UBE3C_HUMAN
Evidence for PS localization
Functions
E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either Lys-29- or Lys-48-linked polyubiquitin chains. Has preference for Lys-48 linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in UBE3C_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 32.6531 | 4 | no |
| GO:0046872 | metal ion binding | 28.5714 | 4 | no |
| GO:0019900 | kinase binding | 22.4490 | 4 | no |
| GO:0019901 | protein kinase binding | 22.4490 | 5 | no |
| GO:0017076 | purine nucleotide binding | 22.4490 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 22.4490 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.4082 | 4 | no |
| GO:0004842 | ubiquitin-protein transferase activity | 4.0816 | 4 | yes |
| GO:0061630 | ubiquitin protein ligase activity | 4.0816 | 5 | yes |
| GO:0061659 | ubiquitin-like protein ligase activity | 4.0816 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in UBE3C_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 63.2653 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 61.2245 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 61.2245 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 53.0612 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 51.0204 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 46.9388 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 42.8571 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.8163 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.8163 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 40.8163 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 36.7347 | 5 | no |
| GO:0043412 | macromolecule modification | 32.6531 | 4 | yes |
| GO:0010468 | regulation of gene expression | 32.6531 | 5 | no |
| GO:0006508 | proteolysis | 30.6122 | 4 | yes |
| GO:0009057 | macromolecule catabolic process | 30.6122 | 4 | yes |
| GO:0036211 | protein modification process | 30.6122 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 30.6122 | 4 | no |
| GO:0044265 | cellular macromolecule catabolic process | 28.5714 | 4 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 28.5714 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 28.5714 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 28.5714 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 28.5714 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.5714 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 28.5714 | 5 | no |
| GO:0019941 | modification-dependent protein catabolic process | 26.5306 | 6 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 26.5306 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.5306 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.5306 | 5 | no |
| GO:0051049 | regulation of transport | 26.5306 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.5306 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.5306 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 26.5306 | 6 | no |
| GO:0010646 | regulation of cell communication | 24.4898 | 4 | no |
| GO:0031399 | regulation of protein modification process | 24.4898 | 6 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 24.4898 | 5 | no |
| GO:0009894 | regulation of catabolic process | 24.4898 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.4898 | 5 | no |
| GO:0022607 | cellular component assembly | 22.4490 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.4490 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.4490 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.4490 | 5 | no |
| GO:0010941 | regulation of cell death | 22.4490 | 4 | no |
| GO:0009966 | regulation of signal transduction | 20.4082 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 20.4082 | 7 | no |
| GO:0051338 | regulation of transferase activity | 20.4082 | 4 | no |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 18.3673 | 7 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 18.3673 | 5 | yes |
| GO:0016567 | protein ubiquitination | 14.2857 | 7 | yes |
| GO:0032446 | protein modification by small protein conjugation | 14.2857 | 6 | yes |
| GO:0000209 | protein polyubiquitination | 4.0816 | 8 | yes |
| GO:0035519 | protein K29-linked ubiquitination | 4.0816 | 9 | yes |
| GO:0070936 | protein K48-linked ubiquitination | 4.0816 | 9 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in UBE3C_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 4.0816 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 4.0816 | 5 | no |
| DOID:114 | heart disease | 4.0816 | 3 | no |
| DOID:2843 | long QT syndrome | 4.0816 | 6 | no |
| DOID:1247 | blood coagulation disease | 4.0816 | 3 | no |
| DOID:2218 | blood platelet disease | 4.0816 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RSAD2_HUMAN | [view interactions] | Low throughput | no | yes |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| RAD18_HUMAN | [view interactions] | Low throughput | no | yes |
| PK3C3_HUMAN | [view interactions] | Low throughput | no | yes |
| DOT1L_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2D1_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2D2_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2L3_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2D3_HUMAN | [view interactions] | Low throughput | no | yes |
| CCNB1_HUMAN | [view interactions] | Low throughput | no | no |
| CAND2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PRS8_HUMAN | [view interactions] | Low throughput | no | yes |
| PSMD6_HUMAN | [view interactions] | Low throughput | no | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PSDE_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANXA7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FAM3C_HUMAN | [view interactions] | Low throughput | no | yes |
| MTA1_HUMAN | [view interactions] | Low throughput | no | yes |
| UBE3C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TOP1_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALBU_HUMAN | [view interactions] | High throughput | no | no |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| RIR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTBP1_HUMAN | [view interactions] | High throughput | no | no |
| CALR_HUMAN | [view interactions] | High throughput | no | yes |
