IDH3B_HUMAN
Evidence for PS localization
Functions
Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 132 | Leu | Pro | Retinitispigmentosa46(RP46) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in IDH3B_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 37.9310 | 4 | no |
| GO:0019901 | protein kinase binding | 37.9310 | 5 | no |
| GO:0000166 | nucleotide binding | 34.4828 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 34.4828 | 5 | yes |
| GO:0043169 | cation binding | 34.4828 | 4 | yes |
| GO:0046872 | metal ion binding | 31.0345 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 27.5862 | 6 | yes |
| GO:0000287 | magnesium ion binding | 24.1379 | 6 | yes |
| GO:0003723 | RNA binding | 24.1379 | 4 | no |
| GO:0043168 | anion binding | 24.1379 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 24.1379 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 24.1379 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 20.6897 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.6897 | 4 | no |
| GO:0004448 | isocitrate dehydrogenase [NAD(P)+] activity | 17.2414 | 5 | yes |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 17.2414 | 4 | yes |
| GO:0051287 | NAD binding | 17.2414 | 7 | yes |
| GO:0004449 | isocitrate dehydrogenase (NAD+) activity | 13.7931 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in IDH3B_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 55.1724 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 51.7241 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 48.2759 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 48.2759 | 4 | no |
| GO:0010468 | regulation of gene expression | 48.2759 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 48.2759 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 48.2759 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 48.2759 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 48.2759 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 44.8276 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 44.8276 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 41.3793 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 41.3793 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 41.3793 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 41.3793 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 37.9310 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 37.9310 | 5 | no |
| GO:0010646 | regulation of cell communication | 37.9310 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 37.9310 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 34.4828 | 5 | no |
| GO:0009966 | regulation of signal transduction | 34.4828 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 34.4828 | 5 | no |
| GO:0023057 | negative regulation of signaling | 34.4828 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 34.4828 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 34.4828 | 4 | yes |
| GO:0006996 | organelle organization | 34.4828 | 4 | no |
| GO:0022607 | cellular component assembly | 34.4828 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 34.4828 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 34.4828 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 34.4828 | 6 | no |
| GO:0051246 | regulation of protein metabolic process | 34.4828 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 31.0345 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 31.0345 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.0345 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 31.0345 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 31.0345 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 31.0345 | 6 | no |
| GO:0071310 | cellular response to organic substance | 31.0345 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 31.0345 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 31.0345 | 7 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 27.5862 | 8 | no |
| GO:0032880 | regulation of protein localization | 27.5862 | 5 | no |
| GO:0051049 | regulation of transport | 27.5862 | 4 | no |
| GO:0060341 | regulation of cellular localization | 27.5862 | 4 | no |
| GO:0008104 | protein localization | 27.5862 | 4 | no |
| GO:0043065 | positive regulation of apoptotic process | 27.5862 | 6 | no |
| GO:0043066 | negative regulation of apoptotic process | 27.5862 | 6 | no |
| GO:0043068 | positive regulation of programmed cell death | 27.5862 | 5 | no |
| GO:0043069 | negative regulation of programmed cell death | 27.5862 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.5862 | 6 | no |
| GO:0009894 | regulation of catabolic process | 24.1379 | 4 | no |
| GO:0031399 | regulation of protein modification process | 24.1379 | 6 | no |
| GO:0045892 | negative regulation of DNA-templated transcription | 24.1379 | 8 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 24.1379 | 5 | no |
| GO:0051253 | negative regulation of RNA metabolic process | 24.1379 | 6 | no |
| GO:1902679 | negative regulation of RNA biosynthetic process | 24.1379 | 7 | no |
| GO:0045893 | positive regulation of DNA-templated transcription | 24.1379 | 8 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 24.1379 | 5 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 24.1379 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.1379 | 5 | no |
| GO:1902680 | positive regulation of RNA biosynthetic process | 24.1379 | 7 | no |
| GO:0033043 | regulation of organelle organization | 24.1379 | 5 | no |
| GO:0043523 | regulation of neuron apoptotic process | 24.1379 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.1379 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.1379 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 24.1379 | 4 | no |
| GO:0071702 | organic substance transport | 24.1379 | 4 | no |
| GO:0071705 | nitrogen compound transport | 24.1379 | 4 | no |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | 24.1379 | 9 | no |
| GO:0023056 | positive regulation of signaling | 20.6897 | 4 | no |
| GO:0031400 | negative regulation of protein modification process | 20.6897 | 7 | no |
| GO:0051050 | positive regulation of transport | 20.6897 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 20.6897 | 6 | no |
| GO:0010243 | response to organonitrogen compound | 20.6897 | 4 | no |
| GO:0071417 | cellular response to organonitrogen compound | 20.6897 | 4 | no |
| GO:1901565 | organonitrogen compound catabolic process | 20.6897 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 20.6897 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 20.6897 | 4 | no |
| GO:0072350 | tricarboxylic acid metabolic process | 20.6897 | 6 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 20.6897 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 20.6897 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.6897 | 4 | no |
| GO:0030162 | regulation of proteolysis | 20.6897 | 6 | no |
| GO:0043933 | protein-containing complex organization | 20.6897 | 4 | no |
| GO:0006102 | isocitrate metabolic process | 17.2414 | 5 | yes |
| GO:1902652 | secondary alcohol metabolic process | 17.2414 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| IDH3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IDH3G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IDH3B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CENPC_HUMAN | [view interactions] | High throughput | no | no |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B2L14_HUMAN | [view interactions] | High throughput | no | yes |
| IRF2_HUMAN | [view interactions] | High throughput | no | yes |
| 5NT3A_HUMAN | [view interactions] | High throughput | no | yes |
| TR10A_HUMAN | [view interactions] | High throughput | no | no |
| APBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHLA3_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ATX2_HUMAN | [view interactions] | High throughput | no | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPHP1_HUMAN | [view interactions] | High throughput | no | yes |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| TECT3_HUMAN | [view interactions] | High throughput | no | yes |
| CNTRL_HUMAN | [view interactions] | High throughput | no | yes |
| CE164_HUMAN | [view interactions] | High throughput | no | yes |
| POC5_HUMAN | [view interactions] | High throughput | no | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| TR61B_HUMAN | [view interactions] | High throughput | no | yes |
| FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| MMS19_HUMAN | [view interactions] | High throughput | no | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| ODB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDF3_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| NFAC2_HUMAN | [view interactions] | High throughput | no | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| GPDA_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| HIF1A_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| DCX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CART_HUMAN | [view interactions] | High throughput | no | yes |
| CH3L1_HUMAN | [view interactions] | High throughput | no | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LATS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| KAT6A_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| CASP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDHC_HUMAN | [view interactions] | High throughput | no | no |
| IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYDC_HUMAN | [view interactions] | High throughput | no | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | no |
| EFGM_HUMAN | [view interactions] | High throughput | no | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYAM_HUMAN | [view interactions] | High throughput | no | yes |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| GRID2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |