PTPRO_HUMAN
Evidence for PS localization
Functions
Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PTPRO_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 26.6667 | 4 | no |
| GO:0017076 | purine nucleotide binding | 26.6667 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 26.6667 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.6667 | 4 | no |
| GO:0043168 | anion binding | 26.6667 | 4 | no |
| GO:0043169 | cation binding | 24.4444 | 4 | no |
| GO:0046872 | metal ion binding | 24.4444 | 5 | no |
| GO:0005524 | ATP binding | 24.4444 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 24.4444 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 24.4444 | 5 | no |
| GO:0019900 | kinase binding | 22.2222 | 4 | no |
| GO:0019901 | protein kinase binding | 22.2222 | 5 | no |
| GO:0045296 | cadherin binding | 20.0000 | 4 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 11.1111 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 11.1111 | 4 | yes |
| GO:0016791 | phosphatase activity | 8.8889 | 5 | yes |
| GO:0004725 | protein tyrosine phosphatase activity | 6.6667 | 4 | yes |
| GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity | 6.6667 | 5 | yes |
| GO:0019198 | transmembrane receptor protein phosphatase activity | 6.6667 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PTPRO_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 51.1111 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 48.8889 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 48.8889 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 44.4444 | 4 | no |
| GO:0009966 | regulation of signal transduction | 42.2222 | 4 | yes |
| GO:0010646 | regulation of cell communication | 42.2222 | 4 | yes |
| GO:0036211 | protein modification process | 40.0000 | 4 | yes |
| GO:0043412 | macromolecule modification | 40.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 35.5556 | 4 | yes |
| GO:0008104 | protein localization | 35.5556 | 4 | no |
| GO:0023056 | positive regulation of signaling | 35.5556 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 35.5556 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 35.5556 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 35.5556 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.5556 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 33.3333 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 31.1111 | 5 | no |
| GO:0051049 | regulation of transport | 28.8889 | 4 | no |
| GO:0060341 | regulation of cellular localization | 28.8889 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 28.8889 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.8889 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 26.6667 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 26.6667 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 26.6667 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 26.6667 | 4 | yes |
| GO:0032880 | regulation of protein localization | 26.6667 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.6667 | 5 | no |
| GO:0010468 | regulation of gene expression | 26.6667 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.6667 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.6667 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.6667 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 26.6667 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 26.6667 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 24.4444 | 5 | yes |
| GO:0030155 | regulation of cell adhesion | 24.4444 | 4 | yes |
| GO:0050807 | regulation of synapse organization | 24.4444 | 5 | yes |
| GO:0042127 | regulation of cell population proliferation | 24.4444 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 24.4444 | 6 | no |
| GO:0043933 | protein-containing complex organization | 24.4444 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 24.4444 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.4444 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 24.4444 | 6 | no |
| GO:0030030 | cell projection organization | 22.2222 | 4 | yes |
| GO:0032101 | regulation of response to external stimulus | 22.2222 | 4 | yes |
| GO:0006996 | organelle organization | 22.2222 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.2222 | 5 | no |
| GO:0031399 | regulation of protein modification process | 22.2222 | 6 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 22.2222 | 4 | no |
| GO:0071310 | cellular response to organic substance | 22.2222 | 4 | no |
| GO:0034330 | cell junction organization | 20.0000 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 20.0000 | 5 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 20.0000 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.0000 | 5 | yes |
| GO:0030111 | regulation of Wnt signaling pathway | 17.7778 | 5 | yes |
| GO:0031175 | neuron projection development | 17.7778 | 6 | yes |
| GO:0031344 | regulation of cell projection organization | 17.7778 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 17.7778 | 6 | yes |
| GO:0010975 | regulation of neuron projection development | 15.5556 | 7 | yes |
| GO:0034329 | cell junction assembly | 15.5556 | 5 | yes |
| GO:0060828 | regulation of canonical Wnt signaling pathway | 15.5556 | 6 | yes |
| GO:0010810 | regulation of cell-substrate adhesion | 13.3333 | 5 | yes |
| GO:0050920 | regulation of chemotaxis | 13.3333 | 4 | yes |
| GO:0007043 | cell-cell junction assembly | 11.1111 | 6 | yes |
