PSN1_HUMAN
Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed, PubMed, PubMed, PubMed, PubMed). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed, PubMed, PubMed, PubMed). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed, PubMed). Required for normal embryonic brain and skeleton development, and for normal angiogenesis . Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (PubMed, PubMed). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis (PubMed, PubMed). Involved in the regulation of neurite outgrowth (PubMed, PubMed). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression . [View more on UniProt]
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No data found.
ELM instance | Name | Type | Start | End | Partner |
---|---|---|---|---|---|
ELMI002184 | LIG_PDZ_Class_2 | LIG | 462 | 467 | - |
ELMI003227 | MOD_CDK_SPxxK_3 | MOD | 351 | 358 | - |
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PSN1_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 29.3333 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 28.6667 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 28.0000 | 4 | no |
GO:0046872 | metal ion binding | 27.3333 | 4 | no |
GO:0045296 | cadherin binding | 12.6667 | 4 | yes |
GO:0008324 | cation transmembrane transporter activity | 12.0000 | 4 | yes |
GO:0022890 | inorganic cation transmembrane transporter activity | 11.3333 | 4 | yes |
GO:0046873 | metal ion transmembrane transporter activity | 8.0000 | 5 | yes |
GO:0005216 | ion channel activity | 6.6667 | 4 | yes |
GO:0015267 | channel activity | 6.6667 | 4 | yes |
GO:0005261 | cation channel activity | 5.3333 | 5 | yes |
GO:0015085 | calcium ion transmembrane transporter activity | 5.3333 | 6 | yes |
GO:0005262 | calcium channel activity | 4.6667 | 6 | yes |
GO:0070851 | growth factor receptor binding | 4.0000 | 4 | yes |
GO:0004175 | endopeptidase activity | 3.3333 | 4 | yes |
GO:0051117 | ATPase binding | 3.3333 | 4 | yes |
GO:0004190 | aspartic-type endopeptidase activity | 2.0000 | 5 | yes |
GO:0030165 | PDZ domain binding | 2.0000 | 4 | yes |
GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving | 2.0000 | 6 | yes |
GO:0070001 | aspartic-type peptidase activity | 2.0000 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PSN1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 57.3333 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 44.0000 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 40.6667 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 40.6667 | 4 | yes |
GO:0010646 | regulation of cell communication | 40.6667 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 40.6667 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 39.3333 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 38.6667 | 4 | yes |
GO:0006996 | organelle organization | 33.3333 | 4 | yes |
GO:0051049 | regulation of transport | 32.6667 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 32.0000 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 32.0000 | 4 | yes |
GO:0010468 | regulation of gene expression | 30.6667 | 5 | yes |
GO:0022607 | cellular component assembly | 30.6667 | 4 | yes |
GO:0010941 | regulation of cell death | 30.0000 | 4 | yes |
GO:0009966 | regulation of signal transduction | 29.3333 | 4 | yes |
GO:0043067 | regulation of programmed cell death | 28.0000 | 5 | yes |
GO:0008104 | protein localization | 28.0000 | 4 | yes |
GO:0042981 | regulation of apoptotic process | 26.6667 | 6 | yes |
GO:0071310 | cellular response to organic substance | 26.6667 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 26.6667 | 5 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 26.0000 | 5 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 24.6667 | 5 | yes |
GO:0009889 | regulation of biosynthetic process | 24.0000 | 4 | yes |
GO:0060548 | negative regulation of cell death | 23.3333 | 5 | yes |
GO:0023056 | positive regulation of signaling | 23.3333 | 4 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 23.3333 | 5 | yes |
GO:0060341 | regulation of cellular localization | 22.6667 | 4 | yes |
GO:0071702 | organic substance transport | 22.6667 | 4 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 22.6667 | 5 | yes |
GO:0030030 | cell projection organization | 22.6667 | 4 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 22.0000 | 4 | yes |
GO:0009892 | negative regulation of metabolic process | 22.0000 | 4 | yes |
GO:0071705 | nitrogen compound transport | 21.3333 | 4 | yes |
GO:0010647 | positive regulation of cell communication | 21.3333 | 5 | yes |
GO:0043069 | negative regulation of programmed cell death | 20.6667 | 6 | yes |
GO:0009894 | regulation of catabolic process | 20.6667 | 4 | yes |
GO:0007010 | cytoskeleton organization | 20.6667 | 5 | no |
GO:0032880 | regulation of protein localization | 20.6667 | 5 | yes |
GO:0043412 | macromolecule modification | 20.0000 | 4 | yes |
GO:0051050 | positive regulation of transport | 20.0000 | 4 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 20.0000 | 5 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.0000 | 5 | yes |
GO:0036211 | protein modification process | 20.0000 | 4 | yes |
GO:0043066 | negative regulation of apoptotic process | 19.3333 | 7 | yes |
GO:0051130 | positive regulation of cellular component organization | 19.3333 | 5 | yes |
GO:1902531 | regulation of intracellular signal transduction | 19.3333 | 5 | yes |
GO:0048584 | positive regulation of response to stimulus | 18.6667 | 4 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 18.6667 | 5 | yes |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 18.6667 | 5 | yes |
GO:0051247 | positive regulation of protein metabolic process | 18.6667 | 6 | yes |
GO:0051252 | regulation of RNA metabolic process | 18.6667 | 5 | yes |
GO:0006355 | regulation of DNA-templated transcription | 18.6667 | 6 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 18.6667 | 4 | yes |
GO:0010243 | response to organonitrogen compound | 18.6667 | 4 | yes |
GO:1903506 | regulation of nucleic acid-templated transcription | 18.6667 | 7 | yes |
GO:2001141 | regulation of RNA biosynthetic process | 18.6667 | 6 | yes |
GO:0045595 | regulation of cell differentiation | 18.0000 | 4 | yes |
GO:0048585 | negative regulation of response to stimulus | 18.0000 | 4 | yes |
GO:0120036 | plasma membrane bounded cell projection organization | 18.0000 | 5 | yes |
GO:2000026 | regulation of multicellular organismal development | 18.0000 | 4 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 18.0000 | 5 | yes |
GO:0034330 | cell junction organization | 18.0000 | 4 | yes |
GO:0051094 | positive regulation of developmental process | 17.3333 | 4 | yes |
GO:0051174 | regulation of phosphorus metabolic process | 17.3333 | 5 | yes |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 17.3333 | 6 | yes |
GO:0015031 | protein transport | 17.3333 | 4 | yes |
GO:0019220 | regulation of phosphate metabolic process | 17.3333 | 6 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 17.3333 | 4 | yes |
GO:0031344 | regulation of cell projection organization | 17.3333 | 5 | yes |
GO:0031399 | regulation of protein modification process | 17.3333 | 6 | yes |
GO:0043085 | positive regulation of catalytic activity | 16.6667 | 4 | yes |
GO:0043269 | regulation of ion transport | 16.6667 | 5 | yes |
GO:0010648 | negative regulation of cell communication | 16.6667 | 5 | yes |
GO:0023057 | negative regulation of signaling | 16.6667 | 4 | yes |
GO:0009968 | negative regulation of signal transduction | 16.0000 | 5 | yes |
GO:1901701 | cellular response to oxygen-containing compound | 16.0000 | 4 | yes |
GO:0042325 | regulation of phosphorylation | 15.3333 | 7 | yes |
GO:0006811 | ion transport | 15.3333 | 4 | yes |
GO:0009967 | positive regulation of signal transduction | 15.3333 | 5 | yes |
GO:0010975 | regulation of neuron projection development | 15.3333 | 7 | yes |
GO:0030162 | regulation of proteolysis | 15.3333 | 6 | yes |
GO:0051248 | negative regulation of protein metabolic process | 14.6667 | 6 | yes |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 14.0000 | 6 | yes |
GO:0051338 | regulation of transferase activity | 14.0000 | 4 | yes |
GO:0071417 | cellular response to organonitrogen compound | 14.0000 | 4 | yes |
GO:1901699 | cellular response to nitrogen compound | 14.0000 | 4 | yes |
GO:0031329 | regulation of cellular catabolic process | 14.0000 | 5 | yes |
GO:0051129 | negative regulation of cellular component organization | 13.3333 | 5 | yes |
GO:0001932 | regulation of protein phosphorylation | 13.3333 | 7 | yes |
GO:0070201 | regulation of establishment of protein localization | 12.6667 | 6 | yes |
GO:0009891 | positive regulation of biosynthetic process | 12.6667 | 5 | yes |
GO:0010942 | positive regulation of cell death | 12.6667 | 5 | yes |
GO:1903829 | positive regulation of protein localization | 12.6667 | 5 | yes |
GO:0031328 | positive regulation of cellular biosynthetic process | 12.6667 | 6 | yes |
GO:0042176 | regulation of protein catabolic process | 12.6667 | 5 | yes |
GO:0043549 | regulation of kinase activity | 12.0000 | 5 | yes |
GO:0045862 | positive regulation of proteolysis | 12.0000 | 7 | yes |
GO:0051223 | regulation of protein transport | 12.0000 | 5 | yes |
GO:0051241 | negative regulation of multicellular organismal process | 12.0000 | 4 | yes |
GO:0010628 | positive regulation of gene expression | 12.0000 | 6 | yes |
GO:0034762 | regulation of transmembrane transport | 12.0000 | 4 | yes |
GO:0043408 | regulation of MAPK cascade | 11.3333 | 6 | yes |
GO:0045937 | positive regulation of phosphate metabolic process | 11.3333 | 7 | yes |
GO:0050808 | synapse organization | 11.3333 | 5 | yes |
GO:0051093 | negative regulation of developmental process | 11.3333 | 4 | yes |
GO:0051254 | positive regulation of RNA metabolic process | 11.3333 | 6 | yes |
GO:0051960 | regulation of nervous system development | 11.3333 | 5 | yes |
GO:0006508 | proteolysis | 11.3333 | 4 | yes |
GO:0060284 | regulation of cell development | 11.3333 | 5 | yes |
GO:0006915 | apoptotic process | 11.3333 | 4 | yes |
GO:0009890 | negative regulation of biosynthetic process | 11.3333 | 5 | yes |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 11.3333 | 6 | yes |
GO:0010562 | positive regulation of phosphorus metabolic process | 11.3333 | 6 | yes |
GO:0034765 | regulation of ion transmembrane transport | 11.3333 | 5 | yes |
GO:0045893 | positive regulation of DNA-templated transcription | 10.6667 | 7 | yes |
GO:0048878 | chemical homeostasis | 10.6667 | 4 | yes |
GO:0050890 | cognition | 10.6667 | 4 | yes |
GO:1902533 | positive regulation of intracellular signal transduction | 10.6667 | 6 | yes |
GO:1902680 | positive regulation of RNA biosynthetic process | 10.6667 | 7 | yes |
GO:1903508 | positive regulation of nucleic acid-templated transcription | 10.6667 | 8 | yes |
GO:0031400 | negative regulation of protein modification process | 10.6667 | 7 | yes |
GO:0042327 | positive regulation of phosphorylation | 10.0000 | 8 | yes |
GO:0043065 | positive regulation of apoptotic process | 10.0000 | 7 | yes |
GO:0043068 | positive regulation of programmed cell death | 10.0000 | 6 | yes |
GO:0043270 | positive regulation of ion transport | 10.0000 | 5 | yes |
GO:0043603 | cellular amide metabolic process | 10.0000 | 4 | yes |
GO:0050767 | regulation of neurogenesis | 10.0000 | 6 | yes |
GO:0006357 | regulation of transcription by RNA polymerase II | 10.0000 | 7 | yes |
GO:0006812 | cation transport | 10.0000 | 5 | yes |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 10.0000 | 6 | yes |
GO:1901214 | regulation of neuron death | 10.0000 | 5 | yes |
GO:0010629 | negative regulation of gene expression | 10.0000 | 6 | yes |
GO:0031327 | negative regulation of cellular biosynthetic process | 10.0000 | 6 | yes |
GO:2001233 | regulation of apoptotic signaling pathway | 10.0000 | 5 | yes |
GO:0032386 | regulation of intracellular transport | 10.0000 | 5 | yes |
GO:0045596 | negative regulation of cell differentiation | 9.3333 | 5 | yes |
GO:0045859 | regulation of protein kinase activity | 9.3333 | 6 | yes |
