
ZN785_HUMAN | [view interactions] | High throughput | no | no |
HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
DUS9_HUMAN | [view interactions] | High throughput | no | no |
MGDP1_HUMAN | [view interactions] | High throughput | no | yes |
TP4A1_HUMAN | [view interactions] | High throughput | no | no |
TP4A2_HUMAN | [view interactions] | High throughput | no | yes |
PTN12_HUMAN | [view interactions] | High throughput | no | yes |
STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
P53_HUMAN | [view interactions] | High throughput | no | no |
FEM1A_HUMAN | [view interactions] | High throughput | no | no |
DLGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MTPN_HUMAN | [view interactions] | High throughput | no | yes |
MILK1_HUMAN | [view interactions] | High throughput | no | yes |
TGM1_HUMAN | [view interactions] | High throughput | no | no |
MT1F_HUMAN | [view interactions] | High throughput | no | no |
DPYL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GARE1_HUMAN | [view interactions] | High throughput | no | yes |
CYS1_HUMAN | [view interactions] | High throughput | no | no |
AT7L1_HUMAN | [view interactions] | High throughput | no | yes |
SRSF2_HUMAN | [view interactions] | High throughput | no | yes |
SPXN4_HUMAN | [view interactions] | High throughput | no | no |
DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
K1522_HUMAN | [view interactions] | High throughput | no | yes |
RBX2_HUMAN | [view interactions] | High throughput | no | yes |
CS025_HUMAN | [view interactions] | High throughput | no | no |
MTG16_HUMAN | [view interactions] | High throughput | no | yes |
ERRFI_HUMAN | [view interactions] | High throughput | no | no |
EP300_HUMAN | [view interactions] | High throughput | no | yes |
FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DOK1_HUMAN | [view interactions] | High throughput | no | yes |
ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ERBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NELL1_HUMAN | [view interactions] | High throughput | no | yes |
NTM1A_HUMAN | [view interactions] | High throughput | no | yes |
DLX4_HUMAN | [view interactions] | High throughput | no | no |
EHD4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ICAL_HUMAN | [view interactions] | High throughput | no | yes |
TF3C4_HUMAN | [view interactions] | High throughput | no | no |
DUS15_HUMAN | [view interactions] | High throughput | no | no |
LIMD1_HUMAN | [view interactions] | High throughput | no | yes |
TRAIP_HUMAN | [view interactions] | High throughput | no | yes |
ADPPT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNX17_HUMAN | [view interactions] | High throughput | no | yes |
DPP2_HUMAN | [view interactions] | High throughput | no | yes |
RIC8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PDIA2_HUMAN | [view interactions] | High throughput | no | no |
RL38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
S23A1_HUMAN | [view interactions] | High throughput | no | no |
SARNP_HUMAN | [view interactions] | High throughput | no | yes |
ARHGB_HUMAN | [view interactions] | High throughput | no | yes |
UBR7_HUMAN | [view interactions] | High throughput | no | yes |
EXTL3_HUMAN | [view interactions] | High throughput | no | yes |
WDR61_HUMAN | [view interactions] | High throughput | no | yes |
RRAS_HUMAN | [view interactions] | High throughput | no | yes |
PYGB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RL13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PYRG1_HUMAN | [view interactions] | High throughput | no | no |
MCMBP_HUMAN | [view interactions] | High throughput | no | yes |
PEPL1_HUMAN | [view interactions] | High throughput | no | yes |
PFKAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EFS_HUMAN | [view interactions] | High throughput | no | no |
BRE1B_HUMAN | [view interactions] | High throughput | no | yes |
RGS7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UCHL5_HUMAN | [view interactions] | High throughput | no | yes |
RYR1_HUMAN | [view interactions] | High throughput | no | no |
SKIV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIPRL_HUMAN | [view interactions] | High throughput | no | yes |
CKAP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UN45A_HUMAN | [view interactions] | High throughput | no | yes |
CSN7A_HUMAN | [view interactions] | High throughput | no | yes |
CSN8_HUMAN | [view interactions] | High throughput | no | yes |
ID4_HUMAN | [view interactions] | High throughput | no | no |
CSN2_HUMAN | [view interactions] | High throughput | no | yes |
CSN4_HUMAN | [view interactions] | High throughput | no | yes |
FLNB_HUMAN | [view interactions] | High throughput | no | no |
NCK1_HUMAN | [view interactions] | High throughput | no | yes |
FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CSN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IL3RA_HUMAN | [view interactions] | High throughput | no | yes |
CSN6_HUMAN | [view interactions] | High throughput | no | yes |
CATS_HUMAN | [view interactions] | High throughput | no | no |
SUV92_HUMAN | [view interactions] | High throughput | no | no |
DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SC24B_HUMAN | [view interactions] | High throughput | no | yes |
HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZP2_HUMAN | [view interactions] | High throughput | no | no |
BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FCG2B_HUMAN | [view interactions] | High throughput | no | no |
PIPNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FCG2C_HUMAN | [view interactions] | High throughput | no | no |
NAA40_HUMAN | [view interactions] | High throughput | no | no |
PHAR2_HUMAN | [view interactions] | High throughput | no | yes |
CSMD2_HUMAN | [view interactions] | High throughput | no | no |
ANT3_HUMAN | [view interactions] | High throughput | no | no |
FANCA_HUMAN | [view interactions] | High throughput | no | no |
TGON2_HUMAN | [view interactions] | High throughput | no | yes |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAF1A_HUMAN | [view interactions] | High throughput | no | yes |
MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
I20L2_HUMAN | [view interactions] | High throughput | no | yes |
TDRD1_HUMAN | [view interactions] | High throughput | no | no |
AFF2_HUMAN | [view interactions] | High throughput | no | yes |
AIRE_HUMAN | [view interactions] | High throughput | no | no |
DNLI3_HUMAN | [view interactions] | High throughput | no | yes |
NELFB_HUMAN | [view interactions] | High throughput | no | no |
SNX7_HUMAN | [view interactions] | High throughput | no | yes |
RAG1_HUMAN | [view interactions] | High throughput | no | no |
DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AKAP2_HUMAN | [view interactions] | High throughput | no | no |
PERE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FLNC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MEPE_HUMAN | [view interactions] | High throughput | no | no |
DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MINT_HUMAN | [view interactions] | High throughput | no | yes |
BICRA_HUMAN | [view interactions] | High throughput | no | yes |
ADNP_HUMAN | [view interactions] | High throughput | no | yes |
LIPA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PAR3_HUMAN | [view interactions] | High throughput | no | no |
DLGP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RBP2_HUMAN | [view interactions] | High throughput | no | yes |
NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CD244_HUMAN | [view interactions] | High throughput | no | no |
SH21B_HUMAN | [view interactions] | High throughput | no | no |
KHDR2_HUMAN | [view interactions] | High throughput | no | yes |
DDR1_HUMAN | [view interactions] | High throughput | no | yes |
PRP4B_HUMAN | [view interactions] | High throughput | no | yes |
PTPRC_HUMAN | [view interactions] | High throughput | no | no |
PEAK1_HUMAN | [view interactions] | High throughput | no | yes |
RSSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
P55G_HUMAN | [view interactions] | High throughput | no | yes |
STA5A_HUMAN | [view interactions] | High throughput | no | no |
STA5B_HUMAN | [view interactions] | High throughput | no | yes |
KAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
FGFR4_HUMAN | [view interactions] | High throughput | no | no |
HSC20_HUMAN | [view interactions] | High throughput | no | yes |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
TNR16_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CD79A_HUMAN | [view interactions] | Computational | no | no |
P2RY2_HUMAN | [view interactions] | Computational | no | no |
PI42C_HUMAN | [view interactions] | Computational | no | yes |
KPCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SPHK1_HUMAN | [view interactions] | Computational | no | yes |
SDC2_HUMAN | [view interactions] | Computational | no | yes |
ANGT_HUMAN | [view interactions] | Computational | no | no |
SOMA_HUMAN | [view interactions] | Computational | no | no |
ACHA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
HGF_HUMAN | [view interactions] | Computational | no | yes |
EDNRA_HUMAN | [view interactions] | Computational | no | yes |
DCE1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NET1_HUMAN | [view interactions] | Computational | no | no |
KPCG_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CD4_HUMAN | [view interactions] | Computational | no | no |
EDNRB_HUMAN | [view interactions] | Computational | no | no |
ARI1_HUMAN | [view interactions] | Computational | no | yes |
PK3CG_HUMAN | [view interactions] | Computational | no | yes |
S1PR4_HUMAN | [view interactions] | Computational | no | no |
HS90A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ACM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GNA14_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GRAP2_HUMAN | [view interactions] | Computational | no | no |
MK03_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
BCR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ICAM1_HUMAN | [view interactions] | Computational | no | no |
PI51B_HUMAN | [view interactions] | Computational | no | yes |
GBB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EPHA4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TRPC6_HUMAN | [view interactions] | Computational | no | no |
EGF_HUMAN | [view interactions] | Computational | no | no |
GNAZ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PDGFB_HUMAN | [view interactions] | Computational | no | yes |
GNAQ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GBG1_HUMAN | [view interactions] | Computational | no | no |
GRP1_HUMAN | [view interactions] | Computational | no | no |
NPHN_HUMAN | [view interactions] | Computational | no | no |
CXCR4_HUMAN | [view interactions] | Computational | no | no |
VAV3_HUMAN | [view interactions] | Computational | no | yes |
IL6RA_HUMAN | [view interactions] | Computational | no | no |
TRI25_HUMAN | [view interactions] | Computational | no | yes |
DPB1_HUMAN | [view interactions] | Computational | no | no |
CREB1_HUMAN | [view interactions] | Computational | no | yes |
DQA2_HUMAN | [view interactions] | Computational | no | no |
FCERA_HUMAN | [view interactions] | Computational | no | yes |
KCC4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GNAO_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GNAI3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PLGF_HUMAN | [view interactions] | Computational | no | no |
GNA15_HUMAN | [view interactions] | Computational | no | yes |
KPCT_HUMAN | [view interactions] | Computational | no | no |
TRPC4_HUMAN | [view interactions] | Computational | no | no |
BLK_HUMAN | [view interactions] | Computational | no | no |
UB2L6_HUMAN | [view interactions] | Computational | no | no |
CSN7B_HUMAN | [view interactions] | Computational | no | yes |
GNAI1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
S1PR1_HUMAN | [view interactions] | Computational | no | no |
FCERG_HUMAN | [view interactions] | Computational | no | no |
TPOR_HUMAN | [view interactions] | Computational | no | no |
LYN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CSN5_HUMAN | [view interactions] | Computational | no | yes |
GNA11_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
UBP18_HUMAN | [view interactions] | Computational | no | yes |
EFNA3_HUMAN | [view interactions] | Computational | no | yes |
BTK_HUMAN | [view interactions] | Computational | no | no |
BDNF_HUMAN | [view interactions] | Computational | no | yes |
GNAI2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PODO_HUMAN | [view interactions] | Computational | no | no |
SH22A_HUMAN | [view interactions] | Computational | no | no |
PI5L1_HUMAN | [view interactions] | Computational | no | no |
ARHG7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NOS3_HUMAN | [view interactions] | Computational | no | no |
KCC2D_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CDC42_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PI42B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
KPCD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AGTR2_HUMAN | [view interactions] | Computational | no | no |
CD3Z_HUMAN | [view interactions] | Computational | no | no |
NGF_HUMAN | [view interactions] | Computational | no | no |
YES_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
LCK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
PI51A_HUMAN | [view interactions] | Computational | no | yes |
CCR5_HUMAN | [view interactions] | Computational | no | no |
DRB1_HUMAN | [view interactions] | Computational | no | no |
ITPR3_HUMAN | [view interactions] | Computational | no | yes |
CD3D_HUMAN | [view interactions] | Computational | no | no |
SDF1_HUMAN | [view interactions] | Computational | no | no |
CCL4_HUMAN | [view interactions] | Computational | no | no |
PI51C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CD79B_HUMAN | [view interactions] | Computational | no | no |
DQA1_HUMAN | [view interactions] | Computational | no | yes |
EMAL4_HUMAN | [view interactions] | Computational | no | yes |
PI42A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EFNA5_HUMAN | [view interactions] | Computational | no | yes |
DRB5_HUMAN | [view interactions] | Computational | no | no |
IGSF2_HUMAN | [view interactions] | Computational | no | yes |
FGR_HUMAN | [view interactions] | Computational | no | no |
DQB2_HUMAN | [view interactions] | Computational | no | no |
CSN9_HUMAN | [view interactions] | Computational | no | yes |
VAV2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
HERC5_HUMAN | [view interactions] | Computational | no | yes |
EDN1_HUMAN | [view interactions] | Computational | no | no |
CSN1_HUMAN | [view interactions] | Computational | no | no |
ITPR2_HUMAN | [view interactions] | Computational | no | yes |
TRPC1_HUMAN | [view interactions] | Computational | no | yes |
EPO_HUMAN | [view interactions] | Computational | no | no |
HCST_HUMAN | [view interactions] | Computational | no | no |
DCC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KIRR1_HUMAN | [view interactions] | Computational | no | no |
CD3E_HUMAN | [view interactions] | Computational | no | no |
DPA1_HUMAN | [view interactions] | Computational | no | yes |
KCC2B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
VGFR3_HUMAN | [view interactions] | Computational | no | yes |
DRA_HUMAN | [view interactions] | Computational | no | no |
NTF3_HUMAN | [view interactions] | Computational | no | no |
IP3KB_HUMAN | [view interactions] | Computational | no | no |
FCERB_HUMAN | [view interactions] | Computational | no | no |
NTF4_HUMAN | [view interactions] | Computational | no | no |