| GO:0007411 | axon guidance | 11.1111 | 8 | yes |
| GO:0040013 | negative regulation of locomotion | 11.1111 | 4 | yes |
| GO:0044057 | regulation of system process | 11.1111 | 4 | yes |
| GO:0045216 | cell-cell junction organization | 11.1111 | 5 | yes |
| GO:0097485 | neuron projection guidance | 11.1111 | 7 | yes |
| GO:0007162 | negative regulation of cell adhesion | 8.8889 | 5 | yes |
| GO:0010977 | negative regulation of neuron projection development | 8.8889 | 7 | yes |
| GO:0030178 | negative regulation of Wnt signaling pathway | 8.8889 | 6 | yes |
| GO:0030855 | epithelial cell differentiation | 8.8889 | 4 | yes |
| GO:0031345 | negative regulation of cell projection organization | 8.8889 | 6 | yes |
| GO:0032102 | negative regulation of response to external stimulus | 8.8889 | 5 | yes |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway | 8.8889 | 7 | yes |
| GO:0006470 | protein dephosphorylation | 6.6667 | 5 | yes |
| GO:0010812 | negative regulation of cell-substrate adhesion | 6.6667 | 6 | yes |
| GO:0016311 | dephosphorylation | 6.6667 | 5 | yes |
| GO:0030031 | cell projection assembly | 6.6667 | 5 | yes |
| GO:0030032 | lamellipodium assembly | 6.6667 | 7 | yes |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | 6.6667 | 6 | yes |
| GO:0050922 | negative regulation of chemotaxis | 6.6667 | 5 | yes |
| GO:0060326 | cell chemotaxis | 6.6667 | 4 | yes |
| GO:0097581 | lamellipodium organization | 6.6667 | 6 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 6.6667 | 6 | yes |
| GO:0001977 | renal system process involved in regulation of blood volume | 4.4444 | 5 | yes |
| GO:0002548 | monocyte chemotaxis | 4.4444 | 4 | yes |
| GO:0003071 | renal system process involved in regulation of systemic arterial blood pressure | 4.4444 | 4 | yes |
| GO:0003093 | regulation of glomerular filtration | 4.4444 | 6 | yes |
| GO:0003105 | negative regulation of glomerular filtration | 4.4444 | 5 | yes |
| GO:0035850 | epithelial cell differentiation involved in kidney development | 4.4444 | 5 | yes |
| GO:0036058 | filtration diaphragm assembly | 4.4444 | 7 | yes |
| GO:0036060 | slit diaphragm assembly | 4.4444 | 8 | yes |
| GO:0061005 | cell differentiation involved in kidney development | 4.4444 | 4 | yes |
| GO:0061318 | renal filtration cell differentiation | 4.4444 | 4 | yes |
| GO:0072112 | podocyte differentiation | 4.4444 | 5 | yes |
| GO:0072311 | glomerular epithelial cell differentiation | 4.4444 | 6 | yes |
| GO:0090259 | regulation of retinal ganglion cell axon guidance | 4.4444 | 6 | yes |
| GO:0090260 | negative regulation of retinal ganglion cell axon guidance | 4.4444 | 7 | yes |
| GO:0098801 | regulation of renal system process | 4.4444 | 5 | yes |
| GO:1902667 | regulation of axon guidance | 4.4444 | 5 | yes |
| GO:1902668 | negative regulation of axon guidance | 4.4444 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| WNT3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTPRO_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PAXI_HUMAN | [view interactions] | Low throughput | no | yes |
| KIT_HUMAN | [view interactions] | Low throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VILI_HUMAN | [view interactions] | Low throughput | no | no |
| SPTA1_HUMAN | [view interactions] | Low throughput | no | no |
| KSYK_HUMAN | [view interactions] | Low throughput | no | no |
| FAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DPPA4_HUMAN | [view interactions] | High throughput | no | no |
| DPYL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC3_HUMAN | [view interactions] | High throughput | no | yes |
| DJB11_HUMAN | [view interactions] | High throughput | no | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| PTK7_HUMAN | [view interactions] | High throughput | no | yes |
| SDF2L_HUMAN | [view interactions] | High throughput | no | yes |
| YTHD3_HUMAN | [view interactions] | High throughput | no | no |
| PLXB2_HUMAN | [view interactions] | High throughput | no | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TEC_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PGFRB_HUMAN | [view interactions] | High throughput | no | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| GAB1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PDPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPOR_HUMAN | [view interactions] | High throughput | no | no |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIE2_HUMAN | [view interactions] | High throughput | no | no |
| WASP_HUMAN | [view interactions] | High throughput | no | yes |
| CBL_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| SDF2_HUMAN | [view interactions] | High throughput | no | no |
| ERLEC_HUMAN | [view interactions] | High throughput | no | yes |
| NGLY1_HUMAN | [view interactions] | High throughput | no | yes |
| DJC30_HUMAN | [view interactions] | High throughput | no | no |
| GOLI4_HUMAN | [view interactions] | High throughput | no | yes |
| PGAP4_HUMAN | [view interactions] | High throughput | no | no |
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| TXD12_HUMAN | [view interactions] | High throughput | no | no |
| PDIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SE1L1_HUMAN | [view interactions] | High throughput | no | yes |
| CALR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OS9_HUMAN | [view interactions] | High throughput | no | yes |
| PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERP44_HUMAN | [view interactions] | High throughput | no | yes |
| GPX8_HUMAN | [view interactions] | High throughput | no | no |
| B3GA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIL1_HUMAN | [view interactions] | High throughput | no | yes |
| CNIH4_HUMAN | [view interactions] | High throughput | no | yes |
| SPCS3_HUMAN | [view interactions] | High throughput | no | yes |
| TMX1_HUMAN | [view interactions] | High throughput | no | no |
| RAB7L_HUMAN | [view interactions] | High throughput | no | yes |
| TMED2_HUMAN | [view interactions] | High throughput | no | yes |
| UGGG1_HUMAN | [view interactions] | High throughput | no | yes |
| GANAB_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| NOMO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEP15_HUMAN | [view interactions] | High throughput | no | no |
| TMX4_HUMAN | [view interactions] | High throughput | no | yes |
| UB2G2_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MA1B1_HUMAN | [view interactions] | High throughput | no | yes |
| P210L_HUMAN | [view interactions] | High throughput | no | no |
| CP51A_HUMAN | [view interactions] | High throughput | no | no |
| GLU2B_HUMAN | [view interactions] | High throughput | no | yes |
| HLAC_HUMAN | [view interactions] | High throughput | no | no |
| HLAG_HUMAN | [view interactions] | High throughput | no | no |
| MD2BP_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DJC16_HUMAN | [view interactions] | High throughput | no | no |
| RAB34_HUMAN | [view interactions] | High throughput | no | yes |
| S61A2_HUMAN | [view interactions] | High throughput | no | no |
| AUP1_HUMAN | [view interactions] | High throughput | no | yes |
| DJB12_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAB45_HUMAN | [view interactions] | High throughput | no | no |
| MAIP1_HUMAN | [view interactions] | High throughput | no | yes |
| VAS1_HUMAN | [view interactions] | High throughput | no | yes |
| CLN6_HUMAN | [view interactions] | High throughput | no | no |
| FKB10_HUMAN | [view interactions] | High throughput | no | yes |
| LMAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MA1A2_HUMAN | [view interactions] | High throughput | no | yes |
| SRPRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| ARL1_HUMAN | [view interactions] | High throughput | no | yes |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| CNNM4_HUMAN | [view interactions] | High throughput | no | yes |
| HLAA_HUMAN | [view interactions] | High throughput | no | no |
| AN13A_HUMAN | [view interactions] | High throughput | no | yes |
| ASPH_HUMAN | [view interactions] | High throughput | no | yes |
| RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD109_HUMAN | [view interactions] | High throughput | no | no |
| CLGN_HUMAN | [view interactions] | High throughput | no | no |
| CBPD_HUMAN | [view interactions] | High throughput | no | yes |
| OST48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DJC10_HUMAN | [view interactions] | High throughput | no | yes |
| DSG2_HUMAN | [view interactions] | High throughput | no | no |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA2_HUMAN | [view interactions] | High throughput | no | no |
| ERO1A_HUMAN | [view interactions] | High throughput | no | yes |
| EXT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASTRA_HUMAN | [view interactions] | High throughput | no | no |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T131L_HUMAN | [view interactions] | High throughput | no | yes |
| LAMB1_HUMAN | [view interactions] | High throughput | no | yes |
| LAMB2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMC1_HUMAN | [view interactions] | High throughput | no | yes |
| LCAP_HUMAN | [view interactions] | High throughput | no | yes |
| AGRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRIG2_HUMAN | [view interactions] | High throughput | no | yes |
| LSR_HUMAN | [view interactions] | High throughput | no | yes |
| MLEC_HUMAN | [view interactions] | High throughput | no | no |
| MMP14_HUMAN | [view interactions] | High throughput | no | yes |
| NCLN_HUMAN | [view interactions] | High throughput | no | yes |
| NICA_HUMAN | [view interactions] | High throughput | no | yes |
| NID1_HUMAN | [view interactions] | High throughput | no | no |
| PO210_HUMAN | [view interactions] | High throughput | no | yes |
| PLOD1_HUMAN | [view interactions] | High throughput | no | yes |
| PLOD3_HUMAN | [view interactions] | High throughput | no | yes |
| PRS6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSD11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSD12_HUMAN | [view interactions] | High throughput | no | yes |
| PSD13_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QSOX2_HUMAN | [view interactions] | High throughput | no | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 4F2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMTC3_HUMAN | [view interactions] | High throughput | no | yes |
| TOIP2_HUMAN | [view interactions] | High throughput | no | no |
| TTC13_HUMAN | [view interactions] | High throughput | no | no |
| TTC17_HUMAN | [view interactions] | High throughput | no | yes |
| TXD16_HUMAN | [view interactions] | High throughput | no | yes |
| UBE3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPOT_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| GT2D1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |