Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IDH3B_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
132 Leu Pro Retinitispigmentosa46(RP46) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in IDH3B_HUMAN
GO:0046872 metal ion binding 32.4324 4 yes
GO:0019900 kinase binding 24.3243 4 no
GO:0019901 protein kinase binding 24.3243 5 no
GO:0003723 RNA binding 24.3243 4 no
GO:0051287 NAD binding 18.9189 4 yes
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 13.5135 4 yes
GO:0000287 magnesium ion binding 10.8108 5 yes
GO:0004448 isocitrate dehydrogenase [NAD(P)+] activity 10.8108 5 yes
GO:0004449 isocitrate dehydrogenase (NAD+) activity 8.1081 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in IDH3B_HUMAN
GO:0019752 carboxylic acid metabolic process 45.9459 5 yes
GO:0043436 oxoacid metabolic process 45.9459 4 yes
GO:0060255 regulation of macromolecule metabolic process 29.7297 4 no
GO:0022607 cellular component assembly 29.7297 4 no
GO:0048522 positive regulation of cellular process 27.0270 4 no
GO:0010468 regulation of gene expression 27.0270 5 no
GO:0043648 dicarboxylic acid metabolic process 24.3243 6 yes
GO:0010646 regulation of cell communication 24.3243 4 no
GO:0048523 negative regulation of cellular process 24.3243 4 no
GO:0051171 regulation of nitrogen compound metabolic process 24.3243 4 no
GO:0080090 regulation of primary metabolic process 24.3243 4 no
GO:0031323 regulation of cellular metabolic process 21.6216 4 no
GO:0051128 regulation of cellular component organization 21.6216 4 no
GO:0008104 protein localization 21.6216 4 no
GO:0071310 cellular response to organic substance 21.6216 4 no
GO:1901565 organonitrogen compound catabolic process 21.6216 4 no
GO:0072350 tricarboxylic acid metabolic process 18.9189 6 yes
GO:0006103 2-oxoglutarate metabolic process 16.2162 7 yes
GO:0006102 isocitrate metabolic process 13.5135 5 yes
GO:1902652 secondary alcohol metabolic process 13.5135 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in IDH3B_HUMAN
DOID:0050155 sensory system disease 5.4054 3 yes
DOID:10584 retinitis pigmentosa 5.4054 7 yes
DOID:5614 eye disease 5.4054 4 yes
DOID:8466 retinal degeneration 5.4054 6 yes
DOID:9799 eye degenerative disease 5.4054 5 yes

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
IDH3A_HUMAN [view entry] [view interactions] Low throughput yes yes
IDH3G_HUMAN [view entry] [view interactions] Low throughput yes yes
TECT3_HUMAN [view interactions] High throughput no yes
CNTRL_HUMAN [view interactions] High throughput no yes
CE164_HUMAN [view interactions] High throughput no yes
POC5_HUMAN [view interactions] High throughput no yes
CLPP_HUMAN [view interactions] High throughput no yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
PDK1_HUMAN [view interactions] High throughput no yes
TR61B_HUMAN [view interactions] High throughput no yes
FHI1A_HUMAN [view interactions] High throughput no yes
FHI2B_HUMAN [view interactions] High throughput no yes
MMS19_HUMAN [view interactions] High throughput no yes
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
EGFR_HUMAN [view interactions] High throughput no no
P53_HUMAN [view interactions] High throughput no no
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
CUL7_HUMAN [view interactions] High throughput no yes
ODB2_HUMAN [view entry] [view interactions] High throughput yes yes
GDF3_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
NFAC2_HUMAN [view interactions] High throughput no yes
OXDA_HUMAN [view interactions] High throughput no no
GPDA_HUMAN [view interactions] High throughput no yes
ATX3_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
CDK9_HUMAN [view interactions] High throughput no yes
KC1A_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
HIF1A_HUMAN [view interactions] High throughput no no
BIRC3_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
BRD1_HUMAN [view interactions] High throughput no yes
INS_HUMAN [view interactions] High throughput no no
DDX58_HUMAN [view interactions] High throughput no yes
BAG5_HUMAN [view entry] [view interactions] High throughput yes no
PD1L1_HUMAN [view interactions] High throughput no no
