Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PK3C3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

(Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PK3C3_HUMAN
GO:0000166 nucleotide binding 44.1860 4 yes
GO:0043168 anion binding 44.1860 4 yes
GO:0017076 purine nucleotide binding 41.8605 5 yes
GO:0032555 purine ribonucleotide binding 41.8605 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 41.8605 4 yes
GO:0005524 ATP binding 32.5581 5 yes
GO:0030554 adenyl nucleotide binding 32.5581 6 yes
GO:0032559 adenyl ribonucleotide binding 32.5581 5 yes
GO:0016462 pyrophosphatase activity 23.2558 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 23.2558 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 23.2558 6 no
GO:0019900 kinase binding 20.9302 4 no
GO:0019901 protein kinase binding 20.9302 5 no
GO:0016301 kinase activity 16.2791 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 13.9535 4 yes
GO:0001727 lipid kinase activity 4.6512 5 yes
GO:0016303 1-phosphatidylinositol-3-kinase activity 4.6512 6 yes
GO:0052742 phosphatidylinositol kinase activity 4.6512 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PK3C3_HUMAN
GO:0051128 regulation of cellular component organization 60.4651 4 no
GO:0048523 negative regulation of cellular process 58.1395 4 no
GO:0031323 regulation of cellular metabolic process 58.1395 4 yes
GO:0048522 positive regulation of cellular process 55.8140 4 no
GO:0060255 regulation of macromolecule metabolic process 51.1628 4 no
GO:0010646 regulation of cell communication 51.1628 4 no
GO:0080090 regulation of primary metabolic process 46.5116 4 no
GO:0006996 organelle organization 46.5116 4 yes
GO:0008104 protein localization 44.1860 4 yes
GO:0009966 regulation of signal transduction 44.1860 4 no
GO:0071702 organic substance transport 41.8605 4 yes
GO:0031326 regulation of cellular biosynthetic process 39.5349 5 no
GO:0009889 regulation of biosynthetic process 39.5349 4 no
GO:0010468 regulation of gene expression 39.5349 6 no
GO:0010556 regulation of macromolecule biosynthetic process 39.5349 5 no
GO:0010648 negative regulation of cell communication 37.2093 5 no
GO:0023057 negative regulation of signaling 37.2093 4 no
GO:0042981 regulation of apoptotic process 37.2093 5 no
GO:0043067 regulation of programmed cell death 37.2093 4 no
GO:0048585 negative regulation of response to stimulus 37.2093 4 no
GO:1902531 regulation of intracellular signal transduction 37.2093 5 no
GO:0071705 nitrogen compound transport 37.2093 4 yes
GO:0009892 negative regulation of metabolic process 37.2093 4 no
GO:0009893 positive regulation of metabolic process 37.2093 4 no
GO:0031324 negative regulation of cellular metabolic process 34.8837 5 no
GO:0051246 regulation of protein metabolic process 34.8837 5 no
GO:0009968 negative regulation of signal transduction 34.8837 5 no
GO:0048584 positive regulation of response to stimulus 32.5581 4 no
GO:0044087 regulation of cellular component biogenesis 32.5581 4 no
GO:0009894 regulation of catabolic process 32.5581 4 yes
GO:0015031 protein transport 32.5581 4 yes
GO:0022607 cellular component assembly 32.5581 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 32.5581 5 no
GO:0010605 negative regulation of macromolecule metabolic process 32.5581 5 no
GO:0023056 positive regulation of signaling 30.2326 4 no
GO:0043066 negative regulation of apoptotic process 30.2326 6 no
GO:0043069 negative regulation of programmed cell death 30.2326 5 no
GO:0033043 regulation of organelle organization 30.2326 5 no
GO:0031325 positive regulation of cellular metabolic process 30.2326 5 no
GO:0036211 protein modification process 30.2326 4 yes
GO:0043412 macromolecule modification 30.2326 4 yes
GO:0009967 positive regulation of signal transduction 30.2326 5 no
GO:0010647 positive regulation of cell communication 30.2326 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.9070 5 no
GO:2000026 regulation of multicellular organismal development 27.9070 4 no
GO:0051049 regulation of transport 27.9070 4 no
GO:0051726 regulation of cell cycle 27.9070 4 yes
GO:0009890 negative regulation of biosynthetic process 27.9070 5 no
GO:0031327 negative regulation of cellular biosynthetic process 25.5814 6 no
GO:0051247 positive regulation of protein metabolic process 25.5814 6 no
GO:0006355 regulation of DNA-templated transcription 25.5814 7 no
GO:0031399 regulation of protein modification process 25.5814 6 no
GO:0045595 regulation of cell differentiation 25.5814 4 no
GO:0051129 negative regulation of cellular component organization 25.5814 5 no
GO:0051240 positive regulation of multicellular organismal process 25.5814 4 no
GO:0051252 regulation of RNA metabolic process 25.5814 5 no
GO:2001141 regulation of RNA biosynthetic process 25.5814 6 no
GO:0010558 negative regulation of macromolecule biosynthetic process 25.5814 6 no
GO:0051094 positive regulation of developmental process 23.2558 4 no
GO:0080134 regulation of response to stress 23.2558 4 no
GO:0006796 phosphate-containing compound metabolic process 23.2558 4 yes
GO:0010564 regulation of cell cycle process 23.2558 5 yes
GO:0051248 negative regulation of protein metabolic process 20.9302 6 no
GO:0032880 regulation of protein localization 20.9302 5 no
GO:0060341 regulation of cellular localization 20.9302 4 no
GO:0009891 positive regulation of biosynthetic process 20.9302 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 20.9302 6 no
GO:0031328 positive regulation of cellular biosynthetic process 20.9302 6 no
GO:0031344 regulation of cell projection organization 20.9302 5 no
GO:0043254 regulation of protein-containing complex assembly 20.9302 5 no
GO:0060284 regulation of cell development 20.9302 5 no
GO:0071310 cellular response to organic substance 20.9302 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 20.9302 6 no
GO:0006886 intracellular protein transport 20.9302 4 yes
GO:0010506 regulation of autophagy 20.9302 6 yes
GO:0031329 regulation of cellular catabolic process 20.9302 5 yes
GO:0043933 protein-containing complex organization 20.9302 4 yes
GO:0009267 cellular response to starvation 18.6047 4 yes
GO:0016310 phosphorylation 18.6047 5 yes
GO:0007033 vacuole organization 13.9535 5 yes
GO:0016236 macroautophagy 13.9535 4 yes
GO:0016241 regulation of macroautophagy 13.9535 7 yes
GO:0022411 cellular component disassembly 13.9535 4 yes
GO:0007034 vacuolar transport 11.6279 4 yes
GO:0007041 lysosomal transport 11.6279 5 yes
GO:0042149 cellular response to glucose starvation 11.6279 5 yes
GO:0070925 organelle assembly 11.6279 5 yes
GO:0098657 import into cell 11.6279 4 yes
GO:0000045 autophagosome assembly 9.3023 6 yes
GO:0006605 protein targeting 9.3023 4 yes
GO:0033365 protein localization to organelle 9.3023 5 yes
GO:0044788 modulation by host of viral process 9.3023 5 yes
GO:0051851 modulation by host of symbiont process 9.3023 4 yes
GO:1905037 autophagosome organization 9.3023 6 yes
GO:0006497 protein lipidation 6.9767 5 yes
GO:0032465 regulation of cytokinesis 6.9767 5 yes
GO:0032984 protein-containing complex disassembly 6.9767 5 yes
GO:0034497 protein localization to phagophore assembly site 6.9767 5 yes
GO:0044827 modulation by host of viral genome replication 6.9767 6 yes
GO:0045022 early endosome to late endosome transport 6.9767 5 yes
GO:0051302 regulation of cell division 6.9767 4 yes
GO:0072594 establishment of protein localization to organelle 6.9767 4 yes
GO:0097352 autophagosome maturation 6.9767 6 yes
GO:0098927 vesicle-mediated transport between endosomal compartments 6.9767 4 yes
GO:0006622 protein targeting to lysosome 4.6512 6 yes
GO:0006623 protein targeting to vacuole 4.6512 5 yes
GO:0006644 phospholipid metabolic process 4.6512 4 yes
GO:0006650 glycerophospholipid metabolic process 4.6512 5 yes
GO:0006661 phosphatidylinositol biosynthetic process 4.6512 6 yes
GO:0008610 lipid biosynthetic process 4.6512 4 yes
GO:0008654 phospholipid biosynthetic process 4.6512 5 yes
GO:0030242 autophagy of peroxisome 4.6512 4 yes
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process 4.6512 8 yes
GO:0044794 positive regulation by host of viral process 4.6512 6 yes
GO:0044829 positive regulation by host of viral genome replication 4.6512 7 yes
GO:0045017 glycerolipid biosynthetic process 4.6512 4 yes
GO:0046474 glycerophospholipid biosynthetic process 4.6512 5 yes
GO:0046486 glycerolipid metabolic process 4.6512 4 yes
GO:0046488 phosphatidylinositol metabolic process 4.6512 6 yes
GO:0046854 phosphatidylinositol phosphate biosynthetic process 4.6512 7 yes
GO:0048015 phosphatidylinositol-mediated signaling 4.6512 4 yes
GO:0061462 protein localization to lysosome 4.6512 7 yes
GO:0072665 protein localization to vacuole 4.6512 6 yes
GO:0072666 establishment of protein localization to vacuole 4.6512 5 yes
GO:0090407 organophosphate biosynthetic process 4.6512 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
1433T_HUMAN [view entry] [view interactions] Low throughput yes yes
CASP8_HUMAN [view interactions] Low throughput no yes
NHLC1_HUMAN [view interactions] Low throughput no no
RBCC1_HUMAN [view interactions] Low throughput no no
ULK1_HUMAN [view interactions] Low throughput no no
BECN1_HUMAN [view interactions] Low throughput no yes
UVRAG_HUMAN [view interactions] Low throughput no yes
PI3R4_HUMAN [view interactions] Low throughput no yes
UBP11_HUMAN [view interactions] Low throughput no yes
NRBF2_HUMAN [view interactions] Low throughput no yes
BAKOR_HUMAN [view interactions] Low throughput no yes
RUBIC_HUMAN [view interactions] Low throughput no no
RB39A_HUMAN [view interactions] Low throughput no no