GO:0031401 | positive regulation of protein modification process | 9.3333 | 7 | yes |
GO:0050770 | regulation of axonogenesis | 8.6667 | 5 | yes |
GO:0050801 | ion homeostasis | 8.6667 | 5 | yes |
GO:0051222 | positive regulation of protein transport | 8.6667 | 5 | yes |
GO:0051347 | positive regulation of transferase activity | 8.6667 | 5 | yes |
GO:0055080 | cation homeostasis | 8.6667 | 6 | yes |
GO:0006518 | peptide metabolic process | 8.6667 | 4 | yes |
GO:0098771 | inorganic ion homeostasis | 8.6667 | 6 | yes |
GO:1901215 | negative regulation of neuron death | 8.6667 | 6 | yes |
GO:0030001 | metal ion transport | 8.6667 | 6 | yes |
GO:1904951 | positive regulation of establishment of protein localization | 8.6667 | 6 | yes |
GO:0032388 | positive regulation of intracellular transport | 8.6667 | 5 | yes |
GO:0033157 | regulation of intracellular protein transport | 8.6667 | 6 | yes |
GO:0043086 | negative regulation of catalytic activity | 8.0000 | 4 | yes |
GO:0043393 | regulation of protein binding | 8.0000 | 4 | yes |
GO:0043523 | regulation of neuron apoptotic process | 8.0000 | 6 | yes |
GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 8.0000 | 6 | yes |
GO:0045936 | negative regulation of phosphate metabolic process | 8.0000 | 7 | yes |
GO:0001934 | positive regulation of protein phosphorylation | 8.0000 | 8 | yes |
GO:0055065 | metal ion homeostasis | 8.0000 | 7 | yes |
GO:0006820 | anion transport | 8.0000 | 5 | yes |
GO:0006873 | cellular ion homeostasis | 8.0000 | 4 | yes |
GO:0009896 | positive regulation of catabolic process | 8.0000 | 5 | yes |
GO:0010563 | negative regulation of phosphorus metabolic process | 8.0000 | 6 | yes |
GO:0030003 | cellular cation homeostasis | 8.0000 | 5 | yes |
GO:0033674 | positive regulation of kinase activity | 8.0000 | 6 | yes |
GO:0042326 | negative regulation of phosphorylation | 7.3333 | 8 | yes |
GO:0043410 | positive regulation of MAPK cascade | 7.3333 | 7 | yes |
GO:0045892 | negative regulation of DNA-templated transcription | 7.3333 | 7 | yes |
GO:0051253 | negative regulation of RNA metabolic process | 7.3333 | 6 | yes |
GO:0006875 | cellular metal ion homeostasis | 7.3333 | 6 | yes |
GO:0072507 | divalent inorganic cation homeostasis | 7.3333 | 7 | yes |
GO:0090316 | positive regulation of intracellular protein transport | 7.3333 | 6 | yes |
GO:0098656 | anion transmembrane transport | 7.3333 | 4 | yes |
GO:1901652 | response to peptide | 7.3333 | 4 | yes |
GO:1902679 | negative regulation of RNA biosynthetic process | 7.3333 | 7 | yes |
GO:1902903 | regulation of supramolecular fiber organization | 7.3333 | 5 | yes |
GO:1903507 | negative regulation of nucleic acid-templated transcription | 7.3333 | 8 | yes |
GO:0030111 | regulation of Wnt signaling pathway | 7.3333 | 5 | yes |
GO:2001234 | negative regulation of apoptotic signaling pathway | 7.3333 | 6 | yes |
GO:0031345 | negative regulation of cell projection organization | 7.3333 | 6 | yes |
GO:0034764 | positive regulation of transmembrane transport | 7.3333 | 5 | yes |
GO:0034767 | positive regulation of ion transmembrane transport | 7.3333 | 6 | yes |
GO:0001817 | regulation of cytokine production | 6.6667 | 4 | yes |
GO:0001933 | negative regulation of protein phosphorylation | 6.6667 | 8 | yes |
GO:0051348 | negative regulation of transferase activity | 6.6667 | 5 | yes |
GO:0002684 | positive regulation of immune system process | 6.6667 | 4 | yes |
GO:0055074 | calcium ion homeostasis | 6.6667 | 8 | yes |
GO:0060828 | regulation of canonical Wnt signaling pathway | 6.6667 | 6 | yes |
GO:0072503 | cellular divalent inorganic cation homeostasis | 6.6667 | 6 | yes |
GO:0010977 | negative regulation of neuron projection development | 6.6667 | 7 | yes |
GO:0015711 | organic anion transport | 6.6667 | 5 | yes |
GO:0045732 | positive regulation of protein catabolic process | 6.0000 | 6 | yes |
GO:0046822 | regulation of nucleocytoplasmic transport | 6.0000 | 6 | yes |
GO:0050776 | regulation of immune response | 6.0000 | 4 | yes |
GO:0051099 | positive regulation of binding | 6.0000 | 4 | yes |
GO:0001819 | positive regulation of cytokine production | 6.0000 | 5 | yes |
GO:0006874 | cellular calcium ion homeostasis | 6.0000 | 7 | yes |
GO:0061136 | regulation of proteasomal protein catabolic process | 6.0000 | 6 | yes |
GO:0070925 | organelle assembly | 6.0000 | 5 | yes |
GO:0071900 | regulation of protein serine/threonine kinase activity | 6.0000 | 7 | yes |
GO:0007613 | memory | 6.0000 | 4 | yes |
GO:1900180 | regulation of protein localization to nucleus | 6.0000 | 6 | yes |
GO:1901653 | cellular response to peptide | 6.0000 | 5 | yes |
GO:0010721 | negative regulation of cell development | 6.0000 | 6 | yes |
GO:1903050 | regulation of proteolysis involved in protein catabolic process | 6.0000 | 7 | yes |
GO:0015849 | organic acid transport | 6.0000 | 5 | yes |
GO:0043405 | regulation of MAP kinase activity | 5.3333 | 8 | yes |
GO:0043524 | negative regulation of neuron apoptotic process | 5.3333 | 7 | yes |
GO:0045860 | positive regulation of protein kinase activity | 5.3333 | 7 | yes |
GO:0046942 | carboxylic acid transport | 5.3333 | 6 | yes |
GO:0050768 | negative regulation of neurogenesis | 5.3333 | 6 | yes |
GO:0002009 | morphogenesis of an epithelium | 5.3333 | 4 | yes |
GO:0051402 | neuron apoptotic process | 5.3333 | 4 | yes |
GO:0051961 | negative regulation of nervous system development | 5.3333 | 5 | yes |
GO:0006816 | calcium ion transport | 5.3333 | 7 | yes |
GO:0009895 | negative regulation of catabolic process | 5.3333 | 5 | yes |
GO:0106027 | neuron projection organization | 5.3333 | 6 | yes |
GO:1903320 | regulation of protein modification by small protein conjugation or removal | 5.3333 | 7 | yes |
GO:1904645 | response to amyloid-beta | 5.3333 | 5 | yes |
GO:1904646 | cellular response to amyloid-beta | 5.3333 | 6 | yes |
GO:1905039 | carboxylic acid transmembrane transport | 5.3333 | 4 | yes |
GO:0031331 | positive regulation of cellular catabolic process | 5.3333 | 6 | yes |
GO:0033673 | negative regulation of kinase activity | 5.3333 | 6 | yes |