DCX_HUMAN [view entry] [view interactions] High throughput yes yes
CART_HUMAN [view interactions] High throughput no yes
CH3L1_HUMAN [view interactions] High throughput no no
EP300_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
FBX32_HUMAN [view interactions] High throughput no no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
CASP3_HUMAN [view interactions] High throughput no yes
IDHC_HUMAN [view interactions] High throughput no no
IDHP_HUMAN [view entry] [view interactions] High throughput yes yes
TRI14_HUMAN [view interactions] High throughput no yes
AUHM_HUMAN [view entry] [view interactions] High throughput yes yes
GAL3A_HUMAN [view interactions] High throughput no yes
GAL3B_HUMAN [view interactions] High throughput no yes
EFGM_HUMAN [view interactions] High throughput no yes
LEG9_HUMAN [view interactions] High throughput no yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
SYAM_HUMAN [view interactions] High throughput no yes
COX8A_HUMAN [view interactions] High throughput no yes
CISY_HUMAN [view entry] [view interactions] High throughput yes yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
MK06_HUMAN [view interactions] High throughput no yes
OTUB1_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
GRID2_HUMAN [view entry] [view interactions] High throughput yes no
CENPC_HUMAN [view interactions] High throughput no no
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
B2L14_HUMAN [view interactions] High throughput no yes
IRF2_HUMAN [view interactions] High throughput no yes
5NT3A_HUMAN [view interactions] High throughput no yes
TR10A_HUMAN [view interactions] High throughput no no
APBB1_HUMAN [view interactions] High throughput no yes
PHLA3_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
HSC20_HUMAN [view interactions] High throughput no yes
CAV3_HUMAN [view interactions] High throughput no no
AT1B1_HUMAN [view entry] [view interactions] High throughput yes no
ITM2B_HUMAN [view interactions] High throughput no yes
ATX2_HUMAN [view interactions] High throughput no yes
ANM1_HUMAN [view interactions] High throughput no yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
NPHP1_HUMAN [view interactions] High throughput no yes
OFD1_HUMAN [view interactions] High throughput no yes
PCM1_HUMAN [view interactions] High throughput no yes
FTM_HUMAN [view interactions] High throughput no yes
NDUS2_HUMAN [view entry] [view interactions] Computational yes yes
AATM_HUMAN [view entry] [view interactions] Computational yes yes
NDUA9_HUMAN [view entry] [view interactions] Computational yes yes
MPPB_HUMAN [view interactions] Computational no yes
ACOHC_HUMAN [view interactions] Computational no yes
RAB28_HUMAN [view interactions] Computational no yes
ATPG_HUMAN [view interactions] Computational no yes
MDHM_HUMAN [view entry] [view interactions] Computational yes yes
OXLA_HUMAN [view interactions] Computational no no
ALAT1_HUMAN [view interactions] Computational no no
DLDH_HUMAN [view entry] [view interactions] Computational yes yes
NDUV1_HUMAN [view entry] [view interactions] Computational yes yes
AATC2_HUMAN [view interactions] Computational no no
QCR1_HUMAN [view entry] [view interactions] Computational yes yes
SSDH_HUMAN [view entry] [view interactions] Computational yes yes
RIMKB_HUMAN [view interactions] Computational no no
CY1_HUMAN [view entry] [view interactions] Computational yes yes
NIT2_HUMAN [view interactions] Computational no yes
ARLY_HUMAN [view interactions] Computational no no
SDHA_HUMAN [view interactions] Computational no yes
DHE4_HUMAN [view interactions] Computational no yes
DHE3_HUMAN [view entry] [view interactions] Computational yes yes
ATPB_HUMAN [view interactions] Computational no yes
ODO1_HUMAN [view entry] [view interactions] Computational yes yes
AATC_HUMAN [view entry] [view interactions] Computational yes yes
PUR8_HUMAN [view interactions] Computational no yes
ACON_HUMAN [view entry] [view interactions] Computational yes yes
SDHB_HUMAN [view interactions] Computational no yes
OGDHL_HUMAN [view entry] [view interactions] Computational yes yes
ALAT2_HUMAN [view interactions] Computational no yes
SUCA_HUMAN [view entry] [view interactions] Computational yes yes