DPYL4_HUMAN
Evidence for PS localization
Functions
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DPYL4_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 23.0769 | 4 | no |
| GO:0000166 | nucleotide binding | 23.0769 | 4 | no |
| GO:0017076 | purine nucleotide binding | 23.0769 | 5 | no |
| GO:0031625 | ubiquitin protein ligase binding | 23.0769 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 23.0769 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.0769 | 4 | no |
| GO:0043168 | anion binding | 23.0769 | 4 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 23.0769 | 4 | no |
| GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides | 19.2308 | 4 | yes |
| GO:0031005 | filamin binding | 11.5385 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DPYL4_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 57.6923 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 53.8462 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 42.3077 | 4 | no |
| GO:0009966 | regulation of signal transduction | 38.4615 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 38.4615 | 4 | no |
| GO:0022607 | cellular component assembly | 34.6154 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 34.6154 | 5 | no |
| GO:0030030 | cell projection organization | 30.7692 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 30.7692 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 30.7692 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.7692 | 4 | no |
| GO:0051049 | regulation of transport | 30.7692 | 4 | no |
| GO:0043933 | protein-containing complex organization | 30.7692 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 26.9231 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.9231 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.9231 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 26.9231 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.9231 | 4 | no |
| GO:0031175 | neuron projection development | 26.9231 | 6 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.9231 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 26.9231 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 26.9231 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 26.9231 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 26.9231 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 26.9231 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 26.9231 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 26.9231 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 26.9231 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 26.9231 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 23.0769 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 23.0769 | 7 | no |
| GO:0045597 | positive regulation of cell differentiation | 23.0769 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.0769 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.0769 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 23.0769 | 5 | no |
| GO:0060284 | regulation of cell development | 23.0769 | 5 | no |
| GO:0071310 | cellular response to organic substance | 23.0769 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 23.0769 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 23.0769 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.0769 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.0769 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 23.0769 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.0769 | 5 | no |
| GO:0007399 | nervous system development | 15.3846 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SH3G2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOE2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLDC3_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SKP2_HUMAN | [view interactions] | High throughput | no | yes |
| LEG7_HUMAN | [view interactions] | High throughput | no | no |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| TRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| PCH2_HUMAN | [view interactions] | High throughput | no | no |
| RBPMS_HUMAN | [view interactions] | High throughput | no | no |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGFR2_HUMAN | [view interactions] | High throughput | no | no |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPRE1_HUMAN | [view interactions] | High throughput | no | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SOX4_HUMAN | [view interactions] | High throughput | no | yes |
| TRI54_HUMAN | [view interactions] | High throughput | no | no |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| RHG25_HUMAN | [view interactions] | High throughput | no | no |
| LIPH_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| DOCK5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYPD4_HUMAN | [view interactions] | High throughput | no | no |
| DEFI8_HUMAN | [view interactions] | High throughput | no | yes |
| WDFY3_HUMAN | [view interactions] | High throughput | no | yes |
| UBP47_HUMAN | [view interactions] | High throughput | no | yes |
| UBIP1_HUMAN | [view interactions] | High throughput | no | no |
| KLHL8_HUMAN | [view interactions] | High throughput | no | no |
| M4K2_HUMAN | [view interactions] | High throughput | no | yes |
| CTG1B_HUMAN | [view interactions] | High throughput | no | no |
| PLCG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYS_HUMAN | [view interactions] | High throughput | no | no |
| DPYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNG1C_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MMAB_HUMAN | [view interactions] | High throughput | no | yes |
| FA9_HUMAN | [view interactions] | High throughput | no | no |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| ATPF2_HUMAN | [view interactions] | High throughput | no | yes |
| SYJ2B_HUMAN | [view interactions] | High throughput | no | no |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| TTP_HUMAN | [view interactions] | High throughput | no | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |