Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PSN1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed, PubMed, PubMed, PubMed, PubMed). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed, PubMed, PubMed, PubMed). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed, PubMed). Required for normal embryonic brain and skeleton development, and for normal angiogenesis . Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (PubMed, PubMed). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis (PubMed, PubMed). Involved in the regulation of neurite outgrowth (PubMed, PubMed). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI002184 LIG_PDZ_Class_2 LIG 462 467 -
ELMI003227 MOD_CDK_SPxxK_3 MOD 351 358 -
ELMI002184 LIG_PDZ_Class_2 LIG 462 467 -
ELMI003227 MOD_CDK_SPxxK_3 MOD 351 358 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PSN1_HUMAN
GO:0043168 anion binding 34.4595 4 no
GO:0043169 cation binding 33.1081 4 no
GO:0046872 metal ion binding 32.4324 5 no
GO:0000166 nucleotide binding 28.3784 4 no
GO:0017076 purine nucleotide binding 27.7027 5 no
GO:0032555 purine ribonucleotide binding 25.6757 4 no
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 no
GO:0045296 cadherin binding 12.1622 4 yes
GO:0008324 monoatomic cation transmembrane transporter activity 11.4865 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 11.4865 4 yes
GO:0046873 metal ion transmembrane transporter activity 6.7568 5 yes
GO:0005216 monoatomic ion channel activity 5.4054 4 yes
GO:0015267 channel activity 5.4054 4 yes
GO:0005261 monoatomic cation channel activity 4.0541 5 yes
GO:0015085 calcium ion transmembrane transporter activity 4.0541 6 yes
GO:0005262 calcium channel activity 3.3784 6 yes
GO:0004175 endopeptidase activity 2.7027 4 yes
GO:0030165 PDZ domain binding 2.7027 4 yes
GO:0051117 ATPase binding 2.7027 4 yes
GO:0004190 aspartic-type endopeptidase activity 2.0270 5 yes
GO:0042500 aspartic endopeptidase activity, intramembrane cleaving 2.0270 6 yes
GO:0070001 aspartic-type peptidase activity 2.0270 4 yes
GO:0070851 growth factor receptor binding 2.0270 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PSN1_HUMAN
GO:0048522 positive regulation of cellular process 54.0541 4 yes
GO:0010646 regulation of cell communication 45.2703 4 yes
GO:0048523 negative regulation of cellular process 45.2703 4 yes
GO:0051128 regulation of cellular component organization 39.1892 4 yes
GO:0060255 regulation of macromolecule metabolic process 38.5135 4 yes
GO:0031323 regulation of cellular metabolic process 37.1622 4 yes
GO:0080090 regulation of primary metabolic process 36.4865 4 yes
GO:0006996 organelle organization 34.4595 4 yes
GO:0009966 regulation of signal transduction 31.7568 4 yes
GO:0008104 protein localization 31.0811 4 yes
GO:0043067 regulation of programmed cell death 30.4054 4 yes
GO:0051049 regulation of transport 30.4054 4 yes
GO:0009889 regulation of biosynthetic process 29.7297 4 yes
GO:0022607 cellular component assembly 29.7297 4 yes
GO:0031326 regulation of cellular biosynthetic process 29.7297 5 yes
GO:0042981 regulation of apoptotic process 29.7297 5 yes
GO:0010468 regulation of gene expression 29.0541 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 29.0541 5 yes
GO:0009893 positive regulation of metabolic process 28.3784 4 yes
GO:0051246 regulation of protein metabolic process 27.7027 5 yes
GO:0023056 positive regulation of signaling 24.3243 4 yes
GO:0009892 negative regulation of metabolic process 23.6486 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 23.6486 5 yes
GO:0051240 positive regulation of multicellular organismal process 23.6486 4 yes
GO:0071702 organic substance transport 22.9730 4 yes
GO:0031325 positive regulation of cellular metabolic process 22.9730 5 yes
GO:0071310 cellular response to organic substance 22.2973 4 yes
GO:0030030 cell projection organization 22.2973 4 yes
GO:0048584 positive regulation of response to stimulus 22.2973 4 yes
GO:0071705 nitrogen compound transport 21.6216 4 yes
GO:1902531 regulation of intracellular signal transduction 21.6216 5 no
GO:0010647 positive regulation of cell communication 21.6216 5 no
GO:0010605 negative regulation of macromolecule metabolic process 21.6216 5 yes
GO:0043069 negative regulation of programmed cell death 21.6216 5 yes
GO:0060341 regulation of cellular localization 20.9459 4 yes
GO:0099177 regulation of trans-synaptic signaling 20.9459 4 yes
GO:0007010 cytoskeleton organization 20.9459 5 no
GO:0031324 negative regulation of cellular metabolic process 20.9459 5 yes
GO:0043066 negative regulation of apoptotic process 20.9459 6 yes
GO:0050804 modulation of chemical synaptic transmission 20.9459 5 yes
GO:0009894 regulation of catabolic process 19.5946 4 yes
GO:0032880 regulation of protein localization 19.5946 5 yes
GO:0006355 regulation of DNA-templated transcription 18.9189 7 yes
GO:0009891 positive regulation of biosynthetic process 18.9189 5 yes
GO:2000026 regulation of multicellular organismal development 18.9189 4 yes
