PIPNA_HUMAN
Evidence for PS localization
Functions
Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes (PubMed, PubMed, PubMed, PubMed, PubMed). Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions (PubMed, PubMed). Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3 (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PIPNA_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 41.1765 | 4 | yes |
| GO:0003723 | RNA binding | 29.4118 | 4 | no |
| GO:0043169 | cation binding | 23.5294 | 4 | yes |
| GO:0000166 | nucleotide binding | 23.5294 | 4 | no |
| GO:0017076 | purine nucleotide binding | 23.5294 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 23.5294 | 6 | no |
| GO:0035091 | phosphatidylinositol binding | 11.7647 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PIPNA_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 47.0588 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 41.1765 | 4 | no |
| GO:0071702 | organic substance transport | 35.2941 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 35.2941 | 4 | no |
| GO:0009966 | regulation of signal transduction | 29.4118 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.4118 | 4 | no |
| GO:0071705 | nitrogen compound transport | 29.4118 | 4 | no |
| GO:0006996 | organelle organization | 29.4118 | 4 | no |
| GO:0051049 | regulation of transport | 29.4118 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 29.4118 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 23.5294 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 23.5294 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 23.5294 | 4 | no |
| GO:0008104 | protein localization | 23.5294 | 4 | no |
| GO:0009894 | regulation of catabolic process | 23.5294 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.5294 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 23.5294 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.5294 | 4 | no |
| GO:0006644 | phospholipid metabolic process | 23.5294 | 4 | no |
| GO:0006869 | lipid transport | 11.7647 | 5 | yes |
| GO:0015748 | organophosphate ester transport | 11.7647 | 5 | yes |
| GO:0015914 | phospholipid transport | 11.7647 | 6 | yes |
| GO:0030030 | cell projection organization | 11.7647 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SCP2_HUMAN | [view interactions] | Low throughput | no | no |
| HSDL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MO4L2_HUMAN | [view interactions] | High throughput | no | yes |
| MLKL_HUMAN | [view interactions] | High throughput | no | no |
| PMVK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CASP6_HUMAN | [view interactions] | High throughput | no | no |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T2FB_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| PIPNB_HUMAN | [view interactions] | High throughput | no | no |
| LSHR_HUMAN | [view interactions] | High throughput | no | no |
| SSUH2_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| PPAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIX23_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NECP1_HUMAN | [view interactions] | High throughput | no | no |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2L3_HUMAN | [view interactions] | High throughput | no | yes |
| PK3C3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLCG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CND1_HUMAN | [view interactions] | High throughput | no | yes |
| SNX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ISOC1_HUMAN | [view interactions] | High throughput | no | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC26_HUMAN | [view interactions] | High throughput | no | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| S1PR4_HUMAN | [view interactions] | High throughput | no | no |
| SIR3_HUMAN | [view interactions] | High throughput | no | yes |