GO:0046824 | positive regulation of nucleocytoplasmic transport | 4.6667 | 6 | yes |
GO:0048666 | neuron development | 4.6667 | 4 | yes |
GO:0051100 | negative regulation of binding | 4.6667 | 4 | yes |
GO:0051952 | regulation of amine transport | 4.6667 | 5 | yes |
GO:0003333 | amino acid transmembrane transport | 4.6667 | 5 | yes |
GO:0006469 | negative regulation of protein kinase activity | 4.6667 | 7 | yes |
GO:0006835 | dicarboxylic acid transport | 4.6667 | 7 | yes |
GO:0006865 | amino acid transport | 4.6667 | 5 | yes |
GO:0062012 | regulation of small molecule metabolic process | 4.6667 | 4 | yes |
GO:0006974 | cellular response to DNA damage stimulus | 4.6667 | 4 | yes |
GO:0098657 | import into cell | 4.6667 | 4 | yes |
GO:1902905 | positive regulation of supramolecular fiber organization | 4.6667 | 6 | yes |
GO:1903321 | negative regulation of protein modification by small protein conjugation or removal | 4.6667 | 8 | yes |
GO:0030182 | neuron differentiation | 4.6667 | 4 | yes |
GO:0031396 | regulation of protein ubiquitination | 4.6667 | 8 | yes |
GO:0032092 | positive regulation of protein binding | 4.6667 | 5 | yes |
GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 4.0000 | 8 | yes |
GO:0050771 | negative regulation of axonogenesis | 4.0000 | 6 | yes |
GO:0050778 | positive regulation of immune response | 4.0000 | 5 | yes |
GO:0000122 | negative regulation of transcription by RNA polymerase II | 4.0000 | 8 | yes |
GO:0001764 | neuron migration | 4.0000 | 4 | yes |
GO:0001919 | regulation of receptor recycling | 4.0000 | 4 | yes |
GO:0051966 | regulation of synaptic transmission, glutamatergic | 4.0000 | 6 | yes |
GO:0007219 | Notch signaling pathway | 4.0000 | 4 | yes |
GO:1900182 | positive regulation of protein localization to nucleus | 4.0000 | 6 | yes |
GO:1901800 | positive regulation of proteasomal protein catabolic process | 4.0000 | 7 | yes |
GO:1903052 | positive regulation of proteolysis involved in protein catabolic process | 4.0000 | 8 | yes |
GO:1903555 | regulation of tumor necrosis factor superfamily cytokine production | 4.0000 | 5 | yes |
GO:0030099 | myeloid cell differentiation | 4.0000 | 4 | yes |
GO:0031397 | negative regulation of protein ubiquitination | 4.0000 | 9 | yes |
GO:0032680 | regulation of tumor necrosis factor production | 4.0000 | 6 | yes |
GO:0042307 | positive regulation of protein import into nucleus | 3.3333 | 7 | yes |
GO:0042982 | amyloid precursor protein metabolic process | 3.3333 | 4 | yes |
GO:0043406 | positive regulation of MAP kinase activity | 3.3333 | 8 | yes |
GO:0043467 | regulation of generation of precursor metabolites and energy | 3.3333 | 5 | yes |
GO:0045861 | negative regulation of proteolysis | 3.3333 | 7 | yes |
GO:0045981 | positive regulation of nucleotide metabolic process | 3.3333 | 6 | yes |
GO:0048732 | gland development | 3.3333 | 4 | yes |
GO:0050818 | regulation of coagulation | 3.3333 | 4 | yes |
GO:0001921 | positive regulation of receptor recycling | 3.3333 | 5 | yes |
GO:0002521 | leukocyte differentiation | 3.3333 | 4 | yes |
GO:0051604 | protein maturation | 3.3333 | 4 | yes |
GO:0051938 | L-glutamate import | 3.3333 | 6 | yes |
GO:0051954 | positive regulation of amine transport | 3.3333 | 5 | yes |
GO:0006109 | regulation of carbohydrate metabolic process | 3.3333 | 5 | yes |
GO:0006140 | regulation of nucleotide metabolic process | 3.3333 | 5 | yes |
GO:0006486 | protein glycosylation | 3.3333 | 4 | yes |
GO:0006509 | membrane protein ectodomain proteolysis | 3.3333 | 6 | yes |
GO:0062013 | positive regulation of small molecule metabolic process | 3.3333 | 5 | yes |
GO:0071902 | positive regulation of protein serine/threonine kinase activity | 3.3333 | 8 | yes |
GO:1900542 | regulation of purine nucleotide metabolic process | 3.3333 | 6 | yes |
GO:1900544 | positive regulation of purine nucleotide metabolic process | 3.3333 | 7 | yes |
GO:1902475 | L-alpha-amino acid transmembrane transport | 3.3333 | 6 | yes |
GO:0015800 | acidic amino acid transport | 3.3333 | 6 | yes |
GO:1903131 | mononuclear cell differentiation | 3.3333 | 5 | yes |
GO:0015807 | L-amino acid transport | 3.3333 | 5 | yes |
GO:0015813 | L-glutamate transmembrane transport | 3.3333 | 5 | yes |
GO:0016485 | protein processing | 3.3333 | 5 | yes |
GO:1903557 | positive regulation of tumor necrosis factor superfamily cytokine production | 3.3333 | 6 | yes |
GO:1903578 | regulation of ATP metabolic process | 3.3333 | 7 | yes |
GO:1903580 | positive regulation of ATP metabolic process | 3.3333 | 8 | yes |
GO:0031330 | negative regulation of cellular catabolic process | 3.3333 | 6 | yes |
GO:0032469 | endoplasmic reticulum calcium ion homeostasis | 3.3333 | 8 | yes |
GO:0032760 | positive regulation of tumor necrosis factor production | 3.3333 | 7 | yes |
GO:0033619 | membrane protein proteolysis | 3.3333 | 5 | yes |
GO:0042110 | T cell activation | 3.3333 | 4 | yes |
GO:0042306 | regulation of protein import into nucleus | 3.3333 | 7 | yes |
GO:0042987 | amyloid precursor protein catabolic process | 2.6667 | 5 | yes |
GO:0043470 | regulation of carbohydrate catabolic process | 2.6667 | 5 | yes |
GO:0044070 | regulation of anion transport | 2.6667 | 6 | yes |
GO:0045913 | positive regulation of carbohydrate metabolic process | 2.6667 | 5 | yes |
GO:0048143 | astrocyte activation | 2.6667 | 4 | yes |
GO:0048534 | hematopoietic or lymphoid organ development | 2.6667 | 4 | yes |
GO:0048538 | thymus development | 2.6667 | 5 | yes |
GO:0048854 | brain morphogenesis | 2.6667 | 4 | yes |
GO:0002429 | immune response-activating cell surface receptor signaling pathway | 2.6667 | 4 | yes |
GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 2.6667 | 4 | yes |
GO:0051955 | regulation of amino acid transport | 2.6667 | 6 | yes |
GO:0051957 | positive regulation of amino acid transport | 2.6667 | 6 | yes |
GO:0060562 | epithelial tube morphogenesis | 2.6667 | 4 | yes |
GO:0060998 | regulation of dendritic spine development | 2.6667 | 4 | yes |
GO:0060999 | positive regulation of dendritic spine development | 2.6667 | 5 | yes |