GO:2001141 regulation of RNA biosynthetic process 18.9189 6 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 18.9189 6 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 18.9189 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 18.9189 6 yes
GO:0051252 regulation of RNA metabolic process 18.9189 5 yes
GO:0045595 regulation of cell differentiation 18.2432 4 yes
GO:0051094 positive regulation of developmental process 18.2432 4 yes
GO:0009890 negative regulation of biosynthetic process 17.5676 5 yes
GO:0015031 protein transport 17.5676 4 yes
GO:0031327 negative regulation of cellular biosynthetic process 17.5676 6 yes
GO:0048585 negative regulation of response to stimulus 17.5676 4 yes
GO:0120036 plasma membrane bounded cell projection organization 16.8919 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 16.8919 6 yes
GO:0010648 negative regulation of cell communication 16.8919 5 yes
GO:0023057 negative regulation of signaling 16.8919 4 yes
GO:0034330 cell junction organization 16.8919 4 yes
GO:0006915 apoptotic process 16.2162 4 yes
GO:0009968 negative regulation of signal transduction 16.2162 5 yes
GO:0010243 response to organonitrogen compound 16.2162 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 16.2162 4 yes
GO:0051130 positive regulation of cellular component organization 15.5405 5 yes
GO:0060284 regulation of cell development 14.8649 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 14.8649 6 yes
GO:0031344 regulation of cell projection organization 14.8649 5 yes
GO:0031399 regulation of protein modification process 14.8649 6 yes
GO:0036211 protein modification process 14.8649 4 yes
GO:0043412 macromolecule modification 14.8649 4 yes
GO:0050807 regulation of synapse organization 14.8649 5 yes
GO:0051050 positive regulation of transport 14.8649 4 yes
GO:0051247 positive regulation of protein metabolic process 14.8649 6 yes
GO:0019220 regulation of phosphate metabolic process 14.1892 6 yes
GO:0051174 regulation of phosphorus metabolic process 14.1892 5 yes
GO:0051248 negative regulation of protein metabolic process 14.1892 6 yes
GO:1901701 cellular response to oxygen-containing compound 13.5135 4 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 13.5135 5 yes
GO:0051129 negative regulation of cellular component organization 13.5135 5 yes
GO:0006357 regulation of transcription by RNA polymerase II 12.8378 8 yes
GO:1901565 organonitrogen compound catabolic process 12.8378 4 yes
GO:0010629 negative regulation of gene expression 12.8378 7 yes
GO:0010975 regulation of neuron projection development 12.8378 7 yes
GO:0031329 regulation of cellular catabolic process 12.8378 5 yes
GO:0042325 regulation of phosphorylation 12.8378 7 yes
GO:0051241 negative regulation of multicellular organismal process 12.8378 4 yes
GO:0051254 positive regulation of RNA metabolic process 12.1622 6 yes
GO:0098657 import into cell 12.1622 4 yes
GO:0006811 monoatomic ion transport 12.1622 4 yes
GO:1902680 positive regulation of RNA biosynthetic process 12.1622 7 yes
GO:0009057 macromolecule catabolic process 12.1622 4 yes
GO:0043085 positive regulation of catalytic activity 12.1622 4 yes
GO:0045893 positive regulation of DNA-templated transcription 12.1622 8 yes
GO:0051093 negative regulation of developmental process 12.1622 4 yes
GO:0051960 regulation of nervous system development 11.4865 5 yes
GO:0060627 regulation of vesicle-mediated transport 11.4865 4 yes
GO:0070201 regulation of establishment of protein localization 11.4865 6 yes
GO:0071417 cellular response to organonitrogen compound 11.4865 4 yes
GO:1901699 cellular response to nitrogen compound 11.4865 4 yes
GO:0010628 positive regulation of gene expression 11.4865 7 yes
GO:0030162 regulation of proteolysis 11.4865 6 yes
GO:0043065 positive regulation of apoptotic process 11.4865 6 yes
GO:0043068 positive regulation of programmed cell death 11.4865 5 yes
GO:0050890 cognition 11.4865 4 yes
GO:0001932 regulation of protein phosphorylation 10.8108 7 yes
GO:0006508 proteolysis 10.8108 4 yes
GO:0006812 monoatomic cation transport 10.8108 5 yes
GO:1903829 positive regulation of protein localization 10.8108 5 yes
GO:2001233 regulation of apoptotic signaling pathway 10.8108 5 yes
GO:0042176 regulation of protein catabolic process 10.8108 5 yes
GO:0045596 negative regulation of cell differentiation 10.8108 5 yes
GO:0050767 regulation of neurogenesis 10.8108 6 yes
GO:0050808 synapse organization 10.8108 5 yes
GO:0030163 protein catabolic process 10.1351 4 yes
GO:0031400 negative regulation of protein modification process 10.1351 7 yes
GO:0055080 monoatomic cation homeostasis 9.4595 4 yes
GO:0030001 metal ion transport 9.4595 6 yes
GO:0034762 regulation of transmembrane transport 9.4595 4 yes
GO:0045862 positive regulation of proteolysis 9.4595 7 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 9.4595 5 yes
GO:0051253 negative regulation of RNA metabolic process 8.7838 6 yes
GO:0002684 positive regulation of immune system process 8.7838 4 yes
GO:1902679 negative regulation of RNA biosynthetic process 8.7838 7 yes
GO:0006873 intracellular monoatomic ion homeostasis 8.7838 4 yes