| BMP7_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| PTN2_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRM_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTPRU_HUMAN | [view interactions] | High throughput | no | yes |
| TPTE_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| MAGA3_HUMAN | [view interactions] | High throughput | no | no |
| ANR55_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD79B_HUMAN | [view interactions] | High throughput | no | no |
| RMXL1_HUMAN | [view interactions] | High throughput | no | yes |
| IL1R2_HUMAN | [view interactions] | High throughput | no | no |
| GLPA_HUMAN | [view interactions] | High throughput | no | no |
| PARN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F234A_HUMAN | [view interactions] | High throughput | no | yes |
| HCST_HUMAN | [view interactions] | High throughput | no | no |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| HIDE1_HUMAN | [view interactions] | High throughput | no | no |
| KAP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRAD1_HUMAN | [view interactions] | High throughput | no | no |
| CNTP3_HUMAN | [view interactions] | High throughput | no | yes |
| TACD2_HUMAN | [view interactions] | High throughput | no | no |
| XRN1_HUMAN | [view interactions] | High throughput | no | yes |
| BRID5_HUMAN | [view interactions] | High throughput | no | no |
| ICAM2_HUMAN | [view interactions] | High throughput | no | no |
| STK16_HUMAN | [view interactions] | High throughput | no | no |
| OPALI_HUMAN | [view interactions] | High throughput | no | yes |
| TNFL8_HUMAN | [view interactions] | High throughput | no | no |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRAH_HUMAN | [view interactions] | High throughput | no | no |
| CD70_HUMAN | [view interactions] | High throughput | no | no |
| PCDB3_HUMAN | [view interactions] | High throughput | no | no |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| DQA1_HUMAN | [view interactions] | High throughput | no | yes |
| LRC25_HUMAN | [view interactions] | High throughput | no | yes |
| KT3K_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRN_HUMAN | [view interactions] | High throughput | no | yes |
| KLRG2_HUMAN | [view interactions] | High throughput | no | no |
| CLC2B_HUMAN | [view interactions] | High throughput | no | yes |
| VIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| CCG4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UPK2_HUMAN | [view interactions] | High throughput | no | no |
| KCMB2_HUMAN | [view interactions] | High throughput | no | yes |
| SGCA_HUMAN | [view interactions] | High throughput | no | yes |
| HLAC_HUMAN | [view interactions] | High throughput | no | no |
| CLC2D_HUMAN | [view interactions] | High throughput | no | yes |
| TMEM9_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| PSA5_HUMAN | [view interactions] | High throughput | no | yes |
| PSA6_HUMAN | [view interactions] | High throughput | no | yes |
| PSB1_HUMAN | [view interactions] | High throughput | no | yes |
| PSB2_HUMAN | [view interactions] | High throughput | no | yes |
| PSB3_HUMAN | [view interactions] | High throughput | no | yes |
| PSB4_HUMAN | [view interactions] | High throughput | no | yes |
| PSB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSB7_HUMAN | [view interactions] | High throughput | no | yes |
| PRS7_HUMAN | [view interactions] | High throughput | no | yes |
| PRS6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
| PRS10_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSD11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSD12_HUMAN | [view interactions] | High throughput | no | yes |
| PSD13_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD3_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD4_HUMAN | [view interactions] | High throughput | no | yes |
| PSME4_HUMAN | [view interactions] | High throughput | no | yes |
| SEML_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THOC2_HUMAN | [view interactions] | High throughput | no | yes |
| RBM15_HUMAN | [view interactions] | High throughput | no | yes |
| THOC7_HUMAN | [view interactions] | High throughput | no | yes |
| WDR74_HUMAN | [view interactions] | High throughput | no | no |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| KPB2_HUMAN | [view interactions] | High throughput | no | yes |
| CPEB4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP13_HUMAN | [view interactions] | High throughput | no | yes |
| UTRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF2K_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PANK4_HUMAN | [view interactions] | High throughput | no | no |
| DAA10_HUMAN | [view interactions] | High throughput | no | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| LTN1_HUMAN | [view interactions] | High throughput | no | no |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX3_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| SCN2B_HUMAN | [view interactions] | High throughput | no | no |
| F234B_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HG2A_HUMAN | [view interactions] | High throughput | no | yes |
| DDX60_HUMAN | [view interactions] | High throughput | no | no |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| TN13B_HUMAN | [view interactions] | High throughput | no | no |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| KCC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| MTA2_HUMAN | [view interactions] | High throughput | no | yes |
| TLK1_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| RAD21_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE3A_HUMAN | [view interactions] | High throughput | no | yes |
| PSA2_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| EFNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| HIF1A_HUMAN | [view interactions] | High throughput | no | no |
| GRWD1_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| AHNK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP14_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UBB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS27A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL40_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RNF32_HUMAN | [view interactions] | Computational | no | no |