GO:0007033 | vacuole organization | 2.6667 | 5 | yes |
GO:0089718 | amino acid import across plasma membrane | 2.6667 | 4 | yes |
GO:1903793 | positive regulation of anion transport | 2.6667 | 6 | yes |
GO:1905906 | regulation of amyloid fibril formation | 2.6667 | 6 | yes |
GO:1905908 | positive regulation of amyloid fibril formation | 2.6667 | 7 | yes |
GO:1990535 | neuron projection maintenance | 2.6667 | 7 | yes |
GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | 2.6667 | 6 | yes |
GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process | 2.6667 | 7 | yes |
GO:0032890 | regulation of organic acid transport | 2.6667 | 5 | yes |
GO:0032892 | positive regulation of organic acid transport | 2.6667 | 5 | yes |
GO:0045821 | positive regulation of glycolytic process | 2.0000 | 6 | yes |
GO:0048705 | skeletal system morphogenesis | 2.0000 | 4 | yes |
GO:0050435 | amyloid-beta metabolic process | 2.0000 | 5 | yes |
GO:0050732 | negative regulation of peptidyl-tyrosine phosphorylation | 2.0000 | 9 | yes |
GO:0050820 | positive regulation of coagulation | 2.0000 | 5 | yes |
GO:0050851 | antigen receptor-mediated signaling pathway | 2.0000 | 5 | yes |
GO:0050852 | T cell receptor signaling pathway | 2.0000 | 6 | yes |
GO:0051101 | regulation of DNA binding | 2.0000 | 4 | yes |
GO:0000045 | autophagosome assembly | 2.0000 | 6 | yes |
GO:0002036 | regulation of L-glutamate import across plasma membrane | 2.0000 | 7 | yes |
GO:0002038 | positive regulation of L-glutamate import across plasma membrane | 2.0000 | 7 | yes |
GO:0002244 | hematopoietic progenitor cell differentiation | 2.0000 | 4 | yes |
GO:0002265 | astrocyte activation involved in immune response | 2.0000 | 4 | yes |
GO:0051438 | regulation of ubiquitin-protein transferase activity | 2.0000 | 5 | yes |
GO:0051444 | negative regulation of ubiquitin-protein transferase activity | 2.0000 | 6 | yes |
GO:0051563 | smooth endoplasmic reticulum calcium ion homeostasis | 2.0000 | 9 | yes |
GO:0002573 | myeloid leukocyte differentiation | 2.0000 | 5 | yes |
GO:0003143 | embryonic heart tube morphogenesis | 2.0000 | 4 | yes |
GO:0006110 | regulation of glycolytic process | 2.0000 | 6 | yes |
GO:0060075 | regulation of resting membrane potential | 2.0000 | 4 | yes |
GO:0061097 | regulation of protein tyrosine kinase activity | 2.0000 | 7 | yes |
GO:0007176 | regulation of epidermal growth factor-activated receptor activity | 2.0000 | 4 | yes |
GO:0007220 | Notch receptor processing | 2.0000 | 4 | yes |
GO:0098712 | L-glutamate import across plasma membrane | 2.0000 | 5 | yes |
GO:0009952 | anterior/posterior pattern specification | 2.0000 | 4 | yes |
GO:0009953 | dorsal/ventral pattern formation | 2.0000 | 4 | yes |
GO:0010958 | regulation of amino acid import across plasma membrane | 2.0000 | 6 | yes |
GO:1903051 | negative regulation of proteolysis involved in protein catabolic process | 2.0000 | 8 | yes |
GO:1903789 | regulation of amino acid transmembrane transport | 2.0000 | 5 | yes |
GO:0021904 | dorsal/ventral neural tube patterning | 2.0000 | 5 | yes |
GO:1903959 | regulation of anion transmembrane transport | 2.0000 | 6 | yes |
GO:1903961 | positive regulation of anion transmembrane transport | 2.0000 | 7 | yes |
GO:1904796 | regulation of core promoter binding | 2.0000 | 6 | yes |
GO:1905037 | autophagosome organization | 2.0000 | 6 | yes |
GO:0030326 | embryonic limb morphogenesis | 2.0000 | 5 | yes |
GO:2000059 | negative regulation of ubiquitin-dependent protein catabolic process | 2.0000 | 7 | yes |
GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | 2.0000 | 7 | yes |
GO:2000272 | negative regulation of signaling receptor activity | 2.0000 | 4 | yes |
GO:2000677 | regulation of transcription regulatory region DNA binding | 2.0000 | 5 | yes |
GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 2.0000 | 8 | yes |
GO:0034205 | amyloid-beta formation | 2.0000 | 6 | yes |
GO:0035108 | limb morphogenesis | 2.0000 | 4 | yes |
GO:0035113 | embryonic appendage morphogenesis | 2.0000 | 4 | yes |
GO:0043011 | myeloid dendritic cell differentiation | 1.3333 | 5 | yes |
GO:0043392 | negative regulation of DNA binding | 1.3333 | 5 | yes |
GO:0043589 | skin morphogenesis | 1.3333 | 4 | yes |
GO:0001773 | myeloid dendritic cell activation | 1.3333 | 4 | yes |
GO:0001947 | heart looping | 1.3333 | 5 | yes |
GO:0002285 | lymphocyte activation involved in immune response | 1.3333 | 4 | yes |
GO:0002286 | T cell activation involved in immune response | 1.3333 | 5 | yes |
GO:0006839 | mitochondrial transport | 1.3333 | 4 | yes |
GO:0061099 | negative regulation of protein tyrosine kinase activity | 1.3333 | 8 | yes |
GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity | 1.3333 | 5 | yes |
GO:0097028 | dendritic cell differentiation | 1.3333 | 6 | yes |
GO:1901184 | regulation of ERBB signaling pathway | 1.3333 | 5 | yes |
GO:1901185 | negative regulation of ERBB signaling pathway | 1.3333 | 6 | yes |
GO:0015695 | organic cation transport | 1.3333 | 5 | yes |
GO:0015871 | choline transport | 1.3333 | 5 | yes |
GO:0021795 | cerebral cortex cell migration | 1.3333 | 6 | yes |
GO:0021870 | Cajal-Retzius cell differentiation | 1.3333 | 7 | yes |
GO:0021885 | forebrain cell migration | 1.3333 | 4 | yes |
GO:0021895 | cerebral cortex neuron differentiation | 1.3333 | 6 | yes |
GO:0021953 | central nervous system neuron differentiation | 1.3333 | 5 | yes |
GO:0022029 | telencephalon cell migration | 1.3333 | 5 | yes |
GO:1904797 | negative regulation of core promoter binding | 1.3333 | 7 | yes |
GO:0031293 | membrane protein intracellular domain proteolysis | 1.3333 | 6 | yes |
GO:2000678 | negative regulation of transcription regulatory region DNA binding | 1.3333 | 6 | yes |
GO:0035282 | segmentation | 1.3333 | 4 | yes |
GO:0042058 | regulation of epidermal growth factor receptor signaling pathway | 1.3333 | 6 | yes |
GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway | 1.3333 | 7 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in PSN1_HUMAN |
---|---|---|---|---|
DOID:331 | central nervous system disease | 3.3333 | 3 | no |
DOID:1289 | neurodegenerative disease | 2.0000 | 4 | no |
DOID:114 | heart disease | 2.0000 | 3 | no |
DOID:936 | brain disease | 1.3333 | 4 | no |
DOID:231 | motor neuron disease | 1.3333 | 5 | no |
DOID:0050700 | cardiomyopathy | 1.3333 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 1.3333 | 5 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GSK3B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
APBA3_HUMAN | [view interactions] | Low throughput | no | yes |
EFNB1_HUMAN | [view interactions] | Low throughput | no | yes |
VPP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
STT3B_HUMAN | [view interactions] | Low throughput | no | yes |
CALR_HUMAN | [view interactions] | Low throughput | no | yes |
TNR16_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
GSAP_HUMAN | [view interactions] | Low throughput | no | no |
FLOT2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
STXB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NEUM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GTR3_HUMAN | [view interactions] | Low throughput | no | yes |
NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
PSN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CSEN_HUMAN | [view interactions] | Low throughput | no | no |
NOTC1_HUMAN | [view interactions] | Low throughput | no | yes |
PEMT_HUMAN | [view interactions] | Low throughput | no | yes |
GFAP_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ICAM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
BCL2_HUMAN | [view interactions] | Low throughput | no | no |
CTND1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
KCIP4_HUMAN | [view interactions] | Low throughput | no | no |
CIB1_HUMAN | [view interactions] | Low throughput | no | no |
YMEL1_HUMAN | [view interactions] | Low throughput | no | yes |
ETFA_HUMAN | [view interactions] | Low throughput | no | yes |
FKBP8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CSTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FBXW7_HUMAN | [view interactions] | Low throughput | no | yes |
CTNA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TF7L2_HUMAN | [view interactions] | Low throughput | no | yes |
HERP1_HUMAN | [view interactions] | Low throughput | no | yes |
ERN1_HUMAN | [view interactions] | Low throughput | no | yes |
TRAF6_HUMAN | [view interactions] | Low throughput | no | yes |
IRAK2_HUMAN | [view interactions] | Low throughput | no | yes |
FLNB_HUMAN | [view interactions] | Low throughput | no | no |
DLL1_HUMAN | [view interactions] | Low throughput | no | no |
FLNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
P85A_HUMAN | [view interactions] | Low throughput | no | yes |
B2CL1_HUMAN | [view interactions] | Low throughput | no | yes |
NMDE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
UBQL1_HUMAN | [view interactions] | Low throughput | no | yes |
TGFR1_HUMAN | [view interactions] | Low throughput | no | no |
PKP4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
S61A1_HUMAN | [view interactions] | Low throughput | no | no |
PE2R4_HUMAN | [view interactions] | Low throughput | no | yes |
CADH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HTRA2_HUMAN | [view interactions] | Low throughput | no | yes |
BACE1_HUMAN | [view interactions] | Low throughput | no | yes |
APH1A_HUMAN | [view interactions] | Low throughput | no | yes |
APBA1_HUMAN | [view interactions] | Low throughput | no | no |
APBA2_HUMAN | [view interactions] | Low throughput | no | yes |
PLD1_HUMAN | [view interactions] | Low throughput | no | no |
TREM2_HUMAN | [view interactions] | Low throughput | no | yes |
RYR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PLAK_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MK09_HUMAN | [view interactions] | Low throughput | no | yes |
PSB1_HUMAN | [view interactions] | Low throughput | no | yes |
PSA5_HUMAN | [view interactions] | Low throughput | no | yes |
ERLN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
BI1_HUMAN | [view interactions] | Low throughput | no | yes |
PEN2_HUMAN | [view interactions] | Low throughput | no | yes |
NICA_HUMAN | [view interactions] | Low throughput | no | yes |
CADH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SYT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
MTCH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ECSIT_HUMAN | [view interactions] | Low throughput | no | yes |
SYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
M2OM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DC121_HUMAN | [view interactions] | High throughput | no | yes |
DC122_HUMAN | [view interactions] | High throughput | no | yes |
NFL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IDH3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS12A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATPB_HUMAN | [view interactions] | High throughput | no | yes |
ATPO_HUMAN | [view interactions] | High throughput | no | yes |
DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BRSK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CTNA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GSTM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ATPG_HUMAN | [view interactions] | High throughput | no | yes |
SYFA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS71L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DCE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAMKV_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KPYM_HUMAN | [view interactions] | High throughput | no | yes |
KCC2D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CPNE6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MAP6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MPCP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SYT5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SMAP1_HUMAN | [view interactions] | High throughput | no | yes |
CPNE4_HUMAN | [view interactions] | High throughput | no | no |
DPYL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMED2_HUMAN | [view interactions] | High throughput | no | yes |
CDC37_HUMAN | [view interactions] | High throughput | no | yes |
GCDH_HUMAN | [view interactions] | High throughput | no | yes |
CDK5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRAM_HUMAN | [view interactions] | High throughput | no | no |
RAB3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TYDP2_HUMAN | [view interactions] | High throughput | no | no |
MYCT_HUMAN | [view interactions] | High throughput | no | yes |
ATP9A_HUMAN | [view interactions] | High throughput | no | yes |
HCN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CNTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GTR14_HUMAN | [view interactions] | High throughput | no | no |
AOFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AP1M2_HUMAN | [view interactions] | High throughput | no | no |
CP2CI_HUMAN | [view interactions] | High throughput | no | no |
CP2C8_HUMAN | [view interactions] | High throughput | no | no |
FXL12_HUMAN | [view interactions] | High throughput | no | yes |
NOS3_HUMAN | [view interactions] | High throughput | no | no |
PDCD4_HUMAN | [view interactions] | High throughput | no | yes |
PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RD23A_HUMAN | [view interactions] | High throughput | no | yes |
RHEB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STALP_HUMAN | [view interactions] | High throughput | no | yes |
RNF32_HUMAN | [view interactions] | High throughput | no | no |
FGF13_HUMAN | [view interactions] | High throughput | no | no |
HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCN1A_HUMAN | [view interactions] | High throughput | no | no |
SOAT_HUMAN | [view interactions] | High throughput | no | no |
APH1B_HUMAN | [view interactions] | High throughput | no | no |
NOTC2_HUMAN | [view interactions] | High throughput | no | yes |
NOTC3_HUMAN | [view interactions] | High throughput | no | yes |
NOTC4_HUMAN | [view interactions] | High throughput | no | no |
E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UNK_HUMAN | [view interactions] | High throughput | no | yes |
ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EFHD1_HUMAN | [view interactions] | High throughput | no | no |
G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPP2B_HUMAN | [view interactions] | High throughput | no | yes |
RMD3_HUMAN | [view interactions] | High throughput | no | yes |
CADH8_HUMAN | [view interactions] | High throughput | no | no |
ENSA_HUMAN | [view interactions] | High throughput | no | yes |
BGAL_HUMAN | [view interactions] | High throughput | no | yes |
COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UMPS_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TSN5_HUMAN | [view interactions] | High throughput | no | no |
F10A1_HUMAN | [view interactions] | High throughput | no | yes |
NAAA_HUMAN | [view interactions] | High throughput | no | yes |
TM11B_HUMAN | [view interactions] | High throughput | no | no |
SIA4A_HUMAN | [view interactions] | High throughput | no | yes |
CAD12_HUMAN | [view interactions] | High throughput | no | no |
VIPR1_HUMAN | [view interactions] | High throughput | no | yes |
HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
SERP2_HUMAN | [view interactions] | High throughput | no | no |
VASN_HUMAN | [view interactions] | High throughput | no | yes |
SNG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DNER_HUMAN | [view interactions] | High throughput | no | yes |
SG196_HUMAN | [view interactions] | High throughput | no | yes |
ANPRA_HUMAN | [view interactions] | High throughput | no | no |
GPR45_HUMAN | [view interactions] | High throughput | no | no |
PXDC2_HUMAN | [view interactions] | High throughput | no | yes |
DOXA2_HUMAN | [view interactions] | High throughput | no | no |
DSG2_HUMAN | [view interactions] | High throughput | no | no |
RAMP3_HUMAN | [view interactions] | High throughput | no | no |
DAG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
P2RY8_HUMAN | [view interactions] | High throughput | no | no |
ANPRC_HUMAN | [view interactions] | High throughput | no | no |
KLRB1_HUMAN | [view interactions] | High throughput | no | yes |
S1PR4_HUMAN | [view interactions] | High throughput | no | no |
ZW10_HUMAN | [view interactions] | High throughput | no | yes |
TX1B3_HUMAN | [view interactions] | High throughput | no | no |
CNOT7_HUMAN | [view interactions] | High throughput | no | no |
AGRE5_HUMAN | [view interactions] | High throughput | no | no |
RHBD2_HUMAN | [view interactions] | High throughput | no | yes |
PTPR2_HUMAN | [view interactions] | High throughput | no | yes |
PCBP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EAA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DJB12_HUMAN | [view interactions] | High throughput | no | yes |
DNJC2_HUMAN | [view interactions] | High throughput | no | yes |
BAP31_HUMAN | [view interactions] | High throughput | no | yes |
VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EMC2_HUMAN | [view interactions] | High throughput | no | yes |
TMM43_HUMAN | [view interactions] | High throughput | no | no |
TMM33_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DESP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
DHX9_HUMAN | [view interactions] | High throughput | no | yes |
TMCO1_HUMAN | [view interactions] | High throughput | no | yes |
DTNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBL3_HUMAN | [view interactions] | High throughput | no | yes |
NDUS8_HUMAN | [view interactions] | High throughput | no | yes |
STT3A_HUMAN | [view interactions] | High throughput | no | yes |
IVD_HUMAN | [view interactions] | High throughput | no | yes |
SSRD_HUMAN | [view interactions] | High throughput | no | yes |
TRXR2_HUMAN | [view interactions] | High throughput | no | yes |
SSRG_HUMAN | [view interactions] | High throughput | no | yes |
MIA40_HUMAN | [view interactions] | High throughput | no | yes |
SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MCFD2_HUMAN | [view interactions] | High throughput | no | yes |
SRPRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AL9A1_HUMAN | [view interactions] | High throughput | no | yes |
SOAT1_HUMAN | [view interactions] | High throughput | no | no |
6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AAAT_HUMAN | [view interactions] | High throughput | no | no |
CC50A_HUMAN | [view interactions] | High throughput | no | yes |
SKP1_HUMAN | [view interactions] | High throughput | no | yes |
TOM22_HUMAN | [view interactions] | High throughput | no | yes |
SCD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SAR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RDH11_HUMAN | [view interactions] | High throughput | no | no |
RAGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HACD3_HUMAN | [view interactions] | High throughput | no | yes |
PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRS6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRS7_HUMAN | [view interactions] | High throughput | no | yes |
PSB5_HUMAN | [view interactions] | High throughput | no | yes |
PSB2_HUMAN | [view interactions] | High throughput | no | yes |
PSA7_HUMAN | [view interactions] | High throughput | no | yes |
PSA6_HUMAN | [view interactions] | High throughput | no | yes |
PSA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSA2_HUMAN | [view interactions] | High throughput | no | yes |
PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MLF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MLEC_HUMAN | [view interactions] | High throughput | no | no |
MAGB2_HUMAN | [view interactions] | High throughput | no | no |
EMC1_HUMAN | [view interactions] | High throughput | no | yes |
HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DHB12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FAF2_HUMAN | [view interactions] | High throughput | no | yes |
FADS2_HUMAN | [view interactions] | High throughput | no | yes |
FADS1_HUMAN | [view interactions] | High throughput | no | yes |
IF4G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
DJB11_HUMAN | [view interactions] | High throughput | no | yes |
DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DNJA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DHC24_HUMAN | [view interactions] | High throughput | no | yes |
DEGS1_HUMAN | [view interactions] | High throughput | no | no |
DDX20_HUMAN | [view interactions] | High throughput | no | no |
OST48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CP51A_HUMAN | [view interactions] | High throughput | no | no |
EMC8_HUMAN | [view interactions] | High throughput | no | no |
CHM1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CDN2A_HUMAN | [view interactions] | High throughput | no | yes |
BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AT2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARL1_HUMAN | [view interactions] | High throughput | no | yes |
ARF4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GSTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
G3PT_HUMAN | [view interactions] | High throughput | no | no |
GSTM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GSTM5_HUMAN | [view interactions] | High throughput | no | yes |
GSTM1_HUMAN | [view interactions] | High throughput | no | yes |
TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBB5_HUMAN | [view interactions] | High throughput | no | yes |
RS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SFXN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CMC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LANC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATPA_HUMAN | [view interactions] | High throughput | no | yes |
TBB4A_HUMAN | [view interactions] | High throughput | no | yes |
EF1A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MBP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBB2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTS_HUMAN | [view interactions] | High throughput | no | no |
2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ADT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EPHB1_HUMAN | [view interactions] | Computational | no | no |
EPHB3_HUMAN | [view interactions] | Computational | no | yes |
FBW1B_HUMAN | [view interactions] | Computational | no | yes |
E2AK3_HUMAN | [view interactions] | Computational | no | yes |
DTX2_HUMAN | [view interactions] | Computational | no | yes |
EPHB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NFX1_HUMAN | [view interactions] | Computational | no | yes |
ZN274_HUMAN | [view interactions] | Computational | no | yes |
KAPCG_HUMAN | [view interactions] | Computational | no | no |
SORT_HUMAN | [view interactions] | Computational | no | yes |
ITPR2_HUMAN | [view interactions] | Computational | no | yes |
KAPCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
DTX4_HUMAN | [view interactions] | Computational | no | yes |
ITPR3_HUMAN | [view interactions] | Computational | no | yes |
DTX1_HUMAN | [view interactions] | Computational | no | yes |
CENPR_HUMAN | [view interactions] | Computational | no | yes |
NFIC_HUMAN | [view interactions] | Computational | no | yes |
GNPTA_HUMAN | [view interactions] | Computational | no | yes |
EPHB4_HUMAN | [view interactions] | Computational | no | yes |
YBOX1_HUMAN | [view interactions] | Computational | no | yes |
IDE_HUMAN | [view interactions] | Computational | no | yes |
ANXA2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RB11A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NGF_HUMAN | [view interactions] | Computational | no | no |
SDC3_HUMAN | [view interactions] | Computational | no | yes |
FGFR3_HUMAN | [view interactions] | Computational | no | yes |
CNTN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NRG2_HUMAN | [view interactions] | Computational | no | yes |
KAPCB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GRB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NRG3_HUMAN | [view interactions] | Computational | no | no |
CAD17_HUMAN | [view interactions] | Computational | no | no |
ERBB4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NRG4_HUMAN | [view interactions] | Computational | no | no |
ACES_HUMAN | [view interactions] | Computational | no | no |