GO:0030003 intracellular monoatomic cation homeostasis 8.7838 5 yes
GO:0045892 negative regulation of DNA-templated transcription 8.7838 8 yes
GO:0051223 regulation of protein transport 8.7838 5 yes
GO:0051402 neuron apoptotic process 8.1081 5 yes
GO:0009896 positive regulation of catabolic process 8.1081 5 yes
GO:2001234 negative regulation of apoptotic signaling pathway 8.1081 6 yes
GO:0030111 regulation of Wnt signaling pathway 8.1081 5 yes
GO:0055074 calcium ion homeostasis 7.4324 4 yes
GO:1902903 regulation of supramolecular fiber organization 7.4324 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 7.4324 6 yes
GO:0010563 negative regulation of phosphorus metabolic process 7.4324 6 yes
GO:0010721 negative regulation of cell development 7.4324 6 yes
GO:0015711 organic anion transport 7.4324 5 yes
GO:0045936 negative regulation of phosphate metabolic process 7.4324 7 yes
GO:0045937 positive regulation of phosphate metabolic process 7.4324 7 yes
GO:0050770 regulation of axonogenesis 7.4324 5 yes
GO:0060828 regulation of canonical Wnt signaling pathway 6.7568 6 yes
GO:0001817 regulation of cytokine production 6.7568 4 yes
GO:0070925 organelle assembly 6.7568 5 yes
GO:0006874 intracellular calcium ion homeostasis 6.7568 5 yes
GO:1904951 positive regulation of establishment of protein localization 6.7568 6 yes
GO:0031401 positive regulation of protein modification process 6.7568 7 yes
GO:0032386 regulation of intracellular transport 6.7568 5 yes
GO:0042326 negative regulation of phosphorylation 6.7568 8 yes
GO:0042327 positive regulation of phosphorylation 6.7568 8 yes
GO:0043523 regulation of neuron apoptotic process 6.7568 6 yes
GO:0000122 negative regulation of transcription by RNA polymerase II 6.0811 9 yes
GO:0001819 positive regulation of cytokine production 6.0811 5 yes
GO:0001933 negative regulation of protein phosphorylation 6.0811 8 yes
GO:0002009 morphogenesis of an epithelium 6.0811 4 yes
GO:0099175 regulation of postsynapse organization 6.0811 6 yes
GO:0006816 calcium ion transport 6.0811 7 yes
GO:0006839 mitochondrial transport 6.0811 4 yes
GO:0007613 memory 6.0811 4 yes
GO:0010977 negative regulation of neuron projection development 6.0811 7 yes
GO:0015849 organic acid transport 6.0811 5 yes
GO:0031345 negative regulation of cell projection organization 6.0811 6 yes
GO:0033157 regulation of intracellular protein transport 6.0811 6 yes
GO:0043393 regulation of protein binding 6.0811 4 yes
GO:0043524 negative regulation of neuron apoptotic process 6.0811 7 yes
GO:0046942 carboxylic acid transport 6.0811 6 yes
GO:0051961 negative regulation of nervous system development 5.4054 5 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 5.4054 6 yes
GO:0061136 regulation of proteasomal protein catabolic process 5.4054 6 yes
GO:0001934 positive regulation of protein phosphorylation 5.4054 8 yes
GO:1900180 regulation of protein localization to nucleus 5.4054 6 yes
GO:1903050 regulation of proteolysis involved in protein catabolic process 5.4054 7 yes
GO:0006974 DNA damage response 5.4054 4 yes
GO:1905039 carboxylic acid transmembrane transport 5.4054 4 yes
GO:0030099 myeloid cell differentiation 5.4054 4 yes
GO:0030182 neuron differentiation 5.4054 4 yes
GO:0031331 positive regulation of cellular catabolic process 5.4054 6 yes
GO:0032388 positive regulation of intracellular transport 5.4054 5 yes
GO:0034764 positive regulation of transmembrane transport 5.4054 5 yes
GO:0045732 positive regulation of protein catabolic process 5.4054 6 yes
GO:0046822 regulation of nucleocytoplasmic transport 5.4054 6 yes
GO:0050768 negative regulation of neurogenesis 5.4054 6 yes
GO:0050776 regulation of immune response 5.4054 4 yes
GO:0051604 protein maturation 4.7297 4 yes
GO:0090316 positive regulation of intracellular protein transport 4.7297 6 yes
GO:0002521 leukocyte differentiation 4.7297 4 yes
GO:0106027 neuron projection organization 4.7297 6 yes
GO:0006835 dicarboxylic acid transport 4.7297 7 yes
GO:1902905 positive regulation of supramolecular fiber organization 4.7297 6 yes
GO:0006865 amino acid transport 4.7297 5 yes
GO:1903131 mononuclear cell differentiation 4.7297 5 yes
GO:0007219 Notch signaling pathway 4.7297 4 yes
GO:1904645 response to amyloid-beta 4.7297 4 yes
GO:1904646 cellular response to amyloid-beta 4.7297 5 yes
GO:0048666 neuron development 4.7297 4 yes
GO:0051099 positive regulation of binding 4.7297 4 yes
GO:0051100 negative regulation of binding 4.7297 4 yes
GO:0051222 positive regulation of protein transport 4.7297 5 yes
GO:0051952 regulation of amine transport 4.0541 5 yes
GO:0060562 epithelial tube morphogenesis 4.0541 4 yes
GO:0001764 neuron migration 4.0541 4 yes
GO:0062012 regulation of small molecule metabolic process 4.0541 4 yes
GO:1900182 positive regulation of protein localization to nucleus 4.0541 6 yes
GO:1901800 positive regulation of proteasomal protein catabolic process 4.0541 7 yes
GO:1903052 positive regulation of proteolysis involved in protein catabolic process 4.0541 8 yes
GO:0007033 vacuole organization 4.0541 5 yes
