Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DPYL3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DPYL3_HUMAN
GO:0017076 purine nucleotide binding 30.4348 4 no
GO:0019900 kinase binding 30.4348 4 no
GO:0019901 protein kinase binding 26.0870 5 no
GO:0032555 purine ribonucleotide binding 26.0870 4 no
GO:0035639 purine ribonucleoside triphosphate binding 26.0870 4 no
GO:0030554 adenyl nucleotide binding 21.7391 5 no
GO:0017124 SH3 domain binding 17.3913 4 yes
GO:0031005 filamin binding 17.3913 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DPYL3_HUMAN
GO:0051128 regulation of cellular component organization 73.9130 4 yes
GO:0030030 cell projection organization 65.2174 4 no
GO:0048522 positive regulation of cellular process 60.8696 4 yes
GO:0031344 regulation of cell projection organization 56.5217 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 56.5217 6 yes
GO:0120036 plasma membrane bounded cell projection organization 56.5217 5 no
GO:0022607 cellular component assembly 52.1739 4 yes
GO:0006996 organelle organization 52.1739 4 no
GO:0010975 regulation of neuron projection development 47.8261 7 yes
GO:0048523 negative regulation of cellular process 47.8261 4 yes
GO:0009966 regulation of signal transduction 47.8261 4 no
GO:0010646 regulation of cell communication 47.8261 4 no
GO:0031323 regulation of cellular metabolic process 47.8261 4 no
GO:0051171 regulation of nitrogen compound metabolic process 47.8261 4 no
GO:0060255 regulation of macromolecule metabolic process 47.8261 4 no
GO:0080090 regulation of primary metabolic process 47.8261 4 no
GO:0051130 positive regulation of cellular component organization 43.4783 5 yes
GO:0071310 cellular response to organic substance 43.4783 4 yes
GO:0031175 neuron projection development 43.4783 6 no
GO:0051246 regulation of protein metabolic process 43.4783 5 no
GO:0044087 regulation of cellular component biogenesis 39.1304 4 yes
GO:0051129 negative regulation of cellular component organization 39.1304 5 yes
GO:0031399 regulation of protein modification process 39.1304 6 no
GO:0009893 positive regulation of metabolic process 39.1304 4 no
GO:0010604 positive regulation of macromolecule metabolic process 39.1304 5 no
GO:0031325 positive regulation of cellular metabolic process 39.1304 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 39.1304 5 no
GO:0048584 positive regulation of response to stimulus 34.7826 4 no
GO:0007010 cytoskeleton organization 34.7826 5 no
GO:0019220 regulation of phosphate metabolic process 34.7826 6 no
GO:0022603 regulation of anatomical structure morphogenesis 34.7826 4 no
GO:0051174 regulation of phosphorus metabolic process 34.7826 5 no
GO:1901701 cellular response to oxygen-containing compound 34.7826 4 no
GO:0008104 protein localization 34.7826 4 no
GO:0051049 regulation of transport 30.4348 4 no
GO:0051338 regulation of transferase activity 30.4348 4 no
GO:1902531 regulation of intracellular signal transduction 30.4348 5 no
GO:0034330 cell junction organization 30.4348 4 no
GO:0036211 protein modification process 30.4348 4 no
GO:0042325 regulation of phosphorylation 30.4348 7 no
GO:0043412 macromolecule modification 30.4348 4 no
GO:0045595 regulation of cell differentiation 30.4348 4 no
GO:0051094 positive regulation of developmental process 30.4348 4 no
GO:0051247 positive regulation of protein metabolic process 30.4348 6 no
GO:0060341 regulation of cellular localization 30.4348 4 no
GO:0009967 positive regulation of signal transduction 30.4348 5 no
GO:0010243 response to organonitrogen compound 30.4348 4 no
GO:0010647 positive regulation of cell communication 30.4348 5 no
GO:0023056 positive regulation of signaling 30.4348 4 no
GO:0071417 cellular response to organonitrogen compound 26.0870 4 no
GO:1901699 cellular response to nitrogen compound 26.0870 4 no
GO:0001932 regulation of protein phosphorylation 26.0870 7 no
GO:0043393 regulation of protein binding 26.0870 4 no
GO:0051100 negative regulation of binding 26.0870 4 no