VMP1_HUMAN [view interactions] Low throughput no yes
SLAF1_HUMAN [view interactions] Low throughput no no
CCZ1B_HUMAN [view interactions] Low throughput no yes
CCZ1_HUMAN [view interactions] Low throughput no yes
RAB5A_HUMAN [view entry] [view interactions] Low throughput yes yes
KRIT1_HUMAN [view interactions] Low throughput no no
TIF1B_HUMAN [view interactions] Low throughput no yes
PRKN_HUMAN [view entry] [view interactions] Low throughput yes yes
RING2_HUMAN [view interactions] Low throughput no yes
AMRA1_HUMAN [view interactions] Low throughput no yes
UBP18_HUMAN [view interactions] Low throughput no yes
FXL20_HUMAN [view interactions] Low throughput no no
ATG13_HUMAN [view interactions] Low throughput no no
ATGA1_HUMAN [view interactions] Low throughput no yes
PGK1_HUMAN [view entry] [view interactions] Low throughput yes yes
TRI13_HUMAN [view interactions] Low throughput no no
STYK1_HUMAN [view interactions] Low throughput no yes
OTU7B_HUMAN [view interactions] Low throughput no yes
PDPK1_HUMAN [view entry] [view interactions] Low throughput yes yes
ZRAN1_HUMAN [view interactions] Low throughput no yes
PSMD4_HUMAN [view interactions] Low throughput no yes
UBE3C_HUMAN [view entry] [view interactions] Low throughput yes yes
NLRX1_HUMAN [view interactions] Low throughput no yes
1433Z_HUMAN [view entry] [view interactions] Low throughput yes yes
TSC1_HUMAN [view entry] [view interactions] Low throughput yes yes
ATG7_HUMAN [view interactions] High throughput no yes
ATG10_HUMAN [view interactions] High throughput no yes
ATG3_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
RIT1_HUMAN [view interactions] High throughput no yes
GNAI2_HUMAN [view entry] [view interactions] High throughput yes yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
BRCC3_HUMAN [view interactions] High throughput no no
PIPNA_HUMAN [view entry] [view interactions] High throughput yes no
VP33A_HUMAN [view entry] [view interactions] High throughput yes no
ZWINT_HUMAN [view entry] [view interactions] High throughput yes no
EIF3G_HUMAN [view interactions] High throughput no yes
CPNE7_HUMAN [view interactions] High throughput no no
DFFA_HUMAN [view interactions] High throughput no yes
TGFA1_HUMAN [view interactions] High throughput no no
RBP2_HUMAN [view interactions] High throughput no yes
RPF2_HUMAN [view interactions] High throughput no yes
DD19B_HUMAN [view interactions] High throughput no yes
MEX3B_HUMAN [view interactions] High throughput no no
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP2_HUMAN [view interactions] High throughput no yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB9A_HUMAN [view interactions] High throughput no yes
ZFPL1_HUMAN [view interactions] High throughput no yes
OPTN_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
CLP1L_HUMAN [view interactions] High throughput no yes
PK3C3_HUMAN [view entry] [view interactions] High throughput yes yes
MLP3C_HUMAN [view interactions] High throughput no no
BECN2_HUMAN [view interactions] High throughput no no
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
LEG7_HUMAN [view interactions] High throughput no no
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
H10_HUMAN [view interactions] High throughput no yes
RET_HUMAN [view interactions] High throughput no yes
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
SHLB1_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
MYH1_HUMAN [view interactions] High throughput no no
KIF1B_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
ANM5_HUMAN [view entry] [view interactions] High throughput yes yes
EXOC8_HUMAN [view entry] [view interactions] High throughput yes yes
EXOC2_HUMAN [view entry] [view interactions] High throughput yes no
DACT1_HUMAN [view entry] [view interactions] High throughput yes yes
JADE2_HUMAN [view interactions] High throughput no yes
SKAP1_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
PACER_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
KEAP1_HUMAN [view interactions] High throughput no yes
MTOR_HUMAN [view entry] [view interactions] High throughput yes yes
RACK1_HUMAN [view interactions] High throughput no yes
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
DIRA3_HUMAN [view interactions] High throughput no yes
CUL7_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
UBP19_HUMAN [view interactions] High throughput no no
UBP28_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
JOS1_HUMAN [view interactions] High throughput no no
JOS2_HUMAN [view interactions] High throughput no no
P53_HUMAN [view interactions] High throughput no no
GLPA_HUMAN [view interactions] High throughput no no
OCAD1_HUMAN [view interactions] High throughput no yes
SPSB4_HUMAN [view interactions] High throughput no no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no