GO:0009895 negative regulation of catabolic process 4.0541 5 yes
GO:0046824 positive regulation of nucleocytoplasmic transport 4.0541 6 yes
GO:0048732 gland development 4.0541 4 yes
GO:0050778 positive regulation of immune response 4.0541 5 yes
GO:0051938 L-glutamate import 3.3784 6 yes
GO:0051954 positive regulation of amine transport 3.3784 5 yes
GO:0062013 positive regulation of small molecule metabolic process 3.3784 5 yes
GO:0001919 regulation of receptor recycling 3.3784 4 yes
GO:0002429 immune response-activating cell surface receptor signaling pathway 3.3784 4 yes
GO:0002573 myeloid leukocyte differentiation 3.3784 5 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 3.3784 4 yes
GO:0003143 embryonic heart tube morphogenesis 3.3784 4 yes
GO:0006486 protein glycosylation 3.3784 4 yes
GO:0006509 membrane protein ectodomain proteolysis 3.3784 6 yes
GO:1902475 L-alpha-amino acid transmembrane transport 3.3784 4 yes
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 3.3784 5 yes
GO:0015800 acidic amino acid transport 3.3784 6 yes
GO:0015807 L-amino acid transport 3.3784 5 yes
GO:0015813 L-glutamate transmembrane transport 3.3784 5 yes
GO:0016485 protein processing 3.3784 5 yes
GO:0030326 embryonic limb morphogenesis 3.3784 5 yes
GO:0032092 positive regulation of protein binding 3.3784 5 yes
GO:0032469 endoplasmic reticulum calcium ion homeostasis 3.3784 6 yes
GO:0032680 regulation of tumor necrosis factor production 3.3784 6 yes
GO:0033619 membrane protein proteolysis 3.3784 5 yes
GO:0035108 limb morphogenesis 3.3784 4 yes
GO:0035113 embryonic appendage morphogenesis 3.3784 4 yes
GO:0042110 T cell activation 3.3784 4 yes
GO:0042306 regulation of protein import into nucleus 3.3784 7 yes
GO:0042307 positive regulation of protein import into nucleus 3.3784 7 yes
GO:0042982 amyloid precursor protein metabolic process 3.3784 4 yes
GO:0045861 negative regulation of proteolysis 3.3784 7 yes
GO:0050771 negative regulation of axonogenesis 3.3784 6 yes
GO:0051955 regulation of amino acid transport 2.7027 6 yes
GO:0051957 positive regulation of amino acid transport 2.7027 6 yes
GO:0000045 autophagosome assembly 2.7027 6 yes
GO:0001773 myeloid dendritic cell activation 2.7027 4 yes
GO:0001921 positive regulation of receptor recycling 2.7027 5 yes
GO:0001947 heart looping 2.7027 5 yes
GO:0089718 amino acid import across plasma membrane 2.7027 4 yes
GO:0097028 dendritic cell differentiation 2.7027 6 yes
GO:0006109 regulation of carbohydrate metabolic process 2.7027 5 yes
GO:0006140 regulation of nucleotide metabolic process 2.7027 5 yes
GO:1900542 regulation of purine nucleotide metabolic process 2.7027 6 yes
GO:1900544 positive regulation of purine nucleotide metabolic process 2.7027 7 yes
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 2.7027 6 yes
GO:1903578 regulation of ATP metabolic process 2.7027 7 yes
GO:1903580 positive regulation of ATP metabolic process 2.7027 8 yes
GO:1905037 autophagosome organization 2.7027 6 yes
GO:1905906 regulation of amyloid fibril formation 2.7027 6 yes
GO:1905908 positive regulation of amyloid fibril formation 2.7027 7 yes
GO:1990535 neuron projection maintenance 2.7027 7 yes
GO:0009952 anterior/posterior pattern specification 2.7027 4 yes
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 2.7027 5 yes
GO:0015695 organic cation transport 2.7027 5 yes
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 2.7027 6 yes
GO:0032760 positive regulation of tumor necrosis factor production 2.7027 7 yes
GO:0032890 regulation of organic acid transport 2.7027 5 yes
GO:0032892 positive regulation of organic acid transport 2.7027 5 yes
GO:0042987 amyloid precursor protein catabolic process 2.7027 5 yes
GO:0043011 myeloid dendritic cell differentiation 2.7027 5 yes
GO:0043467 regulation of generation of precursor metabolites and energy 2.7027 5 yes
GO:0045981 positive regulation of nucleotide metabolic process 2.7027 6 yes
GO:0048143 astrocyte activation 2.7027 4 yes
GO:0048534 hematopoietic or lymphoid organ development 2.7027 4 yes
GO:0048538 thymus development 2.7027 5 yes
GO:0048854 brain morphogenesis 2.7027 4 yes
GO:0050818 regulation of coagulation 2.7027 4 yes
GO:0050851 antigen receptor-mediated signaling pathway 2.7027 5 yes
GO:0050852 T cell receptor signaling pathway 2.7027 6 yes
GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis 2.0270 7 yes
GO:0060075 regulation of resting membrane potential 2.0270 4 yes
GO:0060998 regulation of dendritic spine development 2.0270 4 yes
GO:0060999 positive regulation of dendritic spine development 2.0270 5 yes
GO:0002036 regulation of L-glutamate import across plasma membrane 2.0270 6 yes
GO:0002038 positive regulation of L-glutamate import across plasma membrane 2.0270 6 yes
GO:0002244 hematopoietic progenitor cell differentiation 2.0270 4 yes
GO:0002265 astrocyte activation involved in immune response 2.0270 4 yes
GO:0098693 regulation of synaptic vesicle cycle 2.0270 5 yes
GO:0002285 lymphocyte activation involved in immune response 2.0270 4 yes
GO:0098712 L-glutamate import across plasma membrane 2.0270 5 yes