GO:0010977 negative regulation of neuron projection development 26.0870 7 yes
GO:0031345 negative regulation of cell projection organization 26.0870 6 yes
GO:0031346 positive regulation of cell projection organization 26.0870 6 yes
GO:0044089 positive regulation of cellular component biogenesis 26.0870 5 yes
GO:0009892 negative regulation of metabolic process 26.0870 4 no
GO:0009894 regulation of catabolic process 26.0870 4 no
GO:0030162 regulation of proteolysis 26.0870 6 no
GO:0031324 negative regulation of cellular metabolic process 26.0870 5 no
GO:0031329 regulation of cellular catabolic process 26.0870 5 no
GO:0080134 regulation of response to stress 26.0870 4 no
GO:0080135 regulation of cellular response to stress 26.0870 4 no
GO:0001558 regulation of cell growth 26.0870 4 no
GO:0010468 regulation of gene expression 26.0870 5 no
GO:0032880 regulation of protein localization 26.0870 5 no
GO:0033043 regulation of organelle organization 26.0870 5 no
GO:0034329 cell junction assembly 26.0870 5 no
GO:0050804 modulation of chemical synaptic transmission 26.0870 5 no
GO:0051240 positive regulation of multicellular organismal process 26.0870 4 no
GO:0099177 regulation of trans-synaptic signaling 26.0870 4 no
GO:2000026 regulation of multicellular organismal development 26.0870 4 no
GO:0042127 regulation of cell population proliferation 21.7391 4 no
GO:0051050 positive regulation of transport 21.7391 4 no
GO:0032990 cell part morphogenesis 21.7391 4 no
GO:0048812 neuron projection morphogenesis 21.7391 7 no
GO:0048858 cell projection morphogenesis 21.7391 5 no
GO:0050807 regulation of synapse organization 21.7391 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 21.7391 6 no
GO:0032091 negative regulation of protein binding 21.7391 5 no
GO:0030334 regulation of cell migration 21.7391 5 yes
GO:0034097 response to cytokine 21.7391 4 yes
GO:0060491 regulation of cell projection assembly 21.7391 5 yes
GO:0071345 cellular response to cytokine stimulus 21.7391 5 yes
GO:0097435 supramolecular fiber organization 21.7391 4 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 21.7391 6 yes
GO:2000145 regulation of cell motility 21.7391 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 21.7391 5 no
GO:0010941 regulation of cell death 21.7391 4 no
GO:0031400 negative regulation of protein modification process 21.7391 7 no
GO:0043086 negative regulation of catalytic activity 21.7391 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 21.7391 5 no
GO:0051248 negative regulation of protein metabolic process 21.7391 6 no
GO:0010562 positive regulation of phosphorus metabolic process 21.7391 6 no
GO:0042327 positive regulation of phosphorylation 21.7391 8 no
GO:0043085 positive regulation of catalytic activity 21.7391 4 no
GO:0045597 positive regulation of cell differentiation 21.7391 5 no
GO:0045862 positive regulation of proteolysis 21.7391 7 no
GO:0045937 positive regulation of phosphate metabolic process 21.7391 7 no
GO:0051493 regulation of cytoskeleton organization 21.7391 6 no
GO:0060284 regulation of cell development 21.7391 5 no
GO:0070925 organelle assembly 21.7391 5 no
GO:1903829 positive regulation of protein localization 21.7391 5 no
GO:0009889 regulation of biosynthetic process 21.7391 4 no
GO:0010556 regulation of macromolecule biosynthetic process 21.7391 5 no
GO:0014070 response to organic cyclic compound 21.7391 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.7391 5 no
GO:0031326 regulation of cellular biosynthetic process 21.7391 5 no
GO:0007015 actin filament organization 17.3913 5 yes
GO:0030336 negative regulation of cell migration 17.3913 6 yes
GO:0040013 negative regulation of locomotion 17.3913 4 yes
GO:0048666 neuron development 17.3913 4 yes
GO:0051489 regulation of filopodium assembly 17.3913 7 yes
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 17.3913 6 yes
GO:2000146 negative regulation of cell motility 17.3913 5 yes
GO:0010976 positive regulation of neuron projection development 13.0435 7 yes
GO:0048678 response to axon injury 13.0435 4 yes
GO:0051017 actin filament bundle assembly 13.0435 5 yes
GO:0051491 positive regulation of filopodium assembly 13.0435 7 yes
GO:0061572 actin filament bundle organization 13.0435 6 yes
GO:0051764 actin crosslink formation 8.6957 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DPYL5_HUMAN [view entry] [view interactions] Low throughput yes yes
DPYL1_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTB_HUMAN [view entry] [view interactions] Low throughput yes no
NEUM_HUMAN [view entry] [view interactions] Low throughput yes yes
DPYL3_HUMAN [view entry] [view interactions] Low throughput yes yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
GLUT4_HUMAN [view interactions] High throughput no no
ODFP2_HUMAN [view interactions] High throughput no no
NUFP1_HUMAN [view interactions] High throughput no yes
DPYS_HUMAN [view interactions] High throughput no no
RRP7A_HUMAN [view interactions] High throughput no yes
ARMC1_HUMAN [view interactions] High throughput no yes
BOREA_HUMAN [view interactions] High throughput no yes
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes
DPYL4_HUMAN [view entry] [view interactions] High throughput yes yes
GRN_HUMAN [view interactions] High throughput no no
EYA1_HUMAN [view interactions] High throughput no no
PPM1J_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
ACD_HUMAN [view interactions] High throughput no no
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
BMI1_HUMAN [view interactions] High throughput no yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
TERF1_HUMAN [view interactions] High throughput no no
POTE1_HUMAN [view interactions] High throughput no no
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
MED4_HUMAN [view interactions] High throughput no yes
OTU6A_HUMAN [view interactions] High throughput no no
CDK2_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
HAX1_HUMAN [view interactions] High throughput no no
DGUOK_HUMAN [view interactions] High throughput no yes
KTU_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
WDTC1_HUMAN [view interactions] High throughput no yes
KIZ_HUMAN [view interactions] High throughput no no
PRDM1_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
G3BP1_HUMAN [view interactions] High throughput no yes
SPDLY_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
K1C17_HUMAN [view interactions] High throughput no no
TIA1_HUMAN [view interactions] High throughput no no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
WWP2_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
BAG5_HUMAN [view entry] [view interactions] High throughput yes no
DX39A_HUMAN [view interactions] High throughput no yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
TTLL6_HUMAN [view interactions] High throughput no no
AAPK1_HUMAN [view interactions] High throughput no no
ZN248_HUMAN [view interactions] High throughput no yes
GALT2_HUMAN [view interactions] High throughput no yes
FANCM_HUMAN [view interactions] High throughput no no
UD11_HUMAN [view interactions] High throughput no no
RPB1_HUMAN [view interactions] High throughput no no
OSGEP_HUMAN [view interactions] High throughput no yes
NGN3_HUMAN [view interactions] High throughput no no
RWD2A_HUMAN [view interactions] High throughput no yes
CUL2_HUMAN [view interactions] High throughput no yes
PLAK_HUMAN [view entry] [view interactions] High throughput yes yes
MSH2_HUMAN [view interactions] High throughput no yes
SC23A_HUMAN [view entry] [view interactions] High throughput yes yes
XRCC6_HUMAN [view interactions] High throughput no yes
F10A1_HUMAN [view interactions] High throughput no yes
ACTC_HUMAN [view interactions] High throughput no no
BICD2_HUMAN [view interactions] High throughput no yes
TBB5_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
RHOA_HUMAN [view entry] [view interactions] Computational yes yes
GSK3B_HUMAN [view entry] [view interactions] Computational yes yes
SEM3A_HUMAN [view interactions] Computational no no