GO:0140246 protein catabolic process at synapse 2.0270 5 yes
GO:0140249 protein catabolic process at postsynapse 2.0270 6 yes
GO:0006110 regulation of glycolytic process 2.0270 6 yes
GO:1903051 negative regulation of proteolysis involved in protein catabolic process 2.0270 8 yes
GO:0007220 Notch receptor processing 2.0270 4 yes
GO:1903789 regulation of amino acid transmembrane transport 2.0270 5 yes
GO:0009953 dorsal/ventral pattern formation 2.0270 4 yes
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process 2.0270 6 yes
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 2.0270 6 yes
GO:2000677 regulation of transcription regulatory region DNA binding 2.0270 5 yes
GO:0010958 regulation of amino acid import across plasma membrane 2.0270 6 yes
GO:0021904 dorsal/ventral neural tube patterning 2.0270 5 yes
GO:0030811 regulation of nucleotide catabolic process 2.0270 5 yes
GO:0030813 positive regulation of nucleotide catabolic process 2.0270 6 yes
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 2.0270 7 yes
GO:0033121 regulation of purine nucleotide catabolic process 2.0270 6 yes
GO:0033123 positive regulation of purine nucleotide catabolic process 2.0270 7 yes
GO:0034205 amyloid-beta formation 2.0270 4 yes
GO:0043470 regulation of carbohydrate catabolic process 2.0270 5 yes
GO:0045821 positive regulation of glycolytic process 2.0270 6 yes
GO:0045913 positive regulation of carbohydrate metabolic process 2.0270 5 yes
GO:0048705 skeletal system morphogenesis 2.0270 4 yes
GO:0050820 positive regulation of coagulation 2.0270 5 yes
GO:0051101 regulation of DNA binding 2.0270 4 yes
GO:0002286 T cell activation involved in immune response 1.3514 5 yes
GO:1904796 regulation of core promoter binding 1.3514 6 yes
GO:1904797 negative regulation of core promoter binding 1.3514 7 yes
GO:2000678 negative regulation of transcription regulatory region DNA binding 1.3514 6 yes
GO:0015871 choline transport 1.3514 5 yes
GO:0021795 cerebral cortex cell migration 1.3514 6 yes
GO:0021870 Cajal-Retzius cell differentiation 1.3514 7 yes
GO:0021885 forebrain cell migration 1.3514 4 yes
GO:0021895 cerebral cortex neuron differentiation 1.3514 6 yes
GO:0021953 central nervous system neuron differentiation 1.3514 5 yes
GO:0022029 telencephalon cell migration 1.3514 5 yes
GO:0035282 segmentation 1.3514 4 yes
GO:0043392 negative regulation of DNA binding 1.3514 5 yes
GO:0043589 skin morphogenesis 1.3514 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CADH1_HUMAN [view entry] [view interactions] Low throughput yes no
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
SYT1_HUMAN [view entry] [view interactions] Low throughput yes no
MTCH1_HUMAN [view entry] [view interactions] Low throughput yes yes
ECSIT_HUMAN [view interactions] Low throughput no yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
SYN1_HUMAN [view entry] [view interactions] Low throughput yes no
GSK3B_HUMAN [view entry] [view interactions] Low throughput yes yes
DOCK3_HUMAN [view entry] [view interactions] Low throughput yes yes
APBA3_HUMAN [view interactions] Low throughput no yes
EFNB1_HUMAN [view interactions] Low throughput no yes
VPP1_HUMAN [view entry] [view interactions] Low throughput yes yes
STT3B_HUMAN [view interactions] Low throughput no yes
CALR_HUMAN [view entry] [view interactions] Low throughput yes yes
TNR16_HUMAN [view entry] [view interactions] Low throughput yes no
GSAP_HUMAN [view interactions] Low throughput no no
FLOT2_HUMAN [view entry] [view interactions] Low throughput yes yes
STXB1_HUMAN [view entry] [view interactions] Low throughput yes yes
NEUM_HUMAN [view entry] [view interactions] Low throughput yes yes
GTR3_HUMAN [view interactions] Low throughput no yes
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARC_HUMAN [view entry] [view interactions] Low throughput yes no
PSN2_HUMAN [view entry] [view interactions] Low throughput yes no
CSEN_HUMAN [view interactions] Low throughput no no
NOTC1_HUMAN [view entry] [view interactions] Low throughput yes yes
PEMT_HUMAN [view interactions] Low throughput no yes
GFAP_HUMAN [view entry] [view interactions] Low throughput yes no
ICAM5_HUMAN [view entry] [view interactions] Low throughput yes yes
BCL2_HUMAN [view interactions] Low throughput no no
CTND1_HUMAN [view entry] [view interactions] Low throughput yes no
KCIP4_HUMAN [view interactions] Low throughput no no
CIB1_HUMAN [view interactions] Low throughput no no
YMEL1_HUMAN [view interactions] Low throughput no yes
ETFA_HUMAN [view interactions] Low throughput no yes
FKBP8_HUMAN [view entry] [view interactions] Low throughput yes yes
CSTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
FBXW7_HUMAN [view interactions] Low throughput no yes
CTNA1_HUMAN [view entry] [view interactions] Low throughput yes yes
TF7L2_HUMAN [view interactions] Low throughput no yes
HERP1_HUMAN [view interactions] Low throughput no yes
ERN1_HUMAN [view interactions] Low throughput no yes
TRAF6_HUMAN [view entry] [view interactions] Low throughput yes yes
IRAK2_HUMAN [view interactions] Low throughput no yes
FLNB_HUMAN [view interactions] Low throughput no no
FLNA_HUMAN [view entry] [view interactions] Low throughput yes no
B2CL1_HUMAN [view interactions] Low throughput no yes
DLL1_HUMAN [view interactions] Low throughput no no
UBQL1_HUMAN [view interactions] Low throughput no yes
P85A_HUMAN [view interactions] Low throughput no yes
PKP4_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
TGFR1_HUMAN [view interactions] Low throughput no no
S61A1_HUMAN [view interactions] Low throughput no no
PE2R4_HUMAN [view interactions] Low throughput no yes
CADH2_HUMAN [view entry] [view interactions] Low throughput yes no
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
HTRA2_HUMAN [view interactions] Low throughput no yes
BACE1_HUMAN [view interactions] Low throughput no yes
APH1A_HUMAN [view interactions] Low throughput no yes
APBA1_HUMAN [view interactions] Low throughput no no
APBA2_HUMAN [view interactions] Low throughput no yes
PLD1_HUMAN [view interactions] Low throughput no no
TREM2_HUMAN [view interactions] Low throughput no yes
PSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
RYR2_HUMAN [view entry] [view interactions] Low throughput yes yes
PLAK_HUMAN [view entry] [view interactions] Low throughput yes yes
MK09_HUMAN [view interactions] Low throughput no yes
ERLN2_HUMAN [view entry] [view interactions] Low throughput yes yes
PSA5_HUMAN [view interactions] Low throughput no yes
PSB1_HUMAN [view interactions] Low throughput no yes
BI1_HUMAN [view interactions] Low throughput no yes
NICA_HUMAN [view interactions] Low throughput no yes
PEN2_HUMAN [view interactions] Low throughput no yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
GSTM3_HUMAN [view entry] [view interactions] High throughput yes yes
GSTM5_HUMAN [view interactions] High throughput no yes
AT1A3_HUMAN [view entry] [view interactions] High throughput yes no
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
G3PT_HUMAN [view interactions] High throughput no no
TBA1B_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
HS71L_HUMAN [view entry] [view interactions] High throughput yes no
GSTM1_HUMAN [view interactions] High throughput no yes
GSTM2_HUMAN [view entry] [view interactions] High throughput yes yes
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
NSF_HUMAN [view entry] [view interactions] High throughput yes yes
SYFA_HUMAN [view entry] [view interactions] High throughput yes yes
ATPG_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
CTNA2_HUMAN [view entry] [view interactions] High throughput yes yes
BRSK1_HUMAN [view entry] [view interactions] High throughput yes no
RS16_HUMAN [view entry] [view interactions] High throughput yes yes
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes
ATPO_HUMAN [view interactions] High throughput no yes
ATPB_HUMAN [view interactions] High throughput no yes
HS12A_HUMAN [view entry] [view interactions] High throughput yes yes
ADT1_HUMAN [view entry] [view interactions] High throughput yes yes
MTAP2_HUMAN [view entry] [view interactions] High throughput yes yes
IDH3B_HUMAN [view entry] [view interactions] High throughput yes yes
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
NFL_HUMAN [view entry] [view interactions] High throughput yes yes
DC121_HUMAN [view interactions] High throughput no yes
DC122_HUMAN [view interactions] High throughput no yes
CTND2_HUMAN [view entry] [view interactions] High throughput yes no
M2OM_HUMAN [view entry] [view interactions] High throughput yes yes
ADT2_HUMAN [view entry] [view interactions] High throughput yes yes
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
ACTS_HUMAN [view interactions] High throughput no no
TBB2A_HUMAN [view entry] [view interactions] High throughput yes yes
TBB2B_HUMAN [view entry] [view interactions] High throughput yes yes
RP3A_HUMAN [view entry] [view interactions] High throughput yes yes
GHC1_HUMAN [view entry] [view interactions] High throughput yes yes
EF1A1_HUMAN [view entry] [view interactions] High throughput yes yes
EFTU_HUMAN [view entry] [view interactions] High throughput yes yes
MBP_HUMAN [view entry] [view interactions] High throughput yes no
EF1A2_HUMAN [view entry] [view interactions] High throughput yes yes
TBB4A_HUMAN [view interactions] High throughput no yes
ATPA_HUMAN [view interactions] High throughput no yes
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
AT1B1_HUMAN [view entry] [view interactions] High throughput yes no
LANC1_HUMAN [view entry] [view interactions] High throughput yes yes
S2512_HUMAN [view entry] [view interactions] High throughput yes yes
SFXN3_HUMAN [view entry] [view interactions] High throughput yes yes
AINX_HUMAN [view entry] [view interactions] High throughput yes yes
RS3_HUMAN [view entry] [view interactions] High throughput yes yes
TBB5_HUMAN [view interactions] High throughput no yes
GRPE1_HUMAN [view interactions] High throughput no yes
GSTP1_HUMAN [view entry] [view interactions] High throughput yes no
TBB3_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2D_HUMAN [view entry] [view interactions] High throughput yes yes
KPYM_HUMAN [view interactions] High throughput no yes
CAMKV_HUMAN [view entry] [view interactions] High throughput yes yes
DCE1_HUMAN [view entry] [view interactions] High throughput yes yes
SYT5_HUMAN [view entry] [view interactions] High throughput yes no
S25A3_HUMAN [view entry] [view interactions] High throughput yes no
CPNE6_HUMAN [view entry] [view interactions] High throughput yes yes
MAP6_HUMAN [view entry] [view interactions] High throughput yes yes
DPYL3_HUMAN [view entry] [view interactions] High throughput yes yes
SMAP1_HUMAN [view interactions] High throughput no yes
CPNE4_HUMAN [view interactions] High throughput no no
TMED2_HUMAN [view interactions] High throughput no yes
CDC37_HUMAN [view interactions] High throughput no yes
GCDH_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
APOE_HUMAN [view entry] [view interactions] High throughput yes yes
RAB3A_HUMAN [view entry] [view interactions] High throughput yes yes
PRAM_HUMAN [view interactions] High throughput no no
KANK2_HUMAN [view entry] [view interactions] High throughput yes yes
CDK5_HUMAN [view entry] [view interactions] High throughput yes yes
TYDP2_HUMAN [view interactions] High throughput no no
MYCT_HUMAN [view interactions] High throughput no yes
ATP9A_HUMAN [view interactions] High throughput no yes
HCN2_HUMAN [view entry] [view interactions] High throughput yes no
NDUS7_HUMAN [view entry] [view interactions] High throughput yes no
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
CNTP1_HUMAN [view entry] [view interactions] High throughput yes yes
GTR14_HUMAN [view interactions] High throughput no no
AOFB_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
AP1M2_HUMAN [view interactions] High throughput no no
CP2CI_HUMAN [view interactions] High throughput no no
CP2C8_HUMAN [view interactions] High throughput no no
FXL12_HUMAN [view interactions] High throughput no yes
NOS3_HUMAN [view interactions] High throughput no no
PDCD4_HUMAN [view interactions] High throughput no yes
PRDX2_HUMAN [view entry] [view interactions] High throughput yes yes
RD23A_HUMAN [view interactions] High throughput no yes
RHEB_HUMAN [view entry] [view interactions] High throughput yes yes
STALP_HUMAN [view interactions] High throughput no yes
RNF32_HUMAN [view interactions] High throughput no no
FGF13_HUMAN [view interactions] High throughput no no
HMGB1_HUMAN [view interactions] High throughput no yes
ITSN2_HUMAN [view entry] [view interactions] High throughput yes yes
SCN1A_HUMAN [view interactions] High throughput no no
SOAT_HUMAN [view interactions] High throughput no no
APH1B_HUMAN [view interactions] High throughput no no
NOTC2_HUMAN [view entry] [view interactions] High throughput yes yes
NOTC3_HUMAN [view interactions] High throughput no yes
NOTC4_HUMAN [view interactions] High throughput no no
RMD3_HUMAN [view entry] [view interactions] High throughput yes yes
G3P_HUMAN [view entry] [view interactions] High throughput yes yes
EFHD1_HUMAN [view interactions] High throughput no no
UNK_HUMAN [view interactions] High throughput no yes
ACTN1_HUMAN [view entry] [view interactions] High throughput yes yes
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
COF1_HUMAN [view entry] [view interactions] High throughput yes no
SPP2B_HUMAN [view interactions] High throughput no yes
ENSA_HUMAN [view interactions] High throughput no yes
CADH8_HUMAN [view interactions] High throughput no no
F10A1_HUMAN [view interactions] High throughput no yes
BGAL_HUMAN [view interactions] High throughput no yes
SCOT1_HUMAN [view entry] [view interactions] High throughput yes yes
UMPS_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
TSN5_HUMAN [view interactions] High throughput no no
NAAA_HUMAN [view interactions] High throughput no yes
TM11B_HUMAN [view interactions] High throughput no no
SIA4A_HUMAN [view interactions] High throughput no yes
CAD12_HUMAN [view interactions] High throughput no no
VIPR1_HUMAN [view interactions] High throughput no yes
VASN_HUMAN [view interactions] High throughput no yes
HUMMR_HUMAN [view interactions] High throughput no yes
DNER_HUMAN [view interactions] High throughput no yes
SERP2_HUMAN [view interactions] High throughput no no
ANPRA_HUMAN [view interactions] High throughput no no
SNG1_HUMAN [view entry] [view interactions] High throughput yes yes
PXDC2_HUMAN [view interactions] High throughput no yes
SG196_HUMAN [view interactions] High throughput no yes
DSG2_HUMAN [view interactions] High throughput no no
GPR45_HUMAN [view interactions] High throughput no no
DAG1_HUMAN [view entry] [view interactions] High throughput yes no
DOXA2_HUMAN [view interactions] High throughput no no
ITB1_HUMAN [view entry] [view interactions] High throughput yes no
RAMP3_HUMAN [view interactions] High throughput no no
ANPRC_HUMAN [view interactions] High throughput no no
MFD4A_HUMAN [view interactions] High throughput no yes
P2RY8_HUMAN [view interactions] High throughput no no
KLRB1_HUMAN [view interactions] High throughput no yes
ARF4_HUMAN [view entry] [view interactions] High throughput yes no
S1PR4_HUMAN [view interactions] High throughput no no
ARL1_HUMAN [view interactions] High throughput no yes
TX1B3_HUMAN [view interactions] High throughput no no
AT2A2_HUMAN [view entry] [view interactions] High throughput yes yes
AGRE5_HUMAN [view interactions] High throughput no no
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
PTPR2_HUMAN [view interactions] High throughput no yes
CDN2A_HUMAN [view interactions] High throughput no yes
EAA3_HUMAN [view entry] [view interactions] High throughput yes yes
CHM1A_HUMAN [view entry] [view interactions] High throughput yes no
DNJC2_HUMAN [view interactions] High throughput no yes
CNOT7_HUMAN [view interactions] High throughput no no
VAMP3_HUMAN [view entry] [view interactions] High throughput yes no
EMC8_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
CP51A_HUMAN [view interactions] High throughput no no
CL16A_HUMAN [view interactions] High throughput no yes
OST48_HUMAN [view entry] [view interactions] High throughput yes yes
DDX20_HUMAN [view interactions] High throughput no no
DEGS1_HUMAN [view interactions] High throughput no no
DHC24_HUMAN [view interactions] High throughput no yes
DESP_HUMAN [view entry] [view interactions] High throughput yes no
DNJA1_HUMAN [view entry] [view interactions] High throughput yes yes
DHX9_HUMAN [view interactions] High throughput no yes
DNJA2_HUMAN [view entry] [view interactions] High throughput yes yes
DTNA_HUMAN [view entry] [view interactions] High throughput yes yes
DJB11_HUMAN [view interactions] High throughput no yes
NDUS8_HUMAN [view interactions] High throughput no yes
DNJC7_HUMAN [view interactions] High throughput no yes
IVD_HUMAN [view interactions] High throughput no yes
IF4G1_HUMAN [view entry] [view interactions] High throughput yes yes
TRXR2_HUMAN [view interactions] High throughput no yes
MIA40_HUMAN [view interactions] High throughput no yes
FADS1_HUMAN [view interactions] High throughput no yes
MCFD2_HUMAN [view interactions] High throughput no yes
FADS2_HUMAN [view interactions] High throughput no yes
AL9A1_HUMAN [view interactions] High throughput no yes
FAF2_HUMAN [view interactions] High throughput no yes
6PGD_HUMAN [view entry] [view interactions] High throughput yes no
ESYT1_HUMAN [view entry] [view interactions] High throughput yes yes
CC50A_HUMAN [view interactions] High throughput no yes
DJB12_HUMAN [view interactions] High throughput no yes
TOM22_HUMAN [view interactions] High throughput no yes
DHB12_HUMAN [view entry] [view interactions] High throughput yes yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
STING_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
EMC1_HUMAN [view interactions] High throughput no yes
MAGB2_HUMAN [view interactions] High throughput no no
MLEC_HUMAN [view interactions] High throughput no no
MLF1_HUMAN [view entry] [view interactions] High throughput yes yes
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
PSA2_HUMAN [view interactions] High throughput no yes
PSA4_HUMAN [view entry] [view interactions] High throughput yes yes
PSA6_HUMAN [view interactions] High throughput no yes
PSA7_HUMAN [view interactions] High throughput no yes
PSB2_HUMAN [view interactions] High throughput no yes
PSB5_HUMAN [view interactions] High throughput no yes
PRS7_HUMAN [view interactions] High throughput no yes
PRS6A_HUMAN [view entry] [view interactions] High throughput yes yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
PSMD2_HUMAN [view entry] [view interactions] High throughput yes yes
HACD3_HUMAN [view interactions] High throughput no yes
RAGP1_HUMAN [view entry] [view interactions] High throughput yes yes
RDH11_HUMAN [view interactions] High throughput no no
RL38_HUMAN [view entry] [view interactions] High throughput yes yes
RPN1_HUMAN [view entry] [view interactions] High throughput yes yes
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
SAR1A_HUMAN [view entry] [view interactions] High throughput yes yes
SCD_HUMAN [view entry] [view interactions] High throughput yes yes
SKP1_HUMAN [view interactions] High throughput no yes
AAAT_HUMAN [view interactions] High throughput no no
SOAT1_HUMAN [view interactions] High throughput no no
SRPRB_HUMAN [view entry] [view interactions] High throughput yes no
SSRA_HUMAN [view entry] [view interactions] High throughput yes yes
SSRG_HUMAN [view interactions] High throughput no yes
SSRD_HUMAN [view interactions] High throughput no yes
STT3A_HUMAN [view interactions] High throughput no yes
TBL3_HUMAN [view interactions] High throughput no yes
TMCO1_HUMAN [view interactions] High throughput no yes
TMEDA_HUMAN [view interactions] High throughput no yes
TMM33_HUMAN [view entry] [view interactions] High throughput yes yes
TMM43_HUMAN [view interactions] High throughput no no
EMC2_HUMAN [view interactions] High throughput no yes
ZW10_HUMAN [view interactions] High throughput no yes
BAG6_HUMAN [view entry] [view interactions] High throughput yes yes
BAP31_HUMAN [view interactions] High throughput no yes
PCBP2_HUMAN [view entry] [view interactions] High throughput yes yes
RHBD2_HUMAN [view interactions] High